Heterocycles with Nitrogen (N)

<p>Applications Used in the preparation of Ifosfamide and Ifosfamide analogs.<br></p>

<p>Applications α,α,1,6-Tetramethyl-3-piperidinemethanol, has shown to be able to facilitate new modes of reactivity via constrictive binding in a supramol.-assembly-catalyzed aza-Prins cyclization.<br>References Kaphan, D. M., et al.: Journal of the American Chemical Society, Vol. 137, P: 9202-9205 (2015);<br></p>

<p>Applications Methyl 5-Bromo-1H-pyrrole-2-carboxylate is a chemical reagent used in pharmaceutical synthesis.<br>References Wang, M. et al.: Org. Biomol. Chem., 11, 2574 (2013); Xiang, H. et al.: RSC Adv., 3, 5807 (2013);<br></p>

<p>Applications 6-cyclopropyl-2-oxo-1,2-dihydropyridine-4-carboxylic acid (cas# 150190-28-6) is a useful research chemical.<br></p>

<p>Applications 2-ETHYNYLPYRIDINE (cas# 1945-84-2) is a useful research chemical.<br></p>

<p>Applications 1-(4-Chlorophenyl)pyrazole-4-carboxylic Acid (cas# 138907-80-9) is a useful research chemical.<br></p>

<p>Applications 3,5-Dimethyl-1-phenyl-1H-pyrazole is a reactant used in the synthesis of hedgehog enzyme inhibitors SANT-1 and GANT-61 as anticancer agents.<br>References Chenna, V., et. al.: J. Environ. Sci. Heal. A., 49, 641 (2014)<br></p>

<p>Applications A useful synthetic intermediate.<br></p>

<p>Applications A stable and versatile reagent for the efficient and chemically specific guanylation of sterically unhindered primary and secondary aliphatic amines under mild conditions. Useful reagent in peptide synthesis.<br>References Baslow, M., et al.: J. Inherit. Metab. Dis., 23, 684 (2000), Lee, Y., et al.: Bioorg. Med. Chem. Lett., 10, 2771 (2000), Baslow, M., et al.: Neurochem. Res., 27, 403 (2002),<br></p>

<p>Applications 5-(4’-Benzyloxyphenyl)-2-oxazolidone (cas# 88693-98-5) is a compound useful in organic synthesis.<br></p>

<p>Applications (3S,​4S)​-​4-​Hydroxy-​3-​pyrrolidinyl Carbamic Acid 1,​1-​Dimethylethyl Ester was used as a chiral pyrrolidine to sense chirality with a liquid crystalline dynamic helical poly(phenylacetylene) bearing ethyl phsophonate pendant groups.<br>References Morimoto, M., et al.: J Polym Sci, 48, 1383 (2010).<br></p>

<p>Applications 6-Methyl-2,3'-bipyridine (cas# 78210-78-3) is a useful research chemical.<br></p>

<p>Applications 4-Chloro-1H-imidazo[4,5-c]pyridine is used as a reagent in the synthesis of 3-bromo-3-deazaneplanocin and 3-bromo-3-deazaaristeromycin, compounds which exhibit antiviral activity.<br>References Liu, Ch., et al.: Bioorg. Med. Chem. Lett., 22, 5182 (2012)<br></p>

<p>Applications rac-α-N-Boc-Amino-4-pyridineaceic Acid is a reagent used in the preparation of lactam-containing diaminoalkanes, β/α-amino acids and derivatives of Xa inhibitors.<br></p>

<p>Stability Light Sensitive<br>Applications 5-Bromo-2-iodopyridine is used to prepare substituted (pyridin-​3-​yl)​phenyloxazolidinones as antibacterial agents. It is also used to synthesize indole-​based bisamidine antibiotics.<br>References Reck, F., et al.: J. Med. Chem., 50, 4868 (2007); Williams, J., et al.: Bioorg. Med. Chem., 21, 7790 (2013)<br></p>

<p>Applications 4-Bromo-1H-1,2,3-triazoleare an important class of organic compounds, playing an important role in modern medicinal chemistry. Compounds with 1,2,3-triazole moieties are known to possess fungicidal, antimicrobial, antidepressant, antibacterial, anti-inflammatory, analgesic and antitumor activities.<br>References Sibgatulin, D. A., et al.: Synthesis, No. 7, 1075 (2010); Karivopalov, V. P., et al.: Chem. Rev. (Engl. Trans), 74, 339 (2005);<br></p>

<p>Applications 2-Amino-5-bromopyrazine-3-carboxylic Acid Methyl Ester is used as the starting material in the preparation of pyrazine derivatives that are AxI and c-Met receptor enzyme inhibitors. These inhibitors are useful in the treatment of tumors. 2-Amino-5-bromopyrazine-3-carboxylic Acid Methyl Ester is also used in the preparation of potent and selective inhibitors of ataxia telangiectasia mutated and Rad3 related (ATR) protein kinase as potential anticancer agents.<br>References Rushton, L.; et al.: PCT Int. Appl. 119 pp. Patent 2009 CODEN:PIXXD2; Charrier, J-D.; et al.: J. Med. Chem, 54, 2320 (2011)<br></p>

<p>Applications 2,5-Dioxopyrrolidin-1-yl dodecanoate (cas# 14565-47-0) is a useful research chemical.<br></p>

<p>Applications 2-[[6-Amino-5-(4-bromophenyl)-4-pyrimidinyl]oxy]-ethanol is a degradation product of Macitentan (M105005).<br>References Thummar, Mohit, et al.: Chromatographia, 81(3), 525-531 (2018)<br></p>

<p>Applications An intermediate for the preparation of isotope Labelled Haloperidol.<br></p>

<p>Applications 3-Chloro-6-ethynylpyridazine is an pyridazine triflate intermediate used for the preparation of (alkynyl)pyridazine.<br>References Toussaint, D., et al.: Acta. Chimica, Slovenica., 41, 253 (1994);<br></p>

<p>Applications N-[4-(Aminocarbonyl)phenyl]-2-methyl-4-oxazolecarboxamide (cas# 1119444-26-6) is a compound useful in organic synthesis.<br></p>

<p>Applications 6-Chloro-2,3-dimethoxypyridine (cas# 1087659-30-0) is a useful research chemical.<br></p>

<p>Applications 1H-1,2,4-triazol-5-ol (cas# 930-33-6) is a useful research chemical.<br></p>

<p>Applications bis(4-(2-Methoxyphenyl)piperazine-1-carboximidamide) Sulfuric Acid is an aminopyrimidines derivatives that are used as glycogen synthase kinase 3 inhibitors<br>References Nuss, John M. et al., U.S. Pat. Appl. Publ. (2002)<br></p>

<p>Applications 5-Bromo-2-(N-methylamino)pyridine is useful for the synthetic preparation of halo aminopyridines.<br>References Sun, C., et al.: ACS Omega, 4, 10534 (2019)<br></p>

<p>Applications Ethyl 1-(4-(aminosulfonyl)phenyl)-3-(trifluoromethyl)-5-p-tolyl-1h-pyrazole-4-carboxylate<br></p>

<p>Applications 1-Phenyl-3-pyrrolidinone-d5 is the isotope labelled analog of 1-Phenyl-3-pyrrolidinone (P336730); a reagent used in the synthesis of a series of non-classical antifolates which were evaluated for their in vitro cytotoxicity. Also used in the preparation of azetidine- and pyrrolidine-containing alkynes as mGluR5 regulators.<br>References Huang, Y., et al.: Bioorg. Med. Chem., 11, 145 (2003); Chen, L., et al.: PCT Int. Appl. WO 2014124560 A1 20140821. Aug 21, 2014<br></p>

<p>Applications tert-butyl 4-(5-bromo-1H-indazol-3-yl)piperidine-1-carboxylate (cas# 1198284-77-3) is a useful research chemical.<br></p>

<p>Applications 5-(4-Bromophenyl)-4,6-dichloropyrimidine is a reactant used in the synthesis of Macitentan, an orally active dual endothelin receptor antagonist.<br>References Bolli, M. et al.: J. Med. Chem., 55, 7849 (2012);<br></p>

<p>Applications Imidazo[1,2-a]pyridine-6-boronic acid is a useful intermediate for organic synthesis and other pharmaceutical processes.<br>References Gonzalez C., et al.: J. Med. Chem., 55, 11022 (2012); Cooper, A. B., et al.: Bioorg. Med. Chem. Lett., 27, 4471 (2017)<br></p>

<p>Applications 4-Hydroxypiperidine-d9 is labelled 4-Hydroxypiperidine (H950845) which is used as a reagent for the synthesis of acridine (A190900) derivatives and fibrinogen receptor antagonists.<br>References Yang, D. et al.: Macromol., 35, 5304 (2002); Harrison, R.J. et al.: Bioorg. Med. Chem. Lett., 9, 2463 (1999)<br></p>

<p>Applications 4-Cyclohexyl-2-piperidinecarboxylic Acid is a compound useful in organic synthesis.<br></p>

<p>Applications 6-methyl-2-oxo-4-[(5,6,7,8-tetrahydronaphthalen-2-yl)amino]-1,2-dihydropyridine-3-carboxylic acid (cas# 1239521-17-5) is a useful research chemical.<br></p>

<p>Applications 5-Bromo-1-[2-Fluoro-6-(trifluoromethyl)benzyl]-6-methylpyrimidine-2,4(1H,3H)-dione is an intermediate in the synthesis of Elagolix, a gonadotropin-releasing hormone antagonist (GnRH) used in the treatment of endometriosis.<br>References Tukun, F. et al.: Molecules, 22, 12 (2017);<br></p>

<p>Applications 6-methyl-2-oxo-5-phenyl-1,2-dihydropyridine-3-carboxylic acid (cas# 10176-79-1) is a useful research chemical.<br></p>

<p>Applications 6-Bromo-2-fluoropyridin-3-ol (cas# 850142-72-2) is a useful research chemical.<br></p>

<p>Stability Light Sensitive<br>Applications A reagent for the determination of aldehydes and other reactive chemicals.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Dickinson, R.G. and Jacobsen,N.W. : Chem. Commun., 1719, (1970), Del Nozal, M.J. et al.: J. Liq. Chromatography, 16, 1105 (1993),<br></p>

<p>Applications 2-(Difluoromethoxy)pyridin-4-amine (cas# 1211587-46-0) is a useful research chemical.<br></p>

<p>Applications 5-Nitro-2-(propylthio)pyrimidin-4-ol is an intermediate used in the synthesis of 4-Chloro-5-nitro-2-(propylthio)pyrimidine (C374095), which is an impurity of the drug Ticagrelor (T437700), the first reversible oral P2Y12 receptor antagonist, provides faster, greater, and more consistent ADP-receptor inhibition than Clopidogrel. Ticagrelor is used in the treatment of acute coronary syndromes (ACS).<br>References Matetzky, S., et al.: Circulation, 109, 3171 (2004), Bassand, J., et al.: Eur. Heart J., 28, 1598 (2007), Jakubowski, J., et al.: Cardiovasc. Drug Rev., 25, 357 (2007)<br></p>

<p>Applications 2-​(Methoxy-​d3)​-​3-​(1-​methylethyl)​pyrazine is a useful compound in the study of isotope effect in gas liquid chromatography separation of deuterated and nondeuterated compounds using ionic liquid stationary phases.<br>References Schmarr, H., et al.: J. Chromatogr. A., 1270, 310 (2012);<br></p>

<p>Applications 1-(2-Fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-carboxylic Acid Ethyl Ester is used in various studies of stimulators of soluble guanylate cyclase.<br>References Straub, A., et al.: Bioorg. Med. Chem. Lett., 11, 781 (2001); Mittendorf, J., et al.: ChemMedChem, 4, 853 (2009); Straub, A., et al.: Bioorg. Med. Chem., 10, 1711 (2002)<br></p>

<p>Applications 2,5-Diamino-4,6-dichloropyrimidine is a useful reagent for the preparation of Abacavir impurities, carbocyclic and hexenopyranosy nucleosides.<br>References Satyanarayana, G. V., et al.: Pharma Chemica, 7, 90 (2015)<br></p>

<p>Applications 6-(1H-1,2,4-triazol-1-yl)pyrimidin-4-amine (cas# 1221974-59-9) is a useful research chemical.<br></p>

<p>Applications OXAZOLE-5-CARBOXYLIC ACID HYDRAZIDE (cas# 885274-30-6) is a useful research chemical.<br></p>

<p>Applications 4,5-Dicyanoimidazole is commonly used in activation of nucleoside phosphoramidites during solid-phase oligonucleotide synthesis, and synthesis of nucleoside phosphoramidites, synthesis of novel nucleosides. IT is often used as an alternative to Tetrazole (T307500).<br>References Vargeese, C., et al.: Nucleic Acid Res.,  26 1046 (1998); Jin, Y., et al.: Tetrahedron Lett., 37, 973 (1996); Lackey, J., et al.: J. Am. Chem. Soc., 131, 8496 (2009)<br></p>

<p>Applications 3-(piperidin-4-yl)-6-(pyrrolidin-1-yl)pyridazine (cas# 1955520-87-2) is a useful research chemical.<br></p>

<p>Applications 5-(3-fluorophenyl)-4H-1,2,4-triazol-3-amine (cas# 502685-67-8) is a useful research chemical.<br></p>

<p>Applications 6-(4-(hydroxymethyl)piperidin-1-yl)pyridazine-3-carboxylic acid (cas# 1178931-24-2) is a useful research chemical.<br></p>

<p>Applications 1-isobutyl-1H-pyrazole-3-carboxylic acid (cas# 1006493-64-6) is a useful research chemical.<br></p>