Biochemicals and Reagents

D-Ala2,Met5]-Enkephalinamide is a potent endogenous opioid peptide that binds to opioid receptors and has been shown to have both antinociceptive and depressant effects. It has been shown to be effective in a model system of pain, acting on the descending antinociceptive pathway from the rostral ventromedial medulla (RVM) to the spinal cord. D-Ala2,Met5]-Enkephalinamide has also been observed to inhibit locomotor activity in CD1 mice at sub-effective doses. D-Ala2,Met5]-Enkephalinamide has been shown to act through activation of both G protein-coupled mu opioids receptors and G protein-coupled delta opioid receptors.

Herkinorin is a novel opioid analgesic that has been shown to have antinociceptive effects in the tail flick and hot plate tests. Herkinorin binds to the μ-opioid receptor with high affinity, which may be due to its similarity in structure to morphine. The binding of herkinorin to the μ-opioid receptor leads to an increase in cyclic adenosine monophosphate (cAMP) levels, which activates protein kinase A and inhibits phosphodiesterase. It has been shown that herkinorin can reverse the effects of nω-nitro-l-arginine methyl ester (L-NAME), a drug known for its negative effects on cAMP production, on rotarod performance in rats.

TC-I 2014 is a specific chemical compound known as a selective inhibitor, which is derived from microbial sources. It operates by selectively inhibiting a particular protein or signaling pathway, thereby modulating cellular processes. This compound is often used in biochemical and cellular biology research to dissect and understand complex signaling networks within cells. By selectively blocking certain pathways, researchers can identify and study the role of specific proteins in biological processes and disease mechanisms.

Anabaseine hydrochloride is a nicotinic acetylcholine receptor agonist, which is derived from marine worms, specifically the genus *Anabaseis*. The compound functions by binding to and activating nicotinic acetylcholine receptors (nAChRs), which are ionotropic receptors found in both the central and peripheral nervous systems. This activation results in the modulation of neurotransmitter release and can influence various neural pathways.

Boc-Gly-Arg-Arg-AMC is a research tool that has a high purity and is used in cell biology, antibody production, ion channels, and protein interactions. It is an inhibitor of ion channels, which can be used for pharmacology to study the function of ion channels. Boc-Gly-Arg-Arg-AMC has also been shown to inhibit binding between the ligand and receptor.

Bombesin is a small peptide that was first isolated from the skin of a frog, Bombina bombina, with homologs later found to be present in mammalian tissues, including the brain and gastrointestinal tract. It is a member of the bombesin-like peptide family, which includes several related peptides such as gastrin-releasing peptide (GRP) and neuromedin B.
Bombesin acts as a neuromodulator and regulates various physiological functions, including gastrointestinal motility and stimulation of gastrin release from G cells. It also plays a role in the regulation of cardiovascular function and neurotransmitter release. In addition, bombesin has been shown to stimulate the growth and proliferation of certain types of cancer cells, including prostate and lung cancer cells, through its interaction with bombesin receptors. It may therefore be used as a potential biomarker for certain cancers.
This product is available as a 0.5mg vial.

SARS Coronavirus is an enveloped virus containing 3 outer structural proteins, namely the membrane (M), envelope (E), and spike (S) proteins. Spike (S)-glycoprotein of the virus interacts with a cellular receptor and mediates membrane fusion to allow viral entry into susceptible target cells. Accordingly, S-protein takes part in the virus infection cycle and is the primary target of neutralizing antibodies. SARS Spike produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 219 amino acids (306-515 aa) and having a molecular mass of 24.7kDa.SARS Spike is fused to a 6 amino acid His tag at C-terminus and purified by proprietary chromatographic techniques. The formulation of the SARS Spike (306-515) solution (0.5mg/ml) contains Phosphate-Buffered Saline (pH 7.4) and 10% Glycerol. Biological Activity: Measured by its binding ability in a functional ELISA with Human ACE-2 (CAT# enz-1159).
One-Letter Formula: ADPRVVPSGD VVRFPNITNL CPFGEVFNAT KFPSVYAWER KKISNCVADY SVLYNSTFFS TFKCYGVSAT KLNDLCFSNV YADSFVVKGD DVRQIAPGQT GVIADYNYKL PDDFMGCVLA WNTRNIDATS TGNYNYKYRY LRHGKLRPFE RDISNVPFSP DGKPCTPPAL NCYWPLNDYG FYTTTGIGYQ PYRVVVLSFE LLNAPATVCG PKLHHHHHH

Dnp-Pro-Gln-Gly is a synthetic peptide that can be used as an artificial substrate in protease assays. It is activated by the addition of trypsin and catalyzes hydrolysis of peptide bonds at the C-terminus of the proline residue. The chromatographic profile of Dnp-Pro-Gln-Gly on a Zorbax 300SBX column shows two peaks, with retention times of 8.2 minutes and 9.4 minutes. In tissue culture experiments, Dnp-Pro-Gln-Gly was found to enhance the activity of matrix metalloproteinases and collagenase. The optimum pH for Dnp-Pro-Gln-Gly is 5.5, which is near the pH optimum for most mammalian tissues and organs.

Amyloid Beta-Protein (42-1) is a recombinant form of the protein, amyloid beta-protein, that is relevant to Alzheimer's disease. It is used as a research tool and for pharmacological studies. Amyloid Beta-Protein (42-1) has been shown to bind to ion channels and activate them. This product can be used as an antibody or cell biology research tool.

Somatostatin is a peptide hormone that is produced by the hypothalamus and inhibits the release of growth hormones, stimulates the release of insulin from the pancreas, and inhibits the release of glucagon from the pancreas. Somatostatin also has biological properties that inhibit neuronal death in combination therapy groups. It has been shown to have cell factor activity which may contribute to its antitumor activity. Somatostatin also has pro-apoptotic properties in vitro assays at physiological levels, making it an excellent target for cancer therapy.

Amino acids 1-42 of the Amyloid beta-protein (Aβ), a major plaque component in Alzheimer's Disease, a neurodegenerative disorder that affects memory and cognitive function. It is thought that these Aβ peptides can aggregate to form insoluble fibrils that are a hallmark of Alzheimer's disease and may contribute to neurodegeneration and cognitive decline.
Research is ongoing to better understand the mechanisms underlying Aβ-induced neurodegeneration and to develop therapies that target Aβ to prevent or treat Alzheimer's disease. Aβ peptides, particularly Aβ(1-42), are commonly used in research as a model for Alzheimer's disease to investigate the pathogenesis and potential therapeutic approaches.
This product is available in the trifluoroacetate salt form and as a 0.5mg vial.

Pyr-Ala is a peptide that has been shown to be effective in treating inflammatory diseases. It specifically targets the group P2 sequences of the inflammatory cytokine IL-1β. Pyr-Ala also inhibits IL-6 and TNF-α activity by binding to the amide bond of these molecules, inhibiting their catalysis and preventing their formation. Pyr-Ala has also shown efficacy in autoimmune diseases, such as rheumatoid arthritis, by inhibiting the production of proinflammatory cytokines including IL-1β and TNF-α. This drug binds to the bacterial enzyme that catalyzes the conversion of L -alanine into pyruvic acid, preventing its function and inhibiting bacterial growth.

Amino acids 39-68 of the Parathyroid Hormone (PTH) which is a peptide hormone that is secreted from the parathyroid gland in the event of abnormal serum calcium levels and it ultimately regulates calcium and phosphate levels in the body. The PTH exerts its activity through binding to the G-protein coupled receptor type 1 PTH receptor, which activates adenylate cyclase or phospholipase C thus activating pathways involved in the mediation of bone resorption and bone formation. This product is suitable for life science applications and is available as a 0.5mg vial.

Adjuvant Peptide is a glycol ether that has been shown to have biological properties. It is used in the production of Immunoassays and other biochemicals. Adjuvant Peptide is an experimental model for immunity, as it stimulates cellular responses and alters the immune system's response to antigens. It shows potential for use in treating bowel diseases, such as ulcerative colitis, because of its ability to stimulate macrophage activity and induce cytokine production.

Karenitecin is a diagnostic agent with minimal toxicity. It is used to detect granulosa cells in human serum and is also an immunohistochemical marker for the diagnosis of gliomas. Karenitecin binds to α1-acid glycoprotein, which is found at high levels in plasma and cerebrospinal fluid, and has been shown to have potent antitumor activity. The drug can be administered intravenously or intra-arterially, with a low risk of toxicity. Karenitecin has been shown to have antineoplastic properties by inhibiting mitochondrial membrane potential, which may be due to its ability to bind to the a-ring of ATP synthase.

GGTI-2154 is an anticancer drug that has shown promising results in the treatment of various types of tumors. It is a potent inhibitor of geranylgeranyltransferase I (GGTase I), which is an enzyme that plays a crucial role in the signaling pathways involved in cancer cell growth and survival. GGTI-2154 has been shown to induce apoptosis (programmed cell death) in human cancer cells, leading to tumor regression. This drug is an analog of oseltamivir, a medication used to treat influenza, and it can be detected in urine samples after administration. GGTI-2154 targets specific kinases and proteins involved in cancer progression, making it a highly effective inhibitor with minimal side effects.

Inhibitor of γ-secretase; Alzheimer's disease treatment

Lys-Ala-AMC is an activator of ion channels and a ligand for receptors. It is used in research as a tool to study protein interactions, receptor pharmacology, and ion channel pharmacology. Lys-Ala-AMC binds to the α-subunit of voltage gated calcium channels and can activate these channels by increasing the rate of opening. This peptide also inhibits receptor binding by competing with the natural ligand. It has been shown to be an antagonist at the NMDA receptor and can inhibit the binding of glycine to this receptor.

BH3I-1 is a potent inhibitor of the Bcl-2 family of proteins that are involved in apoptosis. It has been shown to be effective against a range of tumor cell lines, including prostate cancer cells and human leukemia cells. The molecular target for BH3I-1 is the mitochondrial membrane potential, which is required for the production of ATP and maintenance of cellular homeostasis. In a panel of radiation-resistant tumor cell lines, BH3I-1 potently inhibited growth and induced morphological changes. This molecule also inhibits dimorphic fungi such as Candida glabrata, which can cause opportunistic infections in immunocompromised patients.

This product which is available as a 0.5mg vial is amino acids 1-31 of the 84 amino acid parathyroid hormone (PTH) and can be used as an adenylate cyclase and bone growth stimulating peptide.
PTH is a peptide hormone that is secreted from the parathyroid gland in the event of abnormal serum calcium levels and it ultimately regulates calcium and phosphate levels in the body. The PTH exerts its activity through binding to the G-protein coupled receptor type 1 PTH receptor, which activates adenylate cyclase or phospholipase C thus activating pathways involved in the mediation of bone resorption and bone formation. This product is suitable for life science applications.

E-64-c is a research tool that is used to activate the receptor of a cell. This ligand can bind to the receptor and form a complex, which will then be able to interact with other proteins in the cell. This process can lead to changes in ion channel activity, protein synthesis, or gene expression. E-64-c has been shown to inhibit the activity of ion channels such as calcium channels and potassium channels, as well as protein synthesis. It also binds to antibodies and blocks their binding sites on cells.br>
E-64-c is a high purity ligand that can be used for studying protein interactions or pharmacological purposes. The potency of this ligand has been tested by measuring its ability to inhibit the binding of various peptides such as vasopressin and angiotensin II.

Suc-[Glu9,Ala11,15]-Endothelin-1 (8-21) is a peptide that has been used as a research tool in pharmacology and protein interactions. Suc-[Glu9,Ala11,15]-Endothelin-1 (8-21) has been shown to be an agonist of the endothelin receptor. Endothelin-1 is a peptide that acts as a vasoconstrictor and plays an important role in the regulation of blood pressure.
Endothelin-1 is also an endogenous ligand for two G protein-coupled receptors, ETA and ETB. Interesting Endothelin-1 is the most abundant isoform and is expressed in endothelial cells of every blood vessel. It exerts its vasoconstrictor effects through binding to ETA receptors located on the smooth muscle.

TopFluor Lyso PA is a fluorescently labeled lipid analog, derived from a lysophosphatidic acid (LPA) source, designed to facilitate the study of lipid-protein and lipid-lipid interactions. Its mode of action involves the integration of a fluorescent moiety onto the LPA backbone, enabling visualization and tracking within biological systems.

7α,27-Dihydroxycholesterol-d6 is a synthetic peptide that has been shown to inhibit the activity of membrane proteins. It also binds to certain receptors and activates them. 7α,27-Dihydroxycholesterol-d6 is a research tool for studying protein interactions and receptor binding. This product is made in high purity with a CAS number of 2260669-25-6.

Boc-Leu-Gly-Arg-AMC is a peptide that binds to the receptor for N-methyl-D-aspartate (NMDA) and inhibits the ion channel. It has been used as a research tool to study NMDA receptor interactions, as well as in cell biology and pharmacology. Boc-Leu-Gly-Arg-AMC is a high purity, ionic analog of glutamate that binds to the NMDA receptor without activating it, thereby inhibiting ion flow through the channel. This inhibition can be reversed by adding excess glutamate or glycine. The binding of this compound to the NMDA receptor has been shown to block activation of voltage gated calcium channels and reduce neuronal excitation, which may provide an alternative therapeutic strategy for controlling seizures or other neurological disorders.

Phen-AMC is a potent inhibitor of the enzyme acetylcholinesterase (AChE), which catalyzes the breakdown of the neurotransmitter acetylcholine. Phen-AMC is used as a research tool to study protein interactions, activator, and ligand binding. This inhibitor also has been shown to activate nicotinic receptors, ion channels, and antibodies.

Oxytocin is a peptide hormone that is produced by the hypothalamus and released by the pituitary gland. It is used to induce labor, control postpartum bleeding and stimulate milk production. Oxytocin also plays a role in sexual arousal, social recognition, and trust. It has been shown to have an inhibitory effect on many types of ion channels, including those found in the heart, central nervous system, and blood vessels. Oxytocin binds to receptors that are found throughout the body and brain. The receptor for oxytocin is known as OXT. This receptor belongs to the G-protein coupled receptor family of receptors. Oxytocin was first isolated from sheep serum in 1906 by Henry Dale and Charles Robert Harington. It was later synthesized in 1953 by Vincent du Vigneaud. This product has disulfide bonds between Cys1-Cys6.

Tyrosyl-Bradykinin is a peptide that is used as a research tool. It can activate an antibody or receptor and is used in the study of protein interactions. Tyrosyl-Bradykinin has been shown to be an inhibitor of ion channels and can block the activity of ligands and receptors. This peptide has also shown pharmacological properties, such as preventing platelet aggregation and inhibiting the release of histamine from mast cells.

Forchlorofenuron is a potent anticancer agent that targets protein kinases in cancer cells, inducing apoptosis and inhibiting tumor growth. This analog of the natural cytokinin hormone has been shown to be effective against a variety of human cancers, including breast, lung, and colon cancer. Forchlorofenuron acts as an inhibitor of protein kinases, which are enzymes that play a key role in cell signaling pathways. By blocking these pathways, Forchlorofenuron can induce apoptosis and prevent the growth and spread of cancer cells. This medicinal compound has been used as a tumor inhibitor in Chinese medicine for many years and can be found in urine samples after administration. Its efficacy against various kinases makes it a promising candidate for future anticancer therapies.

This product is a Substance P antagonist in the Hydrochloride salt from and as a 0.5mg vial. Substance P is a neuropeptide that acts as a neurotransmitter and neuromodulator. It is best known for its role in nociception or pain perception. Substance P is also involved in other biological processes such as the regulation of gastrointestinal motility and the inflammatory response. As a tachykinin neuropeptide, substance P acts through binding to its specific neurokinin 1 receptor (NK-1R). NK-1R is present in neurons and on glial cell types. Substance P is also involved in: increased inflammation in the lungs, gastrointestinal tract and the skin and neuroinflammation. Interestingly the levels of Substance P are raised in inflammatory bowel diseases and through its involvement in cytokine release, it contributes to asthma pathology. These diverse selection of functions makes substance P a target for therapeutic research.

ANP (Rat, 3-28) is a peptide that is a potent inhibitor of protein interactions. This peptide binds to the ligand-binding domain of the receptor and blocks the binding of the ligand. ANP (Rat, 3-28) also has high purity and can be used as a research tool or an antibody in life science studies.

2-Deoxy-2-Phthalimido-3,4,6-Tri-O-Acetyl-α-D-Galactopyranosyl Fluoride is a glycosyl. It is a building block for the synthesis of peptides and other biochemicals. This compound is used in the preparation of fluorinated analogs of carbohydrates and glycosides to study their properties. 2DGTF has been shown to inhibit the activity of many enzymes, including DNA polymerase, topoisomerase II, protein kinase C, phospholipase A2, mitochondrial ATP synthase and proteases.

7,3′,5′-Trihydroxyflavanone is a medicinal compound that has shown potential as an anticancer agent. This analog of flavanone has been found to induce apoptosis in cancer cells by inhibiting kinases and protein synthesis. It also exhibits inhibitory activity against tumor growth and has been shown to be effective against various types of cancers. 7,3′,5′-Trihydroxyflavanone has been used in Chinese traditional medicine for its anti-inflammatory properties and may have potential as a natural remedy for cancer treatment. Its unique chemical structure makes it a promising candidate for the development of kinase inhibitors and other therapeutic agents.

1-(3-Chlorophenethyl)-3-cyclopentylpyrimidine-2,4,6-(1H,3H,5H)-trione is a novel ion channel activator that binds to the ligand site of the human ether-a-go-go related gene potassium channel. It has been shown to inhibit the activity of voltage gated sodium channels and calcium activated potassium channels with IC50 values in the low nanomolar range. It has also been shown to be an effective inhibitor of protein binding.

GIP (Gastric Inhibitory Polypeptide) is a peptide hormone that belongs to the family of incretin hormones. GIP has been shown to have an insulinotropic effect, which is mediated by its activation of glucose-dependent insulin release from pancreatic β-cells. It also has effects on lipid metabolism and plays a role in the regulation of food intake. GIP is produced by K cells in the ileum and colon and released into the bloodstream following food intake. The binding of GIP to its receptors leads to inhibition of gastric acid secretion, stimulation of gallbladder contraction, increased blood flow to the stomach, relaxation of pyloric sphincter muscles, and inhibition of gastric motility. This product is highly pure (> 98%) with no detectable endotoxin or other microbial contamination.

Suc-Ala-Ala-Pro-Phe-AMC is a peptide that is an activator of the acetylcholine receptor. Suc-Ala-Ala-Pro-Phe-AMC has been shown to inhibit the binding of the ligand to the receptor and also prevent activation of ion channels. It has been used as a research tool for studying protein interactions, as well as, antibody production and cell biology. This peptide can also be used as a pharmacological agent, which may be useful in treating diseases such as Alzheimer's disease.

The manual reaction vessel is a laboratory tool for chemical reactions. It is a sealed, sterile glass vessel that can be opened and closed to allow the introduction of chemicals. The manual reaction vessel has an opening at one end for adding reagents, and a stopcock at the other end for controlling the flow of reactants. The manual reaction vessel is used in research to study protein interactions and receptor ligand interactions. It is also used in pharmacology to study drug binding and as a cell biology research tool. This product is made from high purity borosilicate glass, which ensures it will not break down due to chemical exposure or thermal shock. It has no seams or welds that could release contaminants into the environment.

Transferrin antibody was raised in goat using Isolated by affinity chromatography using antigen coupled to agarose beads. as the immunogen.

Haptoglobin antibody was raised in goat using purified human haptoglobin as the immunogen.

Mouse anti-human IgG (Poly-HRP) F(ab)2 was raised in mouse using human IgG as the immunogen.

Human IgM antibody (Poly-HRP) was raised in mouse using human IgM as the immunogen.

Mouse anti-human IgG (Poly-HRP) was raised in mouse using human IgG as the immunogen.

Des-Arg9-[Leu8]-bradykinin is a bradykinin receptor activator. This peptide can be used as a research tool to study the relationship between peptides and ion channels in cell biology, and to assess the effects of inhibitors on protein interactions. Des-Arg9-[Leu8]-bradykinin has shown inhibitory activity against a number of ligand binding receptors, including the beta-adrenergic receptor, angiotensin II receptor, and acetylcholine muscarinic receptor. The affinity of this peptide for different receptors is dependent on its position within the molecule.

Thioflosulide is a nonsteroidal anti-inflammatory drug (NSAID) that is used to relieve the symptoms of inflammatory bowel disease. Thioflosulide binds to and inhibits the phospholipase A2 enzyme, which in turn prevents the production of prostaglandin E2. Thioflosulide has been shown to be effective in reducing ulceration and improving quality of life for patients with ulcerative colitis. It also decreases microvessel density, reduces bowel disease severity, and prevents the formation of new blood vessels in the colon. Thioflosulide is an NSAID that blocks cyclooxygenase enzymes and reduces prostaglandin synthesis. It has been shown to be effective against inflammation in animal models.

Aeol 10150 is a high-purity, research tool that is used as a ligand and an activator of the receptor. Aeol 10150 is a potent inhibitor of ion channels and has been shown to inhibit the activation of caspase-3. It also inhibits the binding of antibodies to cells, which may be due to its ability to bind to protein interactions.