PI3K/Akt/mTOR Signaling
PI3K/Akt/mTOR signaling inhibitors are compounds that target the phosphoinositide 3-kinase (PI3K), Akt kinase, and mammalian target of rapamycin (mTOR) pathways. These pathways are critical regulators of cell growth, survival, metabolism, and autophagy, making them key targets in cancer research and metabolic disorders. Inhibiting these pathways can help to control tumor growth and proliferation, offering potential therapeutic strategies for various cancers and other diseases characterized by dysregulated cell signaling. At CymitQuimica, we offer a comprehensive selection of high-quality PI3K/Akt/mTOR inhibitors to support your research in oncology, cellular signaling, and metabolic diseases.
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Subcategories of "PI3K/Akt/mTOR Signaling"
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Products of "PI3K/Akt/mTOR Signaling"
Mavelertinib
CAS:1776112-90-3
Mavelertinib (PF-06747775) is an EGFR tyrosine kinase (EGFR TKI) inhibitor that inhibits T790M/L858R and can …
Formula:
C18H22FN9O2
Purity:
100%
Color and Shape:
Solid
Molecular weight:
415.42
Ref: TM-T21322
| 1mg | 66.00 € | ||
| 5mg | 142.00 € | ||
| 10mg | 206.00 € | ||
| 25mg | To inquire | ||
| 50mg | To inquire | ||
| 1mL*10mM (DMSO) | 212.00 € |
Estimated delivery in United States, on Wednesday 4 Dec 2024
740 Y-P
CAS:1236188-16-1
740 Y-P (740YPDGFR) is a potent and cell-permeable activator of PI3K.
Formula:
C141H222N43O39PS3
Purity:
98.3% - 99.87%
Color and Shape:
Solid
Molecular weight:
3270.7
Ref: TM-TQ0003
| 1mg | 97.00 € | ||
| 2mg | 135.00 € | ||
| 5mg | 249.00 € | ||
| 10mg | 368.00 € | ||
| 25mg | 615.00 € | ||
| 50mg | 876.00 € |
Estimated delivery in United States, on Wednesday 4 Dec 2024
EGFR vIII Protein, Human, Recombinant (hFc)
EGFR vIII Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-Fc tag.
Color and Shape:
Liquid
Molecular weight:
90-120 KDa (reducing condition)
Ref: TM-TMPJ-00647
| 1mg | 2,591.00 € | ||
| 10µg | 134.00 € | ||
| 50µg | 391.00 € | ||
| 500µg | 1,803.00 € |
Estimated delivery in United States, on Wednesday 4 Dec 2024
EGFRVIII Protein, Human, Recombinant (His & Avi), Biotinylated
The epidermal growth factor receptor (EGFR) is overexpressed in a variety of human epithelial tumors, …
Color and Shape:
Solid
Molecular weight:
41.6 kDa (predicted). Due to glycosylation, the protein migrates to 60-78 kDa based on Tris-Bis PAGE result.
Ref: TM-TMPK-00692
| 1mg | 5,185.00 € | ||
| 100µg | 802.00 € | ||
| 500µg | 3,098.00 € |
Estimated delivery in United States, on Wednesday 4 Dec 2024
EGFR Protein, Rhesus macaque, Recombinant (His)
EGFR Protein, Rhesus macaque, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag.
Color and Shape:
Liquid
Molecular weight:
69.8 kDa (predicted). Due to glycosylation, the protein migrates to 85-100 kDa based on Tris-Bis PAGE result.
Ref: TM-TMPK-00902
| 1mg | 2,221.00 € | ||
| 100µg | 349.00 € | ||
| 500µg | 1,378.00 € |
Estimated delivery in United States, on Wednesday 4 Dec 2024
Brivanib
CAS:649735-46-6
Brivanib (BMS-540215) is an ATP-competitive inhibitor against VEGFR2 with IC50 of 25 nM, moderate potency …
Formula:
C19H19FN4O3
Purity:
98.87%
Color and Shape:
Solid
Molecular weight:
370.38
Ref: TM-T6036
| 1mg | 46.00 € | ||
| 5mg | 88.00 € | ||
| 10mg | 143.00 € | ||
| 25mg | 256.00 € | ||
| 50mg | 371.00 € | ||
| 100mg | 553.00 € | ||
| 200mg | 804.00 € | ||
| 1mL*10mM (DMSO) | 96.00 € |
Estimated delivery in United States, on Wednesday 4 Dec 2024
EGFR vIII Protein, Human, Recombinant (His)
EGFR vIII Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with C-6xHis tag.
Color and Shape:
Liquid
Molecular weight:
61-75 Kda (reducing condition)
Ref: TM-TMPJ-00648
| 1mg | 2,594.00 € | ||
| 10µg | 134.00 € | ||
| 50µg | 391.00 € | ||
| 500µg | 1,806.00 € |
Estimated delivery in United States, on Wednesday 4 Dec 2024
Neratinib maleate
CAS:915942-22-2
Neratinib maleate is a selective HER2/EGFR inhibitor (IC50: 59/92 nM) used in breast and prostate …
Formula:
C34H33ClN6O7
Purity:
99.64%
Color and Shape:
Solid
Molecular weight:
673.11
Ref: TM-T67385
| 25mg | 47.00 € | ||
| 50mg | 62.00 € | ||
| 100mg | 88.00 € |
Estimated delivery in United States, on Wednesday 4 Dec 2024
AV-412 free base
CAS:451492-95-8
AV-412 free base is an EGFR inhibitor (IC50s: 0.75, 0.79, 0.5, 2.3, 19 nM for …
Formula:
C27H28ClFN6O
Color and Shape:
Solid
Molecular weight:
507
Ref: TM-TQ0293
| 2mg | 71.00 € |
Estimated delivery in United States, on Wednesday 4 Dec 2024
S6K1-IN-DG2
CAS:871340-88-4
S6K1-IN-DG2(S6K1InhibitorDG2) is a potent p70S6K inhibitor with an IC50 value of less than 100 nM.
Formula:
C16H17BrN6O
Purity:
99.25%
Color and Shape:
Solid
Molecular weight:
389.25
Ref: TM-T28652
| 5mg | 96.00 € | ||
| 10mg | 134.00 € | ||
| 25mg | 260.00 € | ||
| 50mg | 391.00 € | ||
| 100mg | 555.00 € |
Estimated delivery in United States, on Wednesday 4 Dec 2024
EGFRVIII Protein, Human, Recombinant (His & Avi)
The epidermal growth factor receptor (EGFR) is overexpressed in a variety of human epithelial tumors, …
Color and Shape:
Solid
Molecular weight:
41.6 kDa (predicted). Due to glycosylation, the protein migrates to 68-80 kDa based on Tris-Bis PAGE result.
Ref: TM-TMPK-00691
| 1mg | 2,955.00 € | ||
| 100µg | 468.00 € | ||
| 500µg | 1,764.00 € |
Estimated delivery in United States, on Wednesday 4 Dec 2024
EGFR Protein, Human, Recombinant (His & Avi), Biotinylated
EGFR Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with …
Color and Shape:
Solid
Molecular weight:
71.5 kDa (predicted). Due to glycosylation, the protein migrates to 90-120 kDa based on Tris-Bis PAGE result.
Ref: TM-TMPK-00427
| 1mg | 5,185.00 € | ||
| 100µg | 802.00 € | ||
| 500µg | 3,098.00 € |
Estimated delivery in United States, on Wednesday 4 Dec 2024
RLY-2608
CAS:2733573-94-7
RLY-2608 is a variant PI3Kalpha inhibitor that inhibits tumor growth in a PIK3CA mutant xenograft …
Formula:
C29H14ClF5N6O2
Purity:
98.7% - 98.96%
Color and Shape:
Liquid
Molecular weight:
608.91
Ref: TM-T81264
| 1mg | 502.00 € | ||
| 5mg | 997.00 € | ||
| 10mg | 1,612.00 € | ||
| 25mg | 2,404.00 € | ||
| 50mg | 3,243.00 € | ||
| 1mL*10mM (DMSO) | 1,331.00 € |
Estimated delivery in United States, on Wednesday 4 Dec 2024
Cavutilide
CAS:1276186-19-6
Cavutilide has antiarrhythmic activity, inhibits hERG K(+) channels, and can be used to study heart …
Formula:
C22H26FN3O3
Purity:
99.26% - 99.70%
Color and Shape:
Liquid
Molecular weight:
399.458
Ref: TM-T61913
| 1mg | 276.00 € | ||
| 5mg | 679.00 € | ||
| 10mg | 928.00 € | ||
| 25mg | 1,430.00 € | ||
| 50mg | 1,862.00 € |
Estimated delivery in United States, on Wednesday 4 Dec 2024
SYR127063
CAS:871026-18-5
SYR127063 (BDBM-92454) (BDBM92454) is a potent and selective HER2 inhibitor, binds to HER2 in a …
Formula:
C23H20ClF3N4O3
Purity:
98.57%
Color and Shape:
Solid
Molecular weight:
492.88
Ref: TM-T34760
| 1mg | 128.00 € | ||
| 5mg | 281.00 € | ||
| 10mg | 423.00 € | ||
| 25mg | 694.00 € | ||
| 50mg | 978.00 € | ||
| 1mL*10mM (DMSO) | 352.00 € |
Estimated delivery in United States, on Tuesday 10 Dec 2024
CP-724714
CAS:383432-38-0
CP-724714 (CP724714) is an effective and selective HER2/ErbB2 inhibitor (IC50: 10 nM), >640-fold selectivity against …
Formula:
C27H27N5O3
Purity:
97.10% - 98.82%
Color and Shape:
Solid
Molecular weight:
469.54
Ref: TM-T4014
| 1mg | 43.00 € | ||
| 2mg | 57.00 € | ||
| 5mg | 94.00 € | ||
| 10mg | 153.00 € | ||
| 25mg | 267.00 € | ||
| 50mg | 445.00 € | ||
| 100mg | 646.00 € | ||
| 1mL*10mM (DMSO) | 89.00 € |
Estimated delivery in United States, on Tuesday 10 Dec 2024
CP21R7
CAS:125314-13-8
CP21 is a specific GSK3β inhibitor, used to activate stem cells for differentiation, often paired …
Formula:
C19H15N3O2
Purity:
96.14% - 98.21%
Color and Shape:
Solid
Molecular weight:
317.34
Ref: TM-T3684
| 1mg | 62.00 € | ||
| 2mg | 84.00 € | ||
| 5mg | 95.00 € | ||
| 10mg | 152.00 € | ||
| 25mg | 267.00 € | ||
| 50mg | 453.00 € | ||
| 100mg | 662.00 € | ||
| 1mL*10mM (DMSO) | 81.00 € |
Estimated delivery in United States, on Tuesday 10 Dec 2024
AZ7550
CAS:1421373-99-0
AZ7550, an active metabolite of AZD9291, inhibits the activity of IGF1R (IC50: 1.6 μM).
Formula:
C27H31N7O2
Purity:
97.07%
Color and Shape:
Solid
Molecular weight:
485.58
Ref: TM-T13564
| 1mg | 129.00 € | ||
| 5mg | 282.00 € | ||
| 10mg | 417.00 € | ||
| 25mg | 689.00 € | ||
| 50mg | 920.00 € | ||
| 100mg | 1,287.00 € |
Estimated delivery in United States, on Tuesday 10 Dec 2024
GNE-477
CAS:1032754-81-6
GNE-477 is a potent and efficacious dual PI3K/mTOR inhibitor.
Formula:
C21H28N8O3S2
Purity:
98.88% - 99.55%
Color and Shape:
Solid
Molecular weight:
504.63
Ref: TM-T3692
| 1mg | 70.00 € | ||
| 5mg | 135.00 € | ||
| 10mg | 224.00 € | ||
| 25mg | 411.00 € | ||
| 50mg | 617.00 € | ||
| 100mg | 862.00 € | ||
| 1mL*10mM (DMSO) | 151.00 € |
Estimated delivery in United States, on Tuesday 10 Dec 2024
O-304
CAS:1261289-04-6
O-304 is a pan-activator of AMP-activated protein kinase (AMPK).
Formula:
C16H11Cl2N3O2S
Purity:
99.80% - ≥98%
Color and Shape:
Solid
Molecular weight:
380.25
Ref: TM-T7362
| 1mg | 66.00 € | ||
| 2mg | 95.00 € | ||
| 5mg | 145.00 € | ||
| 10mg | 217.00 € | ||
| 25mg | 433.00 € | ||
| 50mg | 640.00 € | ||
| 100mg | 910.00 € | ||
| 200mg | 718.00 € | ||
| 500mg | 1,783.00 € | ||
| 1mL*10mM (DMSO) | 160.00 € |
Estimated delivery in United States, on Tuesday 10 Dec 2024
