Toxicology

Stability Light Sensitive
Applications Labelled Rifabutin (R505000). Semisynthetic derivative of Rifamycin S that inhibits nucleic acid synthesis. An antibacterial (tuberculostatic).
References O’Brien, R.J., et al.: Infect. Dis., 9, 519 (1987), Anand, R., et al.: Antimicrob. AG. Chemother., 32 (684 (1988), Skinner, M.H., et al.: Antimicrob. Agent Chemother., 33, 1237 (1989),

Impurity Ceftazidime EP Impurity A
Stability Hygroscopic, Light Sensitive
Applications ∆2-Ceftazidime, 90% (Ceftazidime EP Impurity A) is a Ceftazidime isomer, an impurity of Ceftazidime (C244100).
References Vilanova, B., et al.: Helv. Chim. Acta, 76, 2789 (1993), Zhou, M., et al.: J. Pharm. Sci., 84, 534 (1995), Baertschi, S., et al.: Chemother. 8, 353 (1997), Porra, R., et al.: J. Pharm. Biomed. Anal., 18, 241 (1998),

Applications Antipsychotic used in the treatment of schizophrenia.
References Nourian, Z., et al.: Eur. J. Pharmacol., 596, 32 (2008), Karczewski, J., et al.: Biochem. Pharmacol., 77, 1602 (2009), Isoherranen, N., et al.: Chem. Res. Toxicol., 22, 294 (2009), Goetghebeur, P., et al.: Psychopharmacol., 202, 287 (2009),

Applications N-Isopropyl quaternary salt of Atropine. Nonselective muscarinic acetylcholine receptor antagonist; bronchodilator.
References Groeben, H., et al.: Anesthesiology, 85, 867 (1996), Haddad, et al.: Br. J. Pharmacol., 127, 413 (1999), Barnes, P. J., et al.: Chest, 117, 63S (2000),

Applications Labelled Febuxostat (F229000). Xanthine oxidase/xanthine dehydrogenase inhibitor. Used for treatment of hyperuricemia and chronic gout.
References Osada, Y., et al.: Eur. J. Pharmacol., 241, 183 (1993), Okamoto, K., et al.: J. Biol. Chem., 278, 1848 (2003), Mayer, M.D., et al.: Am. J. Therap., 12, 22 (2005), Tomlinson, B., et al.: Curr. Opin. Invest. Drugs, 6, 1168 (2005),

Applications Dimethachlor-d6 is an intermediate used in the synthesis of Dimethachlor Ethane Sulfonic Acid Sodium Salt-d6 (D460284), which is the deuterium labelled form of Dimethachlor Ethane Sulfonic Acid Sodium Salt (D460283), which is a pesticide metabolite and pollutant found in groundwater, surface water, and wastewater.
References Huntscha, S., et al.: J. Chromatogr. A, 1268, 74 (2012); Reemtsma, T., et al.: J. Chromatogr. A, 1271, 95 (2013);

Stability Hygroscopic
Applications A metabolite of Tramadol.
References Raffa, R., et al.: J. Pharmacol. Exp. Ther., 267, 331 (1993), Pospisilova, M., et al.: J. Pharm. Biomed. Anal., 18, 777 (1998), Scott, L., et al.: Drugs, 60, 139 (2000), Wu, W., et al.: Xenobiotica, 32, 411 (2002),

Applications Primary alkaloid of various species of Cinchona (Rubiaceae). Optical isomer of Quinidine. Antimalarial; muscle relaxant (skeletal).
References Muhtadi, F.J., et al.: Anal. Profiles Drug Subs., 12, 547 (1983), Kremsner, P.G., et al.: J. Infect. Dis., 169, 467 (1994),

Stability Light Sensitive
Applications α-Chlordane is an organochlorine pesticide/insecticide used in the protection of crops from pests.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Shoeib, M., et al.: Env. Toxicol. Chem., 21, 984 (2002); Parlar, H. et al.: J. Agric. Food. Chem., 27, 278 (1979);

Applications Ethyl 2,2,2-trichloroacetate (CAS# 515-84-4) is a useful research chemical compound.

Applications Diniconazole is a pesticide.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Lehotay, S., et al.: J. AOAC Int., 88, 595 (2005); Hiemstra, M., et al.: J. Chromat. A, 1154, 3 (2007)

Applications Labelled Trimethylamine. Trimethylamine is a versatile building block used in the synthesis of various compounds ranging from cholines, plant growth regulators, strongly basic anion exchange resins, dye leveling agents as well as a number of basic dyes.
References Miroshnichenko, E.A. et al.: Zhur. Obshch. Khim., 63, 2375 (1993); Liu, X. et al.: Jiang. HUag., 33, 173 (2005); Xu, J. et al.: Color. Technol., 120, 316 (2004);

Applications Perampanel-d5, is the labeled analogue of Perampanel (P285520), an antiepileptic drug.
References Shih, J., et al.: Therap. Clinical Risk Management, 9, 285 (2013); Rogawski, M. A., et al.: Epilepsy Curr., 11, 56 (2011);

Applications Flurochloridon

Applications 2-(Methylthio)Benzothiazole could be useful for removing pollutants in drinking water.
References Di Marcantonio, C., et al.: Chemosphere, 260, 127630 (2020)

Applications Amylocaine Hydrochloride, is used mostly in spinal anesthesia.
References Fourneau, E.: Bulletin des sciences pharmacologiques, 10, 141 (1904); Debue-Barazer, C., et al.: Gesnerus, 64, 24 (2007)

Applications Macitentan, is an orally active endothelin receptor antagonist used for pulmonary arterial hypertension.
References Emoto, N. Ensho to Men'eki, 20, 487 (2012);

Applications 2-PHENOXYBENZOIC ACID (cas# 2243-42-7) is a useful research chemical.

Applications Thiometon-sulfone is a metabolite from Thiometon (D231370) pesticides, used as an insecticide. Cholinesterase inhibitor.
References Edson, E.F., et al.: Pharm. J., 185, 365 (1960); Pozo, O., et al.: Anal. Bioanal. Chem., 389, 1765 (2007); Mezcua, M., et al.: Anal. Chem., 81, 913 (2009);

Stability Hygroscopic
Applications Kasugamycin Hydrochloride is an aminoglycoside antibiotic that inhibits the initiation of translation. It is also a type of fungicide that controls leaf and neck blast disease caused by Pyricularia oryzae and increases rice yields.
References Okuyama, A., et al.: J. Antibiot., 28, 903 (1975); Shinabarger, D., et al.: Antimicrob. Agents Chemother., 41, 2132 (1997); Reddy, A., et al.: Pesticides, 22, 21 (1988);

Applications Dabigatran-d7, is the labeled analogue of Dabigatran (D100090), Nonpeptide, direct thrombin inhibitor. Antithrombotic.
References Hauel, N., et al.: J. Med. Chem., 45, 1757 (2002), Mungall, D., et al.: Curr. Opin. Invest. Drugs, 3, 095 (2002), Stangier, J., et al.: J. Clin. Pharmacol., 45, 555 (2005),

Stability Hygroscopic, Light Sensitive, Moisture Sensitive, Temperature Sensitive
Applications trans-Deltamethrin, is trans isomer of Deltamethrin (D230700), a synthetic pyrethroid insecticide, which acts as a potent inhibitor of calcineurin (protein phosphatase 2B) and has an IC50 of about 100pM.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Kavlock, R., et al.: J. Environ. Pathol. Toxicol., 2, 751 (1979), Enan, E., et al.: Biochem. Pharmacol., 43, 1777 (1992), Tan, J., et al.: Mol. Biol., 32, 445 (2002);

Applications Pantoprazole-d3 is the labeled analogue of Pantoprazole, an antiulcerative. Gastric pump inhibitor.
References Simon, W.A., et al.: Biochem. Pharmacol., 39, 1799 (1990)

Applications Stearoyl Ethanolamide is a prolific fatty acid ethanolamide produced by PLD hydrolysis of membrane phospholipids. Stearoyl Ethanolamide is also used for studying the effect on endocannabinoid signalling and BBB integrity in systemic inflammation.
References Kasatkina, L. A., et al.: Biochem. Pharmacol. 174, 113783 (2020)

Applications Sisapronil is Fluorinated Cyclopropylphenylpyrazole injectable compound.
References Derose, Guy F., et al.: U.S. Pat. Appl. Publ., (2015);

Applications (S)-2-Benzyl-N,N-dimethylaziridine-1-sulfonamide is a reagent for the synthesis of N-alkylsulfamic acid derivatives. It also has utility for preparing pharmaceutical peptide analog agents.
References Sherman, E. S., et al. Science of Synthesis 40b, 1285 (2008); Polniaszek, R., et al.: PCT Int. Appl. WO 2010115000 A2 20101007 (2010)

Applications 1-Chloro-2-(α-chlorophenylmethyl)benzene is used as a reagent in the synthesis of bifonazole analogs which have antibacterial and antifungal activities. It is also used in the preparation of diphenylpiperazine N-type calcium channel inhibitors.
References El Hage, S., et al.: Arch. Pharm., 344, 402 (2011); Pajouhesh, H., et al.: Bioorg. Med. Chem. Lett., 20, 1378 (2010)

Applications An iron chelating agent used in therapy for patients with sickle cell diseases and iron overload. Studies suggest that it can exert potential antioxidant neuroprotective effects in stroke patients
References Inati, A. et al.: Am. J. Hematol., 85, 782 (2010); Selim, M.: Translat. Stroke Res., 1, 35 (2010); Cappellini, M.D. et al.: Hemoblobin, 33, 258 (2009);

Applications Labelled analogue of Boscalid, a fungicide belonging to the class of carboxamides. Boscalid acts by inhibiting spore germination, germ tube elongation and is also effective on all other stages of fungal development. Boscalid is used in the agriculture to protect crops from gray mold, powdery mildew and other fungus. Used in Pesticide detection. Used in Cannabis testing.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Yan, F. et al.: Nongyao, 47, 132 (2008); Lozowicka, B. et al.: Prog. Plant Prot., 48, 1211 (2008); Stammler, G. et al.: Int. Plant Prot. Cong. Proc. 16th Glas. U.K., 1, 40 (2007);

Applications Intermediate used in the synthesis of a variety of antibacterial and antifungal activities of symmetric and asymmetric azines.
References Veena, K., et al.: E-J.Chem, 8, 354 (2011),

References Zeun, R., et al.: Pest Manag. Sci., 69, 527 (2013); Oostendorp, M., et al.: Phytopathology, 101, S133 (2011); Olaya, G., et al.: Phytopathology, 101, S132 (2011)

Applications Chlorfluazuron is benzoyl(pyridiyloxyphenyl)urea based pesticide that acts as a chitin synthesis inhibitor. Chlorfluazuron is commonly used in agriculture as an insect growth regulator for controlling the major insect pests in crops
References Perveen, F.: J. Life Sci., 5, 933 (2011); Elek, J.A.: Entomol. Exp. Appl., 88, 31 (1998); Osbrink, W.L.A. et al.: J. Econ. Entomol., 104, 1009 (2011);

Applications Used as a reference standard for the drug Trimethoprim.Note this compound is a cis / trans mixture.

Applications 2-(1h-1,2,4-Triazol-1-Yl)Acetic Acid (cas# 28711-29-7) is a useful research chemical.

Applications Phenkapton is an antiparasitic agent.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Rico, A., et al.: Environ. Toxicol. Chem., 35, 494 (2016), Bai, G., et al.: Lihua Jianyan, Huaxue Fence, 49, 835 (2013)

Applications Iodosulfuron Methyl Ester Sodium is used as a pesticide.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Klein, J., et al.: J. AOAC Intrnational, 86, 1015 (2003); Pang, G., et al.: J. Chromat. A, 1125, 1 (2006)

Applications Flupirtine-d5, is the labeled analogue of Flupirtine, an Analgesic, having substituted pyridine with central analgesic properties.
References Vaupel, D., et al.: Eur. J. Pharmacol., 162, 447 (1989), Nickel, B., et al.: Arzneim.-Forsch., 40, 909 (1990), Lunemann, J., et al.: J. Immunol., 168, 4881 (2002),

Applications (R,S)-Equol 7-β-D-Glucuronide is a glucuronide metabolite of isoflavone Daidzein (D103500).
References Heinonen, S., et al.: Anal. Biochem., 274, 211 (1999), Setchell, K., et al.: J. Nutr., 132, 3577 (2002), Thigpen, J., et al.: Comp. Med., 53, 607 (2003), Yee, S., et al.: Food Chem. Toxicol., 46, 2713 (2008)

Applications (4R,6S)-rel-5,6-Dihydro-4-hydroxy-6-methyl-4H-thieno[2,3-b]thiopyran-2-sulfonamide 7,7-Dioxide is used as a reactant in the preparation of Dorzolamide Hydrochloride (D535100), which is a carbonic anhydrase inhibitor; antiglaucoma agent.
References Lippa, E.A., et al.: Ophthalmology, 98, 308 (1991); Wang, R.-F., et al.: Arch. Ophthalmol., 109, 1297 (1991); Whikehart, D., et al.: J. Ocul. Pharmacol., 7, 195 (1991); Sjoquist, B., et al.: Drug Metab. Dispos., 26, 745 (1998);

Applications Acid Red 114 is an azo dye used in diagnostics and textiles industry. It is also present in wastewater and textile effluents contributing to environmental hazards.Environmental toxin on US EPA Toxic Release Inventory list (TRI) list.
References Yang, S. et al.: J. Env. Sci. Health., 52, 682 (2017); Ring, M. et al.: PLoS One., 10, e0116488 ((2015);

Applications Cholinesterase inhibitor. Ectoparasiticide. This compound is a contaminant of emerging concern (CECs) and used in Pesticide detection.Useful in cannabis testing kits as a component of pesticide mixes (P698230).
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Chauzat, M., et al.: Env. Entomol., 38, 514 (2009), Raut, P., et al.: Pestol., 33, 21 (2009), Henseler, R., et al.: Toxicol., 261, 9 (2009), Banerjee, K., et al.: J. Agric. Food Chem., 57, 4068 (2009),

Applications Amphotericin B Methyl Ester is the methyl ester derivative of the polyene antibiotic Amphotericin B (A634250). Amphotericin B Methyl Esterin is a cholesterol binding compound that showed inhibiton of human immunodeficiency virus type 1 (HIV-1).
References Waheed, A.A. et al.: J. Biol. Chem., 281, 28699 (2006); Waheed, A. et al.: J. Virol., 82, 9776 (2008); Waheed, A., et al.: J. Biol. Chem., 281, 28699 (2006)

Applications Prometryn is a methylthiotriazine herbicide used for the control of several annual grasses and broadleaf weeds. Prometryn works by inhibiting the electron transport in target broadleaves and grasses.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Qu, J.R.,et al.: Food. Chem., 135, 1148 (2012); Fenoll, J., et al.: J. Photochem. Photobiol., 238, 81 (2012);

Applications 1,2,4-Triazolo[3,4-b]benzothiazole-5-methanol is the major alcohol metabolite of tricyclazole (T291465) which is an common active ingredient in several commercial fungicide products used to control rice blast fungus, in transplanted and direct-seeded rice.
References Koons, J., et al.: J. Agri. Food Chem., 33, 552 (1985)

Applications A novel non-nucleoside reverse transcriptase inhibitor. Rilpivirine seems to be well tolerated with less CNS disturbance than Efavirenz, and has non-teratogenic potential. An anti-HIV agent.
References Sun, et al.: J. Med. Chem., 41, 4648 (1998), Kashiwada, et al.: Bioorg. Med. Chem. Lett., 11, 183 (2001),

Applications Triethylamine Trihydrofluoride is used in the synthesis of modified siRNA’s in vivo used to inhibit hepatitis B replication (1). Used in RNA synthesis in the removal of t-butyldimethylsilyl protection (2). Drinking water contaminant candidate list 3 (CCL 3) compound as per United States Environmental Protection Agency (EPA). Environmental contaminants; Food contaminants.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References 1. Marimani M. et al.: Bioorg Med Chem. 2013 Oct 15;21(20):6145-55. 2. Westman, E. et al.: Nucleic Acids Res. 1994 Jun 25;22(12):2430-1

Applications Diltiazem is a potent vasodilator compound. Antihypertensive.
References Barrios, V. et al.: Exp. Rev. Cardiovasc. Ther., 9, 1375 (2011);

Applications Acyclic phosphonate nucleotide analogue; reverse transcriptase inhibitor. Used as an anti-HIV agent. Antiviral.
References Shaw, J.-P., et al.: Pharm. Res., 14, 1824 (1997), Wyles, D., et al.: Clin Infect. Dis., 40, 174 (2005), Peng, J., et al.: J. Clin. Pharmacol., 46, 265 (2006), Seminari, E., et al.: J. Antimicrob. Chemother., 60, 831 (2007),

Applications 3-Hydroxykynurenine is a metabolite of tryptophan. 3-Hydroxykynurenine filters UV light in the human lens. Studies suggest that Hydroxykynurenine is an endogenous oxidative stress generator and a potential endogenous neurotoxin.
References Malina, H.Z. et al.: Graefes. Arch. Clin. Exp. Ophthalmol., 233, 38 (1995); Okuda, S. et al.: J. Neurochem., 70, 299 (1998);

Applications Pretilachlor is a chloroacetanalide herbicide. Pretilachlor is commonly used for weed control in wet seeded rice
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Mohankumar, P.D. et al.: J. Trop. Agric., 34, 149 (34, 149 (1996); Ravisankar, N. et al.: Ind. J. Agron., 53, 57 (2008); Singh, S. et al.: Crop Prot., 27, 660 (2008);

Applications Benzyl Trisulfide is a secondary metabolite of Petiveria alliacea, on erythrocyte elasticity, relaxation time and membrane morphol. An antibacterial and antifungal agent.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Mohandas, N., et al.: Semin. Hematol., 20, 225 (1983), De Sousa, J., et al.: Phytochem., 29, 3653 (1990),

Applications Labelled Curcumin (C838500). A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. Induces apoptosis in cancer cells and inhibits phorbol ester-induced protein kinase C (PKC) activity. Reported to inhibit production of inflammatory cytokines by peripheral blood monocytes and alveolar macrophages. Potent inhibitor of EGFR tyrosine kinase and IκB kinase. Inhibits inducible nitric oxide synthase (iNOS), cycloxygenase and lipoxygenase. Easily penetrates into the cytoplasm of cells, accumulating in membranous structures such as plasma membrane, endoplasmic reticulum and nuclear envelope.
References Srinivasan, et al.: J. Pharm. Pharmacol., 5, 448 (1953), Tu, B., et al.: J .Cell Biol., 164, 341 (2004), Xu, G., et al.: Biochemistry, 44, 9817 (2005), Johnson, J., et al.: Cancer Lett., 255, 170 (2007),

Stability Hygroscopic
Applications A biochemical marker of bone turnover for management of metabolic bone diseases.
References Turner, W., et al.: Biol. Psychiatry, 14, 177 (1979), Miyata, T., et al.: Kidney Int., 60, 2351 (2001), Politi, P., et al.: Neurosci. Lett., 396, 163 (2006),

Applications Exhibits specific inhibitory activity against tyrosine kinases,including autophosphorylation of epidermal growth factor receptor kinase (IC50 - 2.6uM). Also inhibits other protein kinases through competitive inhibition of ATP. Inhibits tumor cell proliferation and induces tumor cell differentiation. Produces cell-cycle arrest and apoptosis in Jurat T-leukemia cells. However, it prevents anti-CD3 monoclonal antibody-induced thymic apoptosis. Genistein also inhibits topoisomerase II activity in vitro. Genistein has also been shown to inhibit the action of GABA on recombinant GABAA receptors2. uv(max)ethanol: 262.5 nm (e= 138). moderately sol. in hot alcohol
References Akiyama, T., et al.: J. Biol. Chem., 262, 5592 (1987), O'Dell, T.J., et al.: Nature, 353, 588 (1991), Aharonovits, O., et al.: Biochim Biophys. Acta, 1112, 181 (1992), Platanias, L.C., et al.: J. Biol. Chem., 267, 24053 (1992), Yoshida, H., et al.: Biochim. Biophys. Acta, 1137, 321 (1992), Uckun, F.M., et al.: Science, 267, 886 (1995)Merck Index 12th ed. 43952. Huang, R.Q.; Fang, M.J.; Dillon, G.H., Mol. Brain Res. 67: 177-183 (1999)

Applications Asulam-d3 (methoxy-d3) is labelled Asulam (A788750) which is a carbamate herbicide and a folic acid biosynthesis inhibitor.
References Cottrell, H.J., et al.: 207, 655 (1965), Smith, A.E., et al.: Pestic. Sci., 8, 449 (1977), Hossain, M.A., et al.: J. Weed Sci. Tech., 43, 10 (1998),

Applications A labelled metabolite of Desipramine.
References De Jongh, G.D., et al.: Drug Metab. Dispos., 2, 48 (1981), Suckow, R.F., et al.: J. Pharm. Sci., 73, 1745 (1984), Fraser, A.D., et al.: J. Anal. Toxicol., 11,168 (1987),

Applications Cyproconazole is a fungicide treatment for wood preservative that prevents decay from fungi in above-ground applications.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Aiello, D., et al.: Plant. Disease., 97, 37 (2013); Bakirci, G.T., et al.: Food. Chem., 135, 1901 (2012); Sugitate, K., et al.: J. Pesticides. Sci., 37, 148 (2012);

Stability Hygroscopic
Applications A labelled antibacterial, a third-generation cephalosporin.
References Reiner, R., et al.: J. Antibiot., 33, 783 (1980)

Stability Hygroscopic
Applications Monosultap is a type of insecticide that is used in agricultural use to regulate insect growth against Pieris rapae.
References Zhong, G.H., et al.: J. Appl. Ent., 125, 563 (2001);

Applications Systemic post-emergence herbicide for use in food crops and mesquite.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Pik, A.J., J. Agric. Food Chem., 25, 1054 (1977), Bovey, R.W., et al.: Weed. Sci., 33, 349 (1985),

Stability Hygroscopic
Applications Thionazin is a highly toxic organophosphorus pesticide used to protect crops and gardens from microorganisms and pests (such as the glasshouse whitefly and wireworms).
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Critchley, B.: Bull. Entomol. Res., 62, 327 (1972); French, N., et al.: Plant Pathol., 22, 99 (1973); Griffiths, D.: Entomol. Exp. Appl., 10, 171 (1967); Lloyd, G. & Bell, G.: Analyst, 91, 808 (1966)

Applications Ruxolitinib is a selective Janus tyrosine kinase (JAK1 and JAK2) inhibitor used in the treatment of myeloproliferative neoplasms and psoriasis. Potent JAK2 inhibitor.
References Shilling, A.D. et al.: Drug Metab. Disp., 38, 2023 (2010); Mesa, R.A.: IDrugs, 13, 394 (2010); Campas-Moya, C.: Drugs Fut., 35, 457 (2010);

Stability Hygroscopic
Applications A labelled metabolite of L-Carnitine (C184110).
References Millington, D., et al.: J. Inherit. Metab. Dis., 13, 321 (1990), Chace, D., et al.: Clin. Chem., 49, 1797 (2003),

Applications The labelled aglucon of apiin and of apigenin-7-glucoside.
References Chaumontet, C., et al.: Carcinogenesis, 15, 2325 (1994), Sato, F., et al.: Biochem. Biophys. Res. Commun., 204, 578 (1994), Kuo, M.L. et al.: Biochem. Biophys. Res. Commun., 212, 767 (1995)

Applications Fenoprofen is a positive allosteric modulators at melanocortin receptor 3 for treatment of inflammatory diseases in human and mouse model.
References Montero-Melendez, T., et al.: Cell. Mol. Life Sci., 74, 1335 (2017)

Applications Eprazinone Dihydrochloride is a drug used to improve pulmonary function in patients with chronic bronchitis.
References Thrail, R.S., et. al.: Exp. Lung Res., 18, 409 (1992)

Applications A labelled semisynthetic derivative of Paclitaxel. An antimitotic agent that promotes the assembly of micro-tubules and inhibits their de-polymerization to free tubulin. An antineoplastic.
References Ringel, I., et al.: J. Natl. Cancer Inst., 83, 288 (1991), Extra, J.-M., et al.: Cancer Res., 53, 1037 (1993)

Stability Hygroscopic
Applications 4-Hydroxyestradiol 4-O-β-D-Glucuronide Sodium Salt, is a glucuronide derivative of 4-Hydroxy-17β-estradiol (H941895); a metabolite of Estradiol (E888000) which is the major estrogen secreted by the premenopausal ovary.
References Bucala, R., et al.: J. Clin. Endocrinol. Metab., 60, 841 (1985); Telang, N., et al.: Anticancer Res., et al.: 11, 1021 (1991); Seeger, H., et al.: Med. Sci. Res., 26, 481 (1998); Bolton, J., et al.: Chem. Res. Toxicol., 13, 135 (2000); Salole, E.G., et al.: Anal. Profiles Drug Subs., 15, 283 (1986); Lievertz, R.W., et al.: Am. J. Obstet. Gynecol., 156, 1289 (1987)

Applications Esfenvalerate is the most potent insecticidal isomer of Fenvalerate (F279450), a pyrethroid insecticide used to control insects from food crops, animal feed and cotton products.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Nakayama, I. et al.: Adv. Pestic. Sci., Plenary Lect. Symp. Pap. Int. Congr. Pestic. Chem., 2, 174 (1979); Mikami, N. et al.: Pest. Sci., 16, 46 (1985); Palmquist, K.R. et al.: Environ. Toxicol. Chem., 27, 1721 (2008);

Stability Hygroscopic
Applications A metabolite of Carnitine.
References Huang, Z., et al.: Anal. Biochem., 199, 98 (1991), Friolet, R., et al.: J. Clin. Invest., 94, 1490 (1994), Rashed, M., et al.: Pediatr. Res., 38, 324 (1995), Costa, C., et al.: J. Lipid Res., 38, 173 (1997),

Applications A labelled selective cyclooxygenase-2 (COX-2) inhibitor. Anti-inflammatory. Used in the treatment of familial adenomatous polyposis.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Simon, L.S., et al.: Arthritis Rheum., 41, 1591 (1998), Silverstein, F.E., et al.: J. Am. Med. Assoc., 284, 1247 (2000), Steinbach, G., et al.: N. Engl. J. Med., 342, 1946 (2000),

Applications Pre-emergence herbicide used for grass control in crops.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Goldenthal, et al.: Toxicol. Appl. Pharmacol., 18, 185 (1971), Robens, J.F., et al.: Vet. Hum. Toxicol., 22, 328 (1980),

Impurity Fluconazole EP Impurity H
Applications 2-(2,4-Difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)-3-bromopropan-2-ol (Fluconazole EP Impurity H) is an impurity of the antifungal agent Fluconazole (F421000).
References Bourichi, H., et al.: STP Pharma Pratiques, 18, 285 (2008); Richard, K. et al.: Antimicrob. Ag. Chemother., 27, 832 (1985)

Applications N-Isopropyl quaternary salt of Atropine. Nonselective muscarinic acetylcholine receptor antagonist; bronchodilator.
References Groeben, H., et al.: Anesthesiology, 85, 867 (1996), Haddad, et al.: Br. J. Pharmacol., 127, 413 (1999), Barnes, P. J., et al.: Chest, 117, 63S (2000),

Applications δ-Ketoendrin is an isomerization product of Endrin (E555530), a chlorinated hydrocarbon insecticide that produces hepatic and neurologic toxicity. Endrin is also known to produce hyperexcitability of the human central nervous system that could result in convulsions. δ-Ketoendrin is an endocrine disrupting compound that has been found in human fetal and newborn tissues.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Burton, W.B., Pollard, G.E.: B. Environ. Contam. Tox., 12, 113 (1974); Bagchi, M., et al.: Arch. Env. Contam. Toxicol., 23, 1 (1992); Coble, Y., et al.: JAMA, 202, 489 (1967); Eisler, R. & Edmunds, P.: Trans. Am. Fish. Soc., 95, 153 (1966); Cappiello, A., et. al.: Anal. Bioanal. Chem., 406, 2779 (2014)

Applications 3-Isopropylphenyl Methylcarbamate is a potential human-safe insecticide against the malaria mosquito.
References Hartsel, J. A., et al.: Bioorg. Medicinal Chem. Lett., 22, 4593 (2012); Naik, P. K., et al.: SAR QSAR Environ. Res., 20, 551 (2009); Shang, Z., et al.: Nongyaoxue Xuebao, 2, 17 (2000)

Applications A metabolite of Cortisol (H714615).
References Aguilera, R., et al.: Clin. Chem., 47, 292 (2001), Pujos, E., et al.: Anal. Bioanal. Chem., 381, 244 (2005), Flenker, U., et al.: Steroids, 73, 408 (2008),