Toxicology

<p>Applications 4-[4-[2-(2-Pyridinyloxy)propoxy]phenoxy]phenol is a metabolite of Pyriproxyfen (P998850); a pyridine-based pesticide used against a variety of arthropoda, in particular to protect cotton crops against whitefly.<br>References Amiri, A., et al.: J. Agri. Sci. Technol., 14, 1205 (2012); Basit, M., et al.: Crop. Protect., 44, 135 (2013); Yoshino, H., et al.: J. Agr. Food Chem., 43, 2681 (1995); Zhang, L., et al.: Arch. Insect Biochem., 37, 215 (1998)<br></p>

<p>Applications Synthetic mu-opioid agonist. This is a controlled substance (opiate).<br>References James, M.K., et al.: J. Pharmacol. Exp. Ther., 259, 712 (1991), Hoffman, W.E., et al.: Anesthesiology, 79, 107 (1993), Selinger, K., et al.: J. Pharm. Biomed. Anal., 12, 243 (1994), Richardson, T.D., et al.: Expert Opin. Drug Saf., 4, 643 (2005),<br></p>

<p>Stability Hygroscopic<br>Applications Labelled dimethyl phosphorothiolate derivatives used as insecticides.<br>References Suzuki, F., et al.: Jpn. Tokkyo Koho (1976), JP 51009007 B<br></p>

<p>Applications A metabolite of Naproxen.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Rettie, A., et al.: Chem. Res. Toxicol., 5, 54 (1992), Tracy, T., et al.: Biochem. Pharmacol., 52, 1305 (1996), Bonnabry, P., et al.: Eur. J. Clin. Pharmacol., 49, 305 (1996), Rao, S., et al.: J. Med. Chem., 43, 2789 (2000), Hutzler, J., et al.: Drug Metab. Dispos., 29, 1029 (2001),<br></p>

<p>Applications A labelled metabolite of Prochlorperazine.<br>References Finn, A., et al.: J. Clin. Pharmacol., 45, 1383 (2005),<br></p>

<p>Applications 6-(tert-Butylamino)-1,3,5-triazine-2,4(1H,3H)-dione is a metabolite of Terbuthylazine (T110500) a triazine herbicide.<br>References Schenck, F., et al.: Bull Environ. Contam. Toxicol., 73, 24 (2004),<br></p>

<p>Stability Hygroscopic<br>Applications Methomyl is a carbamate insecticide. Useful in cannabis testing kits as a component of pesticide mixes (P698240).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Armes, N., et al.: Bull. Entomol. Res., 86, 499 (1996); Shono, T., et al.: Pest. Biochem. Physiol., 75, 1 (2003)<br></p>

<p>Applications N-Acetyl Mesalazine-d3 is the labeled analogue of N-Acetyl Mesalazine (A168320), a metabolite of Mesalazine. A Salicylic Acid derivative. Inhibitor of recombinant human thiopurine methyltransferase (hTPMT).<br>References Bondesen, S., et al.: Br. J. Clin. Pharmacol., 25, 269 (1988); Brogden, R., et al.: Drugs, 38, 500 (1989); Jensen, J., et al.: Biochem. Pharmacol., 45, 1201 (1993); Liu, Z., et al.: Drug Metab. Dispos., 23, 246 (1995); Vree, T., et al.: Clin. Drug Invest., 20, 35 (2000)<br></p>

<p>Applications Controlled substance (depressant). Anxiolytic. Prototype of the benzodiazepine anxiolytics.<br>References MacDonald, A., et al.: Anal. Profiles Drug Subs., 1, 15 (1972); Greenblatt, D.J., et al.: Clin. Pharmacokinet., 3, 381 (1978);<br></p>

<p>Applications Dichloroacetic Acid, is a highly corrosive compound, but in a salt form is used therapeutically, due to their ability to inhibit the enzyme pyruvate dehydrogenase kinase. The studies has also shown, DCA has potential anticancer applications. This compound is suitable for pyruvate dehydrogenase (PDH) related research.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Kato, M., et al.: Structure, 15(8), 992 (2007); "Cheap, ‘safe’ drug kills most cancers". New Scientist. (2007); Michelakis, E. D., et al.: Sci. Transl. Med., 2(31) (2010);<br></p>

<p>Applications Labelled Irgarol (I764100). Irgarol is a highly specific and effective inhibitor of photosynthesis. This makes it ideal, combined with its very low water solubility, for use in long-life antifouling coatings for marine applications to prevent the growth of algae.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Okamura, H., et al.: J. Environ. Sci. Health, B34, 225 (1999), Comber, S., et al.: Sci. Total Environ., 286, 61 (2002), Gatidou, G, et al.: Environ. Int., 33, 70 (2007),<br></p>

<p>Applications A β-Adrenergic blocker with peripheral vasodilating activity. Antianginal; antihypertensive.<br>References Francis, R.J., et al.: Eur. J. Clin. Pharmacol., 23, 529 (1982), Pfisterer, M., et al.: J. Cardiovasc. Pharmacol., 6, 417 (1984), Narimatsu, S., et al.: J. Pharmacol. Exp. Ther., 303, 172 (2002), Flanagan, J., et al.: Biochem. J., 380, 353 (2004),<br></p>

<p>Stability Moisture Sensitive<br>Applications Fenchlorphos-oxon is a pesticide residue found in fruits and vegetables.<br>References Jadhav, M.R., et. al.: J. Agr. Food Chem., (Ahead of Print) (2015); Li, Y. et. al.: J. Chromatogr. A., 1361, 77 (2014); Li, X., et. al.: Sepu, 32, 268 (2014)<br></p>

<p>Applications Colinesterase inhibitor. Insecticide.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Gaines, T.B., et al.: Toxicol. Appl. Pharmacol., 14, 515 (1969),<br></p>

<p>Applications 3-Hydroxykynurenine is a metabolite of tryptophan. 3-Hydroxykynurenine filters UV light in the human lens. Studies suggest that Hydroxykynurenine is an endogenous oxidative stress generator and a potential endogenous neurotoxin.<br>References Malina, H.Z. et al.: Graefes. Arch. Clin. Exp. Ophthalmol., 233, 38 (1995); Okuda, S. et al.: J. Neurochem., 70, 299 (1998);<br></p>

<p>Applications (1R,2S)-erythro-Dihydro Bupropion is a metabolite of Bupropion (B689625), a selective inhibitor of dopamine uptake.<br>References Writer, J.H., et. al.: Sci. Total Environ., 461 (2013)<br></p>

<p>Applications Linifanib (ABT 869) is an oral tyrosine kinase inhibitor with antineoplasic activity. As a dual inhibitor, Linifanib, is being tested on several different cancers.<br>References Haddley, K., et al.: Drugs of the Future, 35, 106 (2010), Cheng, A., et al.: J. Med. Chem., 53, 4502 (2010),<br></p>

<p>Applications Labelled Curcumin (C838500). A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. Induces apoptosis in cancer cells and inhibits phorbol ester-induced protein kinase C (PKC) activity. Reported to inhibit production of inflammatory cytokines by peripheral blood monocytes and alveolar macrophages. Potent inhibitor of EGFR tyrosine kinase and IκB kinase. Inhibits inducible nitric oxide synthase (iNOS), cycloxygenase and lipoxygenase. Easily penetrates into the cytoplasm of cells, accumulating in membranous structures such as plasma membrane, endoplasmic reticulum and nuclear envelope.<br>References Srinivasan, et al.: J. Pharm. Pharmacol., 5, 448 (1953), Tu, B., et al.: J .Cell Biol., 164, 341 (2004), Xu, G., et al.: Biochemistry, 44, 9817 (2005), Johnson, J., et al.: Cancer Lett., 255, 170 (2007),<br></p>

<p>Applications Labelled Diltiazem (D460620). A calcium channel blocker with vasodilating activity. Antianginal; antihypertensive; antiarrhythmic (class IV).<br>References Sato, et al.: Arzneim.-Forsch., 21, 1338 (1971), Smirnov, S.R.: Eur. J. Pharmacol., 360, 81 (1998), Hansson, L., et al.: Lancet, 356, 359 (2000),<br></p>

<p>Applications Desmedipham is a carbanilate based herbicide used in the weed control programs in sugar beet.<br>References Kittlaus, S., et al.: J. Chromatograph. A., 1283, 98 (2013); Wujek, B., et al.: J. Food. Agri. Environ., 10, 606 (2012);<br></p>

<p>Stability Hygroscopic<br>Applications Ticagrelor, the first reversible oral P2Y12 receptor antagonist, provides faster, greater, and more consistent ADP-receptor inhibition than Clopidogrel. Used in the treatment of acute coronary syndromes (ACS).<br>References Matetzky, S., et al.: Circulation, 109, 3171 (2004), Bassand, J., et al.: Eur. Heart J., 28, 1598 (2007), Jakubowski, J., et al.: Cardiovasc. Drug Rev., 25, 357 (2007),<br></p>

<p>Stability Hygroscopic<br>Applications A biochemical marker of bone turnover for management of metabolic bone diseases.<br>References Turner, W., et al.: Biol. Psychiatry, 14, 177 (1979), Miyata, T., et al.: Kidney Int., 60, 2351 (2001), Politi, P., et al.: Neurosci. Lett., 396, 163 (2006),<br></p>

<p>Applications Exhibits specific inhibitory activity against tyrosine kinases,including autophosphorylation of epidermal growth factor receptor kinase (IC50 - 2.6uM). Also inhibits other protein kinases through competitive inhibition of ATP. Inhibits tumor cell proliferation and induces tumor cell differentiation. Produces cell-cycle arrest and apoptosis in Jurat T-leukemia cells. However, it prevents anti-CD3 monoclonal antibody-induced thymic apoptosis. Genistein also inhibits topoisomerase II activity in vitro. Genistein has also been shown to inhibit the action of GABA on recombinant GABAA receptors2. uv(max)ethanol: 262.5 nm (e= 138). moderately sol. in hot alcohol<br>References Akiyama, T., et al.: J. Biol. Chem., 262, 5592 (1987), O'Dell, T.J., et al.: Nature, 353, 588 (1991), Aharonovits, O., et al.: Biochim Biophys. Acta, 1112, 181 (1992), Platanias, L.C., et al.: J. Biol. Chem., 267, 24053 (1992), Yoshida, H., et al.: Biochim. Biophys. Acta, 1137, 321 (1992), Uckun, F.M., et al.: Science, 267, 886 (1995)Merck Index 12th ed. 43952. Huang, R.Q.; Fang, M.J.; Dillon, G.H., Mol. Brain Res. 67: 177-183 (1999)<br></p>

<p>Applications Chlorfenapyr-d7 is the labelled analogue of Chlorfenapyr (C428500), which is a halogenated pyrrole based pro-insecticide. Chlorfenapyr functions by metabolizing into an active insecticide after entering the host. Chlorfenapyr is used primarily as a means of pest control on cotton. Used as a standard for Pesticide detection. Chlorfenapyr is also useful in cannabis testing kits as a component of pesticide mixes (P698230).<br>References Lovell, J.B. et al.: Bright. Crop Prot. Pests Dis., 1, 37 (1990); Wier, A.T. et al.: J. Agric. Entemol., 11, 311 (1994); Black, B.C. et al.: Pest. Biochem. Physiol., 50, 115 (1994);<br></p>

<p>Applications Strobilurin fungicide; inhibits mitochondrial respiration by blocking electron transfer between cytochromes b and c1. Agricultural fungicide.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Smalling, K., et al.: Environ. Toxicol. Chem., 29, 2593 (2010), Lu, X., et al.: Phytopathol., 100, 1162 (2010), Schafer, R., et al.: Environ. Sci. Technol., 45, 1665 (2011),<br></p>

<p>Applications Labelled Aldicarb (A514650). Aldicar is used as an insecticide. Used in Pesticide detection.<br>References Ashby, J., et al.: Environ. Mutagen., 7, 919 (1985), Ashby, J., et al.: Mutat. Res., 257, 229 (1991), Kazius, J., et al.: J. Med. Chem., 48, 312 (2005), Benigni, R., et al.: Mutagenesis, 25, 335 (2010),<br></p>

<p>Stability Light Sensitive<br>Applications Acrylonitrile_x000D_(stabilized with 35-45 ppm 4-hydroxy anisole (H750015)) (cas# 107-13-1) is a compound useful in organic synthesis.<br> E0<br></p>

<p>Applications A potent inhibitor of estrone sulfatase. Inhibits estrone sulfatase &gt;99% at 0.1uM in intact MCF-7 cells, IC50=65pM.<br>References Woo, L.W., et al.: J. Med. Chem., 41, 1068 (1998)<br></p>

<p>Stability Hygroscopic<br>Applications 2-Chloro-5-[[4,5-dihydro-2-(nitroamino)-1H-imidazol-1-yl]methyl]-3-pyridinol is an analog of Imidacloprid (I274990) which is an active ingredient in certain neuro-active insecticides.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Chauzat, M., et al.: Env. Entomol., 38, 514 (2009), Patial, A., et al.: Env. Ecol., 27, 320 (2009), Fernandez-Bayo, J., et al.: J. Agric., Food Chem., 57, 5435 (2009), Tomizawa, M., et al.: J. Med. Chem., 52, 3735 (2009), Chem. and Eng. News 90: 10 (2012)<br></p>

<p>Applications Capreomycin Sulfate is used in the treatment of MDR-tuberculosis in conjunction with other anti-tuberculosis drugs.<br>References Garcia-C. et al.: Antimicrob. Agents Chemother., 56, 2612 (2012); Reisfeld, B. et al.: Antimicrob. Agents Chemother., 56, 926 (2012);<br></p>

<p>Applications Cyproconazole is a fungicide treatment for wood preservative that prevents decay from fungi in above-ground applications.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Aiello, D., et al.: Plant. Disease., 97, 37 (2013); Bakirci, G.T., et al.: Food. Chem., 135, 1901 (2012); Sugitate, K., et al.: J. Pesticides. Sci., 37, 148 (2012);<br></p>

<p>Stability Hygroscopic<br>Applications A labelled antibacterial, a third-generation cephalosporin.<br>References Reiner, R., et al.: J. Antibiot., 33, 783 (1980)<br></p>

<p>Applications Octanoyl L-Carnitine-d3 Chloride is a metabolite of Carnitine (C184110, L-Carnitine).<br>References Huang, Z., et al.: Anal. Biochem., 199, 98 (1991), Friolet, R., et al.: J. Clin. Invest., 94, 1490 (1994), Rashed, M., et al.: Pediatr. Res., 38, 324 (1995), Costa, C., et al.: J. Lipid Res., 38, 173 (1997),<br></p>

<p>Applications N-(3-Phenylpropionyl)glycine-3C2,15N is a labelled analogue of N-(3-Phenylpropionyl)glycine (P336210), which is a useful diagnostic tool in the diagnosis of many organic acidemias and mitochondrial fatty acid β-oxidation defects. N-(3-Phenylpropionyl)glycine is present in the urine of medium-chain acyl-CoA dehydrogenase deficient (MCAD) patients who orally ingested 3-phenylpropionic acid.<br>References Duran, M. et al.: Prog. Clin. Biol. Res., 321, 419 (1988); Bonafe, L. et al.: Mol. Gen. Metab., 69, 311 (2000); Ombrone, D. et al.: Anal. Biochem., 417, 122 (2011);<br></p>

<p>Applications Niraparib is a novel oral poly(ADP-ribose)polymerase (PARP) inhibitor efficacious in BRCA-1 and -2 mutant tumors.<br>References Jones, P., et al.: J. Med. Chem., 52, 7170 (2009); Giannini, G., et al.: Bioorg. Med. Chem. Lett., 24, 462 (2014)<br></p>

<p>Applications Bromoxynil is a nitrile herbicide. Bromoxynil is effective in post-emergent control of broad leaf weeds in cereal, corn, sorghum, onions, flax, mint, turf, and on non-cropland.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Bhattacharya, S.P. et al.: Pesticides, 22, 7 (1988); Culpepper, A.S. et al.: Weed Technol., 12, 554 (1998); Rosales-Robles, E. et al.: Weed Technol., 19, 385 (2005);<br></p>

<p>Applications Dihexadecyl(dimethyl)azanium bromide is an ionic olefin derivative used in the preparation of metal-containing ionic liquids for use in particle synthesis and materials with magnetic or thermochromic properties.<br>References Zabel, A.; et al.: Int. J. Mol. Sci., 17, 596/1 (2016).<br></p>

<p>Applications A metabolite of Amitraz (A633320).<br>References Knowles, C., et al.: J. Sci. Health, 16, 547 (1981), Zhu, N., et al.: J. Pestic., 33, 32 (1994), Du, X., et al.: Environ. Chem., 14, 258 (1995),<br></p>

<p>Applications Labelled analogue of Glycopyrrolate Bromide, a novel pharmaceutical compound based on PDE IV inhibitors. Glycopyrrolate Bromide is used in the treatment of respiratory complaints.<br>References Gomez, et al.: Br. J. Anaesth., 74, 549 (1995);<br></p>

<p>Applications Fenoprofen is a positive allosteric modulators at melanocortin receptor 3 for treatment of inflammatory diseases in human and mouse model.<br>References Montero-Melendez, T., et al.: Cell. Mol. Life Sci., 74, 1335 (2017)<br></p>

<p>Applications A labelled semisynthetic derivative of Paclitaxel. An antimitotic agent that promotes the assembly of micro-tubules and inhibits their de-polymerization to free tubulin. An antineoplastic.<br>References Ringel, I., et al.: J. Natl. Cancer Inst., 83, 288 (1991), Extra, J.-M., et al.: Cancer Res., 53, 1037 (1993)<br></p>

<p>Applications Dimethenamide-P<br></p>

<p>Applications Fenoxaprop-P is an agro-product, used in pesticide formulations.<br>References Han, Y. et al. et al.: J. Sep. Sci., 40, 878 (2017);<br></p>

<p>Applications Eprazinone Dihydrochloride is a drug used to improve pulmonary function in patients with chronic bronchitis.<br>References Thrail, R.S., et. al.: Exp. Lung Res., 18, 409 (1992)<br></p>

<p>Applications Selective serotonin reuptake inhibitor (SSRI).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Feret, B., et al.: Formulary, 40, 227 (2005),<br></p>

<p>Applications Bazedoxifene Acetate is a nonsteroidal selective estrogen receptor modulator (SERM). Bazedoxifene Acetate is used as an antiosteoporotic.<br>References van Hoorn, W., et al.: J. Med. Chem., 45, 584 (2002); Neubauer, B., et al.: Cancer Res., 63, 6056 (2003); Yan, X., et al.: Biochemistry, 43, 909 (2004);<br></p>

<p>Applications Cortisol 21-m-Maleimidobenzoate is a derivative of Cortisol which is a topical corticosteroid (1), more specifically a glucocorticoid, produced by the zona fasciculata of the adrenal gland (2). Cortisol is released in response to stress and a low level of blood glucocorticoids. Its primary functions are to increase blood sugar through gluconeogenesis (3); suppress the immune system; and aid in fat, protein and carbohydrate metabolism.<br></p>

<p>Stability Hygroscopic<br>Applications EPTC is a pesticide, S-Ethyl-N,N-dipropylthiocarbamate<br></p>

<p>Applications An isotopically labelled version of Valsartan (V095750), a nonpeptide angiotensin II AT1-receptor antagonist. Antihypertensive.<br>References Criscione, L., et al.: Brit. J. Pharmacol., 110, 761 (1993), Muller, P., et al.: Eur. J. Clin. Pharmacol., 47, 231 (1994)<br></p>

<p>Applications Labelled Vorizonazole (V760000), used as an antifungal (systemic). An Ergosterol Biosynthesis inhibitor.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Sanati, H., et al.: Antimicrob. Ag. Chemother., 41, 2492 (1997),<br></p>

<p>Stability Light Sensitive<br>Applications A highly sensitive reagent for α-keto acids. A fluorometric labeling reagent. Dyes and metabolites.<br>References Kajihara, Y., et al.: Carb. Res., 331, 455 (2001)<br></p>

<p>Applications Fenbuconazole is a conazole based fungicide used as a spray for the control of leaf spot, yellow and brown rust, powdery mildew and net blotch on wheat and barley and apple scab, pear scab and apple powdery mildew on apples and pears.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Reiss, R., et al.: Food. Chem. Toxicol., 50, 4421 (2012); Loos, M. et al.: Environ. Sci. Technol., 46, 9830 (2012);<br></p>

<p>Applications Herbicide used to control the spread of weedgrass.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Haith, D., et al.: Environ. Sci. Technol., 44, 6496 (2010), Jabran, K., et al.: Int. J. Agric. Biol., 12, 335 (2010), Rahaman, S., et al.: Environ. Ecol., 28, 1 (2010),<br></p>

<p>Stability Hygroscopic<br>Applications A metabolite of Acrylamide.<br>References Bjellaas, T., et al.: Toxicol. Sci., 100, 374 (2007), Doerge, D., et al.: Toxicol. Lett., 169, 34 (2007), Hartmann, E., et al.: J. Agric. Food Chem., 56, 6061 (2008),<br></p>

<p>Applications Bacitracin is a peptide antibiotic effective against gram-postive bacteria. Bacitracin is an inhibitor of peptidoglycan synthesis. Bacitracin disrupts bacterial cell wall synthesis by inhibiting dephosphorylation of lipid pyrophosphate. Bacitracin also strongly inhibits proline endopeptidase from human muscle.<br>References Ward, J.B. et al.: Biochem. J., 141, 227 (1974); Anastasi, A. et al.: Biochem. J., 290, 601 (1993); Daly, D.J. et al.: Biochem. Soc. Trans., 13, 1161 (1985); Weinberg, E.D. et al.: Antibiot. Ber., 90, (1967);<br></p>

<p>Applications 2-Chloro-N-(4'-chloro-5-hydroxy[1,1'-biphenyl]-2-yl)-3-pyridinecarboxamide is a biscalid (B675850) metabolite that is used as a pesticide or for pesticide tolerance in certain commodities.<br>References Joyner, S., et al.: Federal Register, 75, 29901 (2010); Environmental Protection Agency.: Federal Register, 68, 44640 (2003)<br></p>

<p>Applications Dimethyldimyristylammonium Chloride is used as a surfactant.<br>References Cipiciani, A., et al.: Austr. J. Chem., 44, 1505 (1991); Hueck, H., et al.: Appl. Microbiol., 14, 308 (1966)<br></p>

<p>Applications (5Z)-rel-Cloprostenol Sodium Salt is the d-enantiomer of Cloprostenol (C587300), an aryl-oxymethyl analog of prostaglandin F2α.<br>References Gumen, A., et al.: J. Animal. Sci., 56, 279 (2011); Leterlier, C.A., et al.: Reproduct. Domestic. Animals., 46, 481 (2011); Martins, J.P.N., et al.: J. Diary. Sci., 94, 2815 (2011);<br></p>

<p>Applications Ethoxysulfuron<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Stability Light Sensitive<br>Applications Labelled Thiamethoxam (T344180). A neonicotinoid insecticide. Reports show that when exposed to neonicotinid pesticides honeybees have probelms returnign home after foraging and bumblebee colonies grow poorly and produce fewer queens. Used in Cannabis testing.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Oliver, J., et al.: J. Environ. Horticult., 28, 135 (2010), Ghosh, A., et al.: J. Entomol. Res., 34, 35 (2010), Chem. and Eng. News 90: 10 (2012)<br></p>

<p>Stability Volatile<br>Applications Labelled analiogue of Dimepranol, a component of Inosine pranobex (I822350) that produces a small but significant inhibition of the histamine release from human mast cells. Dimepranol is one of the compounds used to identify the illegal manufacture of methadone.<br>References Gielsdorf, W. et al.: Arch. Kriminol., 164, 83 (1979); Schmutzler, W. et al.: Int. Arch. Allergy Appl. Immunol., 88, 244 (1989);<br></p>

<p>Applications: Has been used as antiseptic, anthelmintic and counter-irritant in alopecia.<br>Dangerous Goods Info: Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Diggle, S., et al.: Chem. Biol., 13, 701 (2006), Tashiro, Y., et al.: J. Bacteriol.,190, 3969 (2008),<br></p>

<p>Applications Flunitrazepam is used as an hypnotic. This is a controlled substance (depressant).<br>References Sternbach, L.H., et al.: J. Med. Chem., 6, 261 (1963), Eidelberg, E., et al.: Neurology, 5, 223 (1965), Caplan, Y., et al.: J. Anal. Toxicol., 25, 396 (2001), Wood, M., et al.: Forensic Sci. Int., 150, 227 (2005),<br></p>

<p>Applications Chlorantraniliprole-D3 is an isotopic labeled compound of Chlorantraniliprole (C325380); a pyrazolylpyridine insecticide and an activator of insect ryanodine receptor. Used in Pesticide detection.<br>References Lahm, G.P., et al.: Bioactive. Heterocyclic. Compound. Class., 251, (2012);<br></p>

<p>Applications bis(8-Quinolinolato-κN1,κO8)-Copper is a disinfectant for vegetables. High polarity pesticide.<br>References Li, Z., et al.: Anal. Lett., 49, 737-743 (2016); Kim, H. S., et al.: Organohalog. Compd., 75, 359-362 (2013)<br></p>

<p>Applications Isotope Labelled Triphenyltin Hydroxide (T809350), an organotin compound. Triphenyltin Hydroxide is used as a fungicide and antifeeding compound for insect control (1,2). Recent studies show that Triphenyltin Hydroxide may have adverse effects on the reproductive and immune systems and may disrupt the endocrine system (3).Drinking water contaminant candidate list 3 (CCL 3) compound as per United States Environmental Protection Agency (EPA), environmental, and food contaminants.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References 1. Sarpa M. et al.: J Toxicol Environ Health A. 2010;73(13-14):965-712. Soderquist, J. et al.: J. Agric. Food. Chem. Jan:28(1);111-1173. 3. Golub, M. et al.: J. Toxicol. Environ. Health B. Crit. Rev. 2004 Jul-Aug;7(4):281-95<br></p>

<p>Applications Methyl-1-Testosterone is a derivative of dihydrotestosterone. Methyl-1-Testosterone is a designer anabolic steroid that is on the world anti-doping agency’s (WADA) prohibited list.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Parr, M.K. et al.: Endocrinology, 152, 4718 (2011); Liu, Y. et al.: Drug Test. Anal., 3, 54 (2011); Jeon, B.W. et al.: Anal. Bioanal. Chem., 401, 1353 (2011);<br></p>

<p>Stability Very Hygroscopic<br>Applications A labelled metabolite of the pesticide Glyphosphate (G765000).<br>References Siehl, D.L. et al.: J. Biol. Chem., 282, 11446 (2007); Env. Prot. Agen. EPA: Fed. Reg., 74, 67129 (2009);<br></p>

<p>Applications Zeatin, purified from Zea mays, is a member of the cytokinin group of plant growth factors, the activity of which is attributed to its more stable trans form. Trans-Zeatin inhibits UVB-induced matrix metalloproteinase-1 expression via MAP kinase signaling in human skin fibroblasts. Trans-Zeatin is a potential agent for the management of skin photoaging.<br>References Murashige, T., et al.: Physiol. Plant, 15, 473 (1962), Brenneisen, P., et al.: J. Biol. Chem., 273, 5279 (1998), Choi, M., et al.: J. Dermatol. Sci., 46, 127 (2007), Bae, J., et al.: Food Chem. Toxicol., 46, 1298 (2008),<br></p>

<p>Stability Hygroscopic<br>Applications Labelled Atropine. Mydriatic; antispasmodic; used in preanesthetic medication.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Brown, R.V., et al.: Br. J. Pharmacol., 15, 170 (1960), Shutt, L.E., et al.: Anaesthesia, 34, 476 (1979), Hinderling, P.H., et al.: J. Pharm. Sci., 74, 703 (1985),<br></p>

<p>Stability Air Sensitive<br>Applications 4,5-Dichloro-2-octyl-3(2H)-isothiazolone (cas# 64359-81-5) is a useful research chemical.<br></p>

<p>Stability Air sensitive, Material darkens in storage with no loss in purity<br>Applications Aniline is used in the manufacture of dyes, medicinals, resins, varnishes, perfumes, as a vulcanizing rubber or even as a solvent (1,2). Hazardous and noxious substance which affects the early life stages of marine animals (3). Drinking water contaminant candidate list 3 (CCL 3) compound as per United States Environmental Protection Agency (EPA), environmental, and food contaminants. Dyes and metabolites, Environmental Testing.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References 1. Barkov, A. et al.: Russ. Chem. Bull. 2012. Aug:61(8) pp1564-92. Zhang, X. et al.: Synthesis. 2013 45(10): 1357-13633. Cunha, I. et. al.: Environ. Sci. Pollut. Res. Int. 2017 Mar 10.<br></p>

<p>Applications An antitumor agent which also acts as a chemosterilant for male houseflies and other insects. Antineoplastic.<br>References Chang, S.C., et al.: Science, 144, 57 (1964), Ames, M.M., et al.: Cancer Res., 39, 5016 (1979), D’Incalci, M., et al.: Br. J. Cancer, 41, 630 (1980),<br></p>

<p>Applications Analgesic (narcotic). Preparation by electrolytic reduction of Morphine.Controlled substance (opiate).<br>References Buchwald, M.E., et al.: J. Pharmacol. Exp. Ther., 71, 197 (1941), Zernig, G., et al.: Life Sci., 57, 2113 (1995), Keith, D., et al.: J. Biol. Chem., 271, 19021 (1996), Pawar, M., et al.: Eur. J. Pharmacol., 563, 92(2007),<br></p>

<p>Applications Carbapenem is an antibiotic and antibacterial.<br>References Sunagawa, M., et al.: J. Antibiot., 43, 519 (1990), Hurst, M., et al.: Drugs, 59, 653 (2000),<br></p>

<p>Applications A novel antiplatelet agent; it is a third-generation thienopyridine. Antiplatelet agent Prasugrel showed greater platelet inhibition and decreased incidence of ischemic events than Clopidogrel but may induce increased incidence of bleeding in patient with acute coronary syndrome<br>References Von Beckerath, N., et al.: Circulation, 112, 2946 (2005), Jernberg, T., et al.: Eur. Heart J., 27, 1166 (2006), Farid, N., et al.: Drug Metab. Dispos., 35, 1096 (2007), Farid, N., et al.: Clin. Pharmacol. Ther., 81, 735 (2007), Jakubowski, J., et al.: J. Cardiovasc. Pharmacol., 49, 167 (2007), Wiviott, S., et al.: N. Engl. J. Med., 357, 2001 (2007),<br></p>

<p>Applications A novel labelled HIV reverse transcriptase inhibitor useful in treatment of HIV infection.<br>References Scholler-Gyure, M., et al.: J. Clin. Pharmacol., 48, 322 (2008), Thakur, A., et al.: Eur. J. Med. Chem., 43, 471 (2008),<br></p>

<p>Applications Dexketoprofen Trometamol is an non-steroidal anti-inflammatory drug used for the treatment of mild to moderate pain.<br>References Gokce, B., et al.: J. Enzyme. Inhibit. Med. Chem., 27, 37 (2012); Sagiroglu, G., et al.: Eurosian. J. Med., 43, 23 (2011);<br></p>

<p>Applications A potent growth inhibitor and cytotoxic agent. It acts as a demethylating agent by inhibiting DNA methyltransferase.<br>References Kusaba, H., et al.: Eur. J. Biochem., 262, 924 (1999), Broday, L., et al.: Mol. Cell Biol., 19, 3198 (1999), Qian, X., et al.: Am. J. Pathol., 153, 1475 (1999), Canova, C., et al.: Mech. Ageing Dev., 101, 153 (1998)<br></p>

<p>Stability Hygroscopic<br>Applications Metabolite of Flurbiprofen (F598700).<br>References Van Breemen, R., et al.: Drug Metab. Disposition, 14, 197 (1986), Spraul, M., et al.: J. Pharm. Biomed. Anal., 11, 1009 (1993),<br></p>

<p>Stability Hygroscopic<br>Applications Methyl Isofenphos is an organophosphorus compound, that according to biological studies, can cause acute toxicity to animals.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Li, S.: Huanjing Wuran Yu Fangzhi, 20, 13 (1998); Yin, Y., et al.: Huanjing Yu Jiankang Zazhi, 28, 583 (2011)<br></p>

<p>Stability Hygroscopic<br>Applications Chromone complex which blocks mast cell degranulation.<br>References Ashton, M.J., et al.: Toxicol. Appl. Pharmacol., 26, 319 (1973), Friday, G.A., et al.: Am. J. Ophthalmol., 95, 169 (1983)<br></p>