Heterocycles with Nitrogen (N)

<p>Applications 2-ETHYNYLPYRIDINE (cas# 1945-84-2) is a useful research chemical.<br></p>

<p>Applications (4-Chlorobenzo[b]thiophen-2-yl)(piperazin-1-yl)methanone is a useful research chemical.<br></p>

<p>Applications 4-Phenyl-2-piperidinecarboxylic Acid is a compound useful in organic synthesis.<br></p>

<p>Applications 2-(1-(4-Bromophenyl)-1H-1,2,3-triazol-4-yl)propan-2-ol<br></p>

<p>Applications tert-Butyl 4-(6-ethylthieno[3,2-d]pyrimidin-4-yl)piperazine-1-carboxylate is an intermediate for the synthesis of 6-Ethyl-4-[4-(1,3,4-thiadiazol-2-yl)-1-piperazinyl]thieno[2,3-d]pyrimidine Hydrochloride (E926745), which is an inhibitor of fusion protein interaction of menin-mixed lineage leukemia (menin-MLL). Menin-MLL inhibitors downregulate the expression of target genes required for MLL fusion protein oncogenic activity and thus effectively reverse MLL fusion protein-mediated leukemic transformation.<br>References Grembecka, J. et al.: Nat. Chem. Biol., 8, 277 (2012)<br></p>

<p>Applications A stable and versatile reagent for the efficient and chemically specific guanylation of sterically unhindered primary and secondary aliphatic amines under mild conditions. Useful reagent in peptide synthesis.<br>References Baslow, M., et al.: J. Inherit. Metab. Dis., 23, 684 (2000), Lee, Y., et al.: Bioorg. Med. Chem. Lett., 10, 2771 (2000), Baslow, M., et al.: Neurochem. Res., 27, 403 (2002),<br></p>

<p>Applications 5-Hydroxy-6-methyl-3,4-pyridinedicarboxylic Acid is used in studies to identify 4-pyridoxic acid dehydrogenase gene in pyridoxine catabolism of Mesorhizobium loti MAFF303099.<br>References Mukherjee, T., et al.: Bioorg. Chem., 35, 458 (2007)<br></p>

<p>Applications (3-(tert-butyl)-1H-pyrazol-5-yl)methanol (cas# 493038-53-2) is a useful research chemical.<br></p>

<p>Applications 4-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)benzonitrile (cas# 31489-18-6) is a useful research chemical.<br></p>

<p>Applications 5-(Aminosulphonyl)-1-methyl-1H-pyrrole-2-carboxylic acid (cas# 306936-62-9) is a useful research chemical.<br></p>

<p>Applications 2-Amino-5-bromopyrazine-3-carboxylic Acid Methyl Ester is used as the starting material in the preparation of pyrazine derivatives that are AxI and c-Met receptor enzyme inhibitors. These inhibitors are useful in the treatment of tumors. 2-Amino-5-bromopyrazine-3-carboxylic Acid Methyl Ester is also used in the preparation of potent and selective inhibitors of ataxia telangiectasia mutated and Rad3 related (ATR) protein kinase as potential anticancer agents.<br>References Rushton, L.; et al.: PCT Int. Appl. 119 pp. Patent 2009 CODEN:PIXXD2; Charrier, J-D.; et al.: J. Med. Chem, 54, 2320 (2011)<br></p>

<p>Applications 2-(4-Chlorophenyl)-4,5-dihydro-1H-imidazole is used in preparation of Arylimidazoline for use as antiobesity agents.<br>References Haga, Y., et al.: U.S. Pat. Appl. Publ. (2012), US 20120029041 A1<br></p>

<p>Applications 5-Ethyl-2-pyridineethanol (cas# 5223-06-3) is a compound useful in organic synthesis.<br></p>

<p>Applications (2S,4R)-4-Aminopyrrolidine-2-carboxylic Acid Dihydrochloride (cas# 16257-89-9) is a useful research chemical.<br></p>

<p>Applications 2-(1-Piperazinyl)-phenol Dihydrochloride, is used to prepare nonpeptidic biaryl inhibitors of human cathepsin K in relation to treatment of osteoporosis. It is also used to synthesize serotonin transporters/histamine H3 receptors.<br>References Robichaud, J., et al.: J. Med. Chem., 46, 3709 (2003); Keith, J., et al.: Bioorg. Med. Chem. Lett., 17, 702 (2007)<br></p>

<p>Applications 5-Acetyl-2H-pyrazole-3-carboxylic Acid Ethyl Ester (cas# 37622-89-2) is a useful research chemical.<br></p>

<p>Applications 2-Bromopyridine-15N (cas# 54267-53-7) is a compound useful in organic synthesis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications 1H-Pyrrole is a five membered heteroaromatic ring that is used as a synthetic intermediate to create products for the pharmaceutical, chemical, food and cosmetic industries. 1H-Pyrrole has the ability to undergo electrochemical polymerization, producing a durable, conductive film that can be used to coat biosensors.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Diaz, A., et al.: J. Chem. Soc. Chem. Comm., 14, 635 (1979); Kaneto, K.: Curr. Appl. Phys., 5, 178 (2005); Lipshutz, B.: Chem. Rev., 86, 795 (1986)<br></p>

<p>Applications 2-OXO-2,3-DIHYDRO-1H-BENZO[D]IMIDAZOL-5-YLBORONIC ACID (cas# 1194483-04-9) is a useful research chemical.<br></p>

<p>Applications 3-(2,6-Dimethylphenyl)-2-oxazolidinone-d6 is an intermediate used in the synthesis of Dimethachlor Ethane Sulfonic Acid Sodium Salt-d6 (D460284), which is the deuterium labelled form of Dimethachlor Ethane Sulfonic Acid Sodium Salt (D460283), which is a pesticide metabolite and pollutant found in groundwater, surface water, and wastewater.<br>References Huntscha, S., et al.: J. Chromatogr. A, 1268, 74 (2012); Reemtsma, T., et al.: J. Chromatogr. A, 1271, 95 (2013);<br></p>

<p>Applications 6-Bromopiperonal is a disubstituted 1,3-benzodioxole that displayed synergistic activity with carbaryl on houseflies. 6-Bromopiperonal is used as an intermediate in the preparation of GPR30-selective agonist G-1.<br>References Wilkinson, C.F. et al.: J. Agric. Food Chem., 15, 139 (1967): Hewlett, P.S. et al.: J. Sci. Food Agric., 18, 279 (1967); Burai, R. et al.: Org. Biomol. Chem., 8, 2252 (2010);<br></p>

<p>Stability Hygroscopic<br>Applications 2,4-Dichloro-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine hydrochloride (cas# 1187830-76-7) is a useful research chemical.<br></p>

<p>Applications Imidazo[1,2-a]pyridine-6-boronic acid is a useful intermediate for organic synthesis and other pharmaceutical processes.<br>References Gonzalez C., et al.: J. Med. Chem., 55, 11022 (2012); Cooper, A. B., et al.: Bioorg. Med. Chem. Lett., 27, 4471 (2017)<br></p>

<p>Applications 4-Hydroxypiperidine-d9 is labelled 4-Hydroxypiperidine (H950845) which is used as a reagent for the synthesis of acridine (A190900) derivatives and fibrinogen receptor antagonists.<br>References Yang, D. et al.: Macromol., 35, 5304 (2002); Harrison, R.J. et al.: Bioorg. Med. Chem. Lett., 9, 2463 (1999)<br></p>

<p>Applications [3-(2-Amino-6-methoxy-4-pyrimidinyl)phenyl](3,6-dihydro-4-methyl-1(2H)-pyridinyl)-methanone is a useful chemical for cancer immunotherapy research.<br></p>

<p>Applications 5-(Bromomethyl)-2-fluoropyridine is a useful reagent for preparation of N-Benzylisatinsulfonamides as potent caspase-3 inhibitors.<br>References Chu, W., et al.: J. Med. Chem., 48, 7637 (2005);<br></p>

<p>Applications 2-Chloro-4-(4-fluorophenyl)-5,6,7,8,9,10-hexahydrocycloocta[b]pyridine is an intermediate in the synthesis of Blonanserin (B595850), a 5-HT2 serotonin receptor and D2 dopamine receptor antagonist, used as an antipsychotic.<br>References Oka, T., et al.: Life Sci., 76, 225 (2004), Singh, A., et al.: Int. Med. J., 12, 175 (2005), Ochi, T., et al.: Bioorg. Med. Chem., Lett., 15, 1055 (2005),<br></p>

<p>Applications 6-methyl-2-oxo-4-[(5,6,7,8-tetrahydronaphthalen-2-yl)amino]-1,2-dihydropyridine-3-carboxylic acid (cas# 1239521-17-5) is a useful research chemical.<br></p>

<p>Applications cis-2,6-Dimethylpiperazine is a very versatile reagent used in the preparation of biologically active compounds such as antibacterial agents.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Cricchio, R. et al.: Farm. Ed. Sci., 30, 605 (1975);<br></p>

<p>Applications 6-methyl-2-oxo-5-phenyl-1,2-dihydropyridine-3-carboxylic acid (cas# 10176-79-1) is a useful research chemical.<br></p>

<p>Applications 1,2-Benzisoxazole has therapeutic uses. It could be useful for treating parkinsonism.<br>References Panza, F., et al.: Expert Opin. Pharmacother., (2020)<br></p>

<p>Applications Homopiperazine acts as a corrosion inhibitor for iron. It has also been used in the preparation of potent H3 receptor antagonists for use as treatments for neurodegenerative conditions such as Alzheimer’s disease.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Granese, S. et al.: Corrosion., 44, 322 (1988); Pippel, D. et al.: Org. Proc. Res. Devel., 15, 638 (2011);<br></p>

<p>Stability Hygroscopic<br>Applications 2-Aminopyrimidine-5-boronic acid<br></p>

<p>Applications 6-Desamino-6-oxo Phenazopyridine is a Phenazopyridine (P313751) degradation product/impurity, and is a useful synthetic intermediate.<br>References Nickerson, B., et al.: J. Liq. Chromatogr., 18, 3947 (1995)<br></p>

<p>Applications 6-Methyl-3-pyridinol is a reagent in the preparation of anilino(pyridyl)quinolinecarbonitriles which has Src kinase inhibitiion and antitumor properties.<br>References Zhang, N., et al.: Bioorg. Med. Chem. Lett., 19, 5071 (2009); Blume-Jensen, P., et al.: Nature, 411, 355 (2001)<br></p>

<p>Applications [1,2,4]triazolo[3,4-b][1,3,4]thiadiazol-6-amine (cas# 3176-50-9) is a useful research chemical.<br></p>

<p>Applications 1-Piperidine-d10-carbonyl Chloride (CAS# 1219803-31-2) is a useful isotopically labeled research compound.<br></p>

<p>Applications 1-(2,6-Dichlorophenyl)piperazine-d8 Hydrochloride is the isotope analog of 1-(2,6-Dichlorophenyl)piperazine Hydrochloride. 1-(2,6-Dichlorophenyl)piperazine Hydrochloride is used in the preparation of pyrazolopyrimidones and pyrazolopyridones as tankyrase inhibitors which are useful in the treatment of cancer.<br>References Feng, J., et al.: PCT Int. Appl., 2013:1906020 (2013)<br></p>

<p>Applications 2-(Difluoromethoxy)pyridin-4-amine (cas# 1211587-46-0) is a useful research chemical.<br></p>

<p>Applications 6-Methyl-3-pyridineacetonitrile is a reactant used in the preparation of pyrazolopyrimidine derivatives as agents for treatment of autoimmune diseases and orally active corticotropin-releasing factor receptor antagonists.<br>References Chen, C. et al.: J. Med. Chem., 47, 4787 (2004)<br></p>

<p>Applications The preparation and incorporation of 2-[2-[2-(2,5-Dihydro-2,5-dioxo-1H-pyrrol-1-yl)ethoxy]ethoxy]acetic Acid into the bilayers of liposomal constructs used for immunization with synthetic peptides.<br>References Frisch, B., et al.: Bioconjugate Chem., 7, 180-186 (1996)<br></p>

<p>Applications 5-Bromo-3-methylpicolinic Acid is used to prepare oxazine derivatives as BACE inhibitors useful in treatment of neurological disorders.<br>References Badiger, S., et al.: PCT Int. Appl., WO 2011009943 A1 20110127 (2011); Tintelnot-Blomley, M., et al.: PCT Int. Appl., WO 2011080176 A1 20110707 (2011)<br></p>

<p>Applications Dimethylhydrazone-1-methyl-4-piperidinone is an intermediate in the synthesis of α-Meprodine Hydrochloride (M224950), which is a narcotic analgesic. An analogue of Proline (P755300).<br>References Iorio, M.A., et al.: J. Med. Chem., 20, 309 (1977),<br></p>

<p>Applications Used for preparation of phthalide derivatives for treatment of diabetes.<br></p>

<p>Applications 4,6-Dichloro-5-fluoropyrimidine<br></p>

<p>Applications 5-Bromo-2-chloro-3-nitropyridine (cas# 67443-38-3) is a compound useful in organic synthesis.<br></p>

<p>Stability Hygroscopic<br>Applications 2-Bromo-5-fluoropyridine-4-boronic acid<br></p>

<p>Applications 4-Oxo-2,2,6,6-tetramethylpiperidine-d16;1-15N-1-oxyl (CAS# 80404-14-4) is a useful isotopically labeled research compound.<br></p>

<p>Applications 4-Chloro-6-ethylthieno[2,3-d]pyrimidine is a useful intermediate for organic synthesis.<br>References Ostrynska, O. V., et al.: Eur. J. Med. Chem., 115, 148 (2016); Ram, V. J., et al.: J. Heterocycl. Chem., 1277 (1981); Sharma, C., et al.: E-J. Chem., 7, 655 (2010)<br></p>

<p>Applications 3-Chloropyridine-d4 (CAS# 1001003-95-7) is a useful isotopically labeled research compound.<br></p>

<p>Applications An intermediate in the production of Zolpidem metabolites<br>References Klupsch, F., et al.: Chem. Pharm. Bull., 54, 1318 (2006),<br></p>

<p>Applications 2-Chloro-4-(trifluoromethyl)pyrimidine (cas# 33034-67-2) is a compound useful in organic synthesis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Stability Moisture Sensitive, Hygroscopic<br>Applications 1,2-dimethyl-1H-imidazole-4-sulfonyl chloride (cas# 137049-02-6) is a useful research chemical.<br></p>

<p>1-(2-Methylphenyl)piperazine 2HCl is a cholinergic agent that has been shown to increase the activity of acetylcholine in the brain. It has been used to study the effects of acetylcholine on locomotor activity and memory. 1-(2-Methylphenyl)piperazine 2HCl can be synthesized by reacting piperazine with paraformaldehyde. The synthesis of 1-(2-Methylphenyl)piperazine 2HCl is dependent on the alkyl substituents on the piperazine molecule, as well as whether or not it has an R group.</p>

<p>2-Aminomethylpyrazine (2-AP) is a molecule that has been studied for its potential as an anti-cancer agent. It has been shown to bind to the DNA of tumor cells and prevent them from dividing, leading to cell death. 2-AP also prevents the production of survivin, which is a protein that promotes cancer cell growth and survival. 2-AP can be used in positron emission tomography (PET) scans to detect tumors, and has shown promise in treating acute myeloid leukemia.</p>

<p>Please enquire for more information about 3,5-Dimethylpyrazine-2-carboxylic acid including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>7-Chlorothieno[3,2-B]pyridine is a nucleophilic compound that is used as an inhibitor of the tyrosine kinase enzyme. It binds to the ATP binding site and blocks the enzymatic activity of the enzyme, preventing cell proliferation. 7-Chlorothieno[3,2-B]pyridine has been shown to inhibit growth in tumour cell lines and has been shown to be effective against tyrosine kinase receptor positive cancer cells. This drug also shows a cytotoxic activity against tumour cells in vivo, which may be due to its ability to inhibit factor receptor and receptor tyrosine.</p>

<p>Dibenzylamine is a tertiary amine with the chemical formula C6H12N2. Dibenzylamine is a colorless liquid that boils at 110°C and freezes at -50°C. It has a density of 0.859 g/mL and a refractive index of 1.539. When heated, it decomposes to form dipropylamine, dibutylamine, and dicyclohexylamine. It also reacts with nitric acid to form an explosive compound called nitrobenzene or dinitrobenzene. Dipropylamine is a colorless volatile liquid that has the chemical formula C6H12N2 and boils at 130°C. When heated, it decomposes to form dibutylamine and dicyclohexylamine. Dibutylamine is a colorless volatile liquid that has the chemical formula C6</p>