Heterocycles with Nitrogen (N)

<p>Applications 2,5-Diamino-4,6-dichloropyrimidine is a useful reagent for the preparation of Abacavir impurities, carbocyclic and hexenopyranosy nucleosides.<br>References Satyanarayana, G. V., et al.: Pharma Chemica, 7, 90 (2015)<br></p>

<p>Applications 1-(2-Fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-carboxylic Acid Ethyl Ester is used in various studies of stimulators of soluble guanylate cyclase.<br>References Straub, A., et al.: Bioorg. Med. Chem. Lett., 11, 781 (2001); Mittendorf, J., et al.: ChemMedChem, 4, 853 (2009); Straub, A., et al.: Bioorg. Med. Chem., 10, 1711 (2002)<br></p>

<p>Applications 2-​(Methoxy-​d3)​-​3-​(1-​methylethyl)​pyrazine is a useful compound in the study of isotope effect in gas liquid chromatography separation of deuterated and nondeuterated compounds using ionic liquid stationary phases.<br>References Schmarr, H., et al.: J. Chromatogr. A., 1270, 310 (2012);<br></p>

<p>Applications 4-Bromo-2-(methoxymethyl)pyridine (cas# 864412-04-4) is a useful research chemical.<br></p>

<p>Applications 5-[2-(trifluoromethyl)phenyl]-1,2-oxazole-4-carboxylic acid (cas# 1003561-80-5) is a useful research chemical.<br></p>

<p>Stability Light Sensitive<br>Applications A reagent for the determination of aldehydes and other reactive chemicals.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Dickinson, R.G. and Jacobsen,N.W. : Chem. Commun., 1719, (1970), Del Nozal, M.J. et al.: J. Liq. Chromatography, 16, 1105 (1993),<br></p>

<p>Applications [5-(pyridin-2-yl)-1H-imidazol-2-yl]methanamine trihydrochloride (cas# 2060007-34-1) is a useful research chemical.<br></p>

<p>Applications 4-(6-hydrazinylpyrimidin-4-yl)morpholine (cas# 5767-36-2) is a useful research chemical.<br></p>

<p>Applications 1-Piperidine-d10-carbonyl Chloride (CAS# 1219803-31-2) is a useful isotopically labeled research compound.<br></p>

<p>Applications 2-Chloro-4-piperidinopyrimidine<br></p>

<p>Applications 6-(Piperidin-1-yl)pyridin-3-ylboronic Acid Hydrochloride Salt is a useful research chemical.<br></p>

<p>Applications 2-Pyridin-4-ylmethyl-morpholine is a useful intermediate.<br></p>

<p>Applications 5-Bromo-1-[2-Fluoro-6-(trifluoromethyl)benzyl]-6-methylpyrimidine-2,4(1H,3H)-dione is an intermediate in the synthesis of Elagolix, a gonadotropin-releasing hormone antagonist (GnRH) used in the treatment of endometriosis.<br>References Tukun, F. et al.: Molecules, 22, 12 (2017);<br></p>

<p>Applications A useful synthetic intermediate.<br></p>

<p>Applications 2-Azido-1-(3-chloro-5,6-dihydroimidazo[1,2-a]pyrazin-7(8H)-yl)ethan-1-one (CAS# 2097997-88-9) is a derivative of 3-​Chloro-​5,​6-​dihydro-​imidazo[1,​2-​a]​pyrazine-​7(8H)​-​carboxylic Acid 1,​1-Dimethylethyl Ester (CAS# 1253801-37-4), which is a useful compound for preparing P2X7 modulators.<br>References Dean, D. K., et al.: U.S. (2013), US 8513248 B2<br></p>

<p>Applications 1,3-benzoxazol-6-ol (cas# 106050-81-1) is a useful research chemical.<br></p>

<p>Applications [3-(Trifluoromethyl)-1H-pyrazol-4-yl]boronic Acid Pinacol Ester is a chemical reagent used in the synthesis of carboxamides used in the treatment of lymphomas, psoriasis and endometriosis.<br></p>

<p>Applications Imidazo[1,2-a]pyridine-6-boronic acid is a useful intermediate for organic synthesis and other pharmaceutical processes.<br>References Gonzalez C., et al.: J. Med. Chem., 55, 11022 (2012); Cooper, A. B., et al.: Bioorg. Med. Chem. Lett., 27, 4471 (2017)<br></p>

<p>Applications 6-Fluoro-4-methyl-2-pyridinamine can be synthesized from 2,6-Dichloro-4-methylpyridine (39621-00-6).<br></p>

<p>Applications 5-(4-Bromophenyl)-4,6-dichloropyrimidine is a reactant used in the synthesis of Macitentan, an orally active dual endothelin receptor antagonist.<br>References Bolli, M. et al.: J. Med. Chem., 55, 7849 (2012);<br></p>

<p>Applications 6-Nitropyrido[2,3-d]pyrimidin-4(3H)-one is a useful research chemical for organic synthesis and other chemical processes.<br></p>

<p>Applications 6-Bromopiperonal is a disubstituted 1,3-benzodioxole that displayed synergistic activity with carbaryl on houseflies. 6-Bromopiperonal is used as an intermediate in the preparation of GPR30-selective agonist G-1.<br>References Wilkinson, C.F. et al.: J. Agric. Food Chem., 15, 139 (1967): Hewlett, P.S. et al.: J. Sci. Food Agric., 18, 279 (1967); Burai, R. et al.: Org. Biomol. Chem., 8, 2252 (2010);<br></p>

<p>Applications Fmoc-1-pyrrolidine-3-carboxylic acid<br></p>

<p>Applications tert-butyl 4-(5-bromo-1H-indazol-3-yl)piperidine-1-carboxylate (cas# 1198284-77-3) is a useful research chemical.<br></p>

<p>Applications 3-(2,6-Dimethylphenyl)-2-oxazolidinone-d6 is an intermediate used in the synthesis of Dimethachlor Ethane Sulfonic Acid Sodium Salt-d6 (D460284), which is the deuterium labelled form of Dimethachlor Ethane Sulfonic Acid Sodium Salt (D460283), which is a pesticide metabolite and pollutant found in groundwater, surface water, and wastewater.<br>References Huntscha, S., et al.: J. Chromatogr. A, 1268, 74 (2012); Reemtsma, T., et al.: J. Chromatogr. A, 1271, 95 (2013);<br></p>

<p>Applications 4-(1-Piperazinyl)-1H-indole Dihydrochloride (cas# 84807-09-0) is a compound useful in organic synthesis.<br></p>

<p>Applications N1,N4-Bis[2-(phenylthio)phenyl]-1,4-piperazine-d8-dicarboxamide is the labeled analog of N1,N4-Bis[2-(phenylthio)phenyl]-1,4-piperazinedicarboxamide (B522635), an impurity of Quetiapine (Q510000), a benzothiazepine with mixed serotonin and dopamine receptor antagonistic properties; used as an antipsychotic.<br>References Stolarczyk, E.U., et. al.: Pharm. Develp. Tech., 14, 27 (2009); Wetzel, H., et al.: Psychopharmacology, 119, 231 (1995)<br></p>

<p>Applications Sulfosuccinimidyl Palmitate Sodium is an analog of Sulfosuccinimidyl Oleate Sodium (S689200).<br></p>

<p>Applications 3-Isopropenyl-2-oxo-1-benzimidazolinebutyric Acid (cas# 52099-78-2) is a compound useful in organic synthesis.<br></p>

<p>Applications 3-Hydroxypyrrolidine, HCl<br></p>

<p>Applications 1H-Pyrrole is a five membered heteroaromatic ring that is used as a synthetic intermediate to create products for the pharmaceutical, chemical, food and cosmetic industries. 1H-Pyrrole has the ability to undergo electrochemical polymerization, producing a durable, conductive film that can be used to coat biosensors.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Diaz, A., et al.: J. Chem. Soc. Chem. Comm., 14, 635 (1979); Kaneto, K.: Curr. Appl. Phys., 5, 178 (2005); Lipshutz, B.: Chem. Rev., 86, 795 (1986)<br></p>

<p>Applications Ethyl 4-Amino-2-mercaptopyrimidine-5-carboxylate (cas# 774-07-2) is a compound useful in organic synthesis.<br></p>

<p>Applications 5-Methyl Tetrazole is used in the preparation of novel antifungal agents based derived from N-iodopropargylazoles and N-triiodoallylazoles. 5-Methyl Tetrazole also in the preparation of novel quinoline derivatives against mycobacterium tuberculosis.<br>References Koyama, M. et al.: J. Med. Chem., 30, 552 (1987); Upadhayaya, R. et al.: Bioorg. Med. Chem., 17, 2830 (2009);<br></p>

<p>Applications 5-Acetyl-2H-pyrazole-3-carboxylic Acid Ethyl Ester (cas# 37622-89-2) is a useful research chemical.<br></p>

<p>Applications N-(2-Chloroethyl)-N'-(4-pyridinyl)urea (cas# 62491-96-7) is a useful research chemical.<br></p>

<p>Applications tert-butyl 6-chloropyridazine-3-carboxylate (cas# 1340506-55-9) is a useful research chemical.<br></p>

<p>Applications 1-(4-aminophenyl)imidazolidin-2-one (cas# 89518-99-0) is a useful research chemical.<br></p>

<p>Applications 2-(4-Chlorophenyl)-4,5-dihydro-1H-imidazole is used in preparation of Arylimidazoline for use as antiobesity agents.<br>References Haga, Y., et al.: U.S. Pat. Appl. Publ. (2012), US 20120029041 A1<br></p>

<p>Applications An intermediate in the production of Rosuvastatin (R700500) derivatives.<br>References Liu, Y. et al.: Guang. Huag., 39, 54 (2011);<br></p>

<p>Applications 1-(3-Bromopropyl)-4-(4-chlorophenyl)piperazine is an intermediate in the synthesis of 2-​[3-​[4-​(4-​Chlorophenyl)​-​1-​piperazinyl]​propyl]​-1,​2,​4-triazolo[4,​3-​a]​pyridin-​3(2H)​-​one Hydrochloride (C433100), which is a related compound of Trazodone (T718500), which is an antidepressant.<br>References Silvestrini, B., et al.: Eur. J. Pharmacol., 12, 231 (1970), Brogden, R.N., et al.: Drugs, 21, 401 (1981), Gorecki, D., et al.: Anal. Profiles Drug Subs., 16, 693 (1986),<br></p>

<p>Applications 5-methyl-1H-pyrazole hydrochloride (cas# 119760-62-2) is a useful research chemical.<br></p>

<p>Applications 2-Amino-5-bromopyrazine-3-carboxylic Acid Methyl Ester is used as the starting material in the preparation of pyrazine derivatives that are AxI and c-Met receptor enzyme inhibitors. These inhibitors are useful in the treatment of tumors. 2-Amino-5-bromopyrazine-3-carboxylic Acid Methyl Ester is also used in the preparation of potent and selective inhibitors of ataxia telangiectasia mutated and Rad3 related (ATR) protein kinase as potential anticancer agents.<br>References Rushton, L.; et al.: PCT Int. Appl. 119 pp. Patent 2009 CODEN:PIXXD2; Charrier, J-D.; et al.: J. Med. Chem, 54, 2320 (2011)<br></p>

<p>Applications 2,3-Pyrazinedicarboxylic Acid has been found to exhibit antifungal and antibacterial acitivity. It has also been used as a reagent in the preparation of transition metal pyrazinedicarboxylate complexes.<br>References Beaula, T.J., et al.: Spectrochim. Acta A, 138, 723 (2015); Premkumar, T., et al.: World J. Microb. Biot., 21, 479 (2005); Gunay, G., et al.: Inorg. Chim. Acta, 399, 19 (2013)<br></p>

<p>Applications rac-α-N-Boc-Amino-4-pyridineaceic Acid is a reagent used in the preparation of lactam-containing diaminoalkanes, β/α-amino acids and derivatives of Xa inhibitors.<br></p>

<p>Applications 4-Formylpyrazole is a reactant in the preparation of 1, 3-disubstituted-pyrazole derivatives as new class I and IIb histone deacetylase inhibitors.<br>References Yao, Y., et. al.: Eur. J. Med. Chem., 86, 639 (2014)<br></p>

<p>Applications 4-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)benzonitrile (cas# 31489-18-6) is a useful research chemical.<br></p>

<p>Applications 2-Amino-5-ethylpyrazine<br></p>

<p>Applications 1-[4-(4-Fluorophenyl)-2-thiazolyl]-3,5-dimethyl-1H-pyrazole-4-propanoic Acid (cas# 1172940-17-8) is a compound useful in organic synthesis.<br></p>

<p>Applications (3-(tert-butyl)-1H-pyrazol-5-yl)methanol (cas# 493038-53-2) is a useful research chemical.<br></p>

<p>Applications 1-Octyl-4-(1-octylpyridin-1-ium-4-yl)pyridin-1-ium dibromide is a viologen and chromophore used in low-energy driven electrochromic devices comprising of polymeric ionic liquids.<br>References Lu, H.; et al.: ACS Appl. Mater. Interfaces, 8, 30351 (2016).<br></p>