Other Inhibitors

2-(4-((4-Chlorophenyl)(phenyl)methyl)piperazin-1-yl)ethanol dihydrochloride is a useful organic compound for research related to life sciences. The catalog number is T64940 and the CAS number is 164726-80-1.

<p>Trk-IN-6 shows excellent in vitro potency on a panel of TRK mutants ( IC 50 = 0.2-0.7 nM).</p>

4-Isobutylpyrrolidin-2-one is a useful organic compound for research related to life sciences. The catalog number is T65647 and the CAS number is 61312-87-6.

N-(3-Chloro-4-hydroxyphenyl)acetamide is a useful organic compound for research related to life sciences. The catalog number is T67206 and the CAS number is 3964-54-3.

Azide-PEG-amine (MW 5000) is a polyethylene glycol (PEG)-derived linker compound with azide functionality, primarily utilized in the synthesis of proteolysis-targeting chimeras (PROTACs)[1].

<p>BPH-252 is a bioactive chemical.</p>

<p>2-(4-Chlorophenyl)quinoline-4-carboxylic acid is a useful organic compound for research related to life sciences. The catalog number is T67172 and the CAS number is 5466-31-9.</p>

5-Bromo-2-(2-methyl-2H-tetrazol-5-yl)pyridine is a useful organic compound for research related to life sciences. The catalog number is T66868 and the CAS number is 380380-64-3.

Boc-Cha-OMe is a useful organic compound for research related to life sciences. The catalog number is T65020 and the CAS number is 98105-41-0.

1-(4-Methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid is a useful organic compound for research related to life sciences. The catalog number is T66214 and the CAS number is 503614-92-4.

(S)-2-Ethylbutyl 2-(((S)-(4-nitrophenoxy)(phenoxy)phosphoryl)amino)propanoate is a useful organic compound for research related to life sciences. The catalog number is T64602 and the CAS number is 1354823-36-1.

n-Undecyl-β-D-Maltopyranoside is a useful organic compound for research related to life sciences. The catalog number is TF0089 and the CAS number is 253678-67-0.

NE58062 is a bioactive chemical.

<p>DL-Glyceraldehyde-3-phosphate (3-Phosphoglyceraldehyde) inhibits acyltransferases and inhibits the growth of E. coli at high concentrations.</p>

Ligustrazine Hydrochloride, is a natural substance discovered in the plant Ligusticum chuanxiong Hort. It inhibits platelet aggregation, improves atherosclerosis situation, protects endothelium injury, and has antithrombotic effects.in vivo,ligustrazine hydrochloride at 10 and 20 mg/kg produced significant analgesic effects against mechanical stimuli,and ligustrazine hydrochloride at 80 mg/kg, also significantly alleviated cold hypersensitivity manifested by reduction in cold vocalization temperature.

(7Z)-Monomyristolein is a useful organic compound for research related to life sciences. The catalog number is TF0001 and the CAS number is 749266-35-1.

<p>Liquiritigenin-7-O-β-D-glucopyranosyl-(1→2)-β-D-apiofuranoside, a flavonoid extracted from Glycyrrhiza roots, exhibits low cytotoxicity on a variety of tumor and normal cells.</p>

Ligustrosidic acid, a natural compound, is extracted from Ligustrum japonicum and Ligustrum lucidum.

Nonathymulin trifluoroacetate is a useful organic compound for research related to life sciences and the catalog number is T64684.

Methanesulfonato[4,6-bis(diphenylphosphino)phenoxazine](2'-amino-1,1'-biphenyl-2-yl)palladium(II) is a useful organic compound for research related to life sciences and the catalog number is T67254.

2-(2-Ethoxyphenoxy)ethanamine is a useful organic compound for research related to life sciences. The catalog number is T66134 and the CAS number is 6781-17-5.

<p>1-(6-Methylpyridin-3-yl)-2-(4-(methylsulfonyl)phenyl)ethanone is a useful organic compound for research related to life sciences. The catalog number is T66913 and the CAS number is 221615-75-4.</p>

<p>ssPalmE-P4C2 is an ionizable lipid based on vitamin E, designed for the formulation of lipid nanoparticles (LNPs) that facilitate RNA delivery to cells.</p>

2-Acetamidothiazole is a useful organic compound for research related to life sciences. The catalog number is T67350 and the CAS number is 2719-23-5.

<p>Di-tert-butyl(2',4',6'-triisopropyl-3,6-dimethoxy-[1,1'-biphenyl]-2-yl)phosphine is a useful organic compound for research related to life sciences. The catalog number is T66183 and the CAS number is 1160861-53-9.</p>

Bicyclo[2.2.1]hept-5-ene-2,3-dicarboxylic anhydride is a useful organic compound for research related to life sciences. The catalog number is T64907 and the CAS number is 826-62-0.

<p>Water-18O is a useful organic compound for research related to life sciences and the catalog number is T64656.</p>

<p>Scy p 1 Protein, Scylla paramamosain, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 33.75 kDa.</p>

<p>Guanylthiourea is a useful organic compound for research related to life sciences. The catalog number is T64909 and the CAS number is 2114-02-5.</p>

<p>PEG2-bis(phosphonic acid) is a PEG Linker.</p>

<p>ssPalmE is an ionizable lipid utilized for delivering plasmid DNA into cells by forming lipid nanoparticles (LNPs).</p>

BisMalt-24 is a useful organic compound for research related to life sciences. The catalog number is TF0007 and the CAS number is 1198081-48-9.

(R)-3-([1,1'-Biphenyl]-4-yl)-2-aminopropanoic acid is a useful organic compound for research related to life sciences and the catalog number is T67381.

Fmoc-PEG6-NHS ester is a PEG-based linker for PROTACs, facilitating the formation of PROTAC molecules by joining two essential ligands. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

DiAzK has a wide range of applications in life science related research.

Ferulenol, a sesquiterpene prenylated coumarin derivative, demonstrates potent antimycobacterial activity and [haemorrhagic] action by selectively targeting succinate ubiquinone reductase within the ubiquinone cycle.

<p>Questiomycin A derivatives 14 is a Questiomycin A derivative.</p>

(S)-N,N-Dimethyl-3-hydroxy-3-(2-thienyl)propanamine is a useful organic compound for research related to life sciences. The catalog number is T65715 and the CAS number is 132335-44-5.

PMAL-C16 has a wide range of applications in life science related research.

4-Chloroquinazoline-6,7-diol is a useful organic compound for research related to life sciences. The catalog number is T66020 and the CAS number is 1145671-36-8.

4-Ethylcyclohexanecarboxylic acid is a useful organic compound for research related to life sciences. The catalog number is T67671 and the CAS number is 91328-77-7.

3-(Cyclopropylmethoxy)-N-(3,5-dichloropyridin-4-yl)-4-hydroxybenzamide is a useful organic compound for research related to life sciences. The catalog number is T66408 and the CAS number is 475271-62-6.

Paromomycin (Sulfate Salt) is an aminoglycoside that is active against Gram-negative and many Gram-positive bacteria as well as some protozoa and cestodes. Paromomycin in combination with sodium stibogluconate has proven to be effective in African and Indian VL (visceral leishmaniasis) and improves survival in African VL[3]. PS (Paromomycin Sulfate) is effective for elimination of B. coli without hematological side effects[4]. The activity of phosphoglucose isomerase was slightly inhibited by 10(-3) M paromomycin sulfate while those of hexokinase, phosphofructokinase and glucose-6-phosphate dehydrogenase were not inhibited[5]. In addition, with regard to correlation of endotoxemia with renal impairment, endogenous creatinine clearance and p-aminohippurate clearance were significantly improved (P less than 0.02) in those patients whose endotoxemia disappeared on paromomycin sulfate administration. Paromomycin sulfate seems to be effective in the prevention of endotoxemia and the associated renal impairment in cirrhosis in man[6]. Significantly higher frequencies of resistance to paromomycin, kanamycin, neomycin and tobramycin were observed in S. aureus isolates from PS (paromomycin supplemented) birds. Paromomycin supplementation resulted in resistance to aminoglycosides in bacteria of PS turkeys. Co-selection for resistance to other antimicrobial agents was observed in E. coli isolates[7].

(S)-2-Amino-3-(2-hydroxyphenyl)propanoic acid hydrochloride is a valuable organic compound for life sciences research [Catalog No. T66634, CAS No. 1810074-88-4].

<p>PROTAC VEGFR-2 degrader-2 has minimal VEGFR-2 inhibition (IC50 &gt; 1μM) and low anti-proliferative effect on EA.hy926 cells (IC50 &gt; 100μM).</p>

1-Methyl-4-nitro-3-propyl-(1H)-pyrazole-5-carboxamide is a useful organic compound for research related to life sciences. The catalog number is T65742 and the CAS number is 139756-01-7.

(R)-2-Aminopent-4-enoic acid hydrochloride is a valuable compound for life sciences research [Catalog No. T66101, CAS No. 108412-04-0].

1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 2-ethoxy-1-((2'-(1-trityl-1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-1H-benzo[d]imidazole-7-carboxylate is a useful organic compound for research related to life sciences. The catalog number is T65490 and the CAS number is 170791-09-0.

N-(4-(4-Acetamido-2-hydroxyphenoxy)phenyl)acetamide is a useful organic compound for research related to life sciences and the catalog number is T64734.

<p>Hantaan virus HTNV (strain 84FLi) Nucleocapsid/NP Protein (His) is expressed in Baculovirus insect cells with His tag.</p>

<p>Lipocalin-2/LCN2 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag.</p>

<p>HT-2 Toxin, a deacetylated metabolite of T-2 toxin, impairs protein synthesis and hinders cell proliferation in plants.</p>

<p>CF502 (STING agonist-23) is a non-nucleotide that activates STING pathway, boosts immune responses, and shows activity against SARS-CoV.</p>

<p>Valiloxibic acid is a prodrug for GHB, a natural psychoactive neurotransmitter and weak GABAB agonist.</p>

<p>Osteopontin (OPN), bone sialoprotein (BSPII), and osteonectin (ON) belong to a family of glycoproteins, which have been linked to cancer metastasis and</p>

<p>CLEC12A/MICL/CLL-1 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag.</p>

<p>HSP70 Protein, Human, Recombinant (His) is expressed in Baculovirus insect cells with His tag.</p>

<p>Alpha-Synuclein Protein, Human, Recombinant is expressed in E.</p>

Intermediates and building blocks - phosphorous compounds; nucleophile

<p>S100A8 &amp; S100A9 Heterodimer Protein, Human, Recombinant (Flag &amp; His) is expressed in Baculovirus insect cells with Flag and His tag.</p>

<p>Signal transducer and activator of transcription that mediates signaling by type I IFNs (IFN-alpha and IFN-beta).</p>

<p>CLEC12A/MICL/CLL-1 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag.</p>

<p>Heterocyclic compounds-pyridine,</p>

<p>BCL-W Protein, Human, Recombinant (His) is expressed in E.</p>

<p>LPL Protein, Chinese hamster, Recombinant (His) is expressed in E.</p>

<p>R-spondin 3 (RSPO3) is a member of the R-Spondin (RSPO) family in vertebrates that activate Wnt/beta-catenin signaling, plays a key role in these processes.</p>

<p>Bikunin/AMBP Protein, Human, Recombinant (aa 1-203, His) is expressed in HEK293 mammalian cells with His tag.</p>

<p>Danoprevir sodium is an NS3/4A protease inhibitor used in the treatment of Hepatitis C</p>

Decyl-TPP bromide ((1-Decyl)triphenylphosphonium bromide) may be used as an intermediate for chemical synthesis and an inactive control or as a reference to

<p>α-Lipoic Acid (Alphalipoic acid) inhibits NF-κB-dependent HIV-1 LTR activation.</p>

<p>Dimethylamine hydrochloride, found in urine, comes from food compound TMAO and NO synthesis inhibitor ADMA, processed by DDAH enzyme.</p>

<p>7-Methoxy-1-tetralone may have insecticidal activity.</p>

<p>Ethyl 4-hydroxyphenylacetate is a selective inhibitor of monoamine oxidase A.</p>

<p>Ammonium Glycyrrhizinate (Glycyram) inhibits the cytopathology and growth of several unrelated DNA/RNA viruses.</p>

<p>Elamipretide (SS-31, MTP-131, Bendavia) is a mitochondria-focused peptide that curbs toxic ROS and stabilizes cardiolipin.</p>

<p>NBQX (FG9202), an AMPA/kainate receptor blocker, counters glutamate toxicity; water-soluble as disodium salt, has anticonvulsant properties.</p>

<p>10Z-Nonadecenoic acid is a long-chain fatty acid with anti-tumor activity.</p>

<p>4-Methoxycoumarine has antitumour effects.</p>

<p>4-Hydroxy-6-methylcoumarin (4-HMC) is a naturally occurring phenolic compound, a derivative of coumarin, found in a variety of plants, fungi, and bacteria. It has anti-inflammatory and anti-tumor activity.4-HMC is used as a flavoring agent, preservative and antioxidant in the food industry.</p>

<p>Tropinone used as an intermediate in the synthesis of atropine sulfate, and is a decane alkaloid.</p>

<p>Oxindole (Indolin-2-one) is an aromatic heterocyclic building block. 2-indolinone derivatives have become lead compounds in the research of kinase inhibitors.Oxindole structure has been used in receptor tyrosine kinases (RTKs) inhibitors such as SU4984 and intedanib, the RTK family represents an important therapeutic target for anti-cancer drug development.</p>

<p>Elamipretide 2TFA (RX-31 2TFA) is a novel mitochondrion-targeted antioxidant.</p>

<p>MTP 131 (acetate) is a small mitochondrially-targeted tetrapeptide.</p>

<p>Salvianolic acid B (Dan Shen Suan B) is a water-soluble antioxidant from Salvia miltiorrhiza extract with antiplatelet aggregation and antithrombotic effects.</p>

<p>FLT3 Ligand Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag.</p>

<p>IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Promotes cell migration. IGFBP-1 Protein, Rat, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 26.9 kDa and the accession number is P21743.</p>

<p>May act as a negative regulator of collagen matrix deposition.</p>

<p>SLC1A2 Protein, Mouse, Recombinant (GST) is expressed in E. coli. The accession number is P43006.</p>

<p>Pomalidomide 4'-PEG5-azide, a cereblon (CRBN) ligand based on Pomalidomide, facilitates the recruitment of CRBN protein. It can be conjugated through a linker to another ligand, forming a proteolysis-targeting chimera (PROTAC) [1].</p>

DPX-3778, a triethanolamine salt, boosts tobacco callus growth 4-5x at 0.124-2.48 μM and slows aging with IAA and kinetin.

Tifenazoxide is an effective and SUR1/Kir6.2 selective KATP channels opener. Tifenazoxide has an anti-diabetic effect, can inhibit glucose-stimulated insulin release in vitro and in vivo.

<p>CCK-inactivating serine protease (tripeptidyl peptidase II) inhibitor</p>

<p>Cebranopadol ((1α,4α)stereoisomer) is a stereoisomer of cebranopadol which is a potent ORL-1 agonist.</p>

Fosfonet sodium is a sodium salt of phosphonoacetic acid, effective against herpesviruses by inhibiting viral DNA polymerase.

<p>Benzovindiflupyr: a fungicide that inhibits SDH (IC50=5.2nM), halts S. sclerotiorum growth (EC50=0.011μg/ml), and protects crops like eggplants.</p>

<p>Phenazolam is an analytical reference standard categorized as a benzodiazepine. [1] This product is intended for research and forensic applications.</p>

<p>BChE-IN-17 (compound 6n) is a potent, selective inhibitor of butyrylcholinesterase (BChE), demonstrating inhibitory half-maximal inhibitory concentrations (</p>

<p>Erythrityl Tetranitrate, a vasodilator similar to nitroglycerin, was first in "sustained release" tablets; may cause "nitro headache."</p>

<p>PL265 is a long-acting dual ENKephalinase inhibitor (DENKi) with analgesic potential.</p>

CK176 is an HIV-1 inhibitor, 11x more effective than I-XW-053 in human PBMCs.

H 35-25 is a beta 2-antagonist.

<p>Culmerciclib is a cell cycle protein-dependent kinase (CDK) inhibitor that exhibits antitumour effects.</p>

Trimetoquinol hydrochloride possesses differential and selective beta-adrenergic properties.

<p>PAD4-IN-2 (compound 5i) is a PAD4 inhibitor with an IC50 value of 1.94 μM, shown to suppress tumor growth in mice through specific inhibition of the PAD4-H3cit-</p>

MDK-2959 is a potent inhibitor of protein tyrosine phosphatase sigma (PTPsigma).

<p>HPK1-IN-18: Potent, specific inhibitor of HPK1, a MAP4K enzyme, for cancer research and treatment.</p>

(Rac)-LM11A-31 dihydrochloride is an isomer of LM11A-31 dihydrochloride, a potent antagonist of proNGF (nerve growth factor).

<p>(E)-Crotylbarbital, a Crotylbarbital isomer, is a sedative with hypnotic, anticonvulsant properties, aiding sleep and mental stability.</p>

Guancydine is an antihypertensive agent.

<p>Radafaxine hydrochloride is an inhibitor of DAT and NET transporters, and nAChR family modulator.</p>

<p>Saxitoxinol is an analog of saxitoxin, a known voltage-gated sodium channel blocker.</p>

IDX-375, a HCV NS5B polymerase inhibitor, is used potentially for the treatment of HCV infection.

Dioxifedrine is a beta-2 -adrenergic agonist with bronchodilator activity.

FM-24 HCl is a long acting beta-adrenergic receptor antagonist.

TRPP3 channel inhibitor

CH-100 is a Chinese herbal medicine previously used in the treatment of human hepatitis C.

<p>KP372-1, an Akt inhibitor, blocks PI3K signaling, arrests cell growth, and triggers apoptosis in head/neck squamous cell carcinoma.</p>

<p>Albuterol stearate, a salt form of Albuterol, is a selective beta2 agonist for treating asthma and COPD, with 29x preference for beta2 over beta1.</p>

PSB-6426 is the first potent and selective human nucleoside triphosphate diphosphohydrolase-2 inhibitor.

<p>Anti-TNBC agent-3 (compound 3g) is a compound that induces apoptosis and possesses anti-cancer cell proliferation properties.</p>

D(-)-Octopamine CSA salt is an agonist of octopamine receptors.

<p>AKOS-22: potent VDAC1 inhibitor, Kd=15.4 μM; prevents mitochondrial dysfunction and apoptosis.</p>

Aminobutane bisphosphonate curbs bone loss; may manage hypercalcemia in cancer.