Organometallic Ligands
In this category, you will be able to find a large number of organometallic molecules used as ligands in biomolecules. These organometallic ligands can be used in organic chemistry and synthesis in the laboratory. They play a critical role in forming coordination complexes and catalyzing various chemical reactions. At CymitQuimica, we offer a diverse selection of high-quality organometallic ligands to support your research and industrial needs.
Subcategories of "Organometallic Ligands"
- Buchwald Ligands(22 products)
- DPEN(4 products)
- DPHEN(4 products)
- JOSIPHOS(4 products)
- Phosphine(497 products)
- Porphirines(75 products)
Found 2889 products of "Organometallic Ligands"
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H 151
CAS:A potent inhibitor of STING protein (stimulator of interferon genes), a protein that partakes in intracellular DNA sensing pathway. H 151 blocks palmitoylation of STING, which is required for the formation of multimeric complexes for recruiting downstream signalling molecules. Inhibition of STING by H 151 reduces pro-inflammatory cytokine synthesis.Formula:C17H17N3OPurity:Min. 95%Color and Shape:SolidMolecular weight:279.34 g/molLafutidine
CAS:Histamine (H2) receptor antagonist; treats ulcers and acid refluxFormula:C22H29N3O4SPurity:Min. 95%Molecular weight:431.55 g/molPonalrestat
CAS:Ponalrestat is an aldose reductase inhibitor, which is a synthetic compound developed for pharmacological purposes. It originates from chemical synthesis designed to target and inhibit the enzyme aldose reductase effectively. The mode of action involves the competitive inhibition of aldose reductase, an enzyme involved in the polyol pathway of glucose metabolism. By preventing the reduction of glucose to sorbitol, it reduces sorbitol accumulation associated with diabetic complications.Formula:C17H12BrFN2O3Purity:Min. 98 Area-%Color and Shape:PowderMolecular weight:391.19 g/molBenazepril HCl - Bio-X ™
CAS:Benazepril is a nonsteroidal anti-inflammatory drug that can be used to treat hypertension, heart failure and renal failure. It is an angiotensin-converting enzyme (ACE) inhibitor that blocks the conversion of angiotensin I to angiotensin II. This inhibition prevents the vasoconstrictive effects of this peptide, which are mediated through activation of the renin-angiotensin system.Formula:C24H28N2O5•HClPurity:Min. 95%Color and Shape:PowderMolecular weight:460.95 g/molNilotinib HCl monohydrate - Bio-X ™
CAS:Nilotinib is a kinase inhibitor that is used for the treatment of Chronic Myeloid Leukemia (CML). This drug is also used for the treatment of CML that is resistant to imatinib. Nilotinib inhibits the tyrosine kinase activity of the BCR-ABL protein. It also inhibits PDGFR and c-kit.
Formula:C28H22F3N7O•HCl•H2OPurity:Min. 95%Color and Shape:PowderMolecular weight:583.99 g/molAG 221
CAS:Inhibitor of isocitrate dehydrogenase 2Formula:C19H17F6N7OPurity:Min. 95%Color and Shape:PowderMolecular weight:473.38 g/molCandesartan - Bio-X ™
CAS:Candesartan is a drug that belongs to the class of angiotensin II receptor antagonists and is used to treat hypertension. It is used in combination therapy with other drugs, such as hydrochlorothiazide and amlodipine, to lower blood pressure. Candesartan inhibits the formation of angiotensin II, the receptor which causes vasoconstriction and increased blood pressure.
Formula:C24H20N6O3Purity:Min. 95%Color and Shape:PowderMolecular weight:440.45 g/molIdelalisib
CAS:Idelalisib is a pharmaceutical drug that functions as a PI3Kδ inhibitor, developed through synthetic chemical processes. Its mode of action involves selectively targeting and inhibiting phosphatidylinositol 3-kinase delta (PI3Kδ), a lipid kinase that plays a crucial role in the signaling pathways responsible for cell proliferation, survival, and differentiation. By inhibiting this enzyme, Idelalisib effectively impedes pathways that are often hyperactivated in certain hematologic malignancies, thereby exerting antitumor effects.Formula:C22H18FN7OPurity:Min. 95%Color and Shape:PowderMolecular weight:415.42 g/molCytochalasin D
CAS:Inhibits actin polymerizationFormula:C30H37NO6Purity:Min. 95%Color and Shape:PowderMolecular weight:507.62 g/molLY 2886721
CAS:Inhibitor of BACE1 proteaseFormula:C18H16F2N4O2SPurity:Min. 98 Area-%Color and Shape:PowderMolecular weight:390.41 g/molPF 06409577
CAS:Potent agonist of a1β1γ1 5′-adenosine monophosphate-activated protein kinase (AMPK). It binds to the allosteric drug and metabolite (ADaM) site at the α- and β- subunit interface of AMPK. It has potential for the treatment of diabetic nephropathy. PF 06409577 reduces infections caused by flaviviruses, mediated by changes in the metabolism of lipids in host cells.
Formula:C19H16ClNO3Purity:Min. 95%Color and Shape:White/Off-White SolidMolecular weight:341.79 g/molCYT 387
CAS:Inhibits JAK1 and JAK2 kinasesFormula:C23H22N6O2Purity:Min. 95%Color and Shape:PowderMolecular weight:414.46 g/molRoflumilast - Bio-X ™
CAS:Roflumilast is a selective phosphodiesterase-4 inhibitor that is used for the treatment of exacerbations in patients with chronic obstructive pulmonary disease (COPD). It is also used to treat plaque psoriasis. This drug has anti-inflammatory and immunomodulatory effects as it aids in increasing levels of cAMP.
Formula:C17H14Cl2F2N2O3Purity:Min. 95%Color and Shape:PowderMolecular weight:403.21 g/molIsradipine
CAS:L-type calcium channel blockerFormula:C19H21N3O5Purity:Min. 95%Color and Shape:Yellow PowderMolecular weight:371.39 g/molAZD-7648
CAS:AZD-7648 is a selective inhibitor of DNA-dependent protein kinase (DNA-PK), which is a pivotal enzyme involved in the non-homologous end joining (NHEJ) pathway of DNA repair. This product is derived from extensive chemical synthesis and optimization, designed for its specificity and efficacy in inhibiting DNA-PK activity. The mode of action involves binding to the ATP-binding site of DNA-PK, thereby obstructing its ability to facilitate the repair of double-strand DNA breaks.Formula:C18H20N8O2Purity:Min. 98 Area-%Color and Shape:PowderMolecular weight:380.4 g/molMitoxantrone hydrochloride
CAS:Inhibits DNA topoisomerase II; antineoplastic; immunomodulatory; antimicrobialFormula:C22H30Cl2N4O6Purity:Min. 97 Area-%Color and Shape:Dark Blue SolidMolecular weight:517.4 g/molPadsevonil
CAS:Padsevonil is an investigational antiseizure medication, which is a synthetic pharmaceutical compound. It is derived from extensive medicinal chemistry research aiming to address complex seizure disorders resistant to conventional treatments. Padsevonil functions by exhibiting a dual mechanism of action. It binds to synaptic vesicle protein 2A (SV2A) with high affinity, similar to levetiracetam but with additional modulation of the benzodiazepine-sensitive gamma-aminobutyric acid-A (GABA-A) receptor. This combined activity potentiates its efficacy in stabilizing neuronal hyperactivity and dampening excitatory neurotransmission, providing a novel angle to tackle refractory seizures.Formula:C14H14ClF5N4O2SPurity:Min. 95%Molecular weight:432.8 g/molToceranib phosphate - Bio-X ™
CAS:Controlled ProductToceranib phosphate is a receptor tyrosine kinase inhibitor. Toceranib phosphate has been shown to be effective in the treatment of skin cancer and other types of cancer, including lung cancer and breast cancer. It is approved in the US as a treatment for canine mastocytoma (mast cell tumours).Formula:C22H25FN4O2·H3O4PPurity:Min. 95%Color and Shape:PowderMolecular weight:494.45 g/molFG 7142
CAS:Partial inverse agonist of benzodiazepine sites of the GABAA receptors with anxiogenic properties. FG 7142 is a pharmacological stressor which generates anxiety in humans and in experimental animals such as rhesus monkeys and rodents. FG 7142 also reduces food intake and frequency of feeding in male and female rats.Formula:C13H11N3OPurity:Min. 95%Color and Shape:Yellow PowderMolecular weight:225.25 g/molDilevalol hydrochloride
CAS:Controlled ProductBeta-adrenoceptor antagonist; anti-hypertensiveFormula:C19H24N2O3·HClPurity:Min. 95%Color and Shape:SolidMolecular weight:364.87Bafilomycin A1
CAS:Inhibitor of vacuolar-type proton pumpFormula:C35H58O9Purity:Min. 95 Area-%Color and Shape:White PowderMolecular weight:622.83 g/mol8-Deschloro-8-bromo-N-methyl desloratadine
CAS:Antagonist of platelet activating factorFormula:C20H21BrN2Purity:Min. 95%Color and Shape:PowderMolecular weight:369.3 g/molRolapitant hydrochloride monohydrate
CAS:Neurokinin-1 (NK-1) receptor antagonistFormula:C25H27ClF6N2O2·H2OPurity:Min. 95%Color and Shape:White To Off-White SolidMolecular weight:554.95 g/molMianserin HCl - Bio-X ™
CAS:Controlled ProductMianserin is a tetracyclic antidepressant drug that has antihistaminic and hypnosedative properties. It is used to treat depression in adults and children, as well as other disorders such as chronic pain and irritable bowel syndrome. This drug’s mechanism of action is not fully understood but is said to block alpha-adrenergic, histamine H1 and serotonin receptors.Formula:C18H20N2•HClPurity:Min. 95%Color and Shape:PowderMolecular weight:300.83 g/molIndomethacin - Bio-X ™
CAS:Indomethacin is a nonsteroidal anti-inflammatory drug that inhibits the production of prostaglandin PGE2. It is used to treat pain, fever, and inflammation. Indomethacin's mechanism of action is not well understood, but it may be due to interference with the ability of PMNs to bind to the surface of bacteria or to release reactive oxygen species. The drug has been shown to reduce mitochondrial membrane potential in mammalian cells, leading to apoptosis. This effect on mitochondria may also contribute to Indomethacin's anti-inflammatory effects. Indomethacin is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready-to-use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.Formula:C19H16ClNO4Purity:(%) Min. 95%Color and Shape:PowderMolecular weight:357.79 g/molDMAT
CAS:Inhibitor of protein kinase CK2
Formula:C9H7Br4N3Purity:Min. 95%Color and Shape:White PowderMolecular weight:476.79 g/molTriptolide
CAS:Inhibits RNAPII-mediated trasncription; immunosuppressant; anti-inflammatoryFormula:C20H24O6Purity:Min. 97 Area-%Color and Shape:PowderMolecular weight:360.4 g/molRN 486
CAS:Bruton's tyrosine kinase antagonist; reduces Fcγ receptor signaling
Formula:C35H35FN6O3Purity:Min. 95%Molecular weight:606.69 g/molGNE 6776
CAS:Specific inhibitor of the ubiquitin specific protease-7 (USP7), which is a validated deubiquitinase of the E3 ubiquitin-protein ligase MDM2. The compound inhibits the USP7 deubiquitinase activity by binding to acidic amino acid residues important for the interaction with ubiquitin. Induces tumor cell death and enhances cytotoxicity of chemotherapeutic agents.Formula:C20H20N4O2Purity:Min. 95%Molecular weight:348.4 g/molEtelcalcetide hydrochloride
CAS:Agonist of calcium sensing receptor CASR; calcimimetic agentFormula:C38H73N21O10S2·xHClPurity:Min. 98 Area-%Color and Shape:White Off-White PowderMolecular weight:1084.71Interleukin-13 human
CAS:Interleukin-13 human is a recombinant cytokine, which is derived from the expression of the human IL-13 gene in suitable host systems, such as E. coli or mammalian cells. This cytokine belongs to the interleukin family and plays a pivotal role in the immune response by modulating inflammatory pathways. The mode of action of interleukin-13 involves binding to specific cell surface receptors, IL-13Rα1 and IL-13Rα2, which facilitates the activation of various intracellular signaling cascades, including the JAK/STAT pathway. This promotes the differentiation and proliferation of certain immune cells, influencing the production of IgE and contributing to the regulation of inflammatory responses.
Purity:Min. 95%PD 169316
CAS:Inhibitor of p38 kinase
Formula:C20H13FN4O2Purity:Min. 95%Color and Shape:PowderMolecular weight:360.34 g/molFingolimod HCl - Bio-X ™
CAS:Fingolimod is a sphingosine 1-phosphate receptor modulator that is used in the treatment of relapsing-remitting form of multiple sclerosis. It is also being studies to manage lung complications in patients with COVID-19. This drug binds to various sphingosine 1-phospahte receptors and suppresses the exit of lymphocytes from lymph nodes.Formula:C19H33NO2•HClPurity:Min. 95%Color and Shape:PowderMolecular weight:343.93 g/molCHIR 99021
CAS:Potent and selective inhibitor of the glycogen synthase kinase GSK-3. Promotes cell renewal in embryonic stem cells by modulating Notch, MAPK and TGF-β signalling pathways, which are involved in pluripotency. It also affects the Wnt/β-catenin pathway and alters expression of genes coding for proteins, epigenetic regulatory elements and non-coding RNAs. The combination of CHIR 99021 and basic fibroblast growth factor (bFGF) allows long-term self-renewal in adult mouse retinal progenitor cells.Formula:C22H18Cl2N8Purity:Min. 95%Color and Shape:PowderMolecular weight:465.34 g/molCamostat mesylate - Bio-X ™
CAS:Camostat is a serine protease inhibitor that is used for the treatment of chronic pancreatitis. This drug has shown to reduce inflammation and pain. Studies have shown that Camostat has also inhibited the entry of SARS-CoV-2 in lung cells by inhibiting the priming process of S-protein, necessary for the viral entry into host cells.Formula:C20H22N4O5•CH4O3SPurity:Min. 95%Color and Shape:PowderMolecular weight:494.52 g/molBosentan - Bio-X ™
CAS:Bosentan is a dual endothelin receptor antagonist that is used to treat hypertension. This drug works by blocking the action of endothelin molecules which prevents the narrowing of blood vessels and decreases blood pressure.
Formula:C27H29N5O6SPurity:Min. 95%Color and Shape:PowderMolecular weight:551.62 g/mol(Z)-Mycophenolic acid
CAS:(Z)-Mycophenolic acid is an immunosuppressive agent derived from the fermentation of fungi, primarily from the Penicillium species. It functions by inhibiting inosine monophosphate dehydrogenase (IMPDH), an enzyme crucial for de novo purine synthesis. This selective blockade of IMPDH specifically affects lymphocyte proliferation due to their heavy reliance on this pathway for DNA synthesis, thereby exerting its immunosuppressive effects.Formula:C17H20O6Purity:Min. 98 Area-%Color and Shape:PowderMolecular weight:320.34 g/molN-Trityl candesartan cilexetil
CAS:Angiotensin II receptor antagonist
Formula:C52H48N6O6Purity:Min. 95%Color and Shape:PowderMolecular weight:852.97 g/molMNI-caged-L-glutamate
CAS:A light-sensitive probe that functionally encapsulates L-glutamate in an inactive form. Irradiation with light at 360-380 nm cleaves the MNI protecting group and allows the release of free L-glutamate. It allows tuneable control of the L-glutamate in neurons and precise control over time, dose and location of L-glutamate release.Formula:C14H17N3O6Purity:Min. 95%Molecular weight:336.8 g/molBIO
CAS:Specific inhibitor of glycogen synthase kinase 3 (GSK-3) with IC50 in low nanomolar range. Studies showed that BIO maintains self-renewal in embryonic stem cells (ESCs) as well as increases activity of β-catenin. In neonatal cardiomyocytes, BIO promotes cell cycle by stimulating cell entry into S phase as well as cytokinesis. In germline stem cells from female mice (FGSCs), BIO promoted proliferation and maintenance of FGSCs by activating β-catenin and up-regulating E-cadherin.Formula:C16H10BrN3O2Purity:Min. 95%Color and Shape:Red To Dark Red SolidMolecular weight:356.17 g/molTezacaftor
CAS:Potentiates cystic fibrosis transmembrane conductance regulator (CFTR)Formula:C26H27F3N2O6Purity:Min. 95%Color and Shape:White PowderMolecular weight:520.5 g/mol7-Prenyloxycoumarin
CAS:7-Prenyloxycoumarin is a naturally occurring compound, often categorized as a phytochemical, which is primarily isolated from various plant sources including the Rutaceae family. This compound exhibits intriguing biochemical properties due to its unique molecular structure, primarily the presence of a prenyloxy group attached to the coumarin core. The mode of action of 7-Prenyloxycoumarin primarily involves its ability to interact with biological membranes and proteins, leading to modulation of enzymatic activity and disruption of pathogen cell walls.Formula:C14H14O3Purity:Min. 98 Area-%Color and Shape:PowderMolecular weight:230.26 g/molCarmustine - Bio-X ™
CAS:Carmustine is a DNA alkylating agent which also cross-links DNA. As a result, Carmustine disrupts the function of DNA, resulting in the arrest the cell cycle and apoptosis. Consequently these properties of Carmustine, in addition to its ability to easily transmit through the blood-brain barrier, means it can be used as a cancer treatment, treating cancers such as, breast, ovarian and pancreatic as well as lymphomas and leukemias. Furthermore Carmustine can contribute to cytotoxic effects through its ability to carbamoylate DNA repair enzymes and proteins.Formula:C5H9Cl2N3O2Purity:Min. 95%Color and Shape:PowderMolecular weight:214.05 g/molSB 239063
CAS:Inhibits p38 MAP kinase; anti-inflammatory; neuroprotectiveFormula:C20H21FN4O2Purity:Min. 95%Color and Shape:PowderMolecular weight:368.4 g/molIcilin - Bio-X ™
CAS:Icilin is a transient receptor potential M8 (TRPM8) agonist drug that is used for the treatment of pruritis. This drug has shown to be effective in producing an extreme cold sensation in both human and animal models. It is used in research for studying TRP channels.Formula:C16H13N3O4Purity:Min. 95%Color and Shape:PowderMolecular weight:311.29 g/molCariprazine
CAS:Partial agonist of D2 and D3 dopamine receptors; anti-psychoticFormula:C21H32Cl2N4OPurity:Min. 95%Color and Shape:White PowderMolecular weight:427.41 g/molPrilocaine HCl - Bio-X ™
CAS:Prilocaine is a drug used as a local anaesthetic in dental procedures. It has been shown to reduce the incidence of pain caused. This drug is also a sodium channel blocker that blocks the influx of sodium into cells.Formula:C13H20N2O•HClPurity:Min. 95%Color and Shape:PowderMolecular weight:256.77 g/molRS 127445 hydrochloride
CAS:A selective antagonist of serotonin 5-HT2B receptors, inhibiting inositol phosphate formation and calcium release. Blocks 5-HT-induced contraction in rat stomach fundus. Reduces fecal output in vivo, upon inhibition of 5-HT2B by RS 127445, demonstrating a potential role for this receptor in colonic motility. Inhibits visceral hypersensitivity induced by restraint stress or colonic inflammation.Formula:C17H16FN3·HClPurity:Min. 95%Color and Shape:White To Yellow SolidMolecular weight:317.79 g/molNabumetone - Bio-X ™
CAS:Nabumetone is a non-steroidal anti-inflammatory drug that is used in the treatment of osteoarthritis and rheumatoid arthritis. This drug is also a cyclooxygenase inhibitor and works by inhibiting this enzyme so that pain and inflammation is reduced.Formula:C15H16O2Purity:Min. 95%Color and Shape:PowderMolecular weight:228.29 g/molBuserelin acetate
CAS:Controlled ProductAgonist of hypothalamic neuropeptide LHRHFormula:C62H90N16O15Purity:Min. 95%Color and Shape:PowderMolecular weight:1,299.48 g/mol
