PI3K/Akt/mTOR Signaling
PI3K/Akt/mTOR signaling inhibitors are compounds that target the phosphoinositide 3-kinase (PI3K), Akt kinase, and mammalian target of rapamycin (mTOR) pathways. These pathways are critical regulators of cell growth, survival, metabolism, and autophagy, making them key targets in cancer research and metabolic disorders. Inhibiting these pathways can help to control tumor growth and proliferation, offering potential therapeutic strategies for various cancers and other diseases characterized by dysregulated cell signaling. At CymitQuimica, we offer a comprehensive selection of high-quality PI3K/Akt/mTOR inhibitors to support your research in oncology, cellular signaling, and metabolic diseases.
Subcategories of "PI3K/Akt/mTOR Signaling"
- AMPK(171 products)
- ATM/ATR(72 products)
- DNA-PK(49 products)
- EGFR(590 products)
- MELK(7 products)
- PDK(9 products)
- PI3K(231 products)
- S6 Kinase(7 products)
- gsk-3(110 products)
- mTOR(163 products)
Show 2 more subcategories
Found 1005 products of "PI3K/Akt/mTOR Signaling"
Sort by
Purity (%)
0
100
|
0
|
50
|
90
|
95
|
100
CNX-2006
CAS:CNX-2006 is a novel irreversible mutant-selective EGFR inhibitor with IC50 of < 20 nM, with very weak inhibition at wild-type EGFR.Formula:C26H27F4N7O2Purity:98.85% - 99.16%Color and Shape:SolidMolecular weight:545.53Sapitinib
CAS:Sapitinib (AZD-8931) , a reversible, ATP competitive inhibitor of EGFR(IC50=4 nM), ErbB2(IC50=3 nM) and ErbB3(IC50=4 nM), is more effective over Gefitinib orFormula:C23H25ClFN5O3Purity:98.89% - 99.83%Color and Shape:SolidMolecular weight:473.93Mobocertinib
CAS:Mobocertinib (tak788) is a potent inhibitor of epidermal growth factor receptor (EGFR) and an antineoplastic agentFormula:C32H39N7O4Purity:99.47% - 99.97%Color and Shape:SolidMolecular weight:585.7CUDC-101
CAS:CUDC-101 is a potent inhibitor of HDAC, EGFR and HER2 with IC50s of 4.4, 2.4 and 15.7 nM, respectively.Formula:C24H26N4O4Purity:95.76% - 99.17%Color and Shape:SolidMolecular weight:434.49Afatinib
CAS:<p>Afatinib (BIBW 2992) is an irreversible and orally EGFR family inhibitor that inhibits EGFR and HER2. Afatinib has antitumor activity. Cost effective and quality assured.</p>Formula:C24H25ClFN5O3Purity:98.56% - 99.9%Color and Shape:Off-White SolidMolecular weight:485.94Duvelisib
CAS:Duvelisib (INK1197, IPI-145) is a selective inhibitor of phosphatidylinositol 3-kinase (PI3K) and p100δ.Cost-effective and quality-assured.Formula:C22H17ClN6OPurity:98.87% - 99.74%Color and Shape:SolidMolecular weight:416.86PIK-75
CAS:<p>PIK-75, a DNA-PK and PI3K inhibitor, suppresses DNA-PK(IC50=2 nM), p110α(IC50=5.8 nM) and p110γ(IC50=76 nM).</p>Formula:C16H14BrN5O4SPurity:98.52% - >99.99%Color and Shape:SolidMolecular weight:452.28PD153035
CAS:PD153035 (NSC-669364) hydrochloride is an effective and selective inhibitor of EGFR (Ki/IC50: 5.2/29 pM, in cell-free assays); little inhibitory against FGFR,Formula:C16H14BrN3O2Purity:98.47% - 99.29%Color and Shape:SolidMolecular weight:360.21Acalisib
CAS:Acalisib (CAL-120) (GS-9820) is a potent and selective inhibitor of PI3Kδ.Formula:C21H16FN7OPurity:98.99% - ≥95%Color and Shape:SolidMolecular weight:401.4Nazartinib
CAS:Nazartinib (EGF816) (EGF816, NVS-816) is a covalent, irreversible, mutant-selective EGFR inhibitor that has nanomolar inhibitory potency against activating mt (Formula:C26H31ClN6O2Purity:98.63% - ≥95%Color and Shape:Solid PowderMolecular weight:495.02Ref: TM-T3506
1mg37.00€5mg79.00€10mg119.00€25mg187.00€50mg354.00€100mg528.00€500mg1,159.00€1mL*10mM (DMSO)87.00€HG-9-91-01
CAS:HG-9-91-01 (SIK inhibitor 1) is a potent and highly selective salt-inducible kinase (SIKs) inhibitor with IC50s of 0.92 nM, 6.6 nM and 9.6 nM for SIK1, SIK2 andFormula:C32H37N7O3Purity:96.86% - 99.71%Color and Shape:SolidMolecular weight:567.68Ref: TM-T4599
1mg84.00€5mg137.00€10mg216.00€25mg432.00€50mg605.00€100mg847.00€200mg1,159.00€1mL*10mM (DMSO)187.00€CZC24832
CAS:CZC24832 is a selective inhibitor of PI 3-kinase γ.Formula:C15H17FN6O2SPurity:99.08% - 99.12%Color and Shape:SolidMolecular weight:364.4Ref: TM-T1949
1mg50.00€2mg66.00€5mg97.00€10mg145.00€25mg240.00€50mg356.00€100mg525.00€1mL*10mM (DMSO)110.00€PD-089828
CAS:PD 089828 inhibits FGFR1, PDGFRβ, EGFR (IC50s: 0.15-5.47 μM), and c-Src (IC50: 0.18 μM).Formula:C18H18Cl2N6OPurity:97.39%Color and Shape:SolidMolecular weight:405.28Parsaclisib hydrochloride
CAS:Parsaclisib hydrochloride (INCB050465 HCl) is a selectve PI3Kδ inhibitor with antitumor activity. Parsaclisib demonstrates potent activity.Formula:C20H23Cl2FN6O2Purity:98%Color and Shape:SolidMolecular weight:469.34Gefitinib hydrochloride
CAS:Obtustatin triacetate is an integrin derived from the venom of Vipera lebetina obtusa and is an α1β1 integrin and in vivo angiogenesis inhibitor.Formula:C22H25Cl2FN4O3Purity:99.8%Color and Shape:SolidMolecular weight:483.36RLY-2608
CAS:RLY-2608 is a variant PI3Kalpha inhibitor that inhibits tumor growth in a PIK3CA mutant xenograft model.Formula:C29H14ClF5N6O2Purity:98.62% - 98.7%Color and Shape:SolidMolecular weight:608.91CHIR 98024
CAS:CHIR 98024: strong GSK-3α/β blocker, IC50 0.65/0.58 nM, selective over Cdc2/ERK2.Formula:C20H17Cl2N9O2Purity:99.45%Color and Shape:SolidMolecular weight:486.31Ref: TM-T3074
1mg44.00€2mg55.00€5mg96.00€10mg153.00€25mg298.00€50mg487.00€100mg705.00€1mL*10mM (DMSO)97.00€Cavutilide
CAS:Cavutilide has antiarrhythmic activity, inhibits hERG K(+) channels, and can be used to study heart failure and persistent atrial fibrillation.Formula:C22H26FN3O3Purity:99.82% - 99.85%Color and Shape:SolidMolecular weight:399.458Almonertinib hydrochloride
CAS:Almonertinib hydrochloride (HS-10296 hydrochloride) is a small molecule inhibitor of EGFR-activating mutations and T790M-resistant mutation.Formula:C30H36ClN7O2Purity:98.01% - 98.12%Color and Shape:SolidMolecular weight:562.1Ref: TM-T5675
1mg92.00€5mg185.00€10mg311.00€25mg537.00€50mg753.00€100mg1,026.00€1mL*10mM (DMSO)240.00€Canertinib dihydrochloride
CAS:Canertinib dihydrochloride (PD-183805 dihydrochloride) is the hydrochloride salt of an orally bio-available quinazoline with potential antineoplastic andFormula:C24H27Cl3FN5O3Purity:99.13% - >99.99%Color and Shape:SolidMolecular weight:558.86
