Other Inhibitors

N-Fmoc-3-nitro-L-tyrosine is a useful organic compound for research related to life sciences. The catalog number is T65730 and the CAS number is 136590-09-5.

Ethyl 4-hydroxycyclohexanecarboxylate is a useful organic compound for research related to life sciences. The catalog number is T65155 and the CAS number is 17159-80-7.

(E)-4-Hydroxy-3-methoxycinnamic acid 4-O-β-D-glucopyranoside is a useful organic compound for research related to life sciences and the catalog number is T64552.

Amino-PEG5-CH2COOH is a PEG-based linker for PROTACs, joining two essential ligands to form PROTAC molecules and enabling selective protein degradation via the ubiquitin-proteasome system within cells (PROTACs) [ubiquitin-proteasome system].

<p>(3S,8S,9S,10R,13R,14S,17R)-10,13-Dimethyl-17-((R)-6-methylheptan-2-yl)-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl (Z)-octadec-9-en-1-yl carbonate is a useful organic compound for research related to life sciences. The catalog number is T65075 and the CAS number is 17110-51-9.</p>

Bromo-PEG5-azide is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

<p>Ethyl 2-(methylthio)-6-oxo-1,6-dihydropyrimidine-5-carboxylate is a useful organic compound for research related to life sciences. The catalog number is T64927 and the CAS number is 53554-29-3.</p>

<p>TL4830031 (8i), quinolone derivative, Axl inhibitor, IC50: 26 nM, blocks Axl phosphorylation, cell invasion &amp; migration; for cancer research.</p>

Ory c 3 Protein, Rabbit, Recombinant is expressed in P. pastoris yeast expression system. The predicted molecular weight is 18.3 kDa.

<p>Pol d 5 Protein, Mediterranean paper wasp, Recombinant is expressed in P. pastoris yeast expression system. The predicted molecular weight is 20 kDa.</p>

3-(Dimethylamino)-1-(naphthalen-1-yl)propan-1-one hydrochloride is a useful organic compound for research related to life sciences. The catalog number is T66115 and the CAS number is 5409-58-5.

((2-Cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl)methyl)triphenylphosphonium bromide is a useful organic compound for research related to life sciences. The catalog number is T66070 and the CAS number is 154057-58-6.

(S)-3-((R)-5-(4-Fluorophenyl)-5-hydroxypentanoyl)-4-phenyloxazolidin-2-one is a useful organic compound for research related to life sciences and the catalog number is T67210.

<p>Methanesulfonato(tricyclohexylphosphine)(2'-amino-1,1'-biphenyl-2-yl)palladium(II) is a useful organic compound for research related to life sciences and the catalog number is T67262.</p>

Dodecylheptaglycol is a useful organic compound for research related to life sciences. The catalog number is T65234 and the CAS number is 3055-97-8.

<p>Mitoquinone is a TPP-based, mitochondrially targeted antioxidant .</p>

6-HAP is a useful organic compound for research related to life sciences and the catalog number is T64946.

4-(Pyridin-2-yl)benzoic acid is a useful organic compound for research related to life sciences. The catalog number is T65363 and the CAS number is 4385-62-0.

3,3'-(Pyrazine-2,5-diyl)dipropanoic acid is a useful organic compound for research related to life sciences. The catalog number is T67050 and the CAS number is 77479-02-8.

<p>Bla g 4 Protein, cockroaches, Recombinant is expressed in P. pastoris yeast expression system. The predicted molecular weight is 30 kDa.</p>

<p>Cinnamyl chloride is a useful organic compound for research related to life sciences. The catalog number is T64913 and the CAS number is 2687-12-9.</p>

<p>CAY10736: Anticancer agent, blocks cell growth &amp; migration in various cancers, effective in mouse models.</p>

<p>Pen a 1 Protein, shrimp, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 36 kDa.</p>

3,4-Difluorobenzamide is a useful organic compound for research related to life sciences. The catalog number is T66971 and the CAS number is 85118-04-3.

<p>N-Methyl-L-isoleucine is a useful organic compound for research related to life sciences. The catalog number is T65964 and the CAS number is 4125-98-8.</p>

<p>3'-O-Angeloylhamaudol is a useful organic compound for research related to life sciences and the catalog number is T124112.</p>

<p>MB07803 is an orally available prodrug of an effective, noncompetitive inhibitor of fructose 1,6-bisphosphatase (FBPase) (EC50: 140 nM and t1/2 of 7.6±2.9 h).</p>

5-Amino-3-(4-chlorophenyl)-5-oxopentanoic acid is a useful organic compound for research related to life sciences. The catalog number is T65689 and the CAS number is 1141-23-7.

DiAzK has a wide range of applications in life science related research.

<p>N2S2-CBMBC, a bromo-benzyl ether, binds to 99mTc for PD-L1 tumor imaging, offering a real-time alternative to immunohistochemistry.</p>

<p>Ald-Ph-amido-PEG2-C2-Boc is a polyethylene glycol (PEG)-based linker used in the synthesis of proteolysis targeting chimeras (PROTACs)[1].</p>

Azide-PEG-amine (MW 5000) is a polyethylene glycol (PEG)-derived linker compound with azide functionality, primarily utilized in the synthesis of proteolysis-targeting chimeras (PROTACs)[1].

D-Luciferin 6′-methyl ether (also known as 6′-Methoxyluciferin or compound 19a) is a highly effective inhibitor of luciferase obtained from the North American firefly Photinus pyralis (PpyLuc), exhibiting an IC50 value of 0.1 μM. This analog of D-luciferin interacts non-specifically with the ATP and luciferin binding sites within the active site of PpyLuc.

Z-Arg-OH.HCl, an amino acid derivative, finds extensive application in life science research.

(S)-N,N-Dimethyl-1,2,4,5,6,7-hexahydrodiindeno[7,1-de:1',7'-fg][1,3,2]dioxaphosphocin-12-amine is a useful organic compound for research related to life sciences. The catalog number is T67218 and the CAS number is 443965-10-4.

PMAL-C16 has a wide range of applications in life science related research.

Tris(4,7-diphenyl-1,10-phenanthroline)ruthenium(II) dichloride is used as a probe for luminescent detection and quantitation of oxygen [absorption λmax=455 nm, luminescence λmax=613 nm], for fibre optic sensors, and in studies on oxygen in skin and skin tumors as well as measurement of oxygen flux through the skin.

N-Carbobenzoxy-4-hydroxy-D-2-phenylglycine (catalog number T66184, CAS number 26787-75-7) is a valuable organic compound for research in the life sciences.

Zinc-EDTA is a useful organic compound for research related to life sciences. The catalog number is T65166 and the CAS number is 14025-21-9.

<p>Der p 21 Protein, Dermatophagoides pteronyssinus, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 15.55 kDa.</p>

<p>22(S)-hydroxy Cholesterol is a synthetic oxysterol and a modulator of the liver X receptor (LXR). [1] t prevents monocyte chemoattractant protein 1 (MCP-1) expression induced by the LXR agonist GW 3965 in primary hepatocytes and downregulates mRNA expression of the LXR target genes CD36, ACSL1, and SCD-1 in human myotubes. It decreases triacylglycerol and diacylglycerol synthesis from labeled palmitate and acetate, respectively, in human myoblasts by 50% when used at a concentration of 10 uM. 22(S)-hydroxy Cholesterol also reduces fatty acid synthase (FAS) reporter activity through an LXR response element in the promoter region in COS-1 cells transfected with RXRα and LXRα and decreases the expression of MCP-1 and CCR2 in a mouse model of chronic ethanol consumption.[1] [2] Dietary supplementation of 22(S)-hydroxy cholesterol (30 mg/kg per day) leads to less body weight gain and lower liver triacylglycerol levels in rats when fed either a regular chow or high-fat diet as well as prevents an increase in plasma triacylglycerol levels resulting from a high-fat diet.[3]</p>

(4R,6R)-tert-Butyl-6-(2-aminoethyl)-2,2-dimethyl-1,3-dioxane-4-acetate is a useful organic compound for research related to life sciences. The catalog number is T67119 and the CAS number is 125995-13-3.

Nab-Paclitaxel is an albumin-bound formulation of Paclitaxel nanoparticles known for its enhanced response rates and tolerability. Leveraging albumin as a delivery vehicle, this compound achieves a favorable pharmacokinetic (PK) profile [1] [2].

1,4-Bis(trifluoromethyl)benzene is a useful organic compound for research related to life sciences. The catalog number is T67081 and the CAS number is 433-19-2.

4-Ethylcyclohexanecarboxylic acid is a useful organic compound for research related to life sciences. The catalog number is T67671 and the CAS number is 91328-77-7.

1-Methyl-4-nitroimidazole is a useful organic compound for research related to life sciences. The catalog number is T65596 and the CAS number is 3034-41-1.

<p>Yimitasvir (Emitasvir) diphosphate，一种针对丙型肝炎病毒(HCV)非结构蛋白5A (NS5A)的口服活性抑制剂，适用于慢性丙型肝炎病毒感染的研究。</p>

Triphenylmethanol is a useful organic compound for research related to life sciences. The catalog number is T65488 and the CAS number is 76-84-6.

<p>Antitubercular agent-10 shows potent antitubercular activity with a MIC value of 30 nM.</p>

<p>HSP70 Protein, Human, Recombinant (His) is expressed in Baculovirus insect cells with His tag.</p>

<p>Bikunin/AMBP Protein, Human, Recombinant (aa 1-203, His) is expressed in HEK293 mammalian cells with His tag.</p>

<p>CLEC12A/MICL/CLL-1 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag.</p>

<p>Osteopontin (OPN), bone sialoprotein (BSPII), and osteonectin (ON) belong to a family of glycoproteins, which have been linked to cancer metastasis and</p>

<p>Lipocalin-2/LCN2 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag.</p>

<p>Signal transducer and activator of transcription that mediates signaling by type I IFNs (IFN-alpha and IFN-beta).</p>

<p>LPL Protein, Chinese hamster, Recombinant (His) is expressed in E.</p>

Intermediates and building blocks - phosphorous compounds; nucleophile

<p>HT-2 Toxin, a deacetylated metabolite of T-2 toxin, impairs protein synthesis and hinders cell proliferation in plants.</p>

<p>Valiloxibic acid is a prodrug for GHB, a natural psychoactive neurotransmitter and weak GABAB agonist.</p>

<p>CF502 (STING agonist-23) is a non-nucleotide that activates STING pathway, boosts immune responses, and shows activity against SARS-CoV.</p>

<p>Alpha-Synuclein Protein, Human, Recombinant is expressed in E.</p>

<p>R-spondin 3 (RSPO3) is a member of the R-Spondin (RSPO) family in vertebrates that activate Wnt/beta-catenin signaling, plays a key role in these processes.</p>

<p>CLEC12A/MICL/CLL-1 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag.</p>

<p>S100A8 &amp; S100A9 Heterodimer Protein, Human, Recombinant (Flag &amp; His) is expressed in Baculovirus insect cells with Flag and His tag.</p>

<p>Hantaan virus HTNV (strain 84FLi) Nucleocapsid/NP Protein (His) is expressed in Baculovirus insect cells with His tag.</p>

<p>BCL-W Protein, Human, Recombinant (His) is expressed in E.</p>

<p>Heterocyclic compounds-pyridine,</p>

<p>4-Methoxycoumarine has antitumour effects.</p>

<p>Ammonium Glycyrrhizinate (Glycyram) inhibits the cytopathology and growth of several unrelated DNA/RNA viruses.</p>

<p>NBQX (FG9202), an AMPA/kainate receptor blocker, counters glutamate toxicity; water-soluble as disodium salt, has anticonvulsant properties.</p>

<p>7-Methoxy-1-tetralone may have insecticidal activity.</p>

<p>Elamipretide (SS-31, MTP-131, Bendavia) is a mitochondria-focused peptide that curbs toxic ROS and stabilizes cardiolipin.</p>

<p>Tropinone used as an intermediate in the synthesis of atropine sulfate, and is a decane alkaloid.</p>

<p>10Z-Nonadecenoic acid is a long-chain fatty acid with anti-tumor activity.</p>

Decyl-TPP bromide ((1-Decyl)triphenylphosphonium bromide) may be used as an intermediate for chemical synthesis and an inactive control or as a reference to

<p>MTP 131 (acetate) is a small mitochondrially-targeted tetrapeptide.</p>

<p>Elamipretide 2TFA (RX-31 2TFA) is a novel mitochondrion-targeted antioxidant.</p>

<p>Ethyl 4-hydroxyphenylacetate is a selective inhibitor of monoamine oxidase A.</p>

<p>Oxindole (Indolin-2-one) is an aromatic heterocyclic building block. 2-indolinone derivatives have become lead compounds in the research of kinase inhibitors.Oxindole structure has been used in receptor tyrosine kinases (RTKs) inhibitors such as SU4984 and intedanib, the RTK family represents an important therapeutic target for anti-cancer drug development.</p>

<p>Salvianolic acid B (Dan Shen Suan B) is a water-soluble antioxidant from Salvia miltiorrhiza extract with antiplatelet aggregation and antithrombotic effects.</p>

<p>4-Hydroxy-6-methylcoumarin (4-HMC) is a naturally occurring phenolic compound, a derivative of coumarin, found in a variety of plants, fungi, and bacteria. It has anti-inflammatory and anti-tumor activity.4-HMC is used as a flavoring agent, preservative and antioxidant in the food industry.</p>

<p>α-Lipoic Acid (Alphalipoic acid) inhibits NF-κB-dependent HIV-1 LTR activation.</p>

<p>Dimethylamine hydrochloride, found in urine, comes from food compound TMAO and NO synthesis inhibitor ADMA, processed by DDAH enzyme.</p>

<p>Danoprevir sodium is an NS3/4A protease inhibitor used in the treatment of Hepatitis C</p>

<p>FLT3 Ligand Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag.</p>

<p>IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Promotes cell migration. IGFBP-1 Protein, Rat, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 26.9 kDa and the accession number is P21743.</p>

<p>SLC1A2 Protein, Mouse, Recombinant (GST) is expressed in E. coli. The accession number is P43006.</p>

<p>May act as a negative regulator of collagen matrix deposition.</p>

<p>Pomalidomide 4'-PEG5-azide, a cereblon (CRBN) ligand based on Pomalidomide, facilitates the recruitment of CRBN protein. It can be conjugated through a linker to another ligand, forming a proteolysis-targeting chimera (PROTAC) [1].</p>

<p>BChE-IN-17 (compound 6n) is a potent, selective inhibitor of butyrylcholinesterase (BChE), demonstrating inhibitory half-maximal inhibitory concentrations (</p>

CK176 is an HIV-1 inhibitor, 11x more effective than I-XW-053 in human PBMCs.

<p>Phenazolam is an analytical reference standard categorized as a benzodiazepine. [1] This product is intended for research and forensic applications.</p>

<p>Anti-TNBC agent-3 (compound 3g) is a compound that induces apoptosis and possesses anti-cancer cell proliferation properties.</p>

<p>AKOS-22: potent VDAC1 inhibitor, Kd=15.4 μM; prevents mitochondrial dysfunction and apoptosis.</p>

<p>Saxitoxinol is an analog of saxitoxin, a known voltage-gated sodium channel blocker.</p>

IDX-375, a HCV NS5B polymerase inhibitor, is used potentially for the treatment of HCV infection.

<p>Cebranopadol ((1α,4α)stereoisomer) is a stereoisomer of cebranopadol which is a potent ORL-1 agonist.</p>

<p>KP372-1, an Akt inhibitor, blocks PI3K signaling, arrests cell growth, and triggers apoptosis in head/neck squamous cell carcinoma.</p>

<p>Questiomycin A derivative 18 TFA exhibits antibacterial, anticancer properties and inhibits GRP78.</p>

FM-24 HCl is a long acting beta-adrenergic receptor antagonist.

D(-)-Octopamine CSA salt is an agonist of octopamine receptors.

<p>PS372424 activates CXCR3, triggers ERK phosphorylation, and inhibits CXCL11's effect on CD45+ cell migration in humanized mice.</p>

<p>Albuterol stearate, a salt form of Albuterol, is a selective beta2 agonist for treating asthma and COPD, with 29x preference for beta2 over beta1.</p>

<p>CCK-inactivating serine protease (tripeptidyl peptidase II) inhibitor</p>

H 35-25 is a beta 2-antagonist.

Tifenazoxide is an effective and SUR1/Kir6.2 selective KATP channels opener. Tifenazoxide has an anti-diabetic effect, can inhibit glucose-stimulated insulin release in vitro and in vivo.

(Rac)-LM11A-31 dihydrochloride is an isomer of LM11A-31 dihydrochloride, a potent antagonist of proNGF (nerve growth factor).

Fosfonet sodium is a sodium salt of phosphonoacetic acid, effective against herpesviruses by inhibiting viral DNA polymerase.

<p>Culmerciclib is a cell cycle protein-dependent kinase (CDK) inhibitor that exhibits antitumour effects.</p>

DPX-3778, a triethanolamine salt, boosts tobacco callus growth 4-5x at 0.124-2.48 μM and slows aging with IAA and kinetin.

Dioxifedrine is a beta-2 -adrenergic agonist with bronchodilator activity.

TRPP3 channel inhibitor

Guancydine is an antihypertensive agent.

Trimetoquinol hydrochloride possesses differential and selective beta-adrenergic properties.

<p>(E)-Crotylbarbital, a Crotylbarbital isomer, is a sedative with hypnotic, anticonvulsant properties, aiding sleep and mental stability.</p>

<p>PAD4-IN-2 (compound 5i) is a PAD4 inhibitor with an IC50 value of 1.94 μM, shown to suppress tumor growth in mice through specific inhibition of the PAD4-H3cit-</p>

MDK-2959 is a potent inhibitor of protein tyrosine phosphatase sigma (PTPsigma).

Aminobutane bisphosphonate curbs bone loss; may manage hypercalcemia in cancer.

<p>Benzovindiflupyr: a fungicide that inhibits SDH (IC50=5.2nM), halts S. sclerotiorum growth (EC50=0.011μg/ml), and protects crops like eggplants.</p>

PSB-6426 is the first potent and selective human nucleoside triphosphate diphosphohydrolase-2 inhibitor.

<p>Radafaxine hydrochloride is an inhibitor of DAT and NET transporters, and nAChR family modulator.</p>

<p>Erythrityl Tetranitrate, a vasodilator similar to nitroglycerin, was first in "sustained release" tablets; may cause "nitro headache."</p>

<p>PL265 is a long-acting dual ENKephalinase inhibitor (DENKi) with analgesic potential.</p>

CH-100 is a Chinese herbal medicine previously used in the treatment of human hepatitis C.