Oligosaccharides

<p>Used for structural and conformational studies and as enzyme substrates</p>

<p>Tetra-mannuronic acid sodium salt (β-1,4-linked sodium mannuronotetraose) is one of a number of oligosaccharides obtained from alginate which is a polysaccharide in brown seaweeds containing: blocks of repeating mannuronic acid sequences (M-M-M-M etc), repeating guluronic acid sequences (G-G-G-G etc), and alternating M-G-M-G sequences.  Oligosaccharides can be released using several methods (Lua, 2015; Yanga, 2004) and claims have been published that mannuronic acid oligosaccharides for example, can be effective in the prophylaxis and treatment of Alzheimer's disease, or for the prophylaxis and treatment of diabetes (USP 8835403B2, 2014).</p>

<p>NGA3B N-Glycan is a high purity, custom synthesis, methylation and fluorination modification of the product. This product is an oligosaccharide that is composed of saccharides and sugars. It has a CAS No. 1620146-04-4.</p>

<p>3'-Sulfated Lewis A sodium salt is a synthetic oligosaccharide that is used as an antigen for the diagnosis of pancreatic cancer. It is conjugated to a monoclonal antibody and binds to the Lewis A epitope on the surface of cells. 3'-Sulfated Lewis A sodium salt has been shown to be useful in bladder cancer, where it can be used as a marker for tumorigenicity. It has also been shown to stimulate selectins and increase sugar residues on cell surfaces, which may lead to increased tumor growth.</p>

<p>This compound has been used in the study of cellulase kinetics</p>

<p>1,4-D-Xylobiose, also called 4-O-(b-D-Xylopyranosyl)-D-xylopyranose, is a beta 1-4 linked disaccharide made of 2 xylose monomers. 1,4-D-Xylobiose is a low-calories sweetener that can be used as an alternative or additive to sucrose. Supplementing a high fat diet with 1,4-D-xylobiose has been shown to prevent and treat obesity in mice.</p>

<p>Glycoside of Sialyl Lewis X</p>

<p>Acetyl 2-acetamido-4-O-acetyl-6-O-benzoyl-2-deoxy-3-O-(2,3,4,6-tetra-O-benzoyl bDgalactopyranosyl)-aDthiogalactopyranoside is a modification of the natural carbohydrate. It is manufactured through a custom synthesis and has high purity with an Oligosaccharide content of 99% by weight. This product is an acetylated glycoside that is made from a monosaccharide and methylated with a fluorine atom. Acetyl 2-acetamido 4 O acetyl 6 O benzoyl 2 deoxy 3 O (2,3,4,6 tetra O benzoyl b D galactopyranosyl) a D thiogalactopyranoside is used in the synthesis of complex carbohydrates.</p>

<p>Di-guluronic acid sodium (DGA) is a custom synthesis of an oligosaccharide that has been modified with methylation and glycosylation. It can be used in the production of Oligosaccharides, which are complex carbohydrates. DGA is synthesized by a process called Click chemistry, which includes a modification called fluorination. DGA is also a polysaccharide and a sugar, as well as being high purity and having high molecular weight.</p>

<p>α 1,4-glucoheptasaccharide derived from starch by hydrolysis and chromatography</p>

<p>2-(2,3,6-Tri-O-acetyl-4-O-[(2,3,4,6-tetra-O-acetyl-a-D-glucopyranosyl)]-b-D-glucopyranosyl) thiopseudourea is a glycosylated oligosaccharide that has been modified using methylation and click chemistry. This compound has been used in the synthesis of various complex carbohydrates. The CAS number for this compound is 905835-79-8 and it can be custom synthesized to meet your needs.</p>

<p>Tetra-guluronic acid sodium salt (1,4-linked α-L-sodium guluronotetraose) is one of a number of oligosaccharides obtained from alginate, a polysaccharide from brown seaweeds. It contains blocks of: repeating mannuronic acid sequences (M-M-M-M etc), repeating guluronic acid sequences (G-G-G-G etc), and alternating M-G-M-G sequences. This oligosaccharide can be released by acid hydrolysis and a number of biological activities have been discussed in a recent review.</p>

<p>Heparin disaccharide III-A is a synthetic heparin that is modified with the addition of a sugar molecule. Heparin disaccharide III-A disodium salt (HDS) is a high purity, custom synthesized product and has been fluorinated to improve its stability. HDS has been shown to be an effective inhibitor of glycosylation in bacteria cells, leading to decreased production of bacterial enzymes and proteins. It also inhibits protein synthesis by preventing the methylation of ribosomes and reducing the number of saccharides available for glycosylation. The HDS molecule is composed of two sugars: N-acetylglucosamine and D-glucuronic acid. This compound also has anti-inflammatory properties due to its ability to inhibit prostaglandin synthesis.</p>

<p>Man-8D1D3 N-Glycan is a custom synthesis carbohydrate that is used as a structural component in polysaccharides and glycoproteins. This compound is used for the modification of saccharides, methylation, glycosylation, and click chemistry. The purity of this substance is high and it has been fluorinated for synthetic purposes.</p>

<p>a1,3-Galactobiosyl b-methyl glycoside is a fluorinated saccharide that possesses the same chemical structure as N-acetylgalactosamine. It has been synthesized by click modification with methyl iodide and methyl bromoacetate. The synthesis of this compound was achieved by glycosylation of galactose with 1,3-diiodo-2,2'-bithiopropane followed by methylation of the resulting glycosylation product with methyl bromoacetate to form the desired compound. This carbohydrate can be used in a variety of applications including anti-inflammatory drugs, antibiotics, and cancer treatments.</p>

<p>Please enquire for more information about Galacturonan oligosaccharide DP7 sodium, 40% HPAEC-PAD including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>GD2 (shown as sodium salt) has a core trisaccharide structure (GalNAc-b-1,4-Gal-b-1,4-Glc) with its two sialic acids linked b-2,3/b-2,8 to the inner galactose residue and ceramide linked to position 1 on the reducing terminal glucose residue. GD2 ganglioside is expressed at a low concentration in the central nervous system, nerves, skin melanocytes and stem cells in healthy adults. On the other hand, GD2 is overexpressed in a number of tumors, including: neuroblastoma, melanoma, small cell lung carcinoma and brain tumors. Recently, it has been found in low concentrations on breast cancer stem cells (CSC) that possess: self-renewal properties (division without disrupting the undifferentiated state), and tumor-initiating capabilities.  It has been suggested that GD2 ganglioside may be developed as an effective target antigen for CSC immunotherapy (Fleurence, 2017).</p>

<p>Mixed DP 7/8 Na galacturonans (α-1,4 galacturonoheptoses and octaoses), are derived from pectin or pectic acid, by enzymatic or partial acid hydrolysis. They are used in galacturonic acid metabolism research as a substrate to identify, differentiate, and characterized endo- and exopolygalacturonase(s), and gluconase(s). The addition of very short fragments of homogalacturonan oligosaccharides, restores development in dark-grown, de-etiolated seedling mutants, suggesting that they are unable to generate de-methylesterified pectin fragments. A model of spatiotemporally separated photoreceptive and signal-responsive cell types has been proposed, that contains overlapping subsets of the regulatory network of light-dependent seedling development.</p>

<p>Ex starch-partial hydrolysis,food ingredient, moderatly sweet, easily digested</p>

<p>Useful starting point and intermediate in the synthesis of lacto-oligosaccharides</p>