Deuterated Compounds

<p>Applications Sodium 6-Hydroxyhexanoate-3,3,4,4,5,5-d6 (CAS# 1219794-58-7) is a useful isotopically labeled research compound.<br></p>

<p>Applications 4-Aminobutyric-4,4-d2 Acid (CAS# 107022-06-0) is a useful isotopically labeled research compound.<br></p>

<p>Applications 3,4-Dimethylphenol-2,5,6-d3,OD (CAS# 1219803-55-0) is a useful isotopically labeled research compound.<br></p>

<p>Applications A labelled antibacterial agent.<br>References Kind, T., et al.: Anal. Biochem., 363, 185 (2007), Spratlin, J., et al.: Clin. Cancer Res., 15, 431 (2009),<br></p>

<p>Applications Pyridine-2,6-d2 (CAS# 17265-96-2) is a useful isotopically labeled research compound.<br></p>

<p>Applications 2’,3’,5’-Tri-O-benzoyl Xanthine-13C5 is an intermediate used in the synthesis of Xanthosine-13C5 (X742102), which is the labeled analogue of Xanthosine (X742100), the deamination product of Guanosine. It is also a potential biomarker for detecting radiation exposure.<br>References Magasanik, B, et al.: J. Bio. Chem., 206, 83 (1954);<br></p>

<p>Applications Pentadecanoic-15,15,15-d3 Acid (CAS# 352431-40-4) is a useful isotopically labeled research compound.<br></p>

<p>Applications Hexadecanoic-7,7,8,8-d4 Acid (CAS# 75736-49-1) is a useful isotopically labeled research compound.<br></p>

<p>Applications Hexadecanoic-13,13-d2 Acid (CAS# 62690-28-2) is a useful isotopically labeled research compound.<br></p>

<p>Applications 4-Chlorobiphenyl-2',3',4',5',6'-d5 (CAS# 51624-37-4) is a useful isotopically labeled research compound.<br></p>

<p>Applications A metabolite of Phosphatidylcholine, also inhibits the production of oxygen radicals during methane production.<br>References Liao, C., et al.: Eur. J. Pharmacol., 566, 103 (2007), Ghyczy, M., et al.: Cell. Physiol. Biochem., 21, 251 (2008),<br></p>

<p>Applications Dexamethasone Hemisuccinate-d4 is the isotope labelled analog of Dexamethasone Hemisuccinate (D298855); a derivative of Dexamethasone (D298800) which is a glucocorticoid used as an anti-inflammatory agent. It regulates T cell survival, growth, and differentiation. Dexamethasone also inhibits the induction of nitric oxide synthase.<br>References Wershil, B.K., et al.: Int. Arch. Allergy Immunol., 107, 323 (1995); Riccardi, C., et al.: Cell Death Diff., 6, 1182 (1999); Llanos, S.L. and Roldan, A.: Bio Cell, 23, 29 (1999)<br></p>

<p>Applications 3',4'-Dimethoxyacetophenone-d3 (methyl-d3) (CAS# 350818-54-1) is a useful isotopically labeled research compound.<br></p>

<p>Applications 2,2-Bis(4-hydroxyphenyl)propanol-d11 is labelled 2,2-Bis(4-hydroxyphenyl)propanol (B447360) which is a metabolite of bisphenol A (B519495). It works as an endocrine disruptor.<br>References Krishnan, A.V., et al.: Endocrinology, 132, 2279 (1993), Steinmetz, R., et al.: Trends Endocrinol. Metab., 9, 124 (1998); Kitamura, S., et al.: Toxicol. Sci., 84, 249 (2005)<br></p>

<p>Applications (±)-Carazolol-d7 is labelled (±)-Carazolol (C175810, HCl salt) which is a promising high-affinity beta-adrenergic receptor ligand for the noninvasive determination of beta receptor status using PET.<br>References Berridge, M.S., et al.: J. Nucl. Med., 35(10), 1665 (1994)<br></p>

<p>Applications 3-Pentanone-d10 (CAS# 54927-77-4) is a useful isotopically labeled research compound.<br></p>

<p>Applications 4-Chloro-N-(methyl-d3)pyridine-2-carboxamide (cas# 1189858-48-7) is a compound useful in organic synthesis.<br></p>

<p>Applications 1-Bromopentadecane-d31 (CAS# 349553-93-1) is a useful isotopically labeled research compound.<br></p>

<p>Applications Fenuron-d5 (phenyl-d5) (CAS# 1219802-06-8) is a useful isotopically labeled research compound. It can be used for the preparation of difunctionalized indoles.<br>References Lv, H., et al.: Org. Biomol. Chem., 15, 8054 (2017)<br></p>

<p>Applications Dimethyl chlorothiophosphate-D6 is a labelled analog of Dimethyl chlorothiophosphate (D473292). Dimethyl chlorothiophosphate is an organophosphorus reagent that is used to synthesize phosphorus analogues of γ-aminobutyric acid, compounds that exhibit anticonvulsant properties. Dimethyl chlorothiophosphate is also used as a reagent to synthesize Parathion (P192220), a widely used pesticide.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Cates, L., et al.: J. Med. Chem., 27, 654 (1984); DeBruin, K. &amp; Boros, E.: J. Org. Chem., 55, 609 (1990); Hall, S.: J. Am. Chem. Soci., 72, 2768 (1950); Kotronarou, A. &amp; Hoffmann, M.: Env. Sci. Tech., 26, 1460 (1992)<br></p>

<p>Applications Tetrabromobisphenol A Diglycidyl Ether-d10 is the isotope labelled analog of Tetrabromobisphenol A Diglycidyl Ether (T291305); a brominated flame retardant (BFR) with good stability and a thermal decomposition temperature over 300°.<br>References Oleszek S., et al.: Waste Manag., 33, 1835 (2013); Jia, X., et al.: Henan Daxue Xuebao, Ziran Kexueban, 36, 44 (2006)<br></p>

<p>Applications An intermediate for the synthesis of analogs of retinoid lactone.<br>References Lewin, A.H., et al.: Pharm. Res., 12, 983 (1995).<br></p>

<p>Applications n-Hexadecyl-2,2,16,16,16-d5 Alcohol (CAS# 1219799-18-4) is a useful isotopically labeled research compound.<br></p>

<p>Applications trans,trans-Muconic-d4 Acid (CAS# 1955496-83-9) is a useful isotopically labeled research compound.<br></p>

<p>Applications Octanoic-8,8,8-d3 Acid (CAS# 156779-05-4) is a useful isotopically labeled research compound.<br></p>

<p>Applications Insecticide.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Nishizawa, Y., et al.: Agric. Biol. Chem., 25, 605 (1961),<br></p>

<p>Applications Cycrimine Hydrochloride-d5 is the isotope labelled analog of Cycrimine Hydrochloride (C991450); a cholinolytic anti-Parkinson drug which can cause neuromuscular blockades in isolated rat diaphragms.<br>References Das, M., et al.: Toxicol. Appl. Pharm., 39, 149 (1977); Vedasiromoni, J.R., et al.: Arch. Int. Pharmacod. T., 219, 64 (1976)<br></p>

<p>Applications 4-Fluorotoluene-alpha,alpha,alpha-d3 (CAS# 4202-91-9) is a useful isotopically labeled research compound.<br></p>

<p>Applications m-Bromofluorobenzene-d4 is a labeled reagent useful for organic synthesis.<br></p>

<p>Applications 1-Iodopropane-d7 is the labelled analogue of 1-Iodopropane [I718790] which is used in the synthesis of a new class of cesium selective ionophores. Also used to preparation of secondary amines and diamines.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Casnati, A. et al.: J. Am. Chem. Soc., 117, 2767 (1995); Fukuyama, T. et al.: Tetrahedron Lett., 38, 5831 (1997);<br></p>

<p>Applications N,N-Diethylbenzamide-d5 is an intermediate in the synthesis of Benz[a]anthracene-7,12-dione-D4 (B197942), a polycyclic aromatic hydrocarbon that is present in the emission soot of biomass fuels combustion.<br></p>

<p>Applications 1,3-Dioleoyl-2-stearoylglycerol-d5 is the isotope labelled analog of 1,3-Dioleoyl-2-stearoylglycerol (D484305); a triglyceride found in various natural sources such as coconut oil, palm oil, rice bran oil, sunflower oil and sesame oil.<br>References Reena, M.B. et al.: Eur. J. Lipid Sci. Technol., 111, 346 (2009); Huey, S. et al.: J. Food Sci., 74, E177 (2009)<br></p>

<p>Applications n-Butyl-3,3,4,4,4-d5 Alcohol (CAS# 64118-16-7) is a useful isotopically labeled research compound.<br></p>

<p>Applications (±)-2-Iodobutane-d9 (CAS# 1219795-41-1) is a useful isotopically labeled research compound.<br></p>

<p>Applications Phenylboronic Acid-13C6 is the isotope labelled 13C6 analog of Phenylboronic Acid (P319590); a compound used in the organic synthesis of various pharmaceutical goods.<br>References Ainley, A.D., et al.: J. Chem. Soc., 2171 (1930)<br></p>

<p>Applications 2-Chloroaniline-d6 (CAS# 1276197-37-5) is a useful isotopically labeled research compound.<br></p>

<p>Applications A labelled metabolite of the antihypertensive agent, Labetalol (L096500). Ractopamine impurity.<br>References Gal, J., et al.: Res. Comm. Chem. Pathol. Pharmacol., 62, 3 (1988),<br></p>

<p>Applications n-Nonyl-d19 Alcohol (CAS# 349553-86-2) is a useful isotopically labeled research compound.<br></p>

<p>Applications 1,14-Tetradecanedioic-d24 Acid (CAS# 130348-88-8) is a useful isotopically labeled research compound.<br></p>

<p>Applications 3-(2,6-Dimethylphenyl)-2-oxazolidinone-d6 is an intermediate used in the synthesis of Dimethachlor Ethane Sulfonic Acid Sodium Salt-d6 (D460284), which is the deuterium labelled form of Dimethachlor Ethane Sulfonic Acid Sodium Salt (D460283), which is a pesticide metabolite and pollutant found in groundwater, surface water, and wastewater.<br>References Huntscha, S., et al.: J. Chromatogr. A, 1268, 74 (2012); Reemtsma, T., et al.: J. Chromatogr. A, 1271, 95 (2013);<br></p>

<p>Applications N,N,N',N'-Tetramethyl-1,3-propanediamine-d18 (CAS# 1398065-52-5) is a useful isotopically labeled research compound.<br></p>

<p>Applications 1-Bromoundecane-1,1,2,2-d4 (CAS# 1219802-82-0) is a useful isotopically labeled research compound.<br></p>

<p>Applications 1,3,5-Triphenylbenzene-d18 (CAS# 34496-33-8) is a useful isotopically labeled research compound.<br></p>

<p>Applications Bromoethane-1,2,2-d3 (CAS# 23705-69-3) is a useful isotopically labeled research compound.<br></p>

<p>Applications Unlabeled 3,3'-Dibromodiphenyl-d8 is used in the synthesis of novel aromatic compounds as electroluminescent materials and organic semiconductor materials for organic light emitting devices.<br>References Ham, H.; et al.: PCT Int. Appl. 64pp. Patent 2016 CODEN:PIXXD2<br></p>

<p>Applications 1,2,4,5-Benzenetetracarboxylic Dianhydride-d2 (CAS# 106426-63-5) is a useful isotopically labeled research compound.<br></p>

<p>Applications cis-Apovincamine-d3 is labelled cis-Apovincamine (A729245) which is a vinca alkaloid and a chemical precursor of Vinpocetine (V332500), a derivative of Vincamine with vasodilating activity. Vasodilator (cerebral).<br>References Han, et al.: J. Biol. Chem., 274, 22337 (1999), O’Donnell, et al.: Pharmacol. Biochem. Behav., 63, 185 (1999),<br></p>

<p>Applications 1-Bromo-3,4-difluorobenzene-d3 (CAS# 1219799-14-0) is a useful isotopically labeled research compound.<br></p>

<p>Applications 1,2-Propylene-d6 Carbonate (cas# 202480-74-8) is a compound useful in organic synthesis.<br></p>

<p>Applications (4-Carboxybutyl-d4)triphenylphosphonium Bromide is a reactant in the preparation of deuterated nocloprost.<br>References Krause, W., et. al.: Prostaglandins, 40, 283 (1990)<br></p>

<p>Applications DL-Lysine-2-15N 2HCl (CAS# 2747-89-9) is a useful isotopically labeled research compound. This compound can be used for spectrophotometric analysis to determine the mechanism of electron-capture-induced dissociation of various peptides.<br>References Holm, A., et.al., J. Phy. Chem.A.,111,9641-9643,(2007); Nakamura, A. Nippon Kagaku Zasshi,86,500-505,(1965);<br></p>

<p>Applications 3,4-Difluorobenzoic-d3 Acid (CAS# 1219798-70-5) is a useful isotopically labeled research compound.<br></p>

<p>Applications N,N-Dimethylacetamide-2,2,2-d3 (CAS# 20255-66-7) is a useful isotopically labeled research compound.<br></p>

<p>Applications Heptanoic Acid (D13, 98%) (cas# 130348-93-5) is a useful research chemical.<br></p>

<p>Applications Decanoic-10,10,10-d3 Acid is the isotope labelled analog of Decanoic Acid (D212525); a compound used in the manufacturing of esters for artificial fruit flavors and perfumes.<br>References Oro, L., et al.: Acta Pharmacol. Toxicol., 18, 141 (1961)<br></p>

<p>Applications 2-((Hexyl-d4)oxy)tetrahydropyran is a proposed intermediate in the synthesis of 1-Octen-3-one-D4 (O239252), a labelled analogue of 1-Octen-3-one (O239250). 1-Octen-3-one is a volatile unsaturated ketone that has a strong mushroom-like odour. 1-Octen-3-one is also a flavour component of the Agaricus bisporus mushroom and is used in a variety of food products.<br>References Culleré, L., et al.: Anal. Chim. Acta, 563, 51 (2006); Fickert, B. &amp; Schieberle, P.: Food/Nahrung, 42, 371 (1998); Husson, F., et al.: Proc. Biochem., 37, 177 (2001)<br></p>

<p>Applications 1-Bromopentane-4,4,5,5,5-d5 (CAS# 83418-34-2) is a useful isotopically labeled research compound.<br></p>

<p>Applications Isotope labelled L-Isomer of D-Idose (I175050), a monosaccharide that has is an important component of dermatan sulfate and heparan sulfate.<br>References Olsen, S.G., et al.: J. Biol. Chem., 264, 15982 (1989);<br></p>

<p>Applications Isotope labelled Hexadecyltrimethylammonium Bromide (CTAB) (H293860), is a cationic surfactant used as a template in the synthesis of Mesoporous γ-Fe2O3.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Yu, H.-h., et al.: Gongneng Cailiao, 42, 2005 (2011),<br></p>

<p>Applications Cyclopropyl Methyl Ketone-d8 (CAS# 1219799-33-3) is a useful isotopically labeled research compound.<br></p>

<p>Applications n-Butyl-1,1,2,2-d4 Alcohol (CAS# 118104-91-9) is a useful isotopically labeled research compound.<br></p>

<p>Applications N-Pentadecane (D32, 98%) (cas# 36340-20-2) is a useful research chemical.<br></p>

<p>Applications 2-Nitrotoluene-3,4,5,6-d4 (CAS# 115049-76-8) is a useful isotopically labeled research compound.<br></p>

<p>Applications Benzimidazole-4,5,6,7-d4 (CAS# 64531-29-9) is a useful isotopically labeled research compound.<br></p>

<p>Applications Nicotinic Acid Riboside-d4 Methyl Ester Triflate O-Acetate is an intermediate used in the synthesis of Nicotinic Acid Riboside-d4 Methyl Ester Triflate (N429407), which is the labelled analogue of an effective agent for increasing nicotinamide adenine dinucleotide (NAD) concentrations in mammalian cells.<br>References Belenky, P. et al.; J. Biol. Chem. 284, 158 (2009); Yang, T. et al.: J. Med. Chem., 50, 6458 (2007);<br></p>

<p>Applications (S)-1-(2-Chloroacetyl)pyrrolidine-2-carboxamide-D3 is the deuterated form of (S)-1-(2-Chloroacetyl)pyrrolidine-2-carboxamide (C363865), which is used in the synthesis of Vildagliptin (V305000), an oral anti-diabetic drug, and its impurities (H971380) (Impurity A).<br>References Kumar, N., et al.: J. Pharmaceut. Biomed.,119, 114 (2016); Deng, Y., et al.: Lett. Org. Chem., 11, 780 (2014);<br></p>

<p>Applications N,N-Dimethyl-d6-acetamide (CAS# 31591-08-9) is a useful isotopically labeled research compound.<br></p>

<p>Applications Bromocyclopropane-d5 is labelled bromocyclopropane (B682760) which is used as a reagent to synthesize substituted (carboxycyclopropyl)glycines as potent and selective group II metabotropic glutamate receptor antagonists.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Ornstein, P., et al.: J. Med. Chem., 41, 358 (1998)<br></p>