Organic Halides

<p>Impurity Adamantane EP Impurity A<br>Stability Light Sensitive<br>Applications 1-Chloroadamantane, an adamantane derivative shown to exhibit virucidal activity against the Newcastle disease virus in chick embryo fibroblasts. (Adamantane EP Impurity A)<br>References Aigami, K., et al.: J. Med. Chem., 18, 713 (1975)<br></p>

<p>Applications 2-Ethoxybenzamidine hydrochloride is an impurity of Vardenafil (diHCl salt: V098001), a phosphodiesterase type 5 inhibitor that is used to treat men of varying aetiology with erectile dysfunction.<br>References Hellstrom, W., et al.: J. Andro., 23, 763 (2002); Keating, G. &amp; Scott, L.: Drugs, 63, 2673 (2003); Krishnaiah, C., et al.: Anal. Chem. Ind. J., 8, 284 (2009); Porst, H., et al.: Int. J. Imp. Res., 13, 192 (2001)<br></p>

<p>Applications 4-Iodophenylhydrazine, HCl<br></p>

<p>Applications An intermediate of racemic Atomoxetine.<br>References Hage, A., et al.: Biotechnol. Bioeng., 73, 69 (2001), La Regina, G., et al.: J. Med., Chem., 51, 3841 (2008),<br></p>

<p>Applications 4-Chloromethylbenzophenone (cas# 42728-62-1) is a compound useful in organic synthesis.<br></p>

<p>Applications (3S)-4-Chloro-3-hydroxybutyronitrile is used in various organic precursor syntheses. It is used in the synthesis of hydroxypyrrolidinones to by used as carbapenem precursors. Also used in the preparation of atorvastatin (A791750) precursors. Impurity in the synthesis of Rosuvastatin (R700500), a selective, competitive HMG-CoA reductase inhibitor. Antilipemic.<br>References Kanno, O. et al.: Hetero., 53, 173 (2000); Watanabe, M., et al.: Bioorg. Med. Chem., 5, 437 (1997), Lee, E., et al.: Clin. Pharmacol. Ther., 78, 330 (2005), Ferdinand, K.C., et al.: Am. J. Cardiol., 97, 229 (2006); Jiang, C. et al.: Lett. Org. Chem., 9, 520 (2012);<br></p>

<p>Applications β-Chlorolactic Acid (cas# 1713-85-5) is a compound useful in organic synthesis.<br></p>

<p>Applications (R,R)-Ethambutol Dihydrochloride shows antitumor properties when complexed with platinum. Also an isomer of Ethambutol (E889800), an antibacterial (tuberculostatic).<br>References Coluccia, M. et al.: Anticanc. Res., 11, 281 (1991); Wilkinson, et al.: J. Med. Chem., 5, 835 (1962), Kulig, et al.: Diss. Pharm. Pharmacol., 23, 463 (1971), Lee, C.S., et al.: Anal. Profiles Drug Subs., 7, 231 (1978)<br></p>

<p>Applications 4-Fluorobenzoic acid<br></p>

<p>Stability Hygroscopic<br>Applications Semicarbazide Hydrochloride is a metabolite of Nitrofuran (N493840), a minor antimicrobial used in veterinary medicine affecting semicarbazide-sensitive amine oxidase (SSAO) activity (1). Semicarbazide may be found in from nitrofuran residues in honey extracts (2) as well as milk from dairy cows (3). Drinking water contaminant candidate list 3 (CCL 3) compound as per United States Environmental Protection Agency (EPA), environmental, and food contaminants.Environmental contaminants; Food contaminants; Heat processing contaminants.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References 1. Elliott J. et al.: J Pharm Pharmacol. 1989 Jan;41(1):37-41. 2. Tribalat L. et al.: Anal Bioanal Chem. 2006 Dec;386(7-8):2161-8. 3. Chu, P. et al.: J. Agric. Food Chem. 2007 Feb:55(6);2129-2135<br></p>

<p>Applications 4-Bromo-2,6-diisopropylaniline is used as a reactant in the preparation of hyperbranched ethylene oligomers.<br>References Wiedemann, T., et. al.: J. Am. Chem. Soc., 136, 2078 (2014)<br></p>

<p>Applications Methyl 5-chloro-2-hydroxy-1-oxo-2,3-dihydro-1H-indene-2-carboxylate (cas# 144172-24-7) is a useful research chemical. It is an intermediate in the synthesis of IN-KG 433 (I627995). IN-KG 433 is an impurity of Indoxacarb (I654000), an oxadiazine pesticide that acts against lepidopteran larvae and is the active ingredient in a number of household insecticides including cockroach baits.<br>References Wang, H., et al.: Water. Sci. Technol., 61, 2733 (2010); Shono, T., et al.: Pesticide. Biochem. Physiol., 75, 1 (2003);<br></p>

<p>Stability Moisture Sensitive<br>Applications Benzoyl Chloride is used in the manufacturing of dye intermediates.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Glotzbach, C. et al.: J. Org. Chem., 78, 4410 (2013); Coskun, A. et al.: J. Am. Chem. Soc., 127, 10464 (2005);<br></p>

<p>Applications Perfluorodecyl iodide is used to prepare 3,5-bis(perfluorodecyl)phenylboronic acid, "green" catalyst for the direct amide condensation reaction. It is also used to synthesize 3-(perfluorodecyl)prop-1-ene.<br>References Ishihara, K, et al.: Synlett., 9, 1371 (2001); Ryu, I., et al.: Tetrahedron Lett., 42, 947 (2001)<br></p>

<p>Applications Benzo[j]fluoranthene is a polycyclic aromatic hydrocarbon that has tumour initiating activity and can be found in soot, oil, water and soil extracts as a common pollutant.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References LaVole, E., et al.: Carcinogenesis, 3, 49 (1982); Nadal, M., et al.: Environ. Pollut., 132, 1 (2004); White, P. &amp; Rasmussen, J.: Mutat. Res., 410, 223 (1998); Wornat, M., et al.: Environ. Sci. Technol., 35, 1943 (2001)<br></p>

<p>Stability Hygroscopic, Moisture Sensitive, Volatile<br>Applications Oxalyl Chloride is used in the preparation of cardiolipin analogs which induce peroxidase activity by Cytochrome C. It is also used in the preparation of fluorescent indicators for cytosolic calcium.<br> E0<br>References Abe, M. et al.: Biochem., 50, 8383 (2011); Minta, A. et al.: J. Biol. Chem., 264, 8171 (1989);<br></p>

<p>Applications Methyl 6-aminohexanoate is used as a reagent to synthesize straight chain hydroxamates, compounds that act as inhibitors of Human Histone Deacetylase (HDAC) that have the potential to treat cancer. Methyl 6-aminohexanoate is also sometimes used as a spacer unit for peptide synthesis.<br>References Matthews, S., et al.: J. Chem. Soc. Chem. Commun., 17, 1809 (1995); Remiszewski, S., et al.: J. Med. Chem., 45, 753 (2002)<br></p>

<p>Applications 1-Bromo-2-chlorobenzene is a reagent in the preparation of arylpiperidines and aryltetrahydropyridines as 5-HT2C agonists.<br>References Conway, R.J., et al.: Bioorg. Med. Chem. Lett., 22, 2560 (2012)<br></p>

<p>Stability Mositure Sensitive<br>Applications Used for the preparation of substituted glycoside sulfamates as anticonvulsant agents for the treatment of epilepsy.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Asano, N., et al.: J. Antibiot., 40, 526 (1987), Ikeuchi, H., et al.: Bioorg. Med. Chem., 17, 6641 (2009),<br></p>

<p>Stability Hygroscopic<br>Applications 2-Chloromandelic acid<br></p>

<p>Applications 4-Azido-2,3,5,6-tetrafluorobenzamide (cas# 122616-98-2) is a compound useful in organic synthesis.<br></p>

<p>Applications 1,8-Dichloroanthraquinone is a reagent in the preparation of anthraquinones, which has antitumor activities.<br>References Barasch, D., et al.: Eur. J. Med. Chem., 34, 597 (1999)<br></p>

<p>Applications 4-[3-(Trifluoromethyl)-3H-diazirin-3-yl]benzoic Acid is a photoreactive aromatic diazirine.<br>References Wiedmann, M .; J. Cell biol.; 104, 201 (1987).<br></p>

<p>Stability Moisture Sensitive<br>Applications Perfluorobutanesulfonic acid (PFBS) is a stable fluorosurfactant because of the strength of carbon–fluorine bonds. PFBS has served as a replacement for the persistent, toxic, and bioaccumulative perfluorooctanesulfonic acid (PFOS) in 3M's Scotchgard stain repellents. PFBS is neither toxic nor bioaccumulative.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Renner R., et al.: Environ. Sci. Technol., 40, 12 (2006), Betts, K.S., et al.: Environ. Health Perspect., 115, 250 (2007),<br></p>

<p>Stability Hygroscopic<br>Applications Used as an intermediate in the industrial preparation of non-ionic X-ray contrast agents such as Iohexol (I729500), Ioversol (I737000), Ioxilan (I737500), Iopamidol (I735600).<br>References Rongved, P., et al.: Carbohydrate Res., 297, 325 (1997),<br></p>

<p>Applications 9-Bromononanol (cas# 55362-80-6) is a compound useful in organic synthesis.<br></p>

<p>Applications Chloramine-T Trihydrate is used as a safe and convenient electrocyclisation (oxidizing) agent in the preparation of 8-chloro-[1,2,4]triazolo[4,3-a]pyrazine derivatives.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Mal, S., et al.: Tetrahedron Lett., 56, 2896-2901 (2015)<br></p>

<p>Stability Moisture Sensitive<br>Applications 1-(3-Chloropropyl)theobromine (cas# 74409-52-2) is a useful research chemical.<br></p>

<p>Applications 1,3-Dibromoadamantane (cas# 876-53-9) is a compound useful in organic synthesis.<br></p>

<p>Applications 3-Chloropropiophenone is an impurity of Fluoxetine (F597100).<br>References Wirth, D.D. et al.: Chromatographia, 46, 511 (1997); Lacroix, P.M. et al.: J. AOAC Int., 78, 334 (1995);<br></p>

<p>Applications 7-(2-Chloroethyl)theophylline (cas# 5878-61-5) is a useful research chemical.<br></p>

<p>Applications Fundamental starting material for organic synthesis.Metabolite of dibromobenzene in urine of rabbit.<br>References Ruzo, L., et al.: J. Agric. Food Chem., 24, 291 (1976),<br></p>

<p>Applications 1-phenyl-2-(propylamino)-1-Butanone Hydrochloride is a α-Aminoketone derivatives and a useful building block.<br>References Koeppe, H.; et al.: DE 1493461 (1972).<br></p>

<p>Applications 3,5-Difluorobenzylamine is a useful reagent for reductive amination.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Cantrill, S., et al.: J. Org. Chem., 66, 6857 (2001);<br></p>

<p>Applications 1,1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8-Heptadecafluoro-10-iododecane<br></p>