Deuterated Compounds

<p>Applications 4-Chloro-2-(methyl-d3)phenol is an intermediate used in the synthesis of (4-Chloro-2-methylphenoxy)acetic Acid-d3 (C369473), which is a deuterated version of (4-Chloro-2-methylphenoxy)acetic Acid (C369470), a herbicide.<br>References Elliott, B., et al.: Mutagenesis, 20, 3 (2005); Pfleeger, T., et al.: Environ. Toxicol. Chem., 30, 455 (2010);<br></p>

<p>Applications 1,4-Bis(trifluoromethyl)benzene-13C6 is an intermediate in the synthesis of Dutasteride-13C6 (D735002), which is a labeled Dutasteride (D735000). Dutasteride is a dual inhibitor of 5α-reductase isoenzymes type 1 and 2; structurally related to Finasteride (F342000). Dutasteride is used in the treatment of benign prostatic hyperplasia.<br>References Bakshi, R.K., et al.: J. Med. Chem., 38, 3189 (1995), Gisleskog, P.O., et al.: Brit. J. Clin. Pharmacol., 47, 53 (1999), Djavan, B., et al.: Expert Opin. Pharmacother., 6, 311 (2005),<br></p>

<p>Applications Benzene-1,4-d2 (CAS# 1684-46-4) is a useful isotopically labeled research compound.<br></p>

<p>Applications m-Toluidine-d9 (CAS# 352431-22-2) is a useful isotopically labeled research compound.<br></p>

<p>Applications Anisole-2,4,6-d3 (CAS# 2567-25-1) is a useful isotopically labeled research compound.<br></p>

<p>Applications 2'-Deoxyuridine-5,6-d2 (CAS# 40632-23-3) is a useful isotopically labeled research compound.<br></p>

<p>Applications Labelled 2,2,4,4-Tetramethyloctane (T303700). 2,2,4,4-Tetramethyloctane is a volatile compound of vegetarian soybean kapi, a fermented Thai food condiment.<br>References Allagheny, N., et al.: Int. J. Food Microbiol., 29, 321 (1996); Han, B., et al.: Food Control., 15, 265 (2004); Ouoba, L., et al.: J .Appl. Microbiol., 99, 1413 (2005); Zhang, J., et al.: Inter. J. Food Sci. Technol., 42, 263 (2007);<br></p>

<p>Applications Hexadecanoic Acid-1,2-13C2 (CAS# 86683-25-2) is a useful isotopically labeled research compound.<br></p>

<p>Applications p-Azoxyanisole-d6 (O,O-dimethyl-d6) (CAS# 34172-21-9) is a useful isotopically labeled research compound.<br></p>

<p>Applications Cholesterol-3,4-13C2 (CAS# 78887-48-6) is a useful isotopically labeled research compound.<br></p>

<p>Applications Hexadecanoic-11,11,12,12-d4 Acid (CAS# 75736-57-1) is a useful isotopically labeled research compound.<br></p>

<p>Applications Formamide-d3 is labelled Formamide (F691780 ). Formamide (F691780) is a compound that is used in biochemistry to prevent RNA samples from degradation due to RNAses. Formamide (F691780) is also used as a plasticizer to prepare thermoplastic starch (TPS), a special type of starch that can be mixed with other synthetic polymers because of its unique ability to “flow”<br>References Chomczynski, P.: Nuc. Acids Res., 20, 3791 (1992); Ma, X. &amp; Yu, J.: Acta Polym. Sinica 2, No vol. given, 240 (2004); Rodriguez-Gonzalez, F., et al.: Polymer, 44, 1517 (2003); Shi, Q., et al.: Polym. Degrad. Stabil., 96, 175 (2011)<br></p>

<p>Applications Isotope labelled Thymine (T412150), nitrogenous base component in the nucleic acid of DNA.<br>References Keum, Y., et al.: App. Microbiol. Biotechnol., 80, 863 (2008), Redzic, Z., et al.: Neurochem. Res., 34, 566 (2009), Lanevskij, K., et al.: J. Pharm. Sci., 98, 122 (2009), Rajendar, B., et al.: Bioorg. Med. Chem., 17, 351 (2009),<br></p>

<p>Stability Hygroscopic<br>Applications Guaiacol-beta-D-gentiobioside-d3, is the labeled analogue of Guaiacol-beta-D-gentiobioside (G245570), a Guaiacol Conjugate, that has shown to present in fermentation of grapes that had been exposed to bushfire smoke and can potentially yield unpalatable, smoke-affected wine.<br>References Hayasaka, Y.m et al.: J. Arg. Food Chem., Vol. 58, Issue 4, P: 2076; 2081 (2010);<br></p>

<p>Applications Benzo[e]pyrene-d12 (CAS# 205440-82-0) is a useful isotopically labeled research compound.<br></p>

<p>Applications 4-Oxo-2,2,6,6-tetramethylpiperidine-d16-1-oxyl (CAS# 36763-53-8) is a useful isotopically labeled research compound.<br></p>

<p>Applications 4-Fluorobenzonitrile-d4 is the labelled version of fluorobenzonitrile, a compound with industrial applications from solar cells to medicinal application as an anti-inflammatory.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Heilman, W.P. et al.: J. Med. Chem., 21, 906 (1978); Woo, S. et al.: J. Nano. Opto., 6, 338 (2011);<br></p>

<p>Applications Methyl-d3 Methacrylate (CAS# 35777-12-9) is a useful isotopically labeled research compound.<br></p>

<p>Applications N-Methyl-d3-acetamide-2,2,2-d3 (CAS# 3669-73-6) is a useful isotopically labeled research compound.<br></p>

<p>Applications Ethylene Glycol-D6 (D, 98%) (cas# 15054-86-1) is a useful research chemical.<br></p>

<p>Applications L-Alanine-2-d1 (CAS# 21386-65-2) is a useful isotopically labeled research compound.<br></p>

<p>Applications 2,4-Dichlorotoluene-3,5,6-d3 (CAS# 1398065-47-8) is a useful isotopically labeled research compound.<br></p>

<p>Applications (3S)-2,3-Dimethyl-4-[(tetrahydro-2H-pyran-2-yl)oxy]-2-butanol-d6 is a compound useful in organic synthesis.<br></p>

<p>Applications 2,5-Bis(Trifluoromethyl)nitrobenzene-13C6 is an intermediate in the synthesis of Dutasteride-13C6 (D735002), which is a labeled Dutasteride (D735000). Dutasteride is a dual inhibitor of 5α-reductase isoenzymes type 1 and 2; structurally related to Finasteride (F342000). Dutasteride is used in the treatment of benign prostatic hyperplasia.<br>References Bakshi, R.K., et al.: J. Med. Chem., 38, 3189 (1995), Gisleskog, P.O., et al.: Brit. J. Clin. Pharmacol., 47, 53 (1999), Djavan, B., et al.: Expert Opin. Pharmacother., 6, 311 (2005),<br></p>

<p>Applications 2-Deuteroindole is a useful reagent in the preparation of deuterated labeled indoles.<br>References Lautie, M. F., et al.: J. Label. Compd. Radiopharm., 16, 735 (1979); Ibaceta-Lizana, J. S. L., et al.: J. Chem. Soc. Perkin Trans 2., 9, 1221 (1987)<br></p>

<p>Applications Benzyl Chloride (D7,98%)(+0.1%Propylene Oxide) (cas# 59502-05-5) is a useful research chemical.<br></p>

<p>Applications 3,5-Dimethyl-d6-cyclohexanone-3,4,4,5-d4 (mixture of isomers) (CAS# 1219804-55-3) is a useful isotopically labeled research compound.<br></p>

<p>Applications N-Des(1,1-dimethylethyl) N-Cyclohexyl Finasteride-d11 is the isotope labelled analog of N-Des(1,1-dimethylethyl) N-Cyclohexyl Finasteride (D289575); an impurity of Finasteride (F342000) which is an inhibitor of 5α-reductase, the enzyme that converts testosterone to the more potent androgen 5α-dihydrotestosterone.Also an antialopecia agent.<br>References Koronkowski, M.J., et al.: Pharmacotherapy, 13, 309 (1993); Tenover, J.L., et al.: Clin. Ther., 19, 243 (1997); McConnell, J.D., et al.: N. Engl. J. Med., 338, 557 (1998)<br></p>

<p>Applications 1,2,3,4-Tetrahydro-5-(2-oxiranylmethoxy)-(2R,3S)-rel-2,3-naphthalenediol-D5 is an isotopic labelled analog of 1,2,3,4-tetrahydro-5-(2-oxiranylmethoxy)-(2R,3S)-rel-2,3-naphthalenediol. 1,2,3,4-Tetrahydro-5-(2-oxiranylmethoxy)-(2R,3S)-rel-2,3-naphthalenediol is used as a reactant in the synthetic preparation of Nadolol (cis-5-{3-[(1,1-dimethylethyl)amino]-2-hydroxypropoxy}-1,2,3,4-tetrahydro-2,3-naphthalenediol) which is a β-adrenergic blocking agent.<br>References Lacroix, P., et al.: J. Pharm. Biomed. Anal., 10, 917 (1992), Lee, S., et al.: J. Food Sci., 72, S497 (2007)<br></p>

<p>Stability Volatile<br>Applications 2-Bromobutane-d9 is labelled 2-Bromobutane (B681835) which is used in the various organic synthesis, existing as a grignard reagent.<br>References Girard, P. et al.: J. Am. Chem. Soc., 102, 2693 (1980); Apsel, B. et al.: Nat. Chem. Biol., 4, 691 (2008);<br></p>

<p>Applications 1-Hexane-d13-thiol is a useful isotopically labeled research compound employed in site selective Inelastic electron tunneling Spectroscopy.<br>References Okabayashi, N., et al.: Rev. Sci. Instr.um., 81, 084101 (2010); Okabayashi, N., et al.: Nano Lett., 10, 2950 (2010)<br></p>

<p>Stability Volatile<br>Applications Labelled Formic Acid is used to improve NMR profiling of amino metabolites in biofluids.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Ye, T. et al.: Anal. Chem., 82, 2303 (2010); Gowda, G.A., Anal. Chem., 82, 8983 (2010);<br></p>

<p>Applications 2,2,2-Trichloroethanol-13C2,D2 (cas# 1216995-48-0) is a compound useful in organic synthesis.<br></p>

<p>Applications 3-(Methoxy-d3)-1-propanol (cas# 86013-00-5) is a compound useful in organic synthesis.<br></p>

<p>Applications Ethylene Glycol Dicaprate-d4 is a deuterated version of Ethylene Glycol Dicaprate (E917474), a plasticizer for chloroethylene polymers.<br>References Van V. G. J., et al.: Kunststoffe, 57, 561 (1967); Van V. G. J., et al.: Plastica, 19, 175 (1966)<br></p>

<p>Applications 1-​Bromo-propane-​1,​1,​2,​2-​d4 is a useful reagent in studying rate coefficient and product branching for OH + bromopropane reaction from 230 to 360 K.<br>References Gilles, M., et al.: J. Phys. Chem. A, 106, 5358 (2002);<br></p>

<p>Applications Furfuryl-d5-amine (CAS# 1219799-26-4) is a useful isotopically labeled research compound.<br></p>

<p>Applications Testosterone Heptanoate-6,6,7,7,7-d5 (CAS# 1263095-31-3) is a useful isotopically labeled research compound.<br></p>

<p>Applications Ethylene Glycol Monolaurate-d4 is a deuterated analog of Ethylene Glycol Monolaurate (E917585), a reactant in the synthesis of neuritogenic gentiside derivatives.<br>References Wang, Guangfa, et al.: Chem. &amp; Pharma. Bul., 64(2), 161-170 (2016)<br></p>

<p>Applications Tryptamine-alpha,alpha-d2 HCl (CAS# 362049-49-8) is a useful isotopically labeled research compound.<br></p>

<p>Applications 1-Chloropropane-1,1-d2 (CAS# 125640-23-5) is a useful isotopically labeled research compound.<br></p>

<p>Applications Isophthalic-2,4,5,6-d4 Acid (CAS# 148472-48-4) is a useful isotopically labeled research compound.<br></p>

<p>Applications 4-Chlorobenzamide-2,3,5,6-d4 (CAS# 1219794-65-6) is a useful isotopically labeled research compound.<br></p>

<p>Applications Biphenyl-4,4'-d2 (CAS# 6120-99-6) is a useful isotopically labeled research compound.<br></p>

<p>Applications Anthracene-d10 is an isotope labelled analogue of Anthracene (A678400), an polycyclic aromatic hydrocarbon found readily as an component in coal tar. Anthracene is also used in the preparation of various dyes.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications Bis(2-methylpentyl) Phthalate-d4, is the labeled analogue of Bis(2-methylpentyl) Phthalate (B486005), used as a plasticizer to impart softness and flexibility to PVC products.<br>References Pierson, J. F., et al.: Angewandte Makromolekulare Chemie, 38, 167 (1979); Kaya, T., et al.: Chem. Res. Toxic., 19 (8), 999 (2006); Matter, H., et al.: Bioorg. Med. Chem., 20 (18), 5352 (2012);<br></p>

<p>Applications 2-Ethylphenol-d10 (CAS# 721429-63-6) is a useful isotopically labeled research compound.<br></p>

<p>Applications 4-Bromophenyl Phenyl-d5 Ether (CAS# 93951-83-8) is a useful isotopically labeled research compound.<br></p>

<p>Applications m-Xylene-d4 (ring-d4) (CAS# 425420-97-9) is a useful isotopically labeled research compound.<br></p>

<p>Applications N-(2,6-Dimethylphenyl)-2,2-dichloroacetamide-d9 is labelled N-(2,6-Dimethylphenyl)-2,2-dichloroacetamide (D434405) which is an intermediate used to prepare Ranolazine (R122500), an antianginal agent.<br>References Aalla, S., et al.: Org. Proc. Res. Dev.,16, 748 (2012)<br></p>

<p>Applications Diethyl-d10-amine HCl (CAS# 285132-87-8) is a useful isotopically labeled research compound.<br></p>

<p>Applications n-Pentyl-2,2,3,3,4,4,5,5,5-d9 Alcohol (CAS# 148587-12-6) is a useful isotopically labeled research compound.<br></p>

<p>Applications Methylphloroglucinol is used for the formation of insoluble azo dyes on blended fabrics. It is also used in the synthesis of inhibitory dihydroxyxanthone derivatives that are active against human tumor cell lines. This is the labeled analog.<br>References Tarakanova, L. et al.: Fiber Chem., 42, 254 (2011); Castanheiro, R. et al.: Bioorg. Med. Chem., 15, 6080 (2007);<br></p>

<p>Applications N,N-Diisopropylamine-d14 is used in the synthesis of trideuterated propantheline bromide;Also, it is an intermediate used in the synthesis of Disopyramide-d14 Tosylate Salt (D493452), which is an anti-arrhythmic (class IA). Sodium channel blocker.<br>References Buckley, P. H., et al.: J. Label. Compd. Radiopharm., 15, 657-664 (1978); Adelstein, et al.: J. Med. Chem., 16, 309 (1973), Czeisler, J.L., et al.: J. Pharm. Sci., 74, 750 (1985), Taylor, E.H., et al.: Ann. Clin. Lab. Sci., 16, 289 (1986)<br></p>

<p>Applications 1,1-Dimethyl-d6-urea (CAS# 1219802-32-0) is a useful isotopically labeled research compound.<br></p>

<p>Applications 3-Pentyl-2,2,3,4,4-d5 Alcohol (CAS# 144032-75-7) is a useful isotopically labeled research compound.<br></p>

<p>Applications 1-Bromopropane-2,2-d2 (CAS# 40422-15-9) is a useful isotopically labeled research compound.<br></p>

<p>Applications 1,3-Propane-d6-dithiol (CAS# 1219803-51-6) is a useful isotopically labeled research compound.<br></p>

<p>Applications N-Acetyl-DL-alanine-3,3,3-d3 is an isotopic analog of N-Acetyl-DL-alanine (A167965), a derivative of DL-Alanine (A481400) and is used as a reagent in the synthesis of potent new agents for the treatment of epilepsy.<br>References Conley, J.D., et al.: J. Med. Chem., 30, 567 (1987)<br></p>

<p>Applications N-Boc-2-(methylthio)ethylamine-d3 is the isotope labelled analog of N-Boc-2-(methylthio)ethylamine (B657055); a compound used as a reagent in the synthesis of anthranilic diamide insecticides and new glycopeptidomimetics based on N-substituted oligoglycines bearing N-linked lactoside side chains.<br>References Hua, X., et al.: Austr. J. Chem., 67, 1491 (2014); Saha, U.K., et al.: J. Chem. Soc. Chem. Comm., no vol., 2571 (1995)<br></p>

<p>Applications Octadecanoic-9,9,10,10-d4 Acid (CAS# 130048-57-6) is a useful isotopically labeled research compound.<br></p>

<p>Applications Used in the preparation of labelled indolizine compounds for use in antifungal combination therapy.<br></p>

<p>Applications 3,5-Dihexanamido-2,4,6-triiodo-benzoic Acid-d22 is the isotope labelled analog of 3,5-Dihexanamido-2,4,6-triiodo-benzoic Acid (D448150); a derivative of 3,5-Diamino-2,4,6-triiodobenzoic Acid (D416820) which is a metabolite of Diatrizoate with mutagenic and cytotoxic properties.<br>References Kalsch, W., et al.: Sci. Total Environ., 225, 143 (1999); Parkesh, R., et al.: Org. Biomol. Chem., 4, 3611 (2006)<br></p>

<p>Applications Labelled 1-Hexadecene. 1-Hexadecene is one of the alpha olefins used as comonomers in polymer such as low density polyethylenes for the properties of lighter, thinner, better flexibility and more tearing resistance.<br>References Conde, R., et al.: Phytomedicine, 18, 1197 (2011),<br></p>

<p>Applications n-Hexadecyltrimethylammonium-d42 Chloride (CAS# 2095863-88-8) is a useful isotopically labeled research compound.<br></p>