Building Blocks

<p>Applications Ferulic Acid Methyl Ester is a derivative of Ferulic Acid (F308900), used as an antioxidant and food preservative. It has less antioxidant capacity than ferulic acid.<br>References Smart, M.G., et al.: Aust. J. Plant Physiol., 6, 485 (1979), Chen, C., et al.: J. Food Lipids, 2, 35,1995, Benzie, I., et al.: Anal. Biochem. 239, 70 (1996), Nardini, M., et al.: Food Chem., 79, 119 (2002), Lee, J., et al.: J. Agric. Food Chem., 52, 2647 (2004),<br></p>

<p>Applications 5,7-Dimethoxycoumarin is a derivitized coumarin compound.<br></p>

<p>Applications (±)-Warfarin Sodium, an anticoagulant drug product.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Nguyenpho, A., et al.: J. Pharm. Sci., 104, 4232-4240, (2015)<br></p>

<p>Applications 2-(2-Nitrophenyl)malondialdehyde (cas# 53868-44-3) is a useful research chemical.<br></p>

<p>Applications N,N-Dicyclohexylmethylamine is used as a reagent in the base preparation of 13C2- and 2H phenethylamines as internal standards for IDMS by Pd-catalyzed double carbonylation of aryl iodides in the presence of amine nucleophiles followed by deoxygenation.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Nielsen, D., J. Org. Chem., 74, 6155 (2012)<br></p>

<p>Applications An Intermediate in the synthesis of risperidone and iloperidone.<br></p>

<p>Applications Ethylenediamine Dihydrochloride (cas# 333-18-6) is a useful research chemical.<br></p>

<p>Stability Hygroscopic<br>Applications 3-Amino-3-azabicyclo[3,3,0]octane is used as a reactant in the synthesis of Gliclazide (G409875), a sulfonylurea hypoglycemic agent. Used as an antidiabetic.<br>References Duhault, J., et al.: Arzneimittel-Forsch., 22, 1686 (1972); Holmes, B., et al.: Drugs, 27, 301 (1984)<br></p>

<p>Applications Z-2-Fluoro-3-(3-pyridyl)acrylic Acid (cas# 359435-42-0) is a compound useful in organic synthesis.<br></p>

<p>Applications 5,5-Dimethyl-1,3-dioxane is used in preparation of Neopentyl Glycol.<br>References Cao, S., et al.: Faming Zhuanli Shenqing, (2013);<br></p>

<p>Applications Phytosphingosine is a natural anti-microbial compound and it is involved in several cellular processes such as cell differentiation and anti-inflammation.<br>References Chuong, C., et al.: Exp. Dermatol., 11, 159 (2002), Bustin, S., et al.: J. Mol. Endocrinol., 29, 23 (2002), Kim, S., et al.: Mol. Med., 12, 17 (2006), Pavicic, T., et al.: Int. J. Cosmetic Sci., 29, 181 (2007),<br></p>

<p>Applications β-(m-Hydroxyphenyl)hydracrylic Acid is a urinary metabolite of phenylalanine from the Clostridium gram-positive bacteria cell line. Urinary metabolite of Rutin (R701800), a capillary protectant in plants.<br>References Harrison, et al.: J. Am. Pharm. Assoc., 39, 557 (1950), Humphreys, et al.: Econ. Bot., 18, 195 (1964), Khalifa, T.I., et al.: Anal. Profiles Drug Subs., 12, 623 (1983); Shigeo, B. et al.: J. Pharm. Sci., 72, 1155 (1983)<br></p>

<p>Applications 3'-Methylacetophenone is a reagent that is used in the preparation of 3-aryl-6-phenylimidazo[2,1-b]thiazoles which has anticancer properties.<br>References Koppireddi, S., et al.: Bioorg. Med. Chem. Lett., 24, 5428 (2014);<br></p>

<p>Applications 6-Hydroxynaphthalene-2-sulfonic Acid Potassium Salt is used the in the synthesis of azo dyes and pigments.<br>References Gao, Pu. et al., Dyes Pigm. 179, 108376(2020);<br></p>

<p>Applications 1-Piperidineethanol (cas# 3040-44-6) is a compound useful in organic synthesis.<br></p>

<p>Stability Hygroscopic<br>Applications N-[4-[(4-Hydroxyphenyl)amino]phenyl]acetamide is used in the synthesis of lithographic plates.<br></p>

<p>Applications 2-Nitrosopyridine is a useful reactant in organic synthesis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Li, Xing, et al.: J. of Org. Chem., 84(7), 4402-4412 (2019);Zhang, Jingchuan, et al.: Chem. - A Euro. J., 24(17), 4289-4293 (2018)<br></p>

<p>Applications 3-Methyl-2(5H)-furanone (cas# 22122-36-7) is a useful research chemical.<br></p>

<p>Applications A powerful complexing agent. A potent acid sphingomyelinase inhibitor.<br>References Marathe, S., et al.: J. Biol. Chem., 273, 4081 (1998), Lang, P., et al.: Nat. Med., 13, 164 (2007), Nara, F., et al.: J. Antibiot., 52, 525 (1999), Szajnman, S., et al.: Bioorg. Med. Chem. Lett., 15, 4685 (2005),<br></p>

<p>Applications A redox buffer that increases the folding rate of disulfide-containing proteins realative to traditional buffers such as glutathione and glutathione-disulfide. A useful synthetic intermediate for the preparation of novel antiinflammatory agents.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Gough, J.D., et al.: JACS, 124 (15), 3885 (2002)<br></p>

<p>Applications 6-Mercapto-1-hexanolcan be used as a chemical linker for anchoring biological molecules to gold surfaces.<br>References McKinlay, C. J. et al.: J. Am. Chem. Soc 138, 3510 (2016)<br></p>

<p>Applications (1R,5S,6R)-Ethyl 5-(Pentan-3-yloxy)-7-oxabicyclo[4.1.0]hept-3-ene-3-carboxylate is the enantiomer of Ethyl (3R,4S,5S)-4,5-Epoxy-3-(1-ethylpropoxy)cyclohex-1-ene-1-carboxylate (E917820), an intermediate of Oseltamivir.<br>References Clark, C., et al.: J. Med. Chem., 31, 831 (1988)<br></p>

<p>Applications 2-Bromo-1-propanol is used in the epoxide productions from Flavobacterium.<br>References Geigert, J., et al.: Appl. Environ. Microbiol. Applied<br></p>

<p>Applications Alizarin is used widely as a prominent red dye for textile facbrics. Alizarin red is now used in biochemical assay to determine quantitatively by colorimetry, the presence of calcific deposition by cells of the osteogenic lineage. Alzarine derivatives was evaluated as new inhibitors of the HIV-1 reverse transcriptase associated DNA polymerase and RNase H. Alizarin was also shown to inhibit proliferation, tumor growth and suppress tumorigenesis in human osteosarcoma and breast cancer cell representative for bone metastasis. Dyes and metabolites.<br>References Yuan, H.S., et al.: Mycol., 3, 100 (2012); Esposito, F. et al.: FEBS. J., 278, 1444 (2011); Fotia, Caterina, J. Orthop. Rsch. 30, 1486 (2012);<br></p>

<p>Applications Ethyl 3-bromopropionate<br></p>

<p>Applications Forest fires are actually beneficial for ecosystems, provided they don’t happen too often. After a fire, plants germinate and grow incredibly fast. KAR1 is a compound in smoke responsible for promoting the seed germination of a wide range of plant species. The researchers named the compounds “the karrikins”, for “karrik”, an aboriginal word for smoke.<br>References Sakuma, H., et al.: .Agric Biol. Chem., 45, 443 (1981), Stevens, J., et al.: Plant Soil, 298, 113 (2007), Nelson, D., et al.: Plant Physiol., 149, 863 (2009),<br></p>

<p>Stability Hygroscopic<br>Applications Nitrosophenidylate is an N-nitroso derivative of Methylphenidate Hydrochloride(M325880), which is a controlled substance (stimulant). CNS stimulant. Four isomers of Methylphenidate are known to exist. One pair of threo isomers and one pair of erythro are distinguished, from which only d-threo-Methylphenidate exhibits the pharmacologically usually desired effects. This compound is a 4:1 mixture of rac-erythro (M325670) and rac-threo (M325671).<br>References Greenblatt, E.N., et al.: J. Pharmacol. Exp. Ther., 131, 115 (1961), Padmanabhan, G.R., Anal. Profiles Drug Subs., 10, 473 (1981), Srinivas, N.R., et al.: Pharm. Res., 10, 14 (1993),<br></p>

<p>Applications Shows some anti-viral activity due to the adamantane structure. In addition it shows anti-microbial activity and cytotoxic application.<br>References Aigami, K. et al.: J. Med. Chem., 18, 713 (1975); Aigami, K. et al.: J. Pharm. Res., 4, 1407 (2011);<br></p>

<p>Impurity Terazosin EP Impurity C<br>Applications 2-Piperazinyl-4-amino-6,7-dimethoxyquinazoline (Terazosin EP Impurity C) is a metabolite of Prazosin. It is also an impurity arising in the synthesis of Terazosin (T105000).<br>References Bolognesi, M., et al.: J. Med. Chem., 44, 362 (2001), Shaw, Y., et al.: J. Med. Chem., 47, 4453 (2004), Erve, J., et al.: Drug Metab. Disposition, 35, 908 (2007), Cavalli, A., et al.: Bioorg. Med. Chem. Lett., 19, 3031 (2009),<br></p>

<p>Applications Tetrahydro-5-methyl-2-furanol is an intermediate in synthesizing 2,3-Dihydro-2-methylfuran (D447355), which is a general reagent used in next generation of biofuels. Dihydrofuranyl derivative.<br>References Simmie, J. et al.: J. Phys Chem., 116, 4528 (2012);<br></p>

<p>Stability Store Under Argon; Air Sensitive<br>Applications 4-Mercaptobenzoic Acid, Technical Grade (cas# 1074-36-8) is a compound useful in organic synthesis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications (8E)-Dodecen-1-ol is used in the study of the photochemical transformations of biologically active mono- and diene derivatives of pheromones.<br>References Sychev, A. Y., et al.: Zh. Fiz. Khim., 60, 2512 (1986)<br></p>

<p>Applications 4-Thiouracil is a derivative of Uracil (U801000), which is a nitrogenous base in RNA nucleic acid. 4-Thiouracil is used for tagging in cell type-specific RNA isolation from intact complex tissues.<br>References Miller, M., et al.: Nat. Methods, 6, 439 (2009); Seth, P., et al.: J. Med. Chem., 53, 8309 (2010); Cui, H., et al.: Eur. J. Med. Chem., 45, 5140 (2010);<br></p>

<p>Applications trans-Campestanyl Ferulate is used for synthesis of trans-feruloyl-β-sitostanol.<br>References Condo, A., et al.: J. Agric. Food Chem., 49, 4961 (2001);<br></p>

<p>Applications 2-Methylpropylboronic Acid is used in the preparation of isocoumarin analogs as inhibitors of γ-secretase cleavage. Also used in the preparation of peptide boronc acid.<br>References Peuchmaur, M. et al.: Bioorg. Med. Chem. Lett., 21, 1018 (2013); Roemmele, R. et al.: Org. Proc. Res. Devel., 17, 422 (2013);<br></p>

<p>Stability Air Sensitive, Light Sensitive<br>Applications 5-Hydroxyindole-3-acetic acid is an impurity of chlorpheniramine (C424300), an antihistaminic agent.<br>References Josko, J., et al.: Annal. Acad. Med. Siles., 66, 13, (2012); Carson, R.P., et al.: Human. Molec. Genetics., 22, 140 (2013);<br></p>

<p>Impurity Cyclophosphamide Impurity A<br>Applications A cytotoxic metabolite of Cyclophosphamide; a deuterated analog of Nor-nitrogen mustard. Cyclophosphamide Impurity A<br>References Colvin, M. et al.: Cancer Res., 36, 1121 (1976); Ludeman, S. et al.: Drug Metab Dispos., 20, 337 (1992); Ludeman, S.M. et al.: J. Pharmaceut. Sci., 84, 393 (1995); Yu, L. et al.: Drug Metab. Dispos., 24, 1254 (1996);<br></p>

<p>Applications 4-Methoxypyridine, is used as a building block for the synthesis of some biologically active compounds. It is used for the preparation of a new series of benzoylated N-ylides as protein farnesyltransferase inhibitors.<br>References Abuhaie, C. et al.: Bioorg. Med. Chem. Lett., 23, 5887 (2013);<br></p>

<p>Applications 4-Morpholineethanesulfonic Acid is used in the synthesis of nanotechnology and nanoparticles, as potential therapy towards Alzheimer’s.<br>References Liu, G. et al.: Methods. Mol. Biol., 610, 123 (2010); Neugart, F. et al.: Nano. Lett., 7, 3588 (2007)<br></p>

<p>Applications Dicyclohexyl Ketone (cas# 119-60-8) is a compound useful in organic synthesis.<br></p>

<p>Applications DL-3-phenyllactic acid had been identified as a urinary food intake biomarker for milk, cheese and soy-based drinks.<br>References Munger, L.H.; et al.: J. Proteome Res., 16, 3321 (2017)<br></p>

<p>Applications Mesitoic acid can be used for its antioxidant.<br>References Thomas, P.S., et.al.: Medicines, 4, 1-7, (2017);<br></p>

<p>Applications 4-Chlorophenyl Phenyl Sulfone is an impurity of Dapson (D193250), an antibacterial used in the treatment of dermatitis herpetiformis.<br>References Dong, X.W., et al.: Bioorg. Med. Chem., 16, 8151 (2008); Schafer, E., et al.: Arch. Environ. Contamin. Toxicol., 12, 355 (1983);<br></p>

<p>Applications (-)-Form is a pyrolysis product of cellulose and cellulose-containing materials including pulp and paper waste products.Known as a pyrolytic product of cellulose, its very useful as a chiral source for synthesizing natural products because of its highly functionalized structure, which contains one chiral center. Used as chiral building block in organic synthesis.<br>References Essig, M.G., et al.: Carbohydr. Res., 156, 225 (1986), Taniguchi, T., et al.: Synlett, 971 (1996),<br></p>

<p>Applications A food metabolite.<br></p>

<p>Applications Tris(2-(2-methoxyethoxy)ethyl)amine (cas# 70384-51-9) is a useful research chemical.<br></p>

<p>Applications 4-Chloromethyl-2,2-dimethyl-1,3-dioxolane is used in biosynthetic preparations.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Spelberg, J.H., Tetrahedron, Asy., 10, 2863 (1999);<br></p>

<p>Applications Formamidine Sulfuric Acid is a reagent used in reduction and synthesis reactions.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Ma, Q. et al.: Carbon, 54, 36 (2013);<br></p>

<p>Applications α-Isopropylbenzylamine Hydrochloride is used in the synthetic preparation of arylalkylamines by addition of Grignard reagents to phosphorylaldimines.<br>References Zwierzak, A., Napieraj, A.: Synthesis, 6, 930 (1999)<br></p>

<p>Applications N-Nitrosohexamethylenimine is a carcinogen.<br>References Goodall, C. M., et al.: Toxicology, 33, 251 (1984); Lijinsky, W., et al.: J. Cancer Res. Clin. Oncol., 108, 46 (1984); Goodall, C. M., et al.: JNCI, J. Natl Cancer Inst., 73, 1215 (1984)<br></p>

<p>Applications Bis(2-butoxyethyl) 2-Hydroxyethyl Phosphate Triester is a metabolite of Tris(2-butyloxyethyl)phosphate (T875030), which is an organophosphate, that can be used in the preparation of flame retardant, such as viscose fiber.<br>References Wang, Y., et al.: Fangzhi Xuebao, 33, 16 (2012); Xiaoshan, L. et al.: Aquatic Toxicology, 114, 173 (2012);<br></p>

<p>Applications N-(2,6-Diisopropylphenylcarbamoylmethyl)iminodiacetic Acid (cas# 65717-97-7) is a compound useful in organic synthesis.<br></p>

<p>Applications N-(2-hydroxyethyl)benzamide (cas# 18838-10-3) is a useful research chemical.<br></p>

<p>Applications 1,3-Diphenylacetone (cas# 102-04-5) is a useful research chemical.<br></p>

<p>Applications Thymol O-β-D-Glucuronide is a glucuronide derivative of Thymol (T413000); an antimicrobial compound which can increase the efficacy of antibiotics involving drug resistant bacteria. It inhibits growth and lactate production as well as reduces cellular glucose uptake within the bacteria.<br>References Palaniappan, K. et al.: Int. J. Food Microbiol., 140, 164 (2010); Evans, J. et al.: Curr. Microbiol., 41, 336 (2000)<br></p>

<p>Stability Hygroscopic<br>Applications Diazolidinyl urea is an antimicrobial agent.<br></p>

<p>Applications A basic 5-membered aromatic heterocycle used as a building block for more complex pharmaceutical compounds. There have been recent studies that showed antitumor, antiinflammatory, analgesic, antifungal, antibacterial and antiviral activities in bioactive triazoles.<br>References Pibiri, I. et al.: Curr. Bioact. Comp., 6, 208 (2010);<br></p>

<p>Applications O,N-Aminomethanylylidene-β-D-arabinofuranose (cas# 27963-98-0) is a compound useful in organic synthesis.<br></p>

<p>Applications 3-BROMOPHENANTHRENE (cas# 715-50-4) is a useful research chemical.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications Diphenylacetylene is a reagent used in the preparation of polysubstituded pyrroles via oxidative nitrene transfer. Also used in the aerobic coupling of salicyaldehydes with alkynes.<br>References Dewan, A. et al.: ACS Omega, 3, 5327 (2018); Yamane, S. et al.: Chem. A Eur. J., 24, 7852 (2018);<br></p>

<p>Applications Triethyl Methanetricarboxylate is used in the synthesis of novel inhibitors of Hsp90. It is also used in the preparation of novel dihydroquinoline-3-carboxylic acids that function as HIV-1 integrase inhibitors.<br>References Day, J. et al.: Chem. A Eur. J., 16, 2758 (2010); Sechi, M. et al.: Bioorg. Med. Chem., 17, 2925 (2009);<br></p>

<p>Applications Methyl 9-octadecenoate can be found in biodiesel synthesized from rocket seed oil. Rocket seed oil commonly used as a lubricant in soap. Methyl 9-octadecenoate is an environmental and food contaminant.Environmental contaminants; food contaminants.<br>References Muhammad, T., et al.: Fuel Sci. Technol. 92, 336 (2011); Ugur, A., et al.: Pharmacogn Mag. 6, 305 (2010)<br></p>

<p>Applications 1,3-Diethynylbenzene (cas# 1785-61-1) is a useful research chemical.<br></p>

<p>Applications 1,3-Adamantanediol is used in the synthesis of novel dimethacrylate as possible dental monomers for dental resin mixtures.<br>References Wang, K. et al.: Mat. Sci. Eng. Mat. Biol. Appl., 32, 1141 (2012); Horino, Y. et al.: J. Mol. Catal. A. Chem.,<br></p>

<p>Applications Dimethyl N-Cyanodithioiminocarbonate is a useful synthetic intermediate. It is used in the synthesis of 4-methylthiopyrazolo[1,5-a]-1,3,5-triazines, methylsulfanyl derivatives of azoloazines, and methylsulfanylpyrimidines.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Elgemeie, G., et al.: Synth. Commun., 31, 3453 (2001); Alqaradawi, S., et al.: Synth. Commun., 34, 805 (2004); Elgemeie, G., et al.: Synth. Commun., 36, 743 (2006)<br></p>

<p>Applications 3-Mercaptoindole (cas# 480-94-4) is a compound useful in organic synthesis.<br>References Harris, R.L.N.: Tetrahedron Letters, 51, 4465 (1969)<br></p>

<p>Applications Dimethyl Yellow can induce cytochrome P-448, monooxygenase activities and UDPGT activity.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Fujita, S., et. al.: Chem-Biol. Interact., 52, 15 (1984);<br></p>

<p>Applications 1,1-Dimethoxycyclohexane (cas# 933-40-4) is a useful research chemical.<br></p>

<p>Applications 6-Bromo-1-hexanol is a useful synthetic intermediate. 6-Bromo-1-hexanol is used as a reagent in the preparation of nitric oxide-donating analogues of Sulindac (S699215), a non-steroidal anti-inflammatory drug that has the ability to prevent colon cancer.<br>References Nortcliffe, A., et al.: Bioorg. Med. Chem., 22, 756 (2014); Pasricha, P., et al.: Gastroenterology, 109, 994 (1995); Yamamoto, Y., et al.: J. Biol. Chem., 274, 27307 (1999)<br></p>

<p>Applications Butylboronic Acid is a boronic acid derivative that can be used as a transport carriers in membrane-based sugar separations. Butylboronic Acid is used as an analytical reagent in the determination of serum glucose.<br>References Smith, B.D. et al.: ACS Symp. Ser., 642, 194 (1996); Prendergast, J.L. et al.: Anal. Bional. Chem., 397, 1779 (2010);<br></p>