Toxicology

Applications Bromantane is an adamantane derivative used as an anxiolytic agent.
References Reznikov, A., et al.: Endokrinologie, 73, 11 (1979), Grekhova, T., et al.: Bull. Eksp. Biol. Med., 119, 302 (1995),

Applications Atazanavir is a novel azapeptide HIV protease inhibitor (PI). Antiviral. Like other antiretrovirals, it is used to treat infection of human immunodeficiency virus (HIV). Newer research has been investigating the potential anticancer effects of atazanavir
References Palella, F.J. Jr., et al.: N. Engl. J. Med., 338(13), 853 (1998), Nolan, D., et al.: Drugs, 63(23), 2555 (2003), Musial, B.L., et al.: Am. J. Health Syst. Pharm., 61, 1365 (2004), Wood, R., et al.: J. Acquir. Immune Defic. Syndr., 36, 684 (2004),

Applications Betamethasone 6α-Bromo 17-Valerate is an impurity of Betamethasone (B327000), which is a glucocorticoid used as an anti-inflammatory agent.
References Ferrante, M.G., et al.: Anal. Profiles Drug Subs., 6, 43 (1977), Li, A., et al.: Chem. Biol. Interact., 142, 7 (2002), Cruz-Monteagudo, M., et al.: Eur. J. Med. Chem., 40, 1030 (2005), Rothfuss, A., et al.: Chem. Res. Toxicol., 19, 1313 (2006),

Stability Light Sensitive
Applications Acrylonitrile_x000D_(stabilized with 35-45 ppm 4-hydroxy anisole (H750015)) (cas# 107-13-1) is a compound useful in organic synthesis.
E0

Applications Labelled analogue of Axitinib, a tyrosine kinase inhibitor. Axitinib is used in cancer therapy.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Wasser, K. et al.: Eur. Radiol., 13, 80 (2003),; Park, J. et al.: Clin. Cancer Res., 8, 1172 (2002); Bergers, G. et al.: J. Clin. Invest., 111, 1287 (2003);

Applications Gliftor is a rodenticide.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Menon, K., et al.: J. Biochem. Mol. Toxicol., 15, 47 (2001); Xie, W., et al.: J. Hygiene Res. 31, 316 (2002)

Applications An intermediate of SCH 51048, an antifungal agent.
References Lovey, R.G., et al.: Bioorg. Med. Chem. Lett., 12, 1739 (2002), Lovey, R., et al.: J. Med. Chem., 35, 4221 (1992),

Impurity Clobetasol Propionate EP Impurity J
Applications 9α-Fluoro-11β-hydroxy-16-β-methyl-3-oxoandrosta-1,4-diene-17(R)-spiro-2’-[4’-chloro-5’-ethylfuran-3’(2’H)-one (Clobetasol Propionate EP Impurity J) is an impurity in the synthesis of Clobetasol 17-Propionate (C583500), a topical corticosteroid. Glucocorticoid; anti-inflammatory.
References Olsen, E.A., et al.: J. Am. Acad. Dermatol., 15, 246 (1986),

Applications A metabolite of Acepromazine (A130900).
References Cossum, P., et al.: Drug Dispos., 9, 321 (1988), Stowell, L., et al.: J. Anal. Toxicol., 22, 166 (1998),

Applications S 23 is a selective androgen receptor modulator.
References Thevis, M., et al.: Drug Testing and Analysis, 2, 589 (2010); Jones, A., et al.; Endocr., 150, 385 (2009)

Applications trans-2-Decenoyl-L-carnitine is a metabolite of L-Carnitine (C184110), which is a essential cofactor of fatty acid metabolism; required for the transport of fatty acids through the inner mitochondrial membrane. Synthetized primarily in the liver and kidney; highest concentrations found in heart and skeletal muscle. Dietary sources include red meat, dairy products, beans, avocado.
References Mitchell, M.E., et al.: Am. J. Clin. Nutr., 31, 293 (1978), Lango, R., et al.: Cardiovasc. Res., 51, 21 (2001), Vaz, F.M., et al.: Biochem. J., et al.: 361, 417 (2002), Karlic, H., et al.: Nutrition, 20, 709 (2004),

Impurity Tranexamic EP Impurity A
Applications Tranexamic Acid Dimer (Tranexamic EP Impurity A) is a Tranexamic Acid (T714505) impurity.

Applications Impurity of Bivalirudin, a direct thrombin inhibitor acting as an anticoagulant through inhibition of the enzyme thrombin.
References Bertrand, O. et al.: Am. J. Cardio., 110, 599 (2012); Patti, G. et al.: Am. J. Cardio., 110, 478 (2012);

Applications Spiromesifen is a useful insecticide and miticide in plant breeding. Also useful in cannabis testing kits as a component of pesticide mixes (P698240).
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package

Applications Nithiazine is a useful building block and insecticide.
References Quaranta, L.; et al.: WO 2018149851 (2018).

Stability Hygroscopic
Applications Rosuvastatin tert-Butyl Ester, is a metabolite of Rosuvastatin (R700500) a selective, competitive HMG-CoA reductase inhibitor.
References Watanabe, M., et al.: Bioorg. Med. Chem., 5, 437 (1997), Lee, E., et al.: Clin. Pharmacol. Ther., 78, 330 (2005), Ferdinand, K.C., et al.: Am. J. Cardiol., 97, 229 (2006),

Impurity Atorvastatin EP Impurity G
Applications Atorvastatin derivative.

Applications Phensuximide is an anticonvulsant drug, used in the treatment of neurological disorders stemming from the brain. Antiepileptic.
References Ferrendelli, J. et al.: Annals Neuro., 5, 533 (1979); Bruno-Blanch, L. et al.: Bioorg. Med. Chem. Lett., 13, 2749 (2003);

Applications: An impurity contained in samples of all trans-retinoic acid.
References Newton, D., et al.: Cancer Res., 40, 3413 (1980), Curley, R., et al.: Bioorg. Med. Chem. Lett., 2, 1133 (1992), Tanaka, H., et al.: Chem. Pharm. Bull., 43, 356 (1995), Patel, J., et al.: J. Med. Chem., 47, 6716 (2004),

Applications Pefloxacinium (cas# 70458-92-3) is a useful research chemical.

Applications Paichongding is a type of neonicotinoid insecticide.
References Xie, Hui, et al.: Turang Xuebao, 53(1), 232-240 (2016)

Applications Quintrione is herbicidal compound comprising Heterocyclic Amide compound and use thereof.
References Wang, Z., et al.:PCT Int. Appl., (2020);

Applications A Nicotine metabolite. Carcinogen.

Applications 4-Hydroxy Propofol sulfate sodium salt is a derivative of Propofol, a hypnotic intravenous agent that is commonly used as an anasthetic for conscious sedation.
References GüLCIN, I., et al.: Chem. Pharm. Bull., 53, 281 (2005); Koshy, G., et al.: Am. J. Gastroenterol., 95, 1476 (2000)

Applications Labelled Benzydamine (B209950). A nonsteroidal anti-inflammatory drug with local anaesthetic, analgesic and antipyretic properties.
References Passali, D., et al.: Clin. Ther., 23, 1508 (2001), Erbagci, Z., et al.: J. Dermatol., 31, 376 (2004), Sarveiya, V., et al.: Eur. J. Pharm. Sci., 26, 39 (2005),

Impurity Calcium Folinate Hydrate EP Impurity E
Stability Unstable in Basic Solution
Applications 5-Formyltetrahydropteroic Acid is an impurity of Folic Acid (F680300); a vitamin needed to synthesize DNA, conduct DNA repair and methylate DNA. It also acts as a cofactor in biological reactions involving folate.
References Xu, L., et al.: Mol. Pharm., 7, 1311 (2010); Everette, J., et al.: J. Agric. Food Chem., 58, 8139 (2010); Alshatwi, A., et al.: Food, Chem., Toxicol., 48, 1881 (2010); McKay, D., et al.: Nut. J., 9 (2010)

Applications Pyrazosulfuron-ethyl

Applications Oxamyl is a pesticide used in the treatment and protection of crops from parasites and insects. Oxamyl is also useful in cannabis testing kits as a component of pesticide mixes (P698240).
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package

Applications Alodane (cas# 2550-75-6) is a compound useful in organic synthesis.

Stability Hygroscopic
Applications 2'-(2H-Tetrazol-5-yl)-[1,1'-biphenyl]-4-carboxylic Acid is a transformation product of Valsartan (V095750); a nonpeptide angiotensin II AT1-receptor antagonist and antihypertensive. 2'-(2H-Tetrazol-5-yl)-[1,1'-biphenyl]-4-carboxylic Acid is also referred to as Valsartan acid.
References Noedler, K., et al.: Water Res., 47, 6650 (2013); Criscione, L., et al.: Brit. J. Pharmacol., 110, 761 (1993); Muller, P., et al.: Eur. J. Clin. Pharmacol., 47, 231 (1994)

Applications 4’-Hydroxyphenprocoumon is a metabolite of the oral anticoagulant Phenprocoumon (P318820).
References De Vries, J. et al.: J. Chrom. Biomed. Appl., 529, 479 (1990);

Stability Hygroscopic
Applications A bile salt formed in the liver from chenodeoxycholate and glycine, usually as the sodium salt. It acts as a detergent to solubilize fats for absorption and is itself absorbed. It is a cholagogue and choleretic.
References Parmentier, G. , et al.: Steroids, 30, 583 (1977), Tserng, K.Y., et al.: Lipids, 13, 479 (1978),

Stability Unstable in Solution
Applications Meropenem-d6 is the labeled analogue of Meropenem, a carbapenem antibiotic. Antibacterial.
References Adams, M.D., et al.: J. Bacteriol., 190, 8053 (2008); Pattanaik, P., et al.: J. Biol. Chem., 284, 945 (2009); Mendes, R., et al.: J. Antimicrob. Chemother., 63, 55 (2009)

Applications di(4-Hydroxy Atorvastatin-d5) Calcium Salt is a labeled metabolite of Atorvastatin Calcium Salt (A791750), a selective, competitive HMG-CoA reductase inhibitor. Atorvastatin is the only drug in its class specfically indicated for lowering both elevated LDL-cholesterol and triglycerides in patients with hypercholesterolemia.
References Kearney, A.S., et al.: Pharm. Res., 10, 1461 (1993); Heinonen, T.M., et al.: Clin. Ther., 18, 853 (1996); Whitfield, L.R., et al.: Eur. J. Drug Metab. Pharmacokinet., 25, 97 (2000)

Stability Hygroscopic
Applications Roxithromycin (R700850) structurally related substance in bulk samples. Roxithromycin impurity.
References Gasc, J., et al.: J. Antibiot., 44, 313 (1991, Chepkwony, H., et al.: J. Chromatogr., 914, 53 (2001),

Applications A triazinetrione anticoccidial. Coccidiostat.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Eberts, T., et al.: Clin. Chem., 25, 1440 (1979), Goodwin, M., et al.: Avian Dis., 29, 630 (1985), Sorensen, S., et al.: Clin. Chim. Acta, 264, 103 (1997), Conway, D., et al.: Poult. Sci., 280, 426 (2001),

Applications Isoprinosine is a new combination of active substances for the treatment of chronic systemic diseases such as cancer. Isoprinosine is an immunomodulator; antiviral. The ratio is between 1: 2 : 2 to 1 : 3 : 3
References Mastino, A., et al.: Int. J. Cancer, 50, 493 (1992), Kim, Y., et al.: Mol. Cancer Therap., 8, 469 (2009),

Applications An enantiomeric impurity of Ezetimibe (E975005), an antihyperlipoproteinemic and cholesterol absorption inhibitor.

Applications Levofloxacin-d3, is the labeled analogue of Levofloxacin (L360000), an antibiotic used against gram-negative organisms.
References Kato, M., et al.: Arzneim.-Forsch., 42, 365 (1992), North, D.S., et al.: Pharmacotherapy, 18, 915 (1998), Hwang, D.G., et al.: Br. J. Ophthalmol., 87, 1004 (2003),

Applications Campesteryl Ferulate is a component of γ-​oryzanol with antioxidant activities.
References Xu, Z., et al.: J. Agric. Food Chem., 49, 2077 (2001);

Applications 3-Cysteinylacetaminophen-D5 (major), Trifluoroacetic Acid Salt is deuterium labeled 3-Cysteinylacetaminophen Trifluoroacetic Acid Salt (C994750), which is a metabolite of Acetaminophen (A161220), an analgesic and antipyretic agent used as a pain reliever to treat headache, muscle aches, and arthritis (1,2,3).Minimum isotopic incorporation d-3, no d-0 present. A representative lot has 64% isotopic incorporation at the 6-position, 89% at the 4-position.
References (1) McGill, M. R. and Jaeschke, H. Pharm Res. 30, 2174 (2013)(2) Fairbrother, J.E., et al.: Anal. Profiles Drug Subs., 3, 1 (1974) (3) Hinson, J.A., et al.: Rev. Biochem. Toxicol., 2, 103 (1980)

Applications rac Fosfomycin-D5 (Major) Benzylamine Salt is the deuterium labelled analogue of Fosfomycin antibiotic. Related to Fosfomycin Disodium Salt (F727500), rac Fosfomycin-13C3 Benzylamine Salt (F727502), Fosfomycin Tromethamine (F727505), and Fosfomycin Calcium (F727508).
References Goto, M., et al.: Antimicrob. Agents Chemother., 20, 393 (1981); Michalopoulos, A. et al.: Int. J. Infect. Dis., 15, e732 (2011); Matsumoto, T. et al.: J. Infection. Chemother., 17, 80 (2011); Keating, G. et al.: Drugs, 73, 1951 (2013); Demir, T. et al.: Int. J. Infect. Dis., 17, e966 (2013);

Stability Hygroscopic
Applications 4-Deoxypyridoxine is the deoxy analogue of Pyridoxine (P991735). 4-Deoxypyridoxine is a vitamin B6 antimetabolite; 4-Deoxypyridoxine can induce a deficient status that alters the function and ultrastructure of EC similar to vascular disease.
References La Pesa, M. et al.: Pathologia, 62, 907 (1970); Chang, S..: J. Nutrit. Sci. Vitaminol., 46, 149 (2000); Yamashita, J.: J. Nutrit. Sci. Vitaminol., 22, 1 (1976);

Applications Labelled Telmisartan (T017000). Telmisartan is an angiotensin II receptor antagonist.
References Wienen, W. et al.: Br. J. Pharmacol., 110, 245 (1993); Neutel, J.M. et al: Adv. Therap., 15, 206 (1998);

Applications 7α-Hydroxy-4-cholesten-3-one is a metabolite of Cholesterol (C432501).
References Connor, W., et al.: J, Clin. Invest., 48, 1363 (1969), Nestel, P., et al.: Metabolism, 24, 189 (1975), Ellegard, L., et al.: Eur. J. Clin. Nutr., 45, 451 (1991), Pedersen, A., et al.: J. Lipid Res., 41, 1901 (2000),

Stability Hygroscopic
Applications Metabolites of butadiene.
References Heavner, D., et al.: J. Pharm. Biomed. Anal., 40, 928 (2006), Carmella, S., et al.: Chem. Res. Toxicol., 22, 734 (2009),

Stability Hygroscopic
Applications Thiamine (T344185) impurity.
References Warnock, L., et al.: Anal. Biochem., 126, 394 (1982), Royer-Morrot, J., et al.: Eur. J. Clin. Pharmacol., 42, 219 (1992),

Applications Labelled derivative of Artemisinin. Antimalarial.
References Zhao, Y., et al.: J. Nat. Prod., 49, 139 (1986), Lin, A.J., et al.: J. Med. Chem., 30, 2147 (1987), Price, R. N., et al.: Expert Opin. Invest. Drugs, 9, 1815 (2000),

Stability Hygroscopic
Applications An active metabolite of Glimepiride (G410150).
References Groop, L., et al.: Diabetes Care, 15, 737 (1992), Muller, G., et al.: Diabetes, 42, 1852 (1993), Kramer, W., et al.: Biochem. Biophys. Acta, 119, 278 (1994),

Applications N3-tert-Butoxycarbonyl Imidacloprid is an intermediate in the synthesis of 5-Hydroxy-Imidacloprid (H943220), which is a metabolite of Imidacloprid (I274990) which is an active ingredient in certain neuro-active insecticides.
References Chauzat, M., et al.: Env. Entomol., 38, 514 (2009), Patial, A., et al.: Env. Ecol., 27, 320 (2009), Fernandez-Bayo, J., et al.: J. Agric., Food Chem., 57, 5435 (2009), Tomizawa, M., et al.: J. Med. Chem., 52, 3735 (2009), Chem. and Eng. News 90: 10 (2012)

Stability Unstable in Solution
Applications Sulfosulfuron is used in the synthetic preparation of herbicidal mixed compositions containing 2-chloro-3-(methylsulfanyl)-N-(1-methyl-1H-tetrazol-5-yl)-4-(trifluoromethyl)benzamide or its salt towards weed control.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Lorentz, L.; et al.: PCT Int. Appl. 340pp. Patent 2017 CODEN:PIXXD2

Applications 2-Hydroxydesipramine Dihydrochloride is a metabolite of Desipramine (D290050), a tricyclic antidepressant that is a more potent inhibitor of the norepinephrine transporter than the serotonin transporter.
References De Jongh, G.D., et al.: Drug Metab. Dispos., 2, 48 (1981); Suckow, R.F., et al.: J. Pharm. Sci., 73, 1745 (1984); Fraser, A.D., et al.: J. Anal. Toxicol., 11,168 (1987); Checkley, S.A, et al.: Br. J. Psychiatry, 138. 248 (1981); Zhu, M.Y., et al.: J. Neurochem., 70, 1547 (1998); Okugawa, G., et al.: J. Neuroindocrinol., 11, 887 (1999); Torres, G.E., et al.: Nat. Rev. Neurosci., 4, 13 (2003)

Applications Fenazaquin is a non-systemic acaricide/insecticide used widely in controlling mites and other related pests in fruits, vegetables and tea.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Kumar, V.,et al.: Food. Chem. Toxicol., 44, 596 (2006); Duhan, A., et al.: Bull. Environ. Contamin. Toxicol., 87, 180 (2011);

Applications Cefodizime is a third generation cephalosporin with a broad spectrum of antibacterial activity. Cefodizime maybe useful in the treatment of otitis media, sinusitis and gynaecological infections, and for the prophylaxis or treatment of surgical infections.
References Barradel, L.B. et al.: Drugs, 44, 800 (1992); Kasai, K. et al.: Jap. J. Antibiot., 37, 1306 (1984);

Applications Zineb is a fungicide that is a potential contaminant in food and has been under biological studies to evaluate the adverse effect and toxicity of low doses on thyroid function in male rat.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Nebbia, C., et al.: Bull. Environ. Contam. Toxicol., 56, 847 (1996)

Applications Celecoxib-d7 is the labeled analogue of Celecoxib (C251000), a selective cyclooxygenase-2 (COX-2) inhibitor. Anti-inflammatory. Used in treatment of familial adenomatous polyposis.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Simon, L.S., et al.: Arthritis Rheum., 41, 1591 (1998); Silverstein, F.E., et al.: J. Am. Med. Assoc., 284, 1247 (2000); Steinbach, G., et al.: N. Engl. J. Med., 342, 1946 (2000)

Applications Triphenyltin Acetate is an organotin compound. Triphenyltin Acetate much like its hydroxide analogue is used as a fungicide and antifeeding compound for insect control. Recent studies show that Triphenyltin Acetate may have adverse effects on the reproductive and immune systems and may disrupt the endocrine system.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Soderquist, J.S. et al.: J. Agric. Food Chem., 28, 111 (1980); J. Toxicol. Environ. Health, 7, 281 (2004); Livingston, J.M. et al.: J. Georgia Entamol. Soc., 13, 148 (1978); Sarpa, M. et al.: J. Toxicol. Environ. Health, 73, 965 (2010);

Applications Penoxsulam is an acetolactate synthase inhibitor herbicide developed for controlling grasses, sedges, and broadleaf weeds in rice culture.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Jabusch, T., and Tjeerdema, R.: J. Agric. Food Chem. 53, 18, 7179-183 (2005); Bamcjero, M., et al.: Sci. Total Environ. 807, 1, 160793 (2021)

Stability Very Very Hygroscopic
Applications Tiazofurin has antitumor activity and is a potential therapeutic agent in the treatment of cancer. Tiazofurin acts as an inhibitor of Inosine-5'-monophosphate (IMP) dehydrogenase.
References Streeter, D.G. et al.: Biochem. Biophys. Res. Comm., 115, 544 (1983); Boritzki, T. et al.: Biochem. Pharmacol., 34, 1109 (1985); Malek, K. et al.: Leuk. Res., 28, 1125 (2004);

Applications Ioxaglic Acid is used as a contrast medium during coronary angiograpy.
References Tragardh, B. et al.: Acta. Radiol. Diag., 24, 43 (1983); Sendo, T., et al.: Invest. Radiology, 35, 472 (2000),

Applications A synthetic derivative of Dehydroepiandrosterone. The reduced androgenicity of Fluasterone may obviate toxicities associated with the androgenicity of the parent compound. Antitumor agent. Used in clinical trials for prostate cancer prevention.
References Bentley, P., et al.: Food Chem. Toxicol., 31, 857 (1993), Rao, K., et al.: Cancer Res., 59, 3084 (1999), Masuzaki, H., et al.: Science, 294, 2166 (2001), Osawa, E., et al.: Life Sci., 70, 2623 (2002),

Applications Insecticide; acaricide.This compound is a contaminant of emerging concern (CECs).Useful in cannabis testing kits as a component of pesticide mixes (P698230).
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Smith, G.N., et al.: J. Agric. Food Chem., 15, 132 (1967), Schafer, et al.: Toxicol. Appl. Pharmacol., 21, 315 (1972)

Applications Diamino-5-phenylthiazole Hydrobromide is an phenylthiazole derivative used in the preparation of antiallergic and antiinflammatory agents.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Ban, M. et al.: Bioorg. Med. Chem., 6, 1069 (1998);

Applications Alclometasone-17,21-dipropionate is an synthetic glucocorticoid steroid used for inflammatory skin conditions. Alclometasone-17,21-dipropionate is topically used in dermatology as an anti-inflammatory, antipruritic, antiallergic, antiproliferative and vasoconstrictive agent.
References Teraki, Y., et al.: Dermatol., 224, 309 (2012); Yamamoto, Y., et al.: int. J. Pharma., 426. 54 (2012); Aggerwal, A., et al.: J. Int. Med. Res., 10, 414 (1982);

Applications Thiobencarb-d10 (diethyl-d10) (CAS# 1219804-12-2) is a useful isotopically labeled research compound.

Applications Auxin-type herbicide.
References Ecker, J., et al.: Science, 268, 667 (1995), Grossmann, K., et al.: Pestic. Sci., 52, 111 (1998), Martin, P., et al.: Environ. Toxicol. Chem. 19, 2987 (2000), Grossmann, K., et al.: J. Exp. Bot., 52, 1811 (2001), van Eerd, L., et al.: Weed Res., 44, 355 (2004),

Applications Herbicide safener.
References Lee, H., et al.: Eur. J. Med. Chem., 40, 862 (2005), Wright, S., et al.: Bioorg. Med. Chem. Lett., 17, 5638 (2007), Brazier-Hicks, M., et al.: J. Biol. Chem., 283, 21102 (2008), Vinggaard, A., et al.: Chem. Res. Toxicol., 21, 813 (2008),

Applications (aS,bR)-Bedaquiline is a diarylquinoline derivative that acts as a mycobacterial inhibitor. Bedaquiline shows promise as potential drug in the treatment of tuberculosis.
References Cheepsattayakorn, A., et al.: Anti-Infect. Drug. Discover.,7, 141 (2012); de Jonge M.R. et al.: Proteins, 67, 971 (2007); Diacon A.H. et al.: N. Eng. J. Med., 360, 2397 (2009);

Applications Isotope labelled o-Cresol is a compound used as a disinfectant and have also been used as antiseptic in surgery.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Razavi, S.M., et al.: Nat. Prod. Res., 26, 2148 (2012); Asadollahi-B. M., et al.: Environ. Toxicol. Pharmacol., 34, 826 (2012);

Applications A nonsteroidal estrogen antagonist.
References Gladek, A., et al.: J. Biol. Chem., 264, 16847 (1989), Han, X., et al.: Cancer Res., 52, 1360 (1992), Williams, G., et al.: Carcinogenesis, 14, 315 (1993),Coradini, D., et al.: Anticancer Res., 14, 1059 (1994),

Applications Dimethyl phosphorodithiolate derivatives used as insecticides.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package

Applications 2-[3-(Aminosulfonyl)-4-chlorobenzoyl]-benzonic Acid is a potential metabolite of Chlorthalidone.
References Salado C., et al.: J. Chromatography. Biomed. App., 690, 195 (1997);

Impurity Rosuvastatin EP Impurity B
Stability Hygroscopic
Applications A diastereomer of Rosuvastatin (R700500) used for treatment, prevention and combination therapy of lipid-related disorders. Rosuvastatin EP Impurity B

Applications A labeled metabolite of Diosmetin (D485000) isolated and identified from Chrysanthemum morifolium L. v. Ramat leaves.
References Porra, R., et al.: Biochem. Biophys Acta, 975, 384 (1989), Watanabe, M., et al.: J. Agric. Food Chem., 47, 4500 (1999),