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PI3K/Akt/mTOR Signaling

PI3K/Akt/mTOR Signaling

PI3K/Akt/mTOR signaling inhibitors are compounds that target the phosphoinositide 3-kinase (PI3K), Akt kinase, and mammalian target of rapamycin (mTOR) pathways. These pathways are critical regulators of cell growth, survival, metabolism, and autophagy, making them key targets in cancer research and metabolic disorders. Inhibiting these pathways can help to control tumor growth and proliferation, offering potential therapeutic strategies for various cancers and other diseases characterized by dysregulated cell signaling. At CymitQuimica, we offer a comprehensive selection of high-quality PI3K/Akt/mTOR inhibitors to support your research in oncology, cellular signaling, and metabolic diseases.

Subcategories of "PI3K/Akt/mTOR Signaling"

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Found 1025 products of "PI3K/Akt/mTOR Signaling"

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  • CC-115 hydrochloride
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    CC-115 hydrochloride

    CAS:
    CC-115 hydrochloride: potent DNA-PK/mTOR inhibitor; IC50s: 13 nM and 21 nM; blocks mTORC1/C2 pathways.
    Formula:C16H17ClN8O
    Color and Shape:Solid
    Molecular weight:372.82

    Ref: TM-T61505

  • Chrysophanol
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    Chrysophanol

    CAS:
    <p>Chrysophanol (Turkey Rhubarb) is an EGFR/mTOR pathway inhibitor, which can be found in rhubarb, and sorrel.</p>
    Formula:C15H10O4
    Purity:99.44% - 99.91%
    Color and Shape:Physical Description Golden Yellow Plates Or Brown Powder Melting Point 196°C
    Molecular weight:254.24

    Ref: TM-T2995

  • PF-6274484
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    PF-6274484

    CAS:
    PF-6274484 is an EGFR inhibitor with Ki values of 0.14 and 0.18 nM for EGFR-L858R/T790M and WT-EGFR, respectively.
    Formula:C18H14ClFN4O2
    Purity:97.71%
    Color and Shape:Solid
    Molecular weight:372.78

    Ref: TM-T22396

  • NS309
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    NS309

    CAS:
    NS309 activates SK/KCa2, IK/KCa3.1 (0.12-1.2 μM EC50, 10-90 nM EC50), and Kv11.1 channels; doesn't affect BK/KCa1.1; modulates neuronal firing.
    Formula:C8H4Cl2N2O2
    Purity:97.55%
    Color and Shape:Solid
    Molecular weight:231.04

    Ref: TM-T4612

  • TDZD-8
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    TDZD-8

    CAS:
    <p>TDZD-8 (NP 01139) is an inhibitor of GSK-3β, with an IC50 of 2 μM; minimal inhibitory effect observed on CDK1, casein kinase II, PKA and PKC.</p>
    Formula:C10H10N2O2S
    Purity:97.13% - 99.61%
    Color and Shape:White Solid
    Molecular weight:222.26

    Ref: TM-T6187

  • GDC-0326
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    GDC-0326

    CAS:
    <p>GDC-0326 is a potent and selective inhibitor of α-Isoform of Phosphoinositide 3-Kinase (PI3Kalpha inhibitor).</p>
    Formula:C19H22N6O3
    Purity:99.35% - >99.99%
    Color and Shape:Solid
    Molecular weight:382.42

    Ref: TM-T3985

  • Butein
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    Butein

    CAS:
    Butein is a cAMP-specific PDE inhibitor, protein tyrosine kinase inhibitor, and SIRT1 activator.Cost-effective and quality-assured.
    Formula:C15H12O5
    Purity:98.76% - >99.99%
    Color and Shape:Solid
    Molecular weight:272.25

    Ref: TM-T6427

  • G5-7
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    G5-7

    CAS:
    G5-7 is an oral JAK2 inhibitor targeting EGFR/STAT3 phosphorylation with potential for glioma research.
    Formula:C22H19F2NO3
    Purity:97.3%
    Color and Shape:Solid
    Molecular weight:383.39

    Ref: TM-T8742

  • Selective PI3Kδ Inhibitor 1
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    Selective PI3Kδ Inhibitor 1

    CAS:
    <p>Selective PI3Kδ Inhibitor 1 is a PI3Kδ Inhibitor( IC50 = 0.9 nM).</p>
    Formula:C23H20FN7O
    Purity:97.96%
    Color and Shape:Solid
    Molecular weight:429.45

    Ref: TM-T5831

  • AZ7550
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    AZ7550

    CAS:
    <p>AZ7550, an active metabolite of AZD9291, inhibits the activity of IGF1R (IC50: 1.6 μM).</p>
    Formula:C27H31N7O2
    Purity:97.07% - 99.75%
    Color and Shape:Solid
    Molecular weight:485.58

    Ref: TM-T13564

  • KenPaullone
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    KenPaullone

    CAS:
    KenPaullone (9-Bromopaullone), a potent CDK1, CDK2 and CDK5 inhibitor, as new enhancer for iTreg cell differentiation.
    Formula:C16H11BrN2O
    Purity:97.14% - 98.99%
    Color and Shape:Tan Solid
    Molecular weight:327.18

    Ref: TM-T2247

  • ZD-4190
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    ZD-4190

    CAS:
    <p>ZD-4190 blocks VEGFR2 and EGFR, aiding cancer treatment.</p>
    Formula:C19H16BrFN6O2
    Purity:99.12%
    Color and Shape:Solid
    Molecular weight:459.27

    Ref: TM-T5475

  • Osimertinib mesylate
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    Osimertinib mesylate

    CAS:
    <p>Osimertinib mesylate (AZD-9291 mesylate) is an EGFR third-generation inhibitor. Osimertinib mesylate has antitumor activity. Cost-effective and quality-assured.</p>
    Formula:C29H37N7O5S
    Purity:99.46% - >99.99%
    Color and Shape:Solid
    Molecular weight:595.71

    Ref: TM-T3634

  • PKI-166 hydrochloride
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    PKI-166 hydrochloride

    CAS:
    EGFR-kinase inhibitor, IC50 0.7 nM, >3000x selective, cuts metastasis and angiogenesis in mice, antihypertensive, oral use.
    Formula:C20H19ClN4O
    Color and Shape:Solid
    Molecular weight:366.85

    Ref: TM-T36643

  • AR-A014418
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    AR-A014418

    CAS:
    <p>AR-A014418 (GSK 3β inhibitor VIII) is an ATP-competitive, and selective GSK3β inhibitor.</p>
    Formula:C12H12N4O4S
    Purity:>99.99% - ≥95%
    Color and Shape:Solid
    Molecular weight:308.31

    Ref: TM-T1881

  • Cetuximab
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    Cetuximab

    CAS:
    <p>Cetuximab (C225) is a monoclonal antibody that is an inhibitor of human epidermal growth factor receptor (EGFR) (Kd=0.201 nM).</p>
    Formula:C107H179N35O36S7
    Purity:95 - 98.60%
    Color and Shape:Liquid
    Molecular weight:152 kDa

    Ref: TM-T9905

  • HTH-01-015
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    HTH-01-015

    CAS:
    <p>HTH-01-015 is a selective NUAK1 inhibitor (IC50=100 nM).</p>
    Formula:C26H28N8O
    Purity:98.38% - 99.70%
    Color and Shape:Solid
    Molecular weight:468.55

    Ref: TM-T2374

  • TG 100713
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    TG 100713

    CAS:
    <p>TG 100713 is a pan-PI3K inhibitor against PI3Kγ, PI3Kδ, PI3Kα and PI3Kβ with IC50 of 50 nM, 24 nM, 165 nM and 215 nM, respectively.</p>
    Formula:C12H10N6O
    Purity:98.17%
    Color and Shape:Solid
    Molecular weight:254.25

    Ref: TM-T6704

  • Neratinib
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    Neratinib

    CAS:
    Neratinib (HKI-272) (HKI-272) is an orally available, irreversible tyrosine kinase inhibitor for HER2 and EGFR (IC50: 59/92 nM), respectively.
    Formula:C30H29ClN6O3
    Purity:96.17% - 99.85%
    Color and Shape:Solid
    Molecular weight:557.04

    Ref: TM-T2325

  • AG 1406
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    AG 1406

    CAS:
    <p>AG 1406 is a selective inhibitor of the receptor tyrosine kinase VEGF receptor 2.</p>
    Formula:C16H18N2O
    Purity:98.12%
    Color and Shape:Solid
    Molecular weight:254.33

    Ref: TM-T4554