Heterocycles with Nitrogen (N)

<p>5-Hydroxyindole-2-carboxylic acid ethyl ester is a fluorescent probe that is used in the detection of hepatitis C virus by micropet assay. The compound reacts with amines and undergoes fluorescence quenching, and can be used to quantitate their concentration. 5-Hydroxyindole-2-carboxylic acid ethyl ester is also used for the determination of the kinetics of amines and other compounds that are involved in the metabolism of drugs and biogenic amines. It can be applied to chromatographic analysis or sample preparation prior to analysis by analytical chemistry methods such as gas chromatography or liquid chromatography.</p>

<p>4,4',6,6'-Tetramethyl-2,2'-bipyridine (TMTB) is a small molecule that can be used as an efficient and cost-effective catalyst for the production of hydrogen from water. TMTB is able to transform solar energy into chemical energy by converting light absorbed in a semiconductor material to an electric current. TMTB has been shown to improve the efficiency of solar cells by boosting the performance of the catalysts that drive chemical reactions in the devices. This effect was found to be synergistic with other materials such as graphene oxide and tungsten disulfide. In addition, TMTB nanoparticles were shown to have a normalizing effect on the charge density in photoelectrochemical cells, which may lead to improved stability and durability.</p>

<p>6-Aminoindole is a model complex that can be used for studying the interactions of primary amines with acidic molecules in bioinorganic chemistry. The molecule was synthesized by electropolymerization, which involves the oxidation of aniline with bifunctional oxidases. 6-Aminoindole has been shown to have protonation and salicylaldehyde properties. It reacts with metal surfaces to form a molecular target.</p>

<p>N-Methyl-4-phenylpyridinium iodide is an experimental drug that has been shown to have a number of biological effects in vitro. These include the inhibition of dopamine uptake and mitochondrial membrane potential, leading to neuronal death. This drug also inhibits the uptake of gamma-aminobutyric acid (GABA) and the synthesis of tubule cells. N-Methyl-4-phenylpyridinium iodide has been shown to cause microglia cell activation by binding with the CB2 receptor on these cells. The compound also causes increased uptake of lithium ions into mitochondria, which leads to a reduction in mitochondrial membrane potential and subsequent neuronal death.</p>

<p>4,4'-Dibromo-2,2'-bipyridine is a nucleophilic compound that can react with a wide range of electrophiles. It has been used in medications as a thermally stable and non-toxic ligand for metal ions. 4,4'-Dibromo-2,2'-bipyridine is an efficient ligand for the coordination of many transition metals. This compound also has high values in light emission and is used in crystallography to study protein binding sites. The n-oxide form of 4,4'-dibromo-2,2'-bipyridine has biological properties that have not yet been studied.</p>

<p>Nicotinoylazide is a skin condition medication that has nitrogen atoms in its structure. It is an inhibitor of the enzyme protease, which breaks down proteins and helps regulate inflammation. Nicotinoylazide also inhibits the activity of other enzymes, such as those involved in fatty acid metabolism. <br>Nicotinoylazide has been shown to be effective in the treatment of diabetic neuropathy and bladder dysfunction caused by interstitial cystitis, although it has not been approved for use in children. The drug may be used for other conditions where protease inhibitors are beneficial, such as pediatric inflammatory bowel disease.</p>

<p>4,6-Diaminopyrimidine is a potent inhibitor of epidermal growth factor receptor. It has been shown to inhibit the production of soluble guanylate cyclase and cGMP in vitro and in vivo. This drug has also been shown to inhibit cancer cell growth in vitro and in vivo. 4,6-Diaminopyrimidine has potential clinical relevance as an anticancer agent due to its ability to inhibit the kinases necessary for cancer proliferation. This drug also has pharmacokinetic properties that are favorable for anticancer drugs, including low plasma protein binding, high clearance rate, and short half-life. The activity of this drug was tested on hepg2 cells (human hepatoma) with an inhibitory effect on growth factor receptors such as EGFR and PDGFRs</p>

<p>4'-(4-Methylphenyl)-2,2':6',2''-terpyridine (TPEN) is a chemical compound with anti-cancer properties that has been shown to induce apoptosis in cancer cells. TPEN also inhibits the growth of tumor cells by interacting with mitochondria and inducing mitochondrial dysfunction. TPEN synergistically induces death in neuronal cells when combined with other agents that are known to cause neuronal cell death. In vivo studies have shown that TPEN produces neuroprotective effects at normoxic temperatures, but can be toxic at hyperthermic temperatures.</p>

<p>Please enquire for more information about 4-Oxo-4-(4-benzylpiperazinyl)but-2-enoic acid including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>3-Amino-2-bromo-4,6-dimethylpyridine is a fine chemical that can be used as a versatile building block in the synthesis of other compounds. It is also an intermediate for the production of organic compounds and research chemicals. 3-Amino-2-bromo-4,6-dimethylpyridine is listed on the Chemical Abstracts Service (CAS) registry with the number 104829-98-3. This compound has a complex structure and is high quality and stable.</p>

<p>N-Nitroso-3-azabicyclo[3.3.0]octane is a nitrosating agent that can be used for the determination of gliclazide in pharmaceuticals and other applications. It is synthesized by reacting 3-azabicyclo[3.3.0]octane with sodium nitrite in an alkaline environment, followed by hydrolysis with hydrochloric acid. Nitrosation reactions are usually slow, but N-nitroso-3-azabicyclo[3.3.0]octane has been shown to have a fast reaction kinetics, which makes it useful for the determination of gliclazide in pharmaceuticals and other applications. The product is analyzed using chromatographic techniques such as high performance liquid chromatography (HPLC) or gas chromatography/mass spectrometry (GC/MS). The product was found to be linear over the range of 0–</p>

<p>1H-Pyrazole is a pharmacological agent that has been shown to have anti-cancer properties. It is a hydrogen-bonding compound that forms 1:1 complexes with coumarin derivatives, which are found in plants and other natural sources. The 1H-pyrazole ring has been shown to bind to the x-ray crystal structures of mitochondrial membranes and induce changes in their potential. This drug also inhibits the growth of solid tumours in vitro by inhibiting the synthesis of DNA and proteins. In addition, 1H-pyrazole has been shown to be an analytical method for measuring the concentration of natural compounds in water samples.</p>

<p>5-Nitro-pyridine-2-sulfonyl chloride is a chemical reagent that is used in the synthesis of various organic compounds. It is a versatile building block and can be used as an intermediate for the synthesis of other compounds. 5-Nitro-pyridine-2-sulfonyl chloride is also a reaction component in the synthesis of some pharmaceutical drugs, such as benzoic acid, which can be used to manufacture more complex compounds, such as antibiotics.</p>

<p>Please enquire for more information about BP fluor 647 NHS ester trisodium including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about Nα-Nim-Bis-Z-L-histidine ethanol including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>1-Phenyl-piperazin-2-one is a versatile chemical that can be used as a building block in the synthesis of complex compounds. This compound is also used as a reagent and speciality chemical. It is an important intermediate in organic synthesis and has been used in the preparation of pharmaceuticals, pesticides, and herbicides. 1-Phenyl-piperazin-2-one can be prepared by reacting phenylacetonitrile with nitrous acid to form the nitrile followed by hydrolysis to produce the corresponding carboxylic acid.</p>

<p>5,6-Dichloroindole is a chemical compound that contains a functional group with acidic properties. The compound has been shown to inhibit the activity of bafilomycin A1, which is an inhibitor of vacuolar ATPase. This inhibition leads to an increase in intracellular phosphate levels and an accumulation of lysosomal membrane proteins. 5,6-Dichloroindole has also been found to inhibit bone resorption in gramine-fed rats. It also has anti-inflammatory effects and inhibits the growth of zoobotryon pinnatum cells and algal cells. 5,6-Dichloroindole can be used as a molecular descriptor for predicting the presence or absence of bryozoan species in a sample.</p>

<p>Please enquire for more information about Cetirizine propanediol ester dihydrochloride, mixture of regioisomers including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>5-Methoxyindole-3-acetic acid is a chemical that can be used to synthesize a variety of compounds. It is a versatile building block that has been used in the synthesis of complex compounds, as well as an intermediate for the production of other chemicals. 5-Methoxyindole-3-acetic acid is also an important reaction component and reagent for organic synthesis. This substance is not currently on the list of speciality chemicals, but it has shown high quality and usefulness in research.</p>

<p>2,2'-Biquinoline-4,4'-dicarboxylic acid disodium salt is a model system for studying the sequence and hydrogen bonding interactions of polymers. It is a biocompatible polymer that has been shown to have inhibitory properties in response to atherosclerotic lesions. 2,2'-Biquinoline-4,4'-dicarboxylic acid disodium salt has shown optical properties that can be used as a signal in recording sequences. This polymerase chain reaction (PCR) substrate is able to bind with DNA and protein molecules when they are present in an appropriate buffer. The sequence of 2,2'-biquinoline-4,4'-dicarboxylic acid disodium salt is controlled by the coordination geometry of the metal ions involved in its formation.</p>

<p>5-Fluoro-4-hydroxy-2-methoxypyrimidine (5FMMP) is a chemical intermediate that is used in the synthesis of various pharmaceuticals, including antibiotics. It can be obtained by reacting phosphorus oxychloride with activated 2-methoxybenzaldehyde. This chemical intermediate is highly reactive and has been shown to be virulent against some strains of bacteria, such as E. coli and Proteus mirabilis. 5FMMP binds to the bacterial cell wall using its primary amine group, which prevents the formation of an antibiotic-inhibitor complex with the enzyme cell wall synthesis that is required for cell wall biosynthesis, inhibiting protein synthesis and cell division. The chlorinating reaction between 5FMMP and sodium hypochlorite results in hydrochloric acid generation. This chemical intermediate can also be synthesized from recycled chemicals such as ethyl chloride or chloroform.</p>

<p>4-Butylpiperidine hydrochloride is a versatile building block for the synthesis of complex compounds. It is a reagent that can be used in research and as a speciality chemical. 4-Butylpiperidine hydrochloride has been shown to have high purity, making it suitable for use as a building block in the synthesis of pharmaceuticals and other useful compounds. CAS No. 372195-85-2</p>

<p>(2S,5R)-5-Hydroxypiperidine-2-carboxylic acid hydrochloride is a fine chemical that is useful as a building block in organic synthesis. It is also used as an intermediate in the production of other chemicals and may be used to synthesize complex compounds. This compound has a CAS number of 824943-40-0 and may be available at competitive prices.</p>

<p>Applications An intermediate in the preparation of labelled Pipradrol Hydrochloride<br></p>

<p>Applications 2-(2-Thenylamino)pyridine is an intermediate in the synthesis of Methapyrilene Hydrochloride (M259970). Methapyrilene is used as antihistaminic agent.<br>References Calandre, E.P., et al.: Clin. Pharmacol. Ther., 29, 527 (1981); Eastmond, D., et al.: Mutagenesis, 24, 341 (2009); Dertinger, S., et al.: Toxicol. Sci., 115, 401 (2010)<br></p>

<p>Applications (4R)-3-(1-Oxo-3-buten-1-yl)-4-(phenylmethyl)-2-oxazolidinone is an intermediate in the synthesis of emericellamide A, a secondary metabolite of marine cyclic depsipeptide with antimicrobial properties.<br>References Ma, J. Y., et al.: Synlett., 8, 1307 (2009);<br></p>

<p>Applications tert-Butyl 4-((tosyloxy)methyl)piperidine-1-carboxylate is a useful intermediate used in the preparation of biologically active molecules with pharmacological applications.<br>References Lowe, P. T., et al.; ChemBioChem, 18, 2156 (2017); Brocklesby, K. L., et al.: Tetrahedron Lett., 58, 1467 (2017); Wei, H., et al.: Molecules, 21, 1693 (2016)<br></p>

<p>Applications 5-Bromo-2-(1H-tetrazol-5-yl)pyridine is a reagent in the synthesis and antibacterial activity of oxazolidinones containing pyridine substituted with heteroaromatic ring.<br>References Jo, Y.W., et al.: Bioorg. Med. Chem., 12, 5909 (2004)<br></p>

<p>Applications A useful synthetic intermediate.<br>References Korosec, T., et al.: Bioorg. Med. Chem., 16, 209 (2008),<br></p>

<p>Impurity Abiraterone Impurity 7<br>Applications 3-(Diethylboryl)pyridine is an intermediate used to prepare inhibitors of ataxia telangiectasia mutated and Rad3 related (ATR) protein kinase as potential anticancer agents. It is also used in the synthesis of trisubstituted pyrimidines from polyhalopyrimidines via Suzuki coupling.<br>References Charrier, J., et al.; J. Med. Pharm. Chem., 54, 2320 (2011); Large, J., et al.: Synlett., 861 (2006)<br></p>

<p>Applications 2-[[[1-(4-Chlorophenyl)-1H-pyrazol-3-yl]oxy]methyl]benzenamine is an intermediate used in the synthesis of (P840402), which is an isotope labelled Pyraclostrobin, a fungicide for use in seed grass and food crops.<br>References Gyldenkaerne, S., et al.: Pestic Sci., 55, 1210 (1999), Pennington, D., et al.: Environ. Sci. Technol., 39, 1119 (2005), Wang, S., et al.: Food Control., 18, 731 (2007),<br></p>

<p>Applications (1S)-3,4-Dihydro-1-phenyl-2(1H)-isoquinolinecarboxylic Acid 2,5-Dioxo-1-pyrrolidinyl Ester is an intermediate in the synthesis of ((R)-1-phenyl-3,4-dihydroisoquinolin-2(1H)-yl)((S)-1-phenyl-3,4-dihydroisoquinolin-2(1H)-yl)methanone (P309025). ((R)-1-phenyl-3,4-dihydroisoquinolin-2(1H)-yl)((S)-1-phenyl-3,4-dihydroisoquinolin-2(1H)-yl)methanone is a possible impurity of solifenacin (S676700) which is a muscarinic M3 receptor antagoinst. Solifenacin is used in treatment of urinary incontinence.<br>References Ikeda K., et al.: Arch. Pharmacol., 366, 97, (2002); Chapple, C.R., et al.: Br. J. Urol., 93, 303 (2004); Ohtake, A., et al.: Eur. J. Pharmacol., 492, 243 (2004); Brunton, S., et al.: Curr. Med. Res. Opin., 21, 71 (2005); Habb, F., et al.: Eur. Urol. 47, 376 (2005); Payne, C.K., et al.: Drugs, 66, 175 (2006)<br></p>

<p>Stability Stable<br>Applications 2,4,5-Triamino-6-pyrimidinol-13C2,15N is an intermediate in the synthesis of labelled Guanine (G836000). Guanine is on one of the five nucleobases incorporated into biological nucleic acids. Guanine, along with adenine and cytosine, is present in both DNA and RNA, whereas thymine is usually seen only in DNA, and uracil only in RNA.<br>References Geslain, R., et al.: J. Biol. Chem., 284, 27760 (2009); Manini, P., et al.: Toxicol. Lett., 190, 41 (2009); Gong, B., et al.: Biochem., 48, 11961 (2009); Sugimoto, M., et al.: J. Agric. Food Chem., 58, 374 (2010)<br></p>

<p>Applications Used in ointments for treatment of psoriasis.<br>References Wetterau, J., et al.: Biochim. Biophys Acta, 1345, 136 (1997), Sorbera, L., et al.: Drugs Future, 25, 1138 (2000), Robl, J., et al.: J. Med. Chem., 44, 851 (2001), Theuns, J., et al.: Neurolog. Aging, 25, S85 (2004),<br></p>

<p>Applications 2,3,7,8-Tetrachloro-[1,4]dioxino[2,3-b:5,6-b']dipyridine is used in analytical studies for the presence and formation of dioxin-like compounds in heat-treated chlorpyrifos herbicide, a potential precursor of pyridine analog of 2,3,7,8-Tetrachloro-p-dioxin (T291370).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Sakiyaama, T., et al.: Organohalogen Compounds, 73, 146 (2011);<br></p>

<p>Applications 1-Cyclohexyl-1-(4-benzyloxycyclohexyl)-2-(2-pyridinyl)ethanol-d11_x000D_(Mixture of Diastereomers) (cas# 1189891-05-1) is a compound useful in organic synthesis.<br></p>

<p>Applications 2-Bromo-5-nitropyridine (cas# 4487-59-6) is a compound useful in organic synthesis.<br></p>

<p>Applications 1,​4-​Dimethyl-​3-​phenyl-​1H-​pyrazol-​5-​ol is a reactant used in the preparation of novel strobilurin derivatives as insecticides.<br>References Li, M. et al.: Nat. Prod. Comm., 4, 1215 (2009);<br></p>

<p>Applications 5H,6H,7H-cyclopenta[b]pyridine-7-carboxylic acid hydrochloride (cas# 1610919-99-7) is a useful research chemical.<br></p>

<p>Applications 2,6-Diamino-4-hydroxy-5-nitrosopyrimidine-13C2 is a labelled 2,6-Diamino-4-hydroxy-5-nitrosopyrimidine (D416350), used in the preparation of pterin-based inhibitors.<br>References Hevener, K. et al.: J. Med. Chem., 53, 166 (2010)<br></p>

<p>Applications 2,4-Dihydroxy-6-amino-5-diethoxyethylpyrimidine (cas# 102879-75-4) is a compound useful in organic synthesis.<br></p>

<p>Applications 5,6-Diamino-2,4-dihydroxypyrimidine-13C2 Bisulfite Salt is a compound useful in organic synthesis.<br></p>

<p>Applications 4-[2-(1-Piperidinyl)ethoxy-d4]benzoic Acid, Hydrochloride Salt (cas# 1246815-60-0) is a compound useful in organic synthesis.<br></p>

<p>Applications An intermediate in the preparation of CDK inhibitors<br>References Jakobsen, P., et al.: Bioorg. Med. Chem., 8, 2803 (2000), Chu, X., et al.: J. Med. Chem., 49, 6549 (2006),<br></p>

<p>Applications 5,6-Diamino-2,4-dihydroxypyrimidine-13C2, Hydrochloride Salt (cas# 1346605-20-6) is a compound useful in organic synthesis.<br></p>

<p>Applications 1,1'-(AZODICARBONYL)DIPIPERIDINE (cas# 10465-81-3) is a useful research chemical.<br></p>

<p>Applications N-Nitro-1H-imidazol-2-amine is used as a reagent in the synthesis of Imidacloprid-olefin (I274995); a metabolite of Imidacloprid (I274990) which is an active ingredient in certain neuro-active insecticides.<br>References Chauzat, M., et al.: Env. Entomol., 38, 514 (2009); Patial, A., et al.: Env. Ecol., 27, 320 (2009); Fernandez-Bayo, J., et al.: J. Agric., Food Chem., 57, 5435 (2009); Tomizawa, M., et al.: J. Med. Chem., 52, 3735 (2009); Chem. and Eng. News 90: 10 (2012)<br></p>

<p>Applications 2,3-Diaminopyridine-d3 is an intermediate in the synthesis of Pentosidine-d3 TFA Salt which is a biochemical marker of bone turnover for management of metabolic bone diseases.<br>References Turner, W., et al.: Biol. Psychiatry, 14, 177 (1979), Miyata, T., et al.: Kidney Int., 60, 2351 (2001), Politi, P., et al.: Neurosci. Lett., 396, 163 (2006),<br></p>

<p>Applications 3-(2-Mercapto-1H-imidazol-4-yl)pyridine (cas# 93103-29-8 ) is a compound useful in organic synthesis.<br></p>

<p>Applications 3-Chloropyridine N-Oxide (cas# 1851-22-5) is a compound useful in organic synthesis.<br></p>

<p>Applications 3-Cyanopyridine N-Oxide is a useful synthetic intermediate in the synthesis of Arimoclomol Maleic Acid (A771270); an orally administered drug used to treat amyotrophic lateral sclerosis.<br>References Kurthy, M., et al.: New. York. Acad. Sci., 967, 482 (2002); Kalmar, B., et al.: Exp. Neurol., 184, 636 (2003)<br></p>

<p>Applications α-Methyl-2-piperidinemethanol-13C2 is a labelled analogue of α-Methyl-2-piperidinemethanol (M324830), which can be used in the preparation of substances with herbicidal activity. α-Methyl-2-piperidinemethanol-13C2 is also an intermediate in synthesizing 2-Acetyl-3,4,5,6-tetrahydropyridine-13C2 Hydrochloride (A188502), which is a labelled 2-Acetyl-3,4,5,6-tetrahydropyridine (A188500), the most important bread flavor component.<br>References Buttery, R.G., et al.: J. Agric. Food Chem., 43, 1878 (1995)<br></p>

<p>Applications N-(Benzyloxycarbonyl)-4-piperidone<br></p>

<p>Applications Boronic acid derivatives and their binding affinities with diols.<br>References Yang, W., et al.: Bioorg. Med. Chem. Lett., 12, 2175 (2002), Yang, W., et al.: Med. Res. Rev., 23, 346 (2003),<br></p>

<p>Applications N-Acetyl-3-acetoxy-5-phenylpyrrole (cas# 100750-39-8) is a compound useful in organic synthesis.<br></p>

<p>Applications 2-[(5-Benzyloxypyridin-2-yl)methylamino]ethanol-d4 (cas# 1794786-87-0) is a compound useful in organic synthesis.<br></p>

<p>Applications 1,4-Bis(tert-boc)piperazine-d8 (cas# 1246816-49-8) is a compound useful in organic synthesis.<br></p>

<p>Applications Octahydro-6-(phenylmethyl)-1H-Pyrrolo[3,4-b]pyridine-d4 is an isotope labelled intermediate in the synthesis of moxifoxacin (M745000), a fluorinated quinolone antibacterial.<br>References Somisetti, N. et al.: Org. Chem. Indian J., 7, 123 (2011);<br></p>

<p>Applications 1-Propylpiperazine dihydrobromide (cas# 64262-23-3) is a useful research chemical.<br></p>

<p>Applications 4-Chloropyridine-2-carboxamide, is a versatile building block used in synthesis of various chemical compounds.<br></p>

<p>Applications 2-Butyl-5-hydroxy-1H-imidazole (cas# 1026802-97-0) is a compound useful in organic synthesis.<br></p>

<p>Applications N6-(2-Chloro-6-methyl-4-pyrimidinyl)-2-methyl-4,6-quinolinediamine is an intermediate in the synthesis of NSC 23766 (N900280), which is a highly soluble and membrane permeable Rac GTPase inhibitor. NSC 23766 inhibits Rac GTPase by targeting Rac activation by guanine nucleotide exchange factor (GEF). NSC 23766 has been shown to inhibit the anchorage-independent growth and invasion phenotypes of human prostate cancer PC-3 cells.<br>References Gao, Y., et. al.: Proc. Natl. Acad. Sci. U.S.A., 101, 7618, (2004); Akbar, H., et. al.: Methods Enzymol, 406, 554 (2006)<br></p>

<p>Applications tert-Butyl 4-(2-(2-Oxoimidazolidin-1-yl)ethyl)piperazine-1-carboxylate is an intermediate in the synthesis of N1-[2-(1-Piperazinyl)ethyl]-1,2-ethanediamine (P481230), which is an impurity of Diethylenetriamine (D444255); a compound that is used in biological studies for polyamines inhibition to carbonic anhydrases by anchoring to the zinc-coordinated water molecule.<br>References Carta, F., et al.: J. Med. Chem., 53, 5511(2010)<br></p>

<p>Applications 2-Hydroxy-4-(trifluoromethyl)pyrimidine (cas# 104048-92-2) is a compound useful in organic synthesis.<br></p>

<p>Applications N-Boc-pyrrolidine is a boc-protected cyclic amine used as a building block in the preparation of diastereomers by usually undergoing α'-lithiations and electrophilic substitution reactions.<br>References Beak, P. et al.: J. Org. Chem., 58, 1109 (1993);<br></p>

<p>Applications 2-Bromopyridine n-oxide hydrochloride<br></p>

<p>Applications 2-Amino-4,6-dihydroxy-5-nitropyrimidine (cas# 80466-56-4) is a compound useful in organic synthesis.<br></p>

<p>Applications 2-[(4-Bromophenyl)methyl]-4,5-dihydro-4,4-dimethyloxazole is an intermediate used in the synthesis of Bilastine-d6 (B385002), which is labelled Bilastine. It is a novel, nonsedating H1-antihistamine developed for symptomatic treatment of allergic rhinitis and chronic idiopathic urticaria.<br>References Van Cauwenberge, P., et al.: Clin. Exp. Allergy, 30, 891 (2000), Bauchau, V., et al.: Eur. Respir. J., 24, 758 (2004), Lehman, J., et al.: Drugs, 66, 2309 (2006),<br></p>

<p>Applications 2-(Tetrazol-1-yl)acetic Acid-13C2,15N is a reactant used in the preparation of labelled β-lactam antibiotics.<br>References Nys, P. et al.: App. Biochem. Biotech., 88, 221 (2000); Won, J. et al.: App. Biochem. Biotech., 69, 1 (1998); Kostadinov, M. et al.: App. Biochem. Biotech., 33, 177 (1992)<br></p>

<p>Applications 2,2,5,5-Tetramethyl-3-amino-pyrrolidine-1-oxyl Free Radical is a highly reactive spin-label compound.<br></p>

<p>Applications 3-Bromopyridine-d4 is the isotope labelled analog of 3-Bromopyridine (B686740). Pyridine as novel substrate for regioselective oxygenation with aromatic peroxygenase from Agrocybe aegerita.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Colby, J., et al.: Biochem. J., 165, 395 (1977), Damani, L., et al.: Xenobiotica, 12, 527 (1982), Balzarini, J., et al.: J. Antimicrob. Chemother., 55, 135 (2005),<br></p>

<p>Applications An intermediate for the synthesis of labelled thiazolidinedione anti-diabetic drugs<br>References Cantello, B., et al.: Bioorg. Med. Chem. Lett., 4, 1181 (1994),<br></p>

<p>Applications Used in the preparation of piperazine-1-carboxamide derivatives as fatty acid amide hydrolase (FAAH) inhibitors.<br>References Glorius, F., et al.: Org. Biomol. Chem., 3, 4171 (2005),<br></p>

<p>Applications Reactant in the preparation of CB1 cannabinoid receptor agonists and brain imaging agents.<br>References Deng, H. et al; J. Med. Chem. 48, 6386 (2005)<br></p>

<p>Applications 2-Oxo-N-(pyridin-4-yl)butanamide is an intermediate in synthesizing 2-Hydroxy-N-(pyridin-4-yl)butanamide (H953495). It is a is a useful synthetic intermediate.<br></p>

<p>Applications 5-Nitro-1H-imidazole-1-ethanol-d4 (cas# 1794791-19-7) is a compound useful in organic synthesis.<br></p>

<p>Applications 5-Hydroxy-6-methyl-4-[[(4-methylphenyl)imino]methyl]-3-pyridinemethanol-d5 is an intermediate in the synthesis of labelled Pyridoxal phosphate.<br>References Sharif, S., et al.: J. Am. Chem. Soc., 129, 4440 (2007);<br></p>

<p>Applications 4-Chloro-2,6-dimethoxypyrimidine (cas# 6320-15-6) is a compound useful in organic synthesis.<br></p>

<p>Applications 3-Bromo-4-formyl-2,5-dihydro-2,2,5,5-tetramethyl-1H-pyrrol-1-yloxy is an intermediate in the synthesis of highly active spin labelling reagents.<br>References Kalaim, T., et al: Synthesis., 10, 1702 (2010); Fawzi, N.L., et al.: J. Biomolec. NMR., 51, 105 (2011);<br></p>

<p>Stability Moisture Sensitive<br>Applications 4-Piperidinopiperidine-1-carbonyl Chloride is used as a reagent in the synthesis of Irinotecan Hydrochloride Trihydrate (I767500); a DNA topoisomerase inhibitor.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Kunimoto, T., et al.: Cancer Res., 47, 5944 (1987); Shimada, Y., et al.: J. Clin. Oncol., 11, 909 (1993)<br></p>

<p>Applications 5-Chloro-4-(3-pyridinyl)-2-pyrimidinamine is an intermediate in the synthesis of 3-((5-Chloro-4-(pyridin-3-yl)pyrimidin-2-yl)amino)-4-methyl-N-(3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)benzamide (C179120), an impurity of Nilotinib (N465300), which might be useful in treatment of chronic myelogenous leukemia.<br>References Corbin, A., et al.: J. Biol. Chem., 277, 32214(2002), Golemovic, M., et al.: Clin. Cancer Res., 11, 4941 (2005), Gleixner, K., et al.: Blood, 107, 752 (2006), Nicolini, F., et al.: Leukemia, 20, 1061 (2006),<br></p>

<p>Applications (S)-1-Nitrosopiperidin-3-ol-d4 is an intermediate in synthesizing Ibrutinib-d4 (I124971), a labelled analogue of Ibrutinib (I124970). Ibrutinib is a highly selective Bruton’s tyrosine kinase (Btk) irreversible inhibitor.<br>References MacGlashan, D., et. al.: Int. Immunol., 11, 475 (2011)<br></p>

<p>Applications 2-(n-Butyl-d9-amino)-4-chloro-6-cyclopropylamino-1,3,5-triazine (cas# 1189997-37-2) is a compound useful in organic synthesis.<br></p>

<p>Applications 1-Benzyl-3-(3-(dimethylamino)propoxy)-1H-pyrazole-5-carboxylic Acid Hydrochloride is an intermediate for the synthesis of CFM 1571 Hydrochloride (C291720), which acts as a soluble guanylyl cyclase (sGC) activator while ignoring adenylyl cyclase. Inhibits collagen-stimulated platelet aggregation in vitro.<br>References Kotzki, S. et al.: J. Pharm. Exp. Ther., 346, 424 (2013); Selwood, D&gt; et al.: J. Med. CHem., 44, 78 (2001)<br></p>

<p>Applications 3-Bromo-2-cyanopyridine (cas# 55758-02-6) is a compound useful in organic synthesis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications Intermediate in the preparation of GABAA receptor agonists used in antidepressants.<br>References Jones, P., et al.: Bioorg. Med. Chem. Lett., 16, 872 (2006), Baraldi, P., et al.: J. Med. Chem., 50, 374 (2007),<br></p>

<p>Applications 2-Cyano-3-chloropyridine (cas# 38180-46-0) is a compound useful in organic synthesis.<br></p>