gsk-3
GSK-3 inhibitors are compounds that target Glycogen Synthase Kinase 3 (GSK-3), an enzyme involved in numerous cellular processes, including glycogen metabolism, gene transcription, and cell proliferation. GSK-3 is implicated in various diseases, such as diabetes, neurodegenerative disorders, and cancer. Inhibitors of GSK-3 are important tools for exploring these pathways and developing potential therapies. At CymitQuimica, we provide GSK-3 inhibitors to support your research in metabolic diseases, neurobiology, and oncology.
Found 112 products of "gsk-3"
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Indazole
CAS:<p>Indazole, a heterocyclic compound, offers diverse biological activities.</p>Formula:C7H6N2Purity:99.59% - 99.85%Color and Shape:White Or Beige Crystalline PowderMolecular weight:118.14BRD0705
CAS:<p>BRD0705: potent, selective GSK3α inhibitor, oral, IC50: 66 nM, 8x more selective than GSK3β.</p>Formula:C20H23N3OPurity:99.01%Color and Shape:SolidMolecular weight:321.42Cyanoacetohydrazide
CAS:<p>Cyanoacetohydrazide (Cyanoacetic hydrazide) is an anti-TB drug. It has also been used to derive compounds that may have antitumor properties.</p>Formula:C3H5N3OPurity:99.78%Color and Shape:Stout Prisms From Alcohol Slightly Brown PowderMolecular weight:99.09GSK-3 inhibitor 4
CAS:<p>Orally active GSK-3 inhibitor 4 targets GSK-3α/β, CDK2/5 (IC50: 0.45-0.68 μM) and may aid in Alzheimer's research by lowering Tau protein.</p>Formula:C22H15F2N5OPurity:99.41%Color and Shape:SoildMolecular weight:403.389-ING-41
CAS:<p>9-ING-41 is a glycogen synthase kinase-3 inhibitor.</p>Formula:C22H13FN2O5Purity:99.32%Color and Shape:SolidMolecular weight:404.35Cromolyn sodium
CAS:<p>Cromolyn sodium (FPL-670) is a chromone complex that acts by inhibiting the release of chemical mediators from sensitized mast cells.</p>Formula:C23H14Na2O11Purity:99.4% - 99.95%Color and Shape:Colorless Crystals From Ethanol + Ether White Crystalline PowderMolecular weight:512.33GSK-3β inhibitor 24
<p>GSK-3β inhibitor24 (Compound 41) is a potent GSK-3β inhibitor with an IC50 of 0.22 nM. It increases GSK-3β phosphorylation at the Ser9 site in a dose-dependent manner and inhibits tau protein hyperphosphorylation by reducing the abundance of p-tau-Ser396. The compound upregulates β-catenin and neurogenesis-related markers (GAP43 and MAP-2), demonstrating significant anti-Alzheimer's disease (AD) activity.</p>Formula:C26H18N4O3Color and Shape:SolidMolecular weight:434.446CHIR-98023
CAS:<p>CHIR-98023 is a bio-active chemical.</p>Formula:C20H16Cl2N8O2Color and Shape:SolidMolecular weight:471.30GSK3β Inhibitor XI
CAS:<p>GSK3β Inhibitor XI has GSK3β inhibitory effect.</p>Formula:C18H15N5O3Color and Shape:SolidMolecular weight:349.35GSK3-IN-4
CAS:<p>GSK3-IN-4 is a GSK-3 inhibitor with IC50 of 0.101-1 μM of GSK-3α and GSK-3β in Calipe Assay.</p>Formula:C18H20N4OPurity:98.33%Color and Shape:SoildMolecular weight:308.38FRATide
CAS:<p>FRATtide inhibits the phosphorylation of Axin and β-catenin, inhibits GSK-3 binding to Axin, and is a peptide derived from the GSK-3 binding protein.</p>Formula:C55H102N2O2Color and Shape:SolidMolecular weight:823.433GSK3β/mTOR modulator 1
<p>GSK3β/mTOR modulator 1 (derivative 2) is an agent that modulates the GSK3β/mTOR signaling pathway. It is applicable in research related to acute lung injury (ALI) and inflammation.</p>Formula:C19H28O5Color and Shape:SolidMolecular weight:336.19367GSK3a-IN-38
CAS:<p>GSK3a-IN-38 is a novel small molecule compound that has inhibitory effects on GSK-3a.</p>Formula:C18H20N4OPurity:99.75%Color and Shape:SoildMolecular weight:308.38GSK-3β inhibitor 21
<p>GSK-3β Inhibitor21 (compound 44) is an ATP-competitive inhibitor of GSK-3β with an IC50 value of 6.06 µM, characterized by its ability to inhibit tau phosphorylation and prevent amyloid protein aggregation. This compound is utilized in the research of Alzheimer's disease.</p>Color and Shape:Odour SolidMeBIO
CAS:<p>MeBIO is an agonist of aryl hydrocarbon receptor, with IC50 of 44 and 55 μM for GSK-3 and CDK1/CyclinB, respectively. MeBIO does not affect GSK-3β.</p>Formula:C17H12BrN3O2Purity:99.64%Color and Shape:SolidMolecular weight:370.2GSK3-IN-1
CAS:<p>GSK3-IN-1 is a GSK3B-glycogen synthase kinase-3 beta inhibitor.</p>Formula:C14H10ClN3OSPurity:99.66%Color and Shape:SolidMolecular weight:303.776-Me-ATP
CAS:<p>6-Me-ATP, a modified ATP, binds well to GSK3 and donates phosphate for GSK3β phosphorylation.</p>Formula:C11H18N5O13P3Color and Shape:SolidMolecular weight:521.21GSK-3β inhibitor 1
CAS:<p>GSK-3β inhibitor 1 is an inhibitor of GSK-3β( IC50 of 4.9 nM) and demonstrates high antidiabetic efficacy.</p>Formula:C14H10N2OPurity:99.40%Color and Shape:SolidMolecular weight:222.242B-(SP)
CAS:<p>Selective phosphopeptide substrate for glycogen synthase kinase-3 (GSK-3)</p>Formula:C71H123N26O29PPurity:98%Color and Shape:SolidMolecular weight:1835.87GSK-3β inhibitor 22
CAS:<p>GSK-3β inhibitor22 (compound 20o) is a GSK-3β inhibitor with an IC50 of 3.1 nM, showing potential for Alzheimer's disease research.</p>Formula:C18H12F3N3O2S2Color and Shape:SolidMolecular weight:423.43GSK-3β inhibitor 14
CAS:<p>GSK-3β inhibitor 14 (1,5-Benzothiazepin-4(5H)-one, 2,3-dihydro-2-methyl-5-(phenylmethyl)-) is a weak GSK-3β inhibitor, IC50﹥ 100μM.</p>Formula:C17H17NOSPurity:99.97%Color and Shape:SolidMolecular weight:283.39GSK3β inhibitor II
CAS:<p>GSK3β inhibitor II is a GSK3β inhibitor. GSK3β inhibitor II exhibits the research potential of Alzheimer's disease (AD).</p>Formula:C14H10IN3OSPurity:99.48%Color and Shape:SolidMolecular weight:395.22GSK-3 inhibitor 3
CAS:<p>GSK-3 inhibitor 3 is a selective, orally active, brain-permeable GSK-3 inhibitor that inhibits GSK-3α and GSK-3β with IC50s of 0.35 nM and 0.25 nM, respectively</p>Formula:C23H15FN6OPurity:99.89%Color and Shape:SoildMolecular weight:410.4GSK-3 Inhibitor 5
CAS:<p>4-Cyanophenacyl bromide, a ketone, used in drug-making and organic synthesis, blocks GSK-3.</p>Formula:C9H6BrNOPurity:99.58%Color and Shape:Off-White To Light Yellow Crystalline PowderMolecular weight:224.05GSK-3β inhibitor 19
<p>GSK-3β Inhibitor 19 (compound 36) is an inhibitor of GSK-3β with an IC50 value of 70 nM. It is applicable in research related to anti-inflammatory and Alzheimer's disease.</p>Formula:C15H12N4O2SColor and Shape:SolidMolecular weight:312.35Kinase Inhibitor Library
<p>A unique collection of 2720 kinase inhibitors/regulators for high throughput screening and high content screening for drug discovery in kinase related diseases;</p>Color and Shape:Odour SolidWnt/β-catenin agonist 2
CAS:<p>Wnt/β-catenin agonist 2 activates Wnt/β-catenin signaling and is an effective Wnt agonist.</p>Formula:C13H12N4O3Purity:99.35%Color and Shape:SolidMolecular weight:272.26BMP agonist 1
<p>BMP Agonist 1 (compound 2 b) is a small-molecule stimulator of bone morphogenic protein (BMP) signaling, crucial for the differentiation of C2C12 cells.</p>Formula:C21H16N2O6Color and Shape:SolidMolecular weight:392.36GSK-3β inhibitor 23
<p>GSK-3β inhibitor23 (Compound 11726169) is an inhibitor of glycogen synthase kinase 3 (GSK-3), effectively inhibiting GSK-3β and GSK-3α with IC50 values of 12.1 nM and 18.8 nM, respectively. It demonstrates antiviral activity against HIV1 and exhibits good metabolic stability in mouse and human liver microsomes and plasma, although it has poor permeability in Caco-2 cells, indicating potentially low oral bioavailability.</p>Formula:C18H13Cl2N5O2SColor and Shape:SolidMolecular weight:434.299Phospho-Glycogen Synthase Peptide-2(substrate)
CAS:<p>Phospho-Glycogen Synthase Peptide-2 is a GSK-3 substrate, useful for serine kinase affinity purification.</p>Formula:C123H191N40O48PColor and Shape:SolidMolecular weight:3029.087Ceftriaxone Sodium
CAS:<p>Ceftriaxone Sodium is a sporotaxin antibiotic that inhibits GSK3β and Aurora B. It is used in the study of sepsis and infective endocarditis.</p>Formula:C18H17N8NaO7S3Color and Shape:SolidMolecular weight:576.562SB 415286
CAS:<p>SB 415286 is a potent GSK3α inhibitor with IC50/Ki of 78 nM/31 nM with equally effective inhibition of GSK-3β.</p>Formula:C16H10ClN3O5Purity:99.55%Color and Shape:SolidMolecular weight:359.72R547
CAS:<p>R547 (Ro 4584820) is a potent ATP-competitive inhibitor of CDK1/2/4 with Ki of 2 nM/3 nM/1 nM.</p>Formula:C18H21F2N5O4SPurity:90% - 99.64%Color and Shape:SolidMolecular weight:441.455-Bromoindole
CAS:<p>5-bromoindole is a potential inhibitor of glycogen synthase kinase 3 (GSK-3)and an important pharmaceutical chemical intermediate</p>Formula:C8H6BrNPurity:99.99%Color and Shape:White To Beige Crystalline PowderMolecular weight:196.04AZD2858
CAS:<p>AZD2858 is a selective GSK-3 inhibitor, inhibiting tau phosphorylation at the S396 site and activating Wnt signaling pathway.</p>Formula:C21H23N7O3SPurity:98% - 99.25%Color and Shape:SolidMolecular weight:453.52PF-04802367
CAS:<p>PF-04802367 is a highly selective GSK-3 inhibitor with an IC50 of 2.1 nM based on a recombinant human GSK-3β enzyme assay and 1.1 nM based on ADP-Glo assay.</p>Formula:C16H16ClN5O3Purity:98.76%Color and Shape:SolidMolecular weight:361.78CHIR-99021
CAS:<p>View and buy CHIR-99021 from TargetMol.CHIR-99021 is a GSK-3α/β inhibitor.Cited in 10 publications.</p>Formula:C22H18Cl2N8Purity:97.94% - ≥95%Color and Shape:SolidMolecular weight:465.34Indirubin-3′-oxime
CAS:<p>Indirubin-3′-oxime is an effective inhibitor of cyclin-dependent protein kinases, and may play an obligate role in neuronal apoptosis in Alzheimer's disease.</p>Formula:C16H11N3O2Purity:98.34%Color and Shape:SolidMolecular weight:277.28TBB
CAS:<p>TBB (NSC-231634)(NSC-231634) is a highly selective, ATP/GTP-competitive inhibitor of casein kinase-2 (CK2).</p>Formula:C6HBr4N3Purity:98.51% - 99.45%Color and Shape:Off-White SolidMolecular weight:434.71GSK3i XIII
CAS:<p>GSK3i XIII (GSK3 inhibitor XIII) is a GSK-3 ATP-binding site inhibitor.</p>Formula:C18H19N5Purity:98.87%Color and Shape:SolidMolecular weight:305.38TDZD-8
CAS:<p>TDZD-8 (NP 01139) is an inhibitor of GSK-3β, with an IC50 of 2 μM; minimal inhibitory effect observed on CDK1, casein kinase II, PKA and PKC.</p>Formula:C10H10N2O2SPurity:97.13% - 99.61%Color and Shape:White SolidMolecular weight:222.26Bisindolylmaleimide I
CAS:<p>Bisindolylmaleimide I (GF109203X) is a potent and highly selective protein kinase C (PKC) inhibitor with a Ki of 14 nM.</p>Formula:C25H24N4O2Purity:98.19% - 98.75%Color and Shape:Orange SolidMolecular weight:412.48SB 216763
CAS:<p>SB 216763 (SB216763) is an effective and specific GSK-3α/β inhibitor (IC50: 34.3 nM).</p>Formula:C19H12Cl2N2O2Purity:98.9% - 99.13%Color and Shape:SolidMolecular weight:371.22CP21R7
CAS:<p>CP21 is a specific GSK3β inhibitor, used to activate stem cells for differentiation, often paired with BMP4 for mesodermal fate.</p>Formula:C19H15N3O2Purity:96.14% - 99.16%Color and Shape:SolidMolecular weight:317.34TWS119
CAS:<p>TWS119 is a GSK-3β inhibitor; capable of inducing neuronal differentiation</p>Formula:C18H14N4O2Purity:98.14% - 99.63%Color and Shape:SolidMolecular weight:318.33Indirubin-3'-monoxime
CAS:<p>Indirubin-3'-monoxime (Indirubin-3'-oxime) is a potent inhibitor of GSK3β (IC50: 22 nM) and also inhibits CDKs ( (IC50s: 100/180/250 nM for Cdk5/p35, Cdk1/</p>Formula:C16H11N3O2Purity:99.55%Color and Shape:Dark Red SolidMolecular weight:277.28GSK 3 Inhibitor IX
CAS:<p>GSK 3 Inhibitor IX (6-BIO) is a selective reversible, ATP-competitive inhibitor of GSK-3α/β and CDK1-cyclinB complex.</p>Formula:C16H10BrN3O2Purity:98% - 99.72%Color and Shape:SolidMolecular weight:356.17KY19382
CAS:<p>KY19382, a dual CXXC5-DVL and GSK3β inhibitor (IC50s: 19/10 nM), boosts Wnt/β-catenin signaling and may help in metabolic disease research.</p>Formula:C17H11Cl2N3O2Purity:98.06%Color and Shape:SolidMolecular weight:360.19IM-12
CAS:<p>IM-12, an effective GSK-3β inhibitor(IC50=53 nM), regulates Wnt signalling.</p>Formula:C22H20FN3O2Purity:99.42% - >99.99%Color and Shape:SolidMolecular weight:377.41Tideglusib
CAS:<p>Tideglusib (NP031112), a non-ATP competitive inhibitor of glycogen synthase kinase 3 (GSK-3), is with anti-inflammatory and neuroprotective activities.</p>Formula:C19H14N2O2SPurity:98.40% - 99.35%Color and Shape:SolidMolecular weight:334.39LY2090314
CAS:<p>LY2090314, a potent GSK-3α/β blocker (IC50: 1.5/0.9 nM), could boost platinum chemo. Tested in leukemia and advanced cancers.</p>Formula:C28H25FN6O3Purity:99.21% - 99.91%Color and Shape:SolidMolecular weight:512.53GS87
CAS:<p>GS87 is a highly specific inhibitor of GSK3 (glycogen synthase kinase 3) that induces extensive differentiation of AML cells.</p>Formula:C16H11N5O2SPurity:98.86%Color and Shape:SolidMolecular weight:337.36AZD1080
CAS:<p>AZD1080 is a selective, orally active, brain permeable GSK3 inhibitor.</p>Formula:C19H18N4O2Purity:97.72% - 99.75%Color and Shape:SolidMolecular weight:334.37BIO-acetoxime
CAS:<p>BIO-acetoxime (GSK-3 Inhibitor X) is a potent dual GSK3α/β inhibitor with IC50 of 10 nM, >240-fold selectivity over CDK5/p25, CDK2/cyclin A and CDK1/cyclin B.</p>Formula:C18H12BrN3O3Purity:97.15%Color and Shape:SolidMolecular weight:398.21Bikinin
CAS:<p>Bikinin (Abrasin), a potent inhibitor of plant GSK-3/Shaggy-like kinase, activates BR signaling downstream of the BR receptor.</p>Formula:C9H9BrN2O3Purity:99.86% - >99.99%Color and Shape:SolidMolecular weight:273.08GSK-3β inhibitor 10
CAS:<p>GSK-3β inhibitor 10 has skin-whitening, anti-oxidizing and PPAR activities.</p>Formula:C12H12N2O3SPurity:98.06%Color and Shape:SolidMolecular weight:264.3RGB-286638 free base
CAS:<p>RGB-286638 free base inhibits CDKs (1-5 nM), weaker on CDK7/6.</p>Formula:C29H35N7O4Purity:98% - 99.91%Color and Shape:SolidMolecular weight:545.63GNF4877
CAS:<p>GNF4877 inhibits DYRK1A/GSK3β (IC50: 6/16 nM), blocks NFATc export, and boosts β-cell growth.</p>Formula:C25H27FN6O4Purity:98.68% - 99.40%Color and Shape:SolidMolecular weight:494.52(E/Z)-GSK-3β inhibitor 1
CAS:<p>(E/Z)-GSK-3β inhibitor 1 is a glycogen synthase kinase 3β (GSK-3β) inhibitor and demonstrates high antidiabetic efficacy.</p>Formula:C14H10N2OPurity:98.60%Color and Shape:SolidMolecular weight:222.247BIO
CAS:<p>7BIO triggers nonapoptotic death, blocks FLT3, DYRK1A/2, Aurora B/C kinases.</p>Formula:C16H10BrN3O2Purity:99.67%Color and Shape:SolidMolecular weight:356.174-Chloro-2'-bromoacetophenone
CAS:<p>4-Chloro-2'-bromoacetophenone against glycogen synthase kinase-3 (GSK-3beta).</p>Formula:C8H6BrClOPurity:98.34% - 99.41%Color and Shape:White To Beige SolidMolecular weight:233.49KenPaullone
CAS:<p>KenPaullone (9-Bromopaullone), a potent CDK1, CDK2 and CDK5 inhibitor, as new enhancer for iTreg cell differentiation.</p>Formula:C16H11BrN2OPurity:97.14% - 98.99%Color and Shape:Tan SolidMolecular weight:327.18VP3.15 dihydrobromide
CAS:<p>VP3.15 dihydrobromide: potent, oral, CNS-penetrant PDE7/GSK3 inhibitor; IC50s: PDE7- 1.59 μM, GSK- 0.88 μM.</p>Formula:C20H24Br2N4OSPurity:99.67% - ≥95%Color and Shape:SolidMolecular weight:528.3CHIR-98014
CAS:<p>CHIR-98014 (CT98014) is a selective GSK3 inhibitor; potentiate insulin activation of glucose transport and utilization in vitro and in vivo.</p>Formula:C20H17Cl2N9O2Purity:97.25% - 99.59%Color and Shape:SolidMolecular weight:486.31ALSTERPAULLONE
CAS:<p>Alsterpaullone is a Cyclin-Dependent Kinase Inhibitor, Mediated Toxicity in HeLa Cells Through Apoptosis-Inducing Effec</p>Formula:C16H11N3O3Purity:99.8%Color and Shape:SolidMolecular weight:293.28AR-A014418
CAS:<p>AR-A014418 (GSK 3β inhibitor VIII) is an ATP-competitive, and selective GSK3β inhibitor.</p>Formula:C12H12N4O4SPurity:>99.99% - ≥95%Color and Shape:SolidMolecular weight:308.31CHIR 98024
CAS:<p>CHIR 98024: strong GSK-3α/β blocker, IC50 0.65/0.58 nM, selective over Cdc2/ERK2.</p>Formula:C20H17Cl2N9O2Purity:96.74%Color and Shape:SolidMolecular weight:486.311-Azakenpaullone
CAS:<p>1-Azakenpaullone (azakenpaullone) is a potent and selective GSK-3β inhibitor with IC50 of 18 nM, >100-fold selectivity over CDK1/cyclin B and CDK5/p25.</p>Formula:C15H10BrN3OPurity:99.73%Color and Shape:Tan SolidMolecular weight:328.16BRD0209
CAS:<p>BRD0209 is a highly selective and potent GSK3 inhibitor.</p>Formula:C22H25N3OPurity:99.92%Color and Shape:SolidMolecular weight:347.45TC-G 24
CAS:<p>GSK-3β inhibitor</p>Formula:C15H11ClN4O3Purity:98%Color and Shape:SolidMolecular weight:330.73Cazpaullone
CAS:<p>Cazpaullone inhibits GSK-3 and briefly boosts Pax4 mRNA expression.</p>Formula:C16H10N4OColor and Shape:SolidMolecular weight:274.28VP3.15
CAS:<p>VP3.15 is an orally bioavailable and CNS-penetrant dual inhibitor of phosphodiesterase (PDE)7- GSK3 (IC50s: 1.59 μM and 0.88 μM for PDE7 and GSK-3).</p>Formula:C20H22N4OSPurity:98%Color and Shape:SolidMolecular weight:366.48BRD1652
CAS:<p>BRD1652 is a highly selective and potent GSK3 inhibitor.</p>Formula:C20H20F3N3OPurity:98%Color and Shape:SolidMolecular weight:375.39ZDWX-25
CAS:<p>ZDWX-25, a strong GSK-3β & DYRK1A inhibitor, kills SH-SY5Y/HL-7702 cells, may aid Alzheimer's research; IC50: 71 nM for GSK-3β.</p>Formula:C17H15N3O3Color and Shape:SolidMolecular weight:309.32PfGSK3/PfPK6-IN-2
CAS:<p>PfGSK3/PfPK6-IN-2 inhibits Plasmodium falciparum GSK3/PK6 (IC50: 172 nM/11 nM) for Malaria research.</p>Formula:C24H25Cl2N5OSColor and Shape:SolidMolecular weight:502.46PIMPC
CAS:<p>PIMPC, a compound endowed with antioxidant and metal-chelating properties, acts as a novel inhibitor of glycogen synthase kinase 3 (GSK-3), and exhibits</p>Formula:C21H19N5OPurity:98%Color and Shape:SolidMolecular weight:357.413F8
CAS:<p>3F8 is a selective GSK-3β inhibitor that can be used as a new tool and potential therapeutic candidate compound for GSK3-related diseases, and can be used in</p>Formula:C15H14N2O4Purity:98.14% - 98.25%Color and Shape:SolidMolecular weight:286.28TCS 2002
CAS:<p>GSK-3β inhibitor 9b: potent, selective, oral, IC50=35 nM, good pharmacokinetics, BBB-permeable, researched for Alzheimer's.</p>Formula:C18H14N2O3SColor and Shape:SolidMolecular weight:338.38GSK-3β inhibitor 12
CAS:<p>GSK-3β inhibitor 12 is a selective GSK-3β inhibitor.GSK-3β inhibitor 12 inhibits 49.11% of 25 μM GSK-3β activity and 37.11% of 50 μM GSK-3β activity.GSK-3β</p>Formula:C14H13N3OSPurity:98.58%Color and Shape:SolidMolecular weight:271.34Aloisine B
CAS:<p>Aloisine B (AloisineB) inhibited cyclin-dependent kinase and glycogen synthase kinase with IC50 values of 0.85 µM and 0.75 µM, respectively.</p>Formula:C15H14ClN3Purity:95.15%Color and Shape:SolidMolecular weight:271.74GSK3-IN-2
CAS:<p>GSK3-IN-2 is a potent GSK3 inhibitor for the treatment of diabetes and neurodegenerative diseases.</p>Formula:C17H19N3OSPurity:98.8%Color and Shape:SolidMolecular weight:313.42BRD3731
CAS:<p>BRD3731 selectively inhibits GSK3β with IC50 of 15 nM; it's promising for PTSD, psychiatric issues, diabetes, and neurodegeneration.</p>Formula:C24H31N3OColor and Shape:SolidMolecular weight:377.5218BIOder
CAS:<p>18BIOder is a neuroprotective inhibitor of GSK-3β, highly selectively inhibiting HIV-1. It is the second generation derivative of 6BIO.</p>Formula:C9H7ClN2O2Purity:98%Color and Shape:SolidMolecular weight:210.62MRT80
CAS:<p>MRT80 is an inhibitor of GSK-3 in vitro. MRT80 de-stabilizes MDM2 and stabilizes p53 protein and E2F-1.</p>Formula:C15H15N5OPurity:98%Color and Shape:SolidMolecular weight:281.31DIF-3
CAS:<p>DIF-3 activates GSK-3β, degrades cyclin D1/c-Myc, and inhibits Wnt/β-catenin in DLD-1 cells, curbing HeLa cell proliferation.</p>Formula:C13H17ClO4Purity:99.57%Color and Shape:SolidMolecular weight:272.72EHT 1610
CAS:<p>EHT 1610 (EHT 5372) is a potent inhibitor of DYRK, with an IC50 of 0.36 nM and 0.59 nM for DYRK1A and DYRK1B, respectively.</p>Formula:C18H14FN5O2SPurity:98.59%Color and Shape:SolidMolecular weight:383.4ARN25068
CAS:<p>ARN25068 inhibits GSK-3β, FYN, DYRK1A kinases; acts in sub-micromolar range; combats tau hyperphosphorylation.</p>Formula:C19H18N6SPurity:99.75%Color and Shape:SolidMolecular weight:362.45GSK-3β inhibitor 2
CAS:<p>GSK-3β inhibitor 2 (5-Thiazolecarboxamide,2-[2-[(cyclopropylcarbonyl)amino]-4-pyridinyl]-4-methoxy-) is a BBB-crossing and selective inhibitor of GSK-3β (IC50</p>Formula:C14H14N4O3SPurity:99.08%Color and Shape:SolidMolecular weight:318.35BIP-135
CAS:<p>BIP-135 is a potent and selective ATP-competitive GSK-3 inhibitor.</p>Formula:C21H13BrN2O3Purity:99.93%Color and Shape:SolidMolecular weight:421.24GSK-3 Inhibitor XIII
CAS:<p>GSK-3 InhibitorXIII, an ATP-competitive GSK-3 inhibitor (Ki: 24 nM), can be used to study diabetes and obesity.</p>Formula:C18H15N5Purity:99.85% - 99.86%Color and Shape:SolidMolecular weight:301.35ABC1183
CAS:<p>ABC1183, an oral diaminothiazole, inhibits GSK3α/β, CDK9, hinders cancer cell growth, induces G2/M arrest, and modulates phosphorylation.</p>Formula:C18H14N4OSPurity:98.92%Color and Shape:SolidMolecular weight:334.39GSK-3β inhibitor 11
CAS:<p>GSK-3β inhibitor 11 (compound 21) is a potent inhibitor of glycogen synthase kinase-3β (GSK-3β) with an inhibitory concentration (IC50) of 10.02 μM.</p>Formula:C20H15N3O4SPurity:97.33%Color and Shape:SolidMolecular weight:393.42BRD5648
CAS:<p>BRD5648 ((R)-BRD0705) is an inactive (R)-enantiomer of BRD0705.</p>Formula:C20H23N3OPurity:99.89%Color and Shape:SolidMolecular weight:321.42PT-65
CAS:<p>PT-65, a potent and selective GSK3 degrader, demonstrates the highest degradation capacity for GSK3α (DC50 = 28.3 nM) and GSK3β (DC50 = 34.2 nM) in SH-SY5Y cells, making it applicable for Alzheimer's disease research [1].</p>Formula:C51H63N13O12SColor and Shape:SolidMolecular weight:1082.19Antitrypanosomal agent 14
CAS:<p>Antitrypanosomal agent 14 (Compound 1), a potent T.</p>Formula:C14H23N3OSPurity:98%Color and Shape:SolidMolecular weight:281.42SAR502250
CAS:<p>SAR502250: potent, selective GSK3 inhibitor, IC50=12nM, oral, brain-penetrant, potential for AD research, antidepressant-like properties.</p>Formula:C19H18FN5O2Color and Shape:SolidMolecular weight:367.38GSK-3β inhibitor 8
CAS:<p>GSK-3β inhibitor 8 (GSK3β Inhibitor XVIII) is a potent and selective GSK-3β inhibitor with an IC50 value of 64 nM.GSK-3β inhibitor 8 is a thienopyrimidine</p>Formula:C20H20ClN5OSPurity:98.46%Color and Shape:SolidMolecular weight:413.92(Rac)-BRD0705
CAS:<p>(Rac)-BRD0705 is a less active racemate of BRD0705. BRD0705 is an effective and selective inhibitor of GSK3α.</p>Formula:C20H23N3OPurity:99.7%Color and Shape:SolidMolecular weight:321.42A 1070722
CAS:<p>A 1070722: potent GSK-3 inhibitor, Ki = 0.6 nM for both α/β isoforms, crosses BBB, potential brain GSK-3 PET radiotracer.</p>Formula:C17H13F3N4O2Purity:99.9%Color and Shape:SolidMolecular weight:362.31TCS 21311
CAS:<p>TCS 21311 (NIBR3049) selectively inhibits JAK3 (IC50: 8 nM) and PKCα/θ & GSK3β; >100x selective over JAK1, JAK2, TYK2.</p>Formula:C27H25F3N4O4Purity:99.39% - ≥98%Color and Shape:SolidMolecular weight:526.51
