PI3K/Akt/mTOR Signaling
PI3K/Akt/mTOR signaling inhibitors are compounds that target the phosphoinositide 3-kinase (PI3K), Akt kinase, and mammalian target of rapamycin (mTOR) pathways. These pathways are critical regulators of cell growth, survival, metabolism, and autophagy, making them key targets in cancer research and metabolic disorders. Inhibiting these pathways can help to control tumor growth and proliferation, offering potential therapeutic strategies for various cancers and other diseases characterized by dysregulated cell signaling. At CymitQuimica, we offer a comprehensive selection of high-quality PI3K/Akt/mTOR inhibitors to support your research in oncology, cellular signaling, and metabolic diseases.
Subcategories of "PI3K/Akt/mTOR Signaling"
- AMPK(170 products)
- ATM/ATR(72 products)
- DNA-PK(49 products)
- EGFR(561 products)
- MELK(7 products)
- PDK(9 products)
- PI3K(231 products)
- S6 Kinase(6 products)
- gsk-3(110 products)
- mTOR(163 products)
Show 2 more subcategories
Found 977 products of "PI3K/Akt/mTOR Signaling"
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JBJ-09-063 hydrochloride
JBJ-09-063 hydrochloride: targeted EGFR inhibitor, effective for various mutations and TKI-resistant lung cancer models.Formula:C31H30ClFN4O3SColor and Shape:SolidMolecular weight:593.11EGFR-IN-25
CAS:EGFR-IN-25, an efficacious EGFR inhibitor, demonstrates IC50 values of 9 nM for BaF3 cells (EGFR DEL19/T790M/C797S) and 60 nM for A431 cells (WT), respectively.Formula:C34H43N9O2Color and Shape:SolidMolecular weight:609.76PI3K-IN-38
CAS:PI3K-IN-38: oral PI3K inhibitor, IC50 of 0.541 µM, anticancer, anti-inflammatory, halts tumors in vivo.Formula:C20H24N6O2Purity:99.89%Color and Shape:SolidMolecular weight:380.44P-2281
CAS:P-2281 is an mTOR inhibitor with anticancer and anti-inflammatory properties.P-2281 inhibits dextran sulfate sodium (DSS)-induced colitis by suppressing T-cellFormula:C9H8ClN3OPurity:99.98%Color and Shape:SolidMolecular weight:209.63MS 154N
CAS:MS 154N is a negative control for MS 154, binds WT/L858R EGFR tightly (Kd 3-4.3nM), doesn't trigger mutant EGFR degradation.Formula:C47H56ClFN8O8Color and Shape:SolidMolecular weight:915.45PI3K/mTOR Inhibitor-9
CAS:PI3K/mTOR Inhibitor-9 acts on mTOR (38 nM IC50) and PI3Kα/γ (6.6 nM IC50), PI3Kδ (0.8 nM IC50).Formula:C23H27N7O2Color and Shape:SolidMolecular weight:433.51EGFR-IN-2
CAS:EGFR-IN-2 is a oral and mutation-selective EGFR inhibito,NSCLC, with high selectivity for resistant single and double mutant T790M.Formula:C26H33N9O3SPurity:98.52% - 99.79%Color and Shape:SolidMolecular weight:551.66EGFR mutant-IN-2
CAS:EGFR mutant-IN-2 (Compound D51) is an inhibitor of EGFR mutants, specifically targeting EGFR L858R/T790M/C797S and EGFR del19/T790M/C797S mutants with IC50 values of 14 nM and 62 nM, respectively. This compound exhibits favorable pharmacokinetic (PK) parameters, safety properties, in vivo stability, and demonstrates antitumor activity [1].Formula:C27H27F3N6O2SColor and Shape:SolidMolecular weight:556.6PI3K-IN-6
CAS:PI3K-IN-6 is an oral active and highly selective inhibitor of phosphoinositide 3-kinase (PI3K) β/δ(IC50 values of 7.8 nM/5.3 nM , respectively).Formula:C17H14Cl2FN9OPurity:98%Color and Shape:SolidMolecular weight:450.26EGFR-IN-53
CAS:EGFR-IN-53 (Compound 7) is a potent inhibitor of EGFR (IC50 = 8.264 μM) that exhibits cytotoxic activity against cancer cell lines [1].Formula:C14H13N3O2SColor and Shape:SolidMolecular weight:287.34EGFR-IN-54
CAS:EGFR-IN-54 (Compound 3c) is a potent inhibitor of EGFR (IC50: 1.623 μM) and is toxic to cancer cells.Formula:C17H14N4O4S3Color and Shape:SolidMolecular weight:434.51GLPG3970
CAS:GLPG3970, a pioneering inhibitor of SIK2/SIK3, is utilized in the investigation of inflammation and autoimmune diseases.Formula:C25H27F3N4O4Purity:99.60% - >99.99%Color and Shape:SolidMolecular weight:504.5Ref: TM-T73384
1mg63.00€5mg130.00€10mg178.00€25mg356.00€50mg537.00€100mg778.00€1mL*10mM (DMSO)147.00€PP30
CAS:PP30 is an inhibitor of mTORC1 and mTORC2. It is selective within the PI3K family, inhibiting other PI3Ks only at high concentrations.Formula:C18H19N7OSPurity:98%Color and Shape:SolidMolecular weight:381.45BRD1652
CAS:BRD1652 is a highly selective and potent GSK3 inhibitor.Formula:C20H20F3N3OPurity:98%Color and Shape:SolidMolecular weight:375.39JR-AB2-011
CAS:JR-AB2-011: selective mTORC2 inhibitor, IC50 = 0.36μM, blocks Rictor-mTOR, Ki = 0.19μM, cytotoxic in glioblastoma.Formula:C17H14Cl2FN3OSPurity:98.33% - 99.41%Color and Shape:SolidMolecular weight:398.28Ref: TM-T11728
1mg90.00€5mg192.00€10mg326.00€25mg597.00€50mg895.00€100mg1,198.00€1mL*10mM (DMSO)212.00€Limertinib
CAS:Limertinib (ASK120067) is a EGFR tyrosine kinase inhibitor targeting EGFR T790M, applicable for the study of non-small cell lung cancer.
Formula:C29H32ClN7O2Purity:97.44%Color and Shape:SolidMolecular weight:546.06SIC-19
CAS:SIC-19, a SIK2 inhibitor, functions by promoting the degradation of SIK2 protein via the ubiquitination pathway. It inhibits the growth of cancer cells and sensitizes cells, ovarian cancer organoids, and xenograft models to PARP inhibitors (such as Olaparib).Formula:C29H26N4O5S2Color and Shape:SolidMolecular weight:574.67MTX-531
CAS:MTX-531 is a selective inhibitor of EGFR and PI3K with IC50 of 14.7 nM and 1.1-233 nM (PI3Kα, PI3Kβ...), respectively. It also acts as a weak agonist of PPARγ, with an EC50 of 3.4 μM in 293H cells.Formula:C22H20ClN5O2SColor and Shape:SoildMolecular weight:453.94EGFR-IN-67
CAS:EGFR-IN-67 (Compound 7d) is a potent inhibitor of EGFR with anticancer activity (IC 50 = 0.34 μM) [1].Formula:C18H17N3SColor and Shape:SolidMolecular weight:307.41Dihydronarwedine
CAS:Dihydronarwedine is a metabolite of Galanthamine, an inhibitor of glycogen synthase kinase 3β (GSK3β)Formula:C17H21NO3Color and Shape:SolidMolecular weight:287.35
