Deuterated Compounds

<p>Applications Sodium n-Decyl-d21 Sulfate (CAS# 933826-83-6) is a useful isotopically labeled research compound.<br></p>

<p>Applications A labelled Voriconazole (V760000) impurity.<br>References Rieke, R., et al.: Science, 246, 1260 (1989), Dickinson, R., et al.: Bioorg. Med. Chem. Lett., 6, 2031 (1996),<br></p>

<p>Applications γ-Valerolactone-d3 is the isotope labelled analog of γ-Valerolactone. γ-Valerolactone is a naturally occurring chemical found in fruits and is frequently used as a food additive. It can be converted to liquid alkenes which can be used as transportation fuels.<br>References Horvath, I.T., et al.: Green Chem., 10, 238 (2008); Bond, J.Q., et al.: Science, 327, 1110 (2010)<br></p>

<p>Applications Estradiol 17-Palmitate-d31 is the isotope analog of Estradiol 17-Palmitate. Estradiol 17-Palmitate is a metabolite of estradiol (E888000) which is the major estrogen secreted by the premenopausal ovary.<br>References Salole, E.G., et al.: Anal. Profiles Drug Subs., 15, 283 (1986), Lievertz, R.W., et al.: Am. J. Obstet. Gynecol., 156, 1289 (1987),<br></p>

<p>Applications trans-Stilbene-alpha,beta-13C2 (CAS# 153610-50-5) is a useful isotopically labeled research compound.<br></p>

<p>Applications n-Propyl-1,1,3,3,3-d5 Alcohol (CAS# 188894-71-5) is a useful isotopically labeled research compound.<br></p>

<p>Applications Tetraethylcystamine-13C8 is the isotope labeled form of Tetraethylcystamine (T291435), which is a reagent used in the addition of Thiobistriethylamine.Also, it is an intermediate used in the synthesis of Tiamulin-13C4 Fumarate (T436603), which is labeled Tiamulin (T436600); a derivative of Pleuromutilin; anti-bacterial.<br>References Evers, M., et al.: Bioorg. Med. Chem. Lett., 13, 4415 (2003); Egger, H., et al.: J. Antibiot., 29, 923 (1976), Baughn, C.O., et al.: Avian Dis., 22, 620 (1978), Goodwin, R.F., et al.: Vet. Rec., 104, 194 (1979), Kitai, K., et al.: Antimicrob. Agents Chemother., 31, 1935 (1987), Aarestrup, F., et al.: Vet. Microbiol., 64, 299 (1999)<br></p>

<p>Applications 1-Bromopentadecane-1,1,2,2-d4 (CAS# 1219798-87-4) is a useful isotopically labeled research compound.<br></p>

<p>Applications 2-Fluorotoluene-alpha,alpha,alpha-d3 (CAS# 25319-49-7) is a useful isotopically labeled research compound.<br></p>

<p>Applications Benzyl-2,3,4,5,6-D5 Alcohol is an isotopically labeled analog of Benzyl Alcohol (T536635), which is used in the synthesis of Cephalosporolide B as a versatile biomimetic synthetic precursor for chemical synthesis of other cephalosporides.<br>References Song, L. et al.: Org. Lett., 15, 5850 (2013);<br></p>

<p>Applications Methoxy Deethoxy Loteprednol Etabonate-d5 is labelled Methoxy Deethoxy Loteprednol Etabonate (M262230), a derivative of Loteprednol Etabonate (L471400) which is an ophthalmic corticosteroid.<br>References Alberth, M., et al.: J. Biopharm.Sci., 2, 115 (1991), Bodor, N., et al.: Pharm. Res., 9, 1275 (1992), Bartlett, J.D., et al.: J. Ocul. Pharmacol., 9, 157 (1993)<br></p>

<p>Applications (+)-cis-Vincaminic Acid Ethyl-d5 Ester is labelled (+)-cis-Vincaminic Acid Ethyl Ester (V314210) which is a derivative of Vinpocetine (D448350). It has been shown that under stressed conditions, vinpocetine equilibrates with Vincaminic Acid Ethyl Ester and hydrolyzes to Apovincaminic Acid (A729250).<br>References Muhammad, N., et al.: J. Pharmaceu. Sci., 77, 126 (1988); Han, et al.: J. Biol. Chem., 274, 22337 (1999), O’Donnell, et al.: Pharmacol. Biochem. Behav., 63, 185 (1999);<br></p>

<p>Applications Hexamidine-d12 Impurity A Hydrochloride is the labeled analogue of Hexamidine Impurity A Hydrochloride is an impurity of Hexamidine (H294205), an amidine compound use in the treatment of amyloid-related diseases; also use as preservative in cosmetics. Antiseptic.<br>References Taylor, P., et al.: J. Pharmaceut. Sci., 72, 1477 (1983); Granel, F., et al.: Clin. Infect. Diseases, 23, 839 (1996); Bailly, C., et al.: Biochem. J., 323, 23 (1997); Enyedy, I., et al.: J. Med. Chem., 44, 1349 (2001)<br></p>

<p>Applications (9β,10α)-4-Chloro-Androst-4-ene-3,17-dione-d4 is an isotope labelled impurity of Androstenedione (A637550), a Testosterone (T155000) precursor and metabolite with androgenic activity.<br>References Walker, V.R., et al.: Anal. Biopchem., 234, 194 (1996); King, D.S., et al.: J. Am. Med. Assoc., 281, 2020 (1999)<br></p>

<p>Applications Methyl(4-methylnaphthalen-1-ylmethyl)amine-d3 is the isotope analog of Methyl(4-methylnaphthalen-1-ylmethyl)amine. Methyl(4-methylnaphthalen-1-ylmethyl)amine is a reagent in the preparation of heterocyclic compounds as enoyl-acyl carrier protein reductase FabI inhibitors and antibacterial agents.<br>References Stuetz, A., et al.: J. Med. Chem., 29, 112 (1986); Berman, J., et al.: PCT Int. Appl., 2004:515512 (2004)<br></p>

<p>Applications 2-(2-Butylamino)ethanol-d4 is labelled 2-(2-Butylamino)ethanol (B693945) which is an intermediate used to prepare 2-arylimino-1,3-thiazolidines as progesterone receptor binding ligands.<br>References Dixon, B., et al.: U.S., US 6353006 B1 20020305 (2002)<br></p>

<p>Applications 1,5-Dibromopentane-d10 (CAS# 1219802-90-0) is a useful isotopically labeled research compound.<br></p>

<p>Applications N-Methyl-d3-epsilon-caprolactam (CAS# 203645-60-7) is a useful isotopically labeled research compound.<br></p>

<p>Applications N-Fmoc-(13C9,15N)-L-Tyrosine O-Tertbutyl Ether is the isotope labelled protected form of L-Tyrosine (T899975), an essential amino acid that exhibits in vitro antioxidant and antiradical activities. L-Tyrosine is used as a precursor to synthesize catecholamines (e.g. Norepinephrine HCl [N674500]) in human keratinocytes, and also for the synthesis of proteins and thyroid hormones.<br>References Gülçin, ?.: Amino Acids, 32, 431 (2007); Langen, K., et al.: Nuc. Med. Biol., 29, 625 (2002); Schallreuter, K., et al.: J. Invest. Derm., 104, 953 (1995); Zhang, W., et al.: Neuropharmacology, 47, 438 (2004)<br></p>

<p>Applications Octanoic-2,2-d2 Acid (CAS# 64118-36-1) is a useful isotopically labeled research compound.<br></p>

<p>Applications Methyl trans-Cinnamate-d5 (phenyl-d5) (CAS# 61764-82-7) is a useful isotopically labeled research compound.<br></p>

<p>Applications Labelled 2-(3,4-Dimethoxyphenyl)-N-methylethylamine (D470710, free amine) which is a methylated metabolite of Dopamine (D533780); a potent inhibitor of brain mitochondrial respiration used in Parkinson’s disease studies.<br>References Gluck, M.R. et al.: J. Neurochem., 91, 788 (2004); Charlton, C.G. et al.: Life Sci., 66, 2159 (2000);<br></p>

<p>Applications Bis(p-cresyl) o-Cresyl Phosphate-d7 is labelled Bis(p-cresyl) o-Cresyl Phosphate (B419210), an isomer of Tricresyl phosphate (TCP) which is used as an anti-wear additive in aircraft turbine engine oil.<br>References De Nola, G., et al.: J. Chrmoat. A, 1200, 211 (2008)<br></p>

<p>Applications n-Hexadecyltrimethylammonium-d42 Chloride (CAS# 2095863-88-8) is a useful isotopically labeled research compound.<br></p>

<p>Applications 1,2,4,5-Tetramethylbenzene-3,6-d2 (CAS# 1859-01-4) is a useful isotopically labeled research compound.<br></p>

<p>Applications Labelled 1-Hexadecene. 1-Hexadecene is one of the alpha olefins used as comonomers in polymer such as low density polyethylenes for the properties of lighter, thinner, better flexibility and more tearing resistance.<br>References Conde, R., et al.: Phytomedicine, 18, 1197 (2011),<br></p>

<p>Applications Dimethyl-d6-cyanamide (cas# 72142-88-2) is a compound useful in organic synthesis.<br></p>

<p>Applications Diethyl-d10-amine HBr (CAS# 1219803-53-8) is a useful isotopically labeled research compound.<br></p>

<p>Applications 3,5-Dihexanamido-2,4,6-triiodo-benzoic Acid-d22 is the isotope labelled analog of 3,5-Dihexanamido-2,4,6-triiodo-benzoic Acid (D448150); a derivative of 3,5-Diamino-2,4,6-triiodobenzoic Acid (D416820) which is a metabolite of Diatrizoate with mutagenic and cytotoxic properties.<br>References Kalsch, W., et al.: Sci. Total Environ., 225, 143 (1999); Parkesh, R., et al.: Org. Biomol. Chem., 4, 3611 (2006)<br></p>

<p>Applications 3-Benzyloxy-α-(N-butyryl-d3)-aminopropionitrile (cas# 1216615-94-9) is a compound useful in organic synthesis.<br></p>

<p>Applications Impurity in the production of labelled Phenylbutazone (P319572)<br>References Fricoteaux, R., et al.: J. Pharm. Biomed. Anal., 7, 1585 (1989), Segrestaa, J., et al.: Chem. Pharm. Bull., 50, 744 (2002),<br></p>

<p>Applications Synaptamide-d4 is labelled Synaptamide (S910000) which is an endocannabinoid-like derivative of docosahexaenoic acid with cannabinoid-independent function. It has potent synaptogenic activity and structural similarity to anandamide. Synaptamide (S910000) is subjected to hydrolysis by fatty acid amide hydrolase, and can be oxygenated to bioactive metabolites.<br>References Kim, H., et al.: Prostaglandins Leukot Essent Fatty Acids, 88, 121 (2013); Burstein, S., et al.: Bioorg. Med. Chem., 16, 9644 (2008); Fu, J., et al.: J. Biol. Chem., 282, 1518 (2007)<br></p>

<p>Applications Testosterone Octanoate-d15 is the isotope analog of Testosterone Octanoate. Testosterone Octanoate is a metabolite of tesosterone (T155000), which is used in biological studies to determine the hemolytic and lipophilic activity of this anabolic steroid.<br>References Biagi, G.L., et al.: J. Med. Chem., 13, 944 (1970); Biagi, G. L., et al.: J. Med. Chem., 18, 873 (1975)<br></p>

<p>Applications 1,8-Octanedioic-d12 Acid (CAS# 169397-99-3) is a useful isotopically labeled research compound.<br></p>

<p>Applications Used in the preparation of labelled indolizine compounds for use in antifungal combination therapy.<br></p>

<p>Applications Octadecanoic-9,9,10,10-d4 Acid (CAS# 130048-57-6) is a useful isotopically labeled research compound.<br></p>

<p>Applications N-Boc-2-(methylthio)ethylamine-d3 is the isotope labelled analog of N-Boc-2-(methylthio)ethylamine (B657055); a compound used as a reagent in the synthesis of anthranilic diamide insecticides and new glycopeptidomimetics based on N-substituted oligoglycines bearing N-linked lactoside side chains.<br>References Hua, X., et al.: Austr. J. Chem., 67, 1491 (2014); Saha, U.K., et al.: J. Chem. Soc. Chem. Comm., no vol., 2571 (1995)<br></p>

<p>Applications N-Acetyl-DL-alanine-3,3,3-d3 is an isotopic analog of N-Acetyl-DL-alanine (A167965), a derivative of DL-Alanine (A481400) and is used as a reagent in the synthesis of potent new agents for the treatment of epilepsy.<br>References Conley, J.D., et al.: J. Med. Chem., 30, 567 (1987)<br></p>

<p>Applications 1,3-Propane-d6-dithiol (CAS# 1219803-51-6) is a useful isotopically labeled research compound.<br></p>

<p>Applications 2-Nitrotoluene-alpha,alpha,alpha-d3 (CAS# 70786-67-3) is a useful isotopically labeled research compound.<br></p>

<p>Applications n-Heptyl-5,5,6,6,7,7,7-d7 Alcohol (CAS# 1219804-99-5) is a useful isotopically labeled research compound.<br></p>

<p>Applications L-Phenyl-d5-alanine-N-FMOC (CAS# 225918-67-2) is a useful isotopically labeled research compound.<br></p>

<p>Applications A labelled metabolite of Propafenone (P757500).<br></p>

<p>Applications 2,4,6-Trimethylpyridine-d11 (CAS# 1219805-54-5) is a useful isotopically labeled research compound.<br></p>

<p>Applications 1-Bromopropane-2,2-d2 (CAS# 40422-15-9) is a useful isotopically labeled research compound.<br></p>

<p>Applications rac Styrene Glycol-D5 is an intermediate in the synthesis of rac Mirabegron-d5 (M364902), which is a potent bladder relaxant and reagent for diabetes remedy.<br></p>

<p>Applications Ethylene Glycol Monodecanoate-d4 is a deuterated version of Ethylene Glycol Monodecanoate (E917555), a reactant in the synthesis of water-woluble phospholipid analogues as inhibitors of phospholipase C.<br>References Franklin, Christopher L., et al.: J. of Org. Chem., 68(19), 7298-7307 (2003)<br></p>

<p>Applications 2-(Ethyl-d5)hexanoic Acid is an intermediate in the synthesis of Alexidine-d10 Dihydrochloride (A525002), which has antibacterial, antiplaque properties against Streptococcus mutans, Actinomyces ciscosus, and Actinomyces naesludii.<br>References Coburn, R.A., et al.: J. Med. Chem., 21, 8, 829 (1978), Takayama, K., et al.: J. Biol. Chem., 269, 2241 (1994), Faure, P., et al.: Biochimie, 86, 411 (2004),<br></p>

<p>Applications n-Octyl-1,1-d2 Alcohol (CAS# 78510-02-8) is a useful isotopically labeled research compound.<br></p>

<p>Applications n-Butyl-4,4,4-d3 Alcohol (CAS# 64156-70-3) is a useful isotopically labeled research compound.<br></p>

<p>Applications rac-threo-Methyl-13C, d3-phenidate Hydrochloride is the labeled analog of rac-threo-Methylphenidate Hydrochloride (M325671), which has shown that the pharmacological activity resides predominantly in the d-threo enantiomer.<br>References Greenblatt, E.N., et al.: J. Pharmacol. Exp. Ther., 131, 115 (1961); Padmanabhan, G.R., et al.: Anal. Profiles Drug Subs., 10, 473 (1981); Kuczenski, R., et al.: J. Pharmacol. Exp. Ther., 296, 876 (2001), Pelham, W.E., et al.: J. Consult. Clin. Psychol., 61, 506 (1993); Srinivas, N.R., et al.: Pharm. Res., 10, 14 (1993)<br></p>

<p>Applications 1-Hexadecane-d33-thiol (CAS# 218956-22-0) is a useful isotopically labeled research compound.<br></p>

<p>Applications A labelled trans-4-Hydroxy-L-proline. A natural constituent of animal structural proteins such as collagen and elastin. Several microorganisms producing proline trans-4- and cis-3-hydroxylase were discovered and these enzymes were applied to the industrial production of trans-4- and cis-3-hydroxy-L-proline.<br>References Langmaier, F. et al.: Int. J. Cosm. Sci., 24, 273 (2002); Lawrence, C., et al.: Biochem. J., 313, 185 (1996); Mori, H., et al.: J. Bacteriol.; 179, 5677 (1997); Clifton, I., et al.: Eur. J. Biochem., 268, 6625 (2001);<br></p>

<p>Applications 3-Pentyl-2,2,3,4,4-d5 Alcohol (CAS# 144032-75-7) is a useful isotopically labeled research compound.<br></p>

<p>Applications Buramate-d7, is the labeled analogue of Buramate (B689700), used for the synthesis of more complex compounds, having antibacterial activity, and also for the synthesis of new antimalarial compounds.<br>References Marrero-Ponce, Y., et al.: Bioorg. Med. Chem., 13 (8), 2881 (2005); Marrero-Ponce, Y., et al.: J. Chem. Info. Model., 45 (4), 1082 (2005);<br></p>

<p>Applications Choline Fenofibrate-d6 is the labeled analogue of Choline Fenofibrate (C432665), a new formulation of fenofibric acid, ABT-335, co-administered with statins.<br>References Athyros, V., et al.: Diabetes Care, 25, 1198 (2002); Sacks, F., et al.: Am. J. Cardiol., 90, 139 (2002); Wierzbicki, A., et al.: Curr. Med. Res. Opin., 19, 155 (2003); Sarwar, N., et al.: Circulation, 115, 450 (2007)<br></p>

<p>Applications Nonyl 4-Hydroxybenzoate-d4 is labelled Nonyl 4-Hydroxybenzoate which was used to prepare 4-[(aminosulfonyl)oxy] benzoic acid derivatives as potent inhibitors of the enzyme estrone sulfatase (ES). It was also used to synthesize sulfonylbenzoic acid esters as potential inhibitors of oestrone sulphatase with antitumor activities.<br>References Ahmed, S., et al.: Bioorg. Med. Chem. Lett., 12, 2391 (2002); Owen, C., et al.: J. Pharm. Pharmacol., 55, 85 (2002)<br></p>

<p>Applications N-[2-(Phenylthio)phenyl]-1-piperazine-d8-carboxamide Hydrochloride is the labeled analog of N-[2-(Phenylthio)phenyl]-1-piperazinecarboxamide Hydrochloride, an impurity of Quetiapine (Q510000), a benzothiazepine with mixed serotonin and dopamine receptor antagonistic properties; used as an antipsychotic.<br>References Stolarczyk, E.U., et. al.: Pharm. Develp. Tech., 14, 27 (2009); Wetzel, H., et al.: Psychopharmacology, 119, 231 (1995)<br></p>

<p>Applications A labelled tryptophan metabolite, is a precursor of kynurenic acid, which is an antagonist of N-methyl-aspartate receptor. An amino acid produced in the body from tryptophan.<br>References Swartz, K., et al.: J. Neurosci., 10, 2965 (1990), Hasegawa, H., et al.: Anal. Bioanal. Chem., 377, 886 (2003), Tsai, Y., et al.: Anal. Biochem., 319, 34 (2003), Mitsuhashi, S., et al.: Anal. Chim. Acta, 584, 315 (2007),<br></p>