Building Blocks

<p>6-Iodopyrimidine-2,4-diamine is an alkynyl compound that can be synthesized efficiently via a cross-coupling reaction. It has cytostatic activity and can be used in the treatment of cancer cells. 6-Iodopyrimidine-2,4-diamine inhibits the growth of cells by binding to DNA and preventing synthesis of proteins. This chemical also reacts with DNA to form covalent bonds, which prevents the replication of cells.</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>2-Bromo-6-(chloromethyl)pyridine is a ligand that binds to transition metal ions. It has been shown to have a high affinity for thionyl, which is an endogenous substrate. The ligand has also been used in the immobilization of biomolecules, such as proteins and DNA. The ligand has been synthesized by reacting cyanuric chloride with 2-bromopyridine. This method is different from the traditional synthetic pathway, which typically involves reacting chloroform with methyl bromide in the presence of a base or acid. The synthesis of this ligand can be done using two methods: (1) reaction of histidine with hydroxylamine hydrochloride and methyl bromide; or (2) reaction of methylamine with ethyl chlorocarbonate and 1,4-diazabicyclo[2.2.2]octane.</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>N-Cyclopentylthiourea is an inhibitor of the NS3 protease that is involved in hepatitis C virus (HCV) replication. It has been shown to inhibit the activity of NS3 protease in vitro and in cell-based assays. N-Cyclopentylthiourea inhibits the enzyme by binding to its active site and blocking access to the substrate. It has also been shown to be effective against hepatitis B virus (HBV) replication, although it is not active against HIV or influenza A. This drug also has anti-inflammatory properties, which may be due to its inhibition of cyclooxygenase and nitric oxide synthase enzymes.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

5-Methylnaphthalen-1-amine is a member of the naphthalene family. The compound is permeable to phospholipid membranes and can be used as a model for membrane penetration by drugs. It has been shown to form reactive carbocations with electron-deficient compounds, such as methoxy groups and nucleophilic compounds, which are useful in synthesizing new molecules. This molecule also has high thermal stability, making it an excellent candidate for techniques that require elevated temperatures, such as microwave-assisted synthesis.

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

(2E)-3-(3-Methylthiophen-2-yl)prop-2-enoic acid is a naturally occurring compound with two stereoisomers, the cis and trans isomers. The cis isomer has been found to have the same physiological properties as pyrantel, while the trans isomer has been shown to be resistant to alkaline hydrolysis. (2E)-3-(3-Methylthiophen-2-yl)prop-2-enoic acid can be isolated from plants by using chromatographic techniques that separate it from other compounds with similar structures. This compound also has a homolog, (4R)-4-(3,5,-dimethylphenyl)butanoic acid, which can be synthesized in the laboratory.

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

Fadrozole is an inhibitor of the enzyme aromatase, which converts androgens to estrogens. It is used in combination with other drugs to treat breast cancer in postmenopausal women and prostate cancer in men. The molecular basis for the inhibitory properties of fadrozole is its ability to bind to the dinucleotide phosphate-binding site of aromatase, thereby inhibiting its activity. Fadrozole inhibits the production of estrogens by competitively binding to the enzyme's active site. The inhibitory effect of fadrozole on aromatase activity has been demonstrated in experimental models and provides a possible explanation for its use in combination with other drugs for breast and prostate cancer treatment.

Versatile small molecule scaffold

4-Propylcyclohexylamine is a versatile compound that finds applications in various industries. It is commonly used as a building block in the synthesis of copolymers, catalysts, and triazine derivatives. This compound exhibits excellent reactivity in organometallic reactions and can act as a pyridinium scavenger. With its high isolated yield and particulate nature, it is ideal for research purposes and as a reagent for the activation of cellulose.

Versatile small molecule scaffold

<p>2,5-Dichloroisonicotinonitrile is a tyrosine kinase inhibitor that is used to treat autoimmune diseases. The compound inhibits the function of the enzyme tyrosine kinase by binding to its ATP binding site. 2,5-Dichloroisonicotinonitrile is also a potent antibacterial agent with activity against both Gram-positive and Gram-negative bacteria. It has been shown to be active against Mycobacterium tuberculosis, methicillin-resistant Staphylococcus aureus (MRSA), and Clostridium perfringens. The drug can cause adverse effects such as pulmonary fibrosis and thyroiditis in animal studies.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>1-Amino-1H-benzo[D]imidazol-2(3H)-one is a heterocyclic compound that belongs to the group of 4-azaindole, chromic acid, substituents, oxidized. It has been shown to be an effective inhibitor of thiosemicarbazones and pyrrole in vitro. Additionally, this compound inhibits bacterial growth by binding to DNA gyrase and topoisomerase IV enzymes. This drug is also being studied as a potential treatment for cancer.</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

3,9-diazabicyclo[4.2.1]nonane, 9-methyl (DZB) is a spasmolytic drug that belongs to the group of aliphatic, aromatic acids, lactams and amides. It has been shown to have spasmolytic activity in animal experiments and has been used as an analgesic in humans. DZB is an analogue of 3,9-diazabicyclo[4.2.1]nonane (DZN) and is synthesized by reacting the corresponding sulfonyl chloride with a primary amine under acidic conditions followed by reduction with sodium borohydride or lithium aluminum hydride to yield the corresponding N-sulfonyl amide. This reaction can also be carried out using chlorosulfonic acid in place of sulfuric acid and an excess of primary amine over sulfonyl chloride.

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

1-Amino-1-phenylpropan-2-ol hydrochloride is an enantioselective, chiral amino alcohol that is synthesized by the reaction of aldehydes or ketones with phenylmagnesium bromide. This reaction yields the corresponding amino alcohols in high yields and with excellent enantioselectivity. 1-Amino-1-phenylpropan-2-ol hydrochloride can be used to synthesize various functional groups such as halides, oxazoline, diselenides, sulfonamides and alkenes. It can also be used for catalytic transformations involving other functional groups such as alcohols and alkyl halides.

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>5-Carboxyoxindole is a synthetic compound that has been shown to be cytotoxic in vitro and in vivo. It has been found to bind to the DNA of cancer cells, preventing DNA synthesis and replication, resulting in cell death. The mechanism of 5-carboxyoxindole is not completely understood but it has been suggested that it inhibits the production of ATP, leading to cell death. Techniques used to synthesize this compound include multistep reactions with yields up to 69%. These reactions are typically carried out at room temperature, although they can also be performed under reflux or microwave conditions.</p>

Versatile small molecule scaffold

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>2-Azido-1,3-difluorobenzene is a photoactive compound that can be used to form an azide. It has been shown to undergo photochemical reactions to form the triplet state and then isomerize to the singlet state. This reaction can be initiated by a laser beam or other light source, such as sunlight. The triplet state of 2-azido-1,3-difluorobenzene has been shown to react with organic molecules containing electron withdrawing groups on their molecules, such as 2-methoxy-2-methylpropane. When these two substances are mixed together, they react to form an isomerized product that has a carbonyl group in its structure. This reaction could be helpful for developing new synthetic methods for producing pharmaceuticals and other compounds with important functions in chemistry and physics.</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

Versatile small molecule scaffold