Deuterated Compounds

<p>Applications Labelled analogue of Potassium Cyanide, a reagent widely used in organic synthesis for the preparation of nitriles and carboxylic acids, particularly in the von Richter reaction.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Kollenz, G. et al.: Org. Prep. Proc. Int., 12, 244 (1980); Subramanian, L. R.: Sci. Synth., 19, 173 (2004);<br></p>

<p>Applications n-Butylamine-ND2 DCl (CAS# 156235-87-9) is a useful isotopically labeled research compound.<br>Chemical Name: n-Butylamine-ND2 DCl (CAS# 156235-87-9) is a useful isotopically labeled research compound.<br></p>

<p>Applications Acetamide-d5 (CAS# 33675-83-1) is a useful isotopically labeled research compound.<br></p>

<p>Applications N-Methyl Lacosamide-d3 is the labeled analogue of N-Methyl Lacosamide (M315210), a methly analogue of Lacosamide (L098500), a medication used for the adjunctive treatment of partial-onset seizures and diabetic neuropathic pain. Lacosamide is a potent anticonvulsant.<br>References Lees, G., et al.: Brain Res., 612, 190 (1993), Kuo, C., et al.: Mol. Pharmacol., 51, 1077 (1997); Barton, M., et al.: Epilepsy Res., 47, 217 (2001); Beyreuther, B., et al.: Eur. J. Pharmacol., 539, 64 (2006); Beyreuther, B., et al.: CNS Drug Rev., 13, 21 (2007)<br></p>

<p>Applications 4-Chlorobenzyl-2,3,5,6-d4 Cyanide (CAS# 1219804-00-8) is a useful isotopically labeled research compound.<br></p>

<p>Applications Lombazole-d9 is deuterium labelled form of Lombazole (L470205), which is imidazole based antimicrobial agent with some antifungal activity.<br>References Barug, D., De Groot, K.: Antimicrob. Agents Chemother., 28, 643 (1985); Barug, D., et al.: Antimicrob. Agents Chemother., 30, 238 (1986);<br></p>

<p>Applications cis-8,11,14-Eicosatrienoic Acid Ethyl Ester-d5 is the isotope labelled analog of cis-8,11,14-Eicosatrienoic Acid Ethyl Ester (E477920); the ethyl ester derivative of cis-8,11,14-Eicosatrienoic Acid (E477930) which is a fatty acid with selective tumoricidal activity.<br>References Das, U., et al.: Cancer Lett., 56, 235 (1991); Rudra, P., et al.: Anticancer Res., 21, 29 (2001); Menendez, J., et al.: Breast Cancer Res. Treat., 72, 203 (2002)<br></p>

<p>Applications 1-Propyl-d5-amine is labelled 1-Propylamine (P833700) which is used in the synthesis of pyrimidine derivatives as novel and highly potent PDE4 inhibitors. It is also used in the preparation of fluorenone analogs with DNA topisomerase I inhibitors.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications 1,4-Cyclohexane-d10-diamine (cis/trans mixture) (CAS# 1219802-80-8) is a useful isotopically labeled research compound.<br></p>

<p>Applications Labelled Isopentenyl Pyrophosphate. Used for the preparation of antitumor agents phosphohalohydrins.<br>References Dhe-Paganon, S., et al.: Biochem., 33, 13355 (1994), Tanaka, Y., et al.: Nature, 375 155 (1995), Wesch, D., et al.: Eur. J. Immunol., 27, 952 (1997),<br></p>

<p>Applications Dodecylphosphocholine (D38, 98%) (cas# 130890-78-7) is a useful research chemical.<br></p>

<p>Applications N,N-Bis-desethyl, N-Methyl Entacapone-d3 is the isotope analog of N,N-Bis-desethyl, N-Methyl Entacapone which is an impurity of Entacapone (E558500). The (E)-Isomer of Entacapone which is a polymorphic form A. Peripherally acting inhibitor of catechol-O-methyl transferase (COMT), an enzyme involved in the metabolism of catecholamine neurotransmitters and related drugs. Antiparkinsonian.<br>References Karlsson, M., et al.: J. Pharm. Biomed. Anal., 10, 593 (1992), Nissinen, E., et al.: Arch. Pharmacol., 346, 262 (1992), Wikberg, T., et al.: Eur. J. Drug Metab. Pharmacokinet., 18, 359 (1993),<br></p>

<p>Applications 2-Iodopropane-d7 is the isotope labelled analog of 2-Iodopropane (I718795); a reagent used in the synthesis of 4'-O-alkyl-chitobiosyl-4-methylumbelliferone as human chitinase fluorogenic substrates.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Duivenvoorden, B.A., et al.: Carbohyd. Res., no vol., no pp. (2014, ahead of print)<br></p>

<p>Applications 2,6-Dimethylnaphthalene-d12 (CAS# 350820-12-1) is a useful isotopically labeled research compound.<br></p>

<p>Applications Phosphoric Acid-D4 Trifluoroboroane Deuterium Oxide is an intermediate in the synthesis of 3-Hydroxy Benzopyrene-d11 (H829402), which is a abelled metabolite of Benzopyrene (BaP), a carcinogenic component of tobacco smoke implicated in lung cancer.<br>References DiBiasio, K., et al.: Drug Metab. Dispos.,19, 227 (1991), Beach, J., et al.: J. Anal. Toxicol., 24, 670 (2000), Borman, S., et al.: Toxicol. Appl. Pharmacol., 167, 191 (2000), Tsai-Turton, M., et al.: Biol. Reprod., 77, 442 (2007),<br></p>

<p>Applications Hydrocinnamic-alpha,alpha-d2 Acid (CAS# 19136-97-1) is a useful isotopically labeled research compound.<br></p>

<p>Applications 2,5-Dimethyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indol-1-one-d3 is the deuterated version of 2,5-Dimethyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indol-1-one (D480165), which is an impurity of Alosetron (A575500) that is a serotonin 5HT3 receptor antagonist, used in treatment of irritable bowel syndrome.<br>References Camilleri, M., et al.: Lancet, 355, 1035 (2000); Nestorov, I., et al.: Drug Metab. Dispos., 30, 276 (2002); Lewis, D., et al.: Drug Metab. Rev., 35, 1 (2003); Tang, H., et al.: J. Pharm. Sci., 95, 1783 (2006); Gleeson, M., et al.: J. Med. Chem., 50, 101 (2007);<br></p>

<p>Applications Methyl Methacrylate-d5 (CAS# 55935-46-1) is a useful isotopically labeled research compound.<br></p>

<p>Applications Reagent used in the addition of labelled cyclopropane.<br></p>

<p>Applications Tetra-n-propyl-d28-ammonium Bromide (CAS# 284474-84-6) is a useful isotopically labeled research compound.<br></p>

<p>Applications N-(4-Bromo-2-picolinoylphenyl)-2-chloroacetamide-d4 is the isotope labelle danalog of N-(4-Bromo-2-picolinoylphenyl)-2-chloroacetamide. N-(4-Bromo-2-picolinoylphenyl)-2-chloroacetamide is a derivative of 2-(2-Amino-5-bromobenzoyl)pyridine (A601785); an intermediate in the preparation of Bromazepam (B678500).<br>References Panderi, I., et al.: J. Pharm. Biomed. Anal., 17, 327 (1998); El-Haj, B., et al.: J. Anal. Toxicol., 25, 316 (2001); Hansen, S., et al.: J. Pharm. Biomed. Anal., 39, 322 (2005)<br></p>

<p>Applications 3-Mercaptopropionic-2,2,3,3-d4 Acid (CAS# 1141488-67-6) is a useful isotopically labeled research compound. It is used for structural proteomics interactions.<br>References Petrotchenko, E., et.al., Mol. Cell Proteomics, 8,273-286,(2009);<br></p>

<p>Applications A is the deuterated isotope of N-Boc-Ethylenediamine (B655006). N-Boc-Ethylenediamine is used in the synthesis of Thyronamine derivatives and analogs.<br>References Anon., et al.: J. Pharmacol., 58, 53 (1936), Boissier, J., et al.: Eur. J. Pharmacol., 22, 141 (1973),<br></p>

<p>Applications n-Butyl-1,1,2,2,3,3-d6 Alcohol (CAS# 1219794-84-9) is a useful isotopically labeled research compound.<br></p>

<p>Applications Flumazenil-D3 is an intermediate in the synthesis of Flumazenil Carboxylic Acid-D3 (F500457), which is an isotope labelled form of Flumazenil Carboxylic Acid (F500455); a derivative of Flumazenil (F500450), a benzodiazepine antagonist that can prevent or abolish (at the receptor level) the effects of a benzodiazepine.<br>References Brogden, R. &amp; Goa, K.: Drugs, 35, 448 (1988); Klotz, U. &amp; Kanto, J.: Clin. Pharmacokinet., 14, 1 (1988)<br></p>

<p>Applications cis-7,10,13,16-Docosatetraenoic Acid Methyl Ester-d3 is a labelled analog of cis-7,10,13,16-Docosatetraenoic Acid Methyl Ester. cis-7,10,13,16-Docosatetraenoic Acid Methyl Ester is used in oregano essential oil as an inhibitor of higher fatty acid oxidation.<br>References Terenina, M.B., et al.: Appl. Biochem. Microbiol., 47, 445 (2011)<br></p>

<p>Applications Ethyl-1,1-d2-methylamine (CAS# 223459-63-0) is a useful isotopically labeled research compound.<br></p>

<p>Applications Tri-p-tolylamine-d21 (CAS# 201944-90-3) is a useful isotopically labeled research compound.<br></p>

<p>Applications Hexadecanoic-4,4-d2 Acid (CAS# 30719-28-9) is a useful isotopically labeled research compound.<br></p>

<p>Applications 1-Pyrenol-d9 Acetate is a compound useful in organic synthesis.<br>References Murray, R., et al.: Carcinogen., 20, 147 (1999),<br></p>

<p>Applications n-Pentyl 2-Methylpentyl Phthalate-d4, is the labeled analogue of n-Pentyl 2-Methylpentyl Phthalate (P283610), used as plasticizers in the manufacture of products made of polyvinyl chloride.<br>References Raether, L. O., et al.: Indust. Engineer. Chem. Produc. Res. Develop., 2, 133 (1963);<br></p>

<p>Applications Bis(2-hydroxyethyl)amine-d11 (CAS# 1219804-08-6) is a useful isotopically labeled research compound.<br></p>

<p>Applications 1,5-Diaminonaphthalene (D416415). Aromatic amines likely to have high carcinogenic potency. QSARs of aromatic amines.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Franke, R., et al.: Carcinogenesis, 22, 1561 (2001), Benigni, R., et al.: Chem. Rev., 105, 1767 (2005), Benigni, R., et al.: Environ. Mol. Mutagen., 50, 152 (2009),<br></p>

<p>Applications 5alpha-Androstan-3beta-ol-17-one-16,16-d2 (CAS# 79037-35-7) is a useful isotopically labeled research compound.<br></p>

<p>Applications An intermediate in the production of labelled Enrofloxacin.<br>References Chao, Q., et al.: J. Med. Chem., 52, 7808 (2009), Bebbington, D., et al.: Bioorg. Med. Chem. Lett., 19, 3586 (2009),<br></p>

<p>Applications N-(Benzoyl)piperazine-2,2,3,3,5,5,6,6-d8 (CAS# 1219805-49-8) is a useful isotopically labeled research compound.<br></p>

<p>Applications 1,3-Propane-2,2-d2-diamine (CAS# 352438-78-9) is a useful isotopically labeled research compound.<br></p>

<p>Applications 1,5-Dibromopentane-1,1,5,5-d4 (CAS# 1219803-90-3) is a useful isotopically labeled research compound.<br></p>

<p>Applications 3-Bromopropionic-2,2,3,3-d4 Acid is the labeled analog of 3-Bromopropionic acid (B687705). 3-Bromopropionic Acid is used as a reagent in the synthesis of nitrogen containing diselenides which exhibit antioxidant activity. Also used as a reagent in the synthesis of indolin-2-one-based multi-targeted receptor tyrosine kinase inhibitors as potential anticancer agents.<br>References Nascimento, V., et al.: Eur. J. Med. Chem., 87, 131 (2014); Zhang, L., et al.: Eur. J. Med. Chem., 82, 139 (2014)<br></p>

<p>Applications Labelled Maleic Anhydride. A heterocyclic compound used in the manufacture of unsaturated polyester resins. Maleic Anhydride has a wide range of other applications; it is used in synthetic tensides, insecticides, herbicides and fungicides.<br>References Hanafi, W.Z.A. et al.: Plast. Rub. Comp. Proc. Appl., 19, 175 (1993); Noma, K. et al.: Shik. Kyok., 36, 225 (1963); Augustin, M. et al.: Wissen. Zeitsch., 25, 5 (1976); Jiang, Q. et al.: Nongyao, 49, 257 (2010);<br></p>

<p>Applications N-Hexadecanoyl-2-amino-1,3-propane-d5-diol (CAS# 949524-35-2) is a useful isotopically labeled research compound.<br></p>

<p>Applications 1-Bromotridecane-1,1,2,2-d4 (CAS# 284474-45-9) is a useful isotopically labeled research compound.<br></p>

<p>Applications Terconazole-d4 is the isotope labelled analog of Terconazole (T110600); a compound used for topical treatment of mycotic vaginitis. Terconazole may also be used in vitro as a potent antifungal agent to prevent the morphogenetic transformation of yeast into the (pseudo-)mycelium form of Candida albicans.<br>References Cauwenbergh, G., Vanden Bossch H.: J. Reprod. Med., 34, 588 (1989); Del Palacio-Hernanz, A., et. al.: Chemioterapia, 3, 192 (1984); Van Cutsem, J., et. al.: Chemotherapy, 29, 322 (1983)<br></p>

<p>Applications 4-Morpholine-d8-carbonyl Chloride (CAS# 1219804-24-6) is a useful isotopically labeled research compound.<br></p>

<p>Applications A labelled major (toxic) metabolite of Styrene (S687790), catalyzed by epoxide hydrolase.<br>References Shen, S. et al.: Drug Metab. Disp., 38, 1934 (2010); Carlson, G.P. et al.: J. Toxicol. Env. Health, 73, 1689 (2010)<br></p>

<p>Applications 1,2-Dimethoxybenzene-d10 (CAS# 362049-43-2) is a useful isotopically labeled research compound.<br></p>

<p>Applications L-Proline-d3-N-Fmoc was used to prepare potent bombesin-like peptides for GRP-receptor targeting of tumors. It was also used to synthesize tetrapeptide aldehyde inhibitors of dengue virus NS3 protease.<br>References Nock, B., et al.: J. Med. Chem., 48, 100 (2005); Yin, Z., et al.: Bioorg. Med. Chem. Lett., 16, 40 (2006)<br></p>

<p>Applications 1-Hydroxyadamantane-d15 (CAS# 33830-11-4) is a useful isotopically labeled research compound. This compound can be used to treat viral diseases.<br>References Atkinson, J., et.al., Can., 16, (1971);<br></p>

<p>Applications Butoxy-d9-acetic Acid (CAS# 669720-55-2) is a useful isotopically labeled research compound.<br></p>

<p>Applications A labelled Voriconazole (V760000) impurity.<br>References Rieke, R., et al.: Science, 246, 1260 (1989), Dickinson, R., et al.: Bioorg. Med. Chem. Lett., 6, 2031 (1996),<br></p>

<p>Applications γ-Valerolactone-d3 is the isotope labelled analog of γ-Valerolactone. γ-Valerolactone is a naturally occurring chemical found in fruits and is frequently used as a food additive. It can be converted to liquid alkenes which can be used as transportation fuels.<br>References Horvath, I.T., et al.: Green Chem., 10, 238 (2008); Bond, J.Q., et al.: Science, 327, 1110 (2010)<br></p>

<p>Applications Tetraethylcystamine-13C8 is the isotope labeled form of Tetraethylcystamine (T291435), which is a reagent used in the addition of Thiobistriethylamine.Also, it is an intermediate used in the synthesis of Tiamulin-13C4 Fumarate (T436603), which is labeled Tiamulin (T436600); a derivative of Pleuromutilin; anti-bacterial.<br>References Evers, M., et al.: Bioorg. Med. Chem. Lett., 13, 4415 (2003); Egger, H., et al.: J. Antibiot., 29, 923 (1976), Baughn, C.O., et al.: Avian Dis., 22, 620 (1978), Goodwin, R.F., et al.: Vet. Rec., 104, 194 (1979), Kitai, K., et al.: Antimicrob. Agents Chemother., 31, 1935 (1987), Aarestrup, F., et al.: Vet. Microbiol., 64, 299 (1999)<br></p>

<p>Applications Cholinesterase inhibitor. Use as systemic insecticide, acaricide, nematocide. Used in Pesticide detection.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Dorough, W.H., et al.: J. Agric. Food Chem., 16, 319 (1968),<br></p>

<p>Applications N-Methyl-d3-epsilon-caprolactam (CAS# 203645-60-7) is a useful isotopically labeled research compound.<br></p>

<p>Applications Methyl trans-Cinnamate-d5 (phenyl-d5) (CAS# 61764-82-7) is a useful isotopically labeled research compound.<br></p>

<p>Applications Butyl Phenyl Phosphate-d9 is the deuterated form of Butyl Phenyl Phosphate (B809590), which is a phosphorus flame retardant additive.<br>References Sundkvist, A. M., et al.: Environ. Monit. Assess., 12, 943 (2010),<br></p>

<p>Applications Diethyl Chlorophosphate-d10 is an intermediate in the synthesis of Chlorpyrifos Oxon-d10 (C425322), which is an isotope labeled analogue of Chlorpyrifos Oxon (C425320). a metabolite of Chlorpyrifos (C425300) in human.<br>References Atterberry, T., et al.: Toxicol. Appl. Pharmacol., 147, 411 (1997), Karanth, S., et al.: Toxicol. Sci., 58, 282 (2000), Barter, Z., et al.: Drug Metab. Dispos., 36, 2405 (2008),<br></p>

<p>Applications tert-Butyl-1,1,1-d3 Alcohol (CAS# 33500-15-1) is a useful isotopically labeled research compound.<br></p>

<p>Applications 2-Nitrotoluene-alpha,alpha,alpha-d3 (CAS# 70786-67-3) is a useful isotopically labeled research compound.<br></p>

<p>Applications 6-Bromo-benzoic-​2,​3,​4,​5-​d4 Acid is used for preparation of isotopologues of isoquinolinone and quinazolinone compounds as PI3K kinase inhibitors.<br>References Evans, C.: PCT Int. Appl. (2017), WO 2017161116 A1 20170921.<br></p>

<p>Applications An intermediate for the synthesis of Labelled Ketoprofen.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Derewenda, Z., et al.: J. Mol. Biol., 227, 818 (1992), Grochulski, P., et al.: J. Biol. Chem., 268, 12843 (1993).<br></p>

<p>Applications rac Styrene Glycol-D5 is an intermediate in the synthesis of rac Mirabegron-d5 (M364902), which is a potent bladder relaxant and reagent for diabetes remedy.<br></p>

<p>Applications n-Octyl-1,1-d2 Alcohol (CAS# 78510-02-8) is a useful isotopically labeled research compound.<br></p>

<p>Applications Nonyl 4-Hydroxybenzoate-d4 is labelled Nonyl 4-Hydroxybenzoate which was used to prepare 4-[(aminosulfonyl)oxy] benzoic acid derivatives as potent inhibitors of the enzyme estrone sulfatase (ES). It was also used to synthesize sulfonylbenzoic acid esters as potential inhibitors of oestrone sulphatase with antitumor activities.<br>References Ahmed, S., et al.: Bioorg. Med. Chem. Lett., 12, 2391 (2002); Owen, C., et al.: J. Pharm. Pharmacol., 55, 85 (2002)<br></p>

<p>Applications A labelled tryptophan metabolite, is a precursor of kynurenic acid, which is an antagonist of N-methyl-aspartate receptor. An amino acid produced in the body from tryptophan.<br>References Swartz, K., et al.: J. Neurosci., 10, 2965 (1990), Hasegawa, H., et al.: Anal. Bioanal. Chem., 377, 886 (2003), Tsai, Y., et al.: Anal. Biochem., 319, 34 (2003), Mitsuhashi, S., et al.: Anal. Chim. Acta, 584, 315 (2007),<br></p>

<p>2-MCPD-d5 is a deuterated fatty acid that can be used to calibrate gas chromatography for the determination of 2-MCPD in infant formula. The compound is processable and can be used as an internal standard. It has been validated by regression analysis and shown to have a good correlation with the sulfate solution method. 2-MCPD-d5 has been shown to produce reaction products that are similar to those produced by the methylation of 2-MCPD. This compound has also been shown to be useful as a model system for studying the formation of MCFA esters, including those containing sulfur, nitrogen, or oxygen.</p>

<p>Please enquire for more information about Bromoacetic acid-13C2 including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about Midazolam-d4 maleate - 100 mg/mL in methanol including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Creatinine-d3 is a radioactive form of creatinine that can be used to measure the degree of renal function in humans. Creatinine-d3 is a metabolite of creatine, which is synthesized primarily in muscle tissue and excreted by the kidney. Creatinine-d3 uptake reflects the glomerular filtration rate (GFR) and can be used as an indicator of renal disease. The metabolism of creatinine-d3 can be monitored using chromatographic methods, such as HPLC, or mass spectrometry. Due to its low detection limit, creatinine-d3 has been used for validation studies in humans and other mammals. It has also been used for the analysis of urine samples from healthy volunteers and patients with chronic kidney disease. Creatinine-d3 is often normalized to creatinine concentration in human urine samples because it does not react with other metabolites found in urine samples. This allows for accurate measurements</p>

<p>3-Amino-2-oxazolidinone-d4 is a methanol solvent that can be used to analyze the muscle tissue. 3-Amino-2-oxazolidinone-d4 can be synthesized by reacting oxalyl chloride and 2 nitrobenzaldehyde in acetonitrile. It can also be prepared by dehydrating and analyzing the synthesis of 3 amino 2 oxazolidinones in chloroform and bromoacetic acid. 3 - Amino - 2 - oxazolidinone - d4 is deuterated, which means it has an extra neutron in its nucleus.</p>