Biochemicals and Reagents

<p>Applications Hydantoin (cas# 461-72-3) is a compound useful in organic synthesis.<br></p>

<p>Stability Light Sensitive<br>Applications Provisionally listed for use in food, drugs and cosmetics. Sunset Yellow is useful in fermented foods which must be heat treated. It may be found in orange sodas, orange jelly, marzipan, Swiss rolls, apricot jam, citrus marmalade, lemon curd, sweets, hot chocolate mix and packet soups, trifle mix, breadcrumbs, snack chips, shelf fresh noodles, cheese sauce mixes. Sunset Yellow is a sulfonated version of Sudan I, a possible carcinogen. Sunset Yellow itself may be responsible for causing an allergic reaction in people with an aspirin intolerance, resulting in various symptoms, including gastric upset, diarrhea, vomiting, nettle rash (urticaria), swelling of the skin (angioedema) and migraines. Dyes and metabolites, Environmental Testing<br>References Radomski, J.L., et al.: J. Pharmacol. Exp. Ther., 136, 259 (1962), Gaunt, I.F., et al.: Food Cosmet. Toxicol., 5, 747 (1967),<br></p>

<p>Stability Hygroscopic<br>Applications Adenosine monophosphate is useful for skin rejuvenation in dermatology and aesthetic dermatology.<br>References Watanabe, M., et al.: Arch. Dermatol., 127, 1689 (1991), Engelke, M., et al.: Br. J. Dermatol., 137, 219 (1997),<br></p>

<p>Applications 1-Methoxy Empagliflozin is an impurity in the synthesis of Empagliflozin drug (E521510), which is potent and selective inhibitor of sodium glucose co-transporter-2 (SGLT-2).<br>References Thomas, L., et al.: Diabetes. Obesity. Metabol. 14, 94 (2012); Grempler, R., et al.: Diabetes. Obesity. Metabol., 14, 83 (2012);<br></p>

<p>Applications D-Homocysteine is the stereoisomer of L-Homocystine, increased levels lead to hyperhomocysteinemia; a cardiovascular risk factor in prediction of coronary heart disease as well as being associated with congenital birth defects, pregnancy complications and cancer.<br>References Geisel, J. et al.: Clin. Chem. Lab. Med., 41, 1513 (2003); Geisel, J. et al.: Clin. Chem. Lab. Med., 41, 1513 (2003);<br></p>

<p>Applications 3-Amino-4-methoxybenzanilide (CAS# 120-35-4) is a useful research chemical compound.<br></p>

<p>This assay employs the competitive inhibition enzyme immunoassay technique. The microtiter plate provided in this kit has been pre-coated with Human LTE4. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human LTE4. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Human LTE4 in the samples is then determined by comparing the OD of the samples to the standard curve.</p>

<p>Applications An enzyme inhibitor.<br></p>

<p>Applications Glycerol Monoleate is used to synthesize water soluble drugs in need of sustained-release for drug delivery.<br>References Chang, C. et al.: Int. J. Pharm., 276, 83 (2004); Chang, C. et al.: Int. J. Pharm., 173, 51 (1998);<br></p>

<p>Applications N-Acetyl-L-cystine is an antioxidant, used in the treatment of influenza A virus pandemic (1). N-Acetyl-L-cystine promotes fertilization by reducing disulfide bonds in zona pellucida of mouse (2).Releases N-Acetyl-L-cysteine, which is an antidote for paracetamol poisoning.<br>References (1) Zhang, R., et al.: (2014) Int. Immunopharmacol. 22: 1-8 (2) Takeo, T., et al.: Biol Reprod. (2015) 92: 1-7<br></p>

<p>Applications Inosine-5'-monophosphate (sodium salt hydrate) (cas# 20813-76-7) is a useful research chemical.<br></p>

<p>Applications Isodeoxycholic Acid is used for comprehensive bile acid profiling in hereditary intrahepatic cholestasis.<br>References Liu, T., et al.: Liver Int. 38, 1676 (2018)<br></p>

<p>Impurity Levodopa EP Impurity A; Levodopa USP Related Compound A<br>Stability Hygroscopic<br>Applications 6-Hydroxy-L-DOPA (Levodopa EP Impurity A; Levodopa USP Related Compound A) is the 6-hydroxy derivative of the amino acid L-DOPA (D533751) with neurotoxic properties. Studies show that exogenously administered 6-Hydroxy-L-DOPA is biotransformed by amino acid decarboxylase to the highly potent and catecholamine-selective neurotoxin, 6-Hydroxydopamine. The treatment of 6-Hydroxy-L-DOPA in rats resulted in the stimulation of acetylcholinesterase.<br>References Jaim-Etcheverry, G. et al.: Brain Res., 100, 699 (1975); Kostrzewa, R.M. et al.: Amino Acids, 14, 175 (1998); Berthet, A. et al.: J. Neurosci., 29, 4829 (2009);<br></p>

<p>Applications 5-Methylcytosine (cas# 554-01-8) is a useful research chemical.<br></p>

<p>Applications (4bS)-trans-8,8-Trimethyl-4b,5,6,7,8,8a,9,10-octahydro-1-isopropylphenanthren-2-ol is a naturally occurring diterpene that exhibits potent antimicrobial activity.<br>References Tian, M., et al.: Records of Natural Products, 14, 219 (2020)<br></p>

<p>Applications N-(4-Cyanophenyl)-glycine (cas# 42288-26-6) is a compound useful in organic synthesis.<br></p>

<p>Applications Zymostenol, is the derivative of Zymosterol (Z701520), which is an sterol intermediate in the biosynthesis of cholesterol (C432501).<br>References Roland, E.D., et al.: J. Am. Chem. Soc., 111, 278 (1989); Echevarria, F., et al.: J. Biol. Chem., 265, 8484 (1990); Baranovskii, A.V., et al.: Russian. J. Bioorg. Chem., 28, 250 (2002); Schoenheimer, et al.: J. Biol. Chem., 105, 355 (1934);<br></p>

<p>Applications α-Hyodeoxycholic Acid is isolated from pig bile. Antitumor agent.<br>References Abadie, C., et al.: Biochem. J., 299, 725 (1994), Taniguchi, T., et al.: J. Biol. Chem., 269, 10071 (1994), Davis, R., et al.: J. Lipid Res., 43, 533 (2002),<br></p>

<p>This assay employs the competitive inhibition enzyme immunoassay technique. The microtiter plate provided in this kit has been pre-coated with EPA. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to EPA. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of EPA in the samples is then determined by comparing the OD of the samples to the standard curve.</p>

<p>Applications L-Alanyl-L-alanyl-L-alanine (cas# 5874-90-8) is a useful research chemical.<br></p>

<p>Stability Light Sensitive<br>Applications Quinaldine Red is a cationic fluorescent probe. Dyes and metabolites.<br></p>

<p>Applications A metabolite of S-propylcysteine.<br>References Jones, A.R., et al.: Xenobiotica, 10, 827 (1980), 25) Ramu, K., et al.: Chem. Res. Toxicol., 8, 515 (1995), Krause, R., et al.: Drug Metab. Dispos., 25, 1013 (1997), Powley, M., et al.: Chem. Res. Toxicol., 16, 1448 (2003),<br></p>

<p>Stability Very Hygroscopic, Light Sensitive<br>Applications Color additive in foods, drugs and cosmetics. It is used as a food dye and has the E number E129. The study found increased levels of hyperactivity and attention deficit hyperactivity disorder and lower IQs were observed in children consuming the chemicals. It is banned in Denmark, Belgium, France, Switzerland, Sweden. Dyes and metabolites, Environmental Testing.<br>References Kirschbaum, J., et al.: Eur. Food Res. Technol., 222, 572 (2006), Yoshioka, N., et al.: Talanta, 74, 1408 (2008), Al-Degs, Y., et al.: Food Chem., 117, 485 (2009),<br></p>

<p>Applications 2-​Oleoyl-​1-​stearoyl-​sn-​glycero-​3-​phosphocholine is used in the assembly of various supported lipid bilayers.<br>References Wu, H-L., et al.: J. Chem. Phys., 144, 154904/1-154904/9 (2016);<br></p>

<p>Applications 2-O-(α-D-Galactopyranosyl)-D-galactose is used in determination of antibody potency in blood serum by ELISA<br>References Abramenko, I.V., et al.: Tsitologiya, 35 (5), 91 (1993), Kelly, R.F., et al.: Mol. Microbiol., 10 (3), 615 (1993), Stortz, C.A., et al.: J. Carbohydr. Chem., 13 (2), 235 (1994), Neethling, F.A., et al.: Transplantation, 57 (6), 959 (1994)<br></p>

<p>Applications Nα-Boc-L-histidine is an N-Boc-protected form of L-Histidine (H456010). L-Histidine is an essential amino acid that plays an important role in mitochondrial glutamine transport and has potential of abolishing oxidative stress caused by brain edema.L-Histidine promotes zinc uptake in human erythrocyes and also has potential as an antioxidant therapy for acute mammary inflammation in cattle.<br>References Chaiyotwittayakun, A., et al.: J. Dairy Sci., 85, 60 (2002); Horn, N., et al.: J. Phys., 489, 73 (1995); Rama Rao, K., et al.: Am. J. Path., 176, 1400 (2010);<br></p>

<p>Applications S-Methyl-L-cysteine is a substrate in the catalytic antioxidant system mediated by methionine sulfoxide reductase A (MSRA). It has been studied as a theurapeutic for neurodegenerative diseases including Parkinson′s.<br>References Wassef, R., et al.: J. Neurosci., 21, 12808 (2007)<br></p>

<p>Stability Hygroscopic<br>Applications A derivative of D-Mannosamine (M167000).<br>References Pukanud, P. et al.: Drug Delivery, 16, 289 (2009);<br></p>

<p>Applications Monolaurin has antibacterial, antiviral, and other antimicrobial effects in vitro.<br>References Li, Q., et al.: Nature, 458, 1034 (2009)<br></p>

<p>Stability Moisture Sensitive<br>Applications A sulfhydryl cross-linking reagent.<br>References Loo, T.W. and Clark, D.M.: J. Biol. Chem., 276, 40, 36877 (2001)<br></p>

<p>Impurity Glimepiride EP Impurity B/ USP Glimepiride Related Compound B<br>Applications 4-[2-[(3-Ethyl-4-methyl-2-oxo-3-pyrrolin-1-yl)carboxamido]ethyl]benzenesulfonamide (Glimepiride EP Impurity B) is an intermediate for the preparation of Glimepiride.<br></p>

<p>Applications A constituent of nucleic acids.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Miles, et al.: Science, 142, 1458 (1963), Bugg, et al.: Biochem. Biophys. Res. Commun., 3, 436 (1968),<br></p>

<p>Applications Potassium p-Nitrophenyl Sulphate (cas# 6217-68-1) is a compound useful in organic synthesis.<br></p>

<p>Applications Androst-4-ene-3,17-dione-2,2,4,6,6,16,16-d7 is an intermediate in the synthesis of Dehydroepiandrosterone-d5 which is the labeled analogue of Dehydro Epiandrosterone (D229585). Dehydro Epiandrosterone is a major secretory steroidal product of the adrenal gland; secretion progresively declines with aging. May have estrogen-or androgen-like effects depending on the hormonal milieu. Intracellularly converted to androstenedione. It is used in treatment of menopausal syndrome.<br>References Yahara, M., et al.: J. Toxicol. Sci., 2, 161 (1977), Morales, A.J., et al.: J. Clin. Endocrinol. Metab., 78, 1360 (1994), Ebeling, P., et al.: Lancet, 343, 1479 (1994),<br></p>

<p>Stability Air Sensitive, Hygroscopic<br>Applications 1-Thioglycerol is generally used as a size-regulating capping agent for nanocrystals. 1-Thioglycerol is also used in bacteriology experiments to induce the synthesis of porphyrin compounds in aerobically growing Escherichia coli.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Harrison, M., et al.: Adv. Mater., 12, 123 (2000); Javor, G. &amp; Febre, E.: J. Bacteriol., 174, 1072 (1992); Wang, Y., et al.: J. Raman Spectrosc.,38, 34 (2007)<br></p>

<p>Applications 1,​6,​13,​18-​Tetraoxacyclotetraco​sane-​7,​12,​19,​24-​tetrone can be used in degradation process investigation of thermoplastic polyurethane elastomer in supercritical methanol.<br>References Liu, L., et al.: Polym Degrad Stabil, 98, 2520 (2013)<br></p>

<p>Applications (E)-2-chloro-3-imino-N,N-dimethylprop-1-en-1-amine Hydrochloride is an impurity of Etoricoxib (E934100), a selective cyclo-oxygenase-2 (COX-2) inhibitor that is used to improve the signs and symptoms of osteoarthritis and rheumatoid arthritis.<br>References Hunt, R., et al.: Am. J. Gastroenterol., 98, 1725 (2003); Schumacher Jr., H., et al.: Bmj, 324, 1488 (2002)<br></p>

<p>Applications Thionin Acetate Salt is a metachromic cationic histology dye. It can also be used in biological use and engineering or chemical process of controlled design and fabrication of SERS-SEF multifunctional nanoparticles for nanoprobe applications. Dyes and metabolites.<br>References Chang, S., et al.: J Phys Chem C, (2017)<br></p>

<p>Stability Light Sensitive<br>Applications Retinyl Propionate is a Vitamin A ester derivative. Retinyl Propionate is a hypermitotic agent that is used in cosmetic formulations.This compound contains an unknown cis isomer.<br>References Ridge, B.D. et al.: Br. J. Dermatol., 118, 167 (1988); Oblong, J.E. et al.: Cosm. Sci. Technol., Ser., 27, 441 (2005); Weisse, S. et al.: J. Drug Del. Sci. Technol., 14, 77 (2004);<br></p>

<p>Applications 2-Chloro-6-[N,N-di(2-hydroxybenzyl)amino]-9-isopropylpurine (cas# 1076199-83-1) is a compound useful in organic synthesis.<br></p>

<p>Stability Moisture, Temperature Sensitive; Hygroscopic<br>Applications A putative lipid second messenger; found to inhibit cellular mobility of melanoma cells at very low concentrations with no toxic effects thereby making it a possible agent for prevention of tumor cell metastasis and inflammatory processes. It mobilizes intracellular calcium stores, decreases cellular cAMP, activates phospholipase D and does not inhibitprotein kinase C.<br>References Yeh, C., et al.: Am. J. Physiol., 296, H1193 (2009), Hagen, N., et al.: J. Biol. Chem., 284, 11346 (2009), Kuehnel, M., et al.: J. Cell Sci., 122, 499 (2009),<br></p>

<p>Applications Danofloxacin is a broad spectrum fluoroquinolone antibacterial compound.<br>References Golet, E., et al.: Anal. Chem., 73, 3632 (2001); Golet, E., et al.: Environ. Sci. Technol., 36, 3645 (2002); Huet, A., et al.: J. Agric. Food Chem., 54, 2822 (2006);<br></p>

<p>Applications 5,6-Dihydro-5-methyluridine (cas# 23067-10-9) is a useful research chemical.<br></p>

<p>Applications An amino acid, first isolated from the juice of watermelon, Citrullus vulgaris Schrad., Cucurbitaceae. Used in the treatment of asthenia.<br>References Kurtz, et al.: J. Biol. Chem., 122, 477 (1938), Rajantie, J., et al.: J. Pediatr., 97, 927 (1980), Carpenter, T.O., et al.: N. Engl. J. Med., 312, 290 (1985),<br></p>

<p>Applications Useful in the study of tyrosine-phosphorylation, which has been linked with the malignant transformation of cells by some RNA tumour viruses.<br>References Sefton, B.M., et al.: Cell, 20, 807 (1980), Erikson, R., et al.: Perspect. Virol., 11, 93 (1981), Lee, E-S, et al.: J. Org. Chem., 59, 2086 (1994)<br></p>

<p>Applications Isoleucine-d10 (mixture of diastereomers) (CAS# 29909-02-2) is a useful isotopically labeled research compound and can be used in gas liquid chromatography.<br>References VandenHeuvel, W., et.al., J. Chromatogr., 50, 405-412, (1970);<br></p>

<p>Stability Moisture Sensitive<br>Applications Chlorotrimethylsilane have been used in the preparation of volatile derivatives of a wide range of compounds for GC analysis. Chlorotrimethylsilane has been used for silylation and as a protection group in the process of various organic synthesis.<br> E0<br>References Casimiro, M., et al.: Org. Lett., 15, 2378 (2013); Lifchits, O., et al.: J. Am. Chem. Soc., 135, 6677 (2013);<br></p>

<p>Stability Hygroscopic<br>Applications Used in the characterization and elucidation of coordination requirements of adenine nucleotides complexes with Fe(II) ions.<br>References Richter, Y., et al.: Nucleos. Nucleot. Nucleic Acids, 22, 1757 (2003),<br></p>

<p>Stability Very Hygroscopic<br>Applications Lactose-3’-sulfate (cas# 159358-51-7) is a compound useful in organic synthesis.<br></p>

<p>Applications 5-Cholenic Acid-3β-ol is a bile acid of which the metabolism in humans results in the primary bile acids lithocholic acid and chenodeoxycholic. It is found in hgher concentrations in meconium of premature human babies when compared to full term babies.<br>References Tohma, M., et al.: Steroids, 44, 47 (1984); Kok, E., et al.: J. Biol. Chem., 256, 6155 (1981); Back, P., et al: Hoppe-Seyler's Zeitschrift fuer Physiologische Chemie, 354, 83 (1973); Javitt, N., et al.: J. Biol. Chem,, 261, 12486 (1986);<br></p>

<p>Applications 1-Methylpiperazine-2,2,3,3,5,5,6,6-d8 is the labeled version of 1-Methylpiperazine (Imatinib EP Impurity G)(M326495) is used in the preparation of 2-(4-Methyl-1-piperazinylmethyl)acrylophenone(MPMAP), an antimicrotubular drug. It is a COVID19-related research product.Is used in preparation of Imidazopyridine compounds for the treatment of inflammatory disorders.<br>References Mallevais, M.L. et al.: Biochimie, 66, 477 (1984); Van der Plas, Steven E., et al.: PCT Int. Appl., (2019);<br></p>

<p>Stability Light Sensitive, Moisture Sensitive<br>Applications A fluoresent compound used for the rapid and selective modification of sulfhydryl groups of enzymes.Fluorescence: max. Abs. 340nm; max. Em. 376nm; e x 10-3: 40<br>References Stauffer, D.A., and Karlin, A.: Biochemistry, 33, 6840 (1994), Yang, N. et al.: Neuron, 16, 113 (1996), Kuner, T. et al.: Neuron, 17, 343 (1996)<br></p>

<p>Applications Propargyl Butylcarbamate is used in the preparation of cosmetic and pharmaceutical products.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Schmaus, G., et al.: PCT Int. Appl. (2007), WO 2007062957 A1 20070607;<br></p>

<p>Applications 4β-Hydroxy Cholesterol-d7 is a labelled metabolite of Cholesterol. It is formed from Cholesterol by the drug-metabolizing enzyme cytochrome P 450 3A4. A potential ligand for the nuclear receptor LXR and also a new endogenous CYP3A marker.<br>References Breuer, O., et al.: J. Lipid Res., 36, 2275 (1995), Pikuleva, I., et al.: J. Biol. Chem., 273, 18153 (1998), Chawla, A., et al.: Science, 294, 1866 (2001), Bodin, K., et al.: J. Biol. Chem., 276, 38685 (2001),<br></p>

<p>Applications Thiazolidine is used as a reactant in the preparation of melanocortin 4 receptor agonists and antagonists containing a succinamide core.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Xi, N., et al.: Bioorg. Med. Chem. Lett., 14, 377 (2004)<br></p>

<p>Stability Hygroscopic<br>Applications A metabolite of Melatonin (M215000).<br>References Reiter, R.J., et al.: J. Biomed. Sci., 7, 444 (2000), Chen, Z., et al.: Am. J. Physiol, 284, 1618 (2003), Barrenetxe, J., et al.: J. Physiol. Biochem., 60, 61 (2004),<br></p>

<p>Applications Disperse Diazo Black 3BF (cas# 6232-57-1) is a useful research chemical. Dyes and metabolites, Environmental Testing.<br></p>

<p>Applications 4-(1H-1,2,4-triazol-1-yl)phenol (cas# 68337-15-5) is a useful research chemical.<br></p>

<p>Applications Aziprotryne is a pesticide.<br></p>

<p>Stability Moisture Sensitive: Desiccate<br>Applications A heterobifunctional sulfhydryl cross-linking reagent.<br></p>

<p>Applications 4α-Methyl-cholest-5-en-3β-ol is a derivative of Cholesterol (C432501), a major component of all biological membranes; ~25% of total brain lipid is Cholesterol. Cholesterol is the principal sterol of the higher animals. Cholesterol was found in all body tissues, especial in the brain, spinal cord, and in animal fats or oils. Cholesterol is the main constituent of gallstones.<br>References Rosin, Z., et al.: Physiol. Chem., 124, 282 (1923), Schoenheimer, et al.: J. Biol. Chem., 105, 355 (1934), Gemant, et al.: Life Sci., 1, 233 (1962), Johnson, K., et al.: 4, 457 (1964),<br></p>

<p>Applications D-Isoleucine is not biosynthesized in the human body and is therefore categorized as an essential amino acid that must be obtained through diet. It is also an important building block that is used in the formation of hemoglobin in humans.<br>References Albanese, A.: J. Biol. Chem., 157, 613 (1945); Martin, R. &amp; Kirk, K.: Blood, 109, 2217 (2007)<br></p>

<p>Stability Hygroscopic<br>Applications 12β-Hydroxyisocholic Acid is a bile acid.<br>References Batta, A.K., et. al.: J. Lipid Res., 32, 977 (1991)<br></p>

<p>Applications The sodium salt hydrate form of rac-Glycerophosphoric acid (G601598), which is a useful research chemical found in bacterial communities.<br>References Wang, K.; et al.: Journal of Hazardous Materials, 360, 471 (2018).<br></p>

<p>Applications Useful as a substrate for UDP-GlcNAc:Gal1-beta-3GalNAc(GlcNAc-GalNAc)-6-beta-GlcNAc transferase and sialytransferase.<br>References Hoh, C., et al.: Bioorg. Med. Chem. Lett., 12, 1031 (2002), Li, M., et al.: Biochem., 47, 11590 (2008),<br></p>

<p>Stability Hygroscopic, moisture sensitive<br>Applications Stearoyl L-α-Lysolecithin is an bioactive lysophosphatidylcholine derived compound found to be released by bronchial epithelial cells. Stearoyl L-α-Lysolecithin have also been utilized in the development of liposomes and michelles by drug transdermal delivery devices.<br>References Zhuge, Y., et al.: Allergy Asthma Immunol Res., 6, 66 (2014)<br></p>

<p>Stability Hygroscopic<br>Applications 2,4,5-Trimethylaniline (T797580(P)) is the free base of 2,4,5-Trimethylaniline Hydrochloride. 2,4,5-Trimethylaniline is a carcinogenic aromatic amine used in the leather and textile industry.<br>References Kawakami, Tsuyoshi, et al.: Kankyo Kagaku, 22(4), 197-204 (2012); Chen, Xiaomei, et al.: Fenxi Ceshi Xuebao, 17(4), 50-53 (1998);<br></p>

<p>The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Pig PYD. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Pig PYD. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added, only those wells that contain Pig PYD, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Pig PYD in the samples is then determined by comparing the OD of the samples to the standard curve.</p>

<p>Stability Hygroscopic<br>Applications α-Glycosidase inhibitor.<br>References van de Water, F., et al.: Drug Metab. Rev., 37, 443 (2005), Koepsell, H., et al.: Pharm. Res., 24, 1227 (2007), Jappar, D., et al.: Pharm. Res., 26, 172 (2009),<br></p>

<p>Stability Hygroscopic<br>Applications Hydroxocobalamin is an intermediate in the synthesis of Nitritocobalamin(N490240) is a useful synthetic intermediate in the synthesis of Hydroxocobalamin Acetate (H826800); a physiological analog of vitamin B12 where the CN group is replaced with OH. Exists in aqueous solution as an equilibrium mixture of the hydroxy isomer and the ionic aqua isomer (aquacobalamin). Precursor of the coenzymes methylcobalamin and cobamamide. Coordination Compound. Vitamin (hematopoietic).<br>References Kaczka, E.A., et al.: Science, 112, 354 (1950); Friedrich, W., et al.: Vitamins, 837 (1988); Forsyth, J.C., et al.: Clin. Toxicol., 31, 277 (1993)<br></p>

<p>Applications Glycocholic Acid (cas# 475-31-0) is a useful research chemical.<br></p>

<p>Applications A novel phenolic antioxidant that showed strong antimutagenic activity against eight carcinogenic heterocyclic amines (HCA), produced during cooking processes. Its antimutagenic activity appeared to inhibit both metabolic activation of HCA and action on activated N-Hydroxy species.<br>References Hirose, M., et al.: Jpn. J. Cancer Res., 84, 481 (1993), Hirsoe, M., et al.: Carcinogenesis, 16, 2, 217 (1995), Hirsoe, M., et al.: Carcinogenesis, 16, 9, 2227 (1995), Hirsoe, M., et al.: Carcinogenesis, 16, 12, 3049 (1995)<br></p>

<p>Applications A metabolite of Acrylonitrile (ACN).<br>References Guengerich, F., et al.: Cancer Res., 41, 4925 (1981), Leonard, A., et al.: Mutation Res., 436, 263 (1999), Stadler, R., et al.: J. Agric. Food Chem., 52, 5550 (2004), Dybing, E., et al.: Food Chem. Toxicol., 43, 365 (2005), Rice, J., et al.: Mutation Res., 580, 3 (2005),<br></p>

<p>Applications Teneligliptin Hydrobromide (2:5) is a dipeptidyl peptidase-4 (DPP-4) inhibitor that is used to treat type 2 diabetes. It is eliminated via excretion, and has a half-life of 24.2 hours in the human body.<br>References Goda, M. &amp; Kadowaki, T.: Drugs Today, 49, 615 (2013); Kishimoto, M.: Diabetes Metab. Syndr. Obes., 6, 187 (2012)<br></p>

<p>Applications (E)-2-Octenoyl-L-carnitine Inner Salt is an L-carnitine metobolite which are often used to diagnose specific inherited metabolic diseases especially glucose related ones.<br>References Yang, S. et l.: J. Chrom. B., Anal. Tech. Biomed. Life Sci., 857, 251 (2007); Anderson, K. et al.: Mol. Endocrinol., 26, 281 (2012);<br></p>

<p>Stability Hygroscopic<br>Applications MG 132 is a potent, membrane-permeable proteasome inhibitor. It induces neurite outgrowth in PC12 cells. Neuroprotective product.<br>References Lee, D., et al.: Trends in Cell Biol., 8, 397 (1998); Tsubuki, S., et al.: J. Biochem., 119., 572 (1996); Grimm, L., et al.: EMBO J., 15, 3835 (1996)<br></p>

<p>Stability Hygroscopic<br>Applications Labelled Cholesterol (C432501). Cholesterol is the principal sterol of the higher animals. Cholesterol was found in all body tissues, especial in the brain, spinal cord, and in animal fats or oils. Cholesterol is the main constituent of gallstones.<br>References Rosin, Z., et al.: Physiol. Chem., 124, 282 (1923), Schoenheimer, et al.: J. Biol. Chem., 105, 355 (1934), Gemant, et al.: Life Sci., 1, 233 (1962), Johnson, K., et al.: 4, 457 (1964),<br></p>

<p>Applications Alkylated Diphenylamines are a derivative of aniline, a common chemical reagent. Good antioxidant agent.<br></p>

<p>Stability Hygroscopic<br>Applications Adenosine 5'-diphosphate monosodium salt (cas# 20398-34-9) is a useful research chemical.<br></p>

<p>Applications ADHP is a non-fluorescent and highly sensitive and stable hydrogen peroxide probe.<br>References Snyrychova et al.; Physiologia Plantarum, 135(1), 1­18 (2009); J.G. Montay et al.; Journal of Immunological Methods 202, 133 (1997); M. Zhou et al.; Analytical Biochemisty 253, 162 (1997); Proc. Soc. Exp. Biol. Med. 206, 53 (1994); Free rad. Biol. Med. 12, 389 (1992)<br></p>

<p>Applications Allolithocholic acid is used as steroid compound as T regulatory lymphocyte modulators and uses for treatment of inflammatory or autoimmune disorders.<br>References Littman, D. R., et al.: PCT Int. Appl. 160pp. (2020)<br></p>

<p>Stability Very Hygroscopic<br>Applications 1-O-Dimethoxytrityl-2-(N-Fmoc)-4-Aminobutyl)-1,3-propanediol is a useful reagent for the synthesis of acridine and​/or lipid containing oligodeoxyribonucleotides.<br>References Marasco, C. J., et al.: Tetra. Lett., 35, 3029 (1994)<br></p>