Building Blocks

<p>Versatile small molecule scaffold</p>

<p>2-(2-Hydroxyethyl)phthalazin-1-one is a molecule that stabilizes benzene rings in the crystal by forming hydrogen bonds with the hydroxyl groups. The interplanar and intermolecular interactions between molecules are weak, but the coplanar and dihedral interactions are strong. This stabilizing effect leads to an increase in the melting point and boiling point of benzene. 2-(2-Hydroxyethyl)phthalazin-1-one has been shown to have a crystalline structure with a space group of P21/c.</p>

<p>5-Phenylpyrimidine-2,4-diamine is an antiparasitic agent that belongs to the group of derivs. It has been shown to inhibit coccidian growth in vitro and has antiparasitic activity against bacteria and protozoa. 5-Phenylpyrimidine-2,4-diamine binds to the enzyme acetyl coenzyme A synthetase in the parasite's mitochondria and prevents the synthesis of ATP. This leads to cell death.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>5,6-Diphenylpyrazinol is a nitrated derivative of pyrazine. It is synthesized by nitrating 5,6-diphenylpyrazine with a mixture of sulfuric and nitric acid. The product is isolated by fractional distillation.</p>

<p>3-Amino-6-methylpyridazine is a pro-apoptotic molecule that interacts with the kinase domain of the pro-apoptotic protein Bax, inducing programmed cell death. This compound has been shown to be homologous with other compounds that inhibit mycobacterium avium and staphylococcus in vitro. 3-Amino-6-methylpyridazine inhibits the replication of tuberculosis bacteria by inhibiting DNA synthesis. It also has a cytotoxic effect on mycobacterium avium cells, which may be due to its ability to induce apoptosis.<br>3-Amino-6-methylpyridazine has an antiinflammatory effect on macrophages by inhibiting cyclooxygenase and lipoxygenase activity.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Methyl 2-amino-6-methylbenzoate (MMAB) is a prophylactic agent that inhibits the growth of tumor cells. It is used for prophylactic treatment of patients with a syndrome in which there is an increased risk of tumor formation. MMAB inhibits the production of DNA and RNA, which are needed for cell division. The drug also inhibits the activity of ribonucleotide reductase and deoxyribonucleotide reductase, which are enzymes involved in DNA synthesis. MMAB has been shown to inhibit the growth of tumor cells and may be useful in preventing tumors from forming.</p>

<p>Versatile small molecule scaffold</p>

<p>5-Iodofuran-2-carboxylic acid is an ionic compound that acts as a serotonin reuptake inhibitor. It is a hardener in liquid crystal display (LCD) screens, and has been used to increase the hardness of epoxy resin in coatings for plastic. 5-Iodofuran-2-carboxylic acid inhibits the serotonin transporter (SERT), which is responsible for the reuptake of serotonin from the synaptic cleft. This inhibition leads to increased extracellular concentrations of serotonin, which can result in serotonergic side effects such as nausea, vomiting, and headache.</p>

<p>Versatile small molecule scaffold</p>

<p>2-Thioxo-1,2-dihydropyridine-4-carboxylic acid (TDPCA) is a molecule that is structurally similar to the protonated form of 2-thioxoimidazole carboxylic acid. TDPCA has been shown to be an antibacterial agent against Staphylococcus aureus with surface-enhanced Raman scattering properties. TDPCA can also act as a fluorescence probe and has pharmacokinetic properties that are dependent on its molecular weight, which can be determined using plasma mass spectrometry. TDPCA absorbs light in the red region of the spectrum and shifts to the blue region when it reacts with silver ions. It also binds to carboxylate groups, which may be used for detection by nanosensors.</p>

<p>2-Ethoxy-6-methylpyridine is a polypeptide chain with anti-oxidant properties. It has been shown to significantly reduce oxidative damage to protein synthesis in the cytoplasm of animals. 2-Ethoxy-6-methylpyridine also inhibits lipid peroxidation and membrane damage, which may be due to its ability to act as an endoplasmic reticulum (ER) template. This compound is able to bind to ER membranes and alter their structure, which may lead to the prevention of cell death.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>5-Chloropyrimidine-2,4-diamine is a chemical compound that has been shown to inhibit the growth of cancer cells in vitro. The compound is an anti-cancer agent that can be used to treat lung cancer. It has been shown to have a cytotoxic effect on human lung cancer cells and to inhibit the proliferation of these cells in vitro. It also inhibits the growth of other types of human cancer cells, including those from breast, colon and prostate cancers. This substance has been shown to bind with high affinity to DNA and RNA and modulate their synthesis. 5-Chloropyrimidine-2,4-diamine also inhibits cell division by binding to the enzyme topoisomerase II, which controls the unwinding of DNA strands during replication.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>2-Tridecyloxirane is a diagnostic agent that is used to identify hydroxy groups in collagen. It reacts with the hydroxyl group on collagen, forming an acyl chloride intermediate. This intermediate can be detected using a gas chromatography technique. The biodegradability of 2-tridecyloxirane has been studied and found to be dependent on the environment in which it is released. It was found to have a half-life of around 4 days in water, but up to 8 months in soil. The viscosity of 2-tridecyloxirane has been shown to decrease as the temperature increases, with the highest rate of change at temperatures above 150°C. This chemical has also been shown to react with primary amines and alicyclic compounds, such as ebola virus.</p>

<p>4-Chloro-2-oxo-2H-chromene-3-sulfonyl chloride is a heterocyclic compound with significant biological activity. It is a salmonicida that kills bacteria by inhibiting the enzyme adenosine triphosphate (ATP). 4-Chloro-2-oxo-2H-chromene-3-sulfonyl chloride has been shown to have significant activity against Staphylococcus aureus, Streptococcus pneumoniae, and Streptococcus pyogenes. This drug also inhibits the growth of Pseudomonas aeruginosa and Escherichia coli.</p>

<p>2,3-Diaminopropionic acid monohydrobromide is a dibenzoylated derivative of 2,3-diaminopropionic acid. It has been shown to be an antibacterial agent. The compound inhibits bacterial growth by binding to the ribosomal protein L5 and blocking the synthesis of proteins necessary for cell division. 2,3-Diaminopropionic acid monohydrobromide has also been found to have neuropathic effects in animals. This compound can be extracted from plants such as lathyrus and eluted with ethanol or hydrobromide.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Bicyclo[2.2.2]octan-2-ol is an antiplasmodial agent that is used to treat malaria caused by Plasmodium falciparum and P. vivax. It binds to the parasite's heme, preventing its conversion of heme to protoporphyrin IX and blocking the synthesis of ATP, leading to cell death. Bicyclo[2.2.2]octan-2-ol has also been shown to be effective against multiresistant strains of plasmodium and has a low toxicity in humans. This substance can be synthesized by epimerization of 2-(bromomethyl)cyclohexanol with maleic anhydride or 2-benzoylcyclohexanol with benzoic acid. The yields from these reactions are low, but the product can be easily tracked due to its distinctive chemical properties (e.g., high boiling point</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>6,7-Dichloro-2,3-dihydro-1H-indole-2,3-dione is a drug that is used to treat high blood pressure. It is a potent inhibitor of the enzyme phosphodiesterase (PDE), which breaks down cyclic adenosine monophosphate (cAMP). 6,7-Dichloro-2,3-dihydro-1H-indole-2,3-dione inhibits PDE and increases the concentration of cAMP in cells. This increase in cAMP leads to an increased effect of the neurotransmitter acetylcholine on the heart and blood vessels. 6,7-Dichloro-2,3-dihydro-1H-indole--2,3--dione also increases calcium binding to membrane receptors and increases membrane hyperpolarization. These changes lead to an increase in nω--nitro--</p>

<p>1-(4-Chlorophenyl)-2-methylpropan-1-one is a phenyl ester that is used as an intermediate in the synthesis of other compounds. 1-(4-Chlorophenyl)-2-methylpropan-1-one can be synthesized by reacting potassium t-butoxide with diethyl succinate, followed by reaction with isopropyl alcohol. This process will result in the production of 1-(4-chlorophenyl)-2-methylpropan-1-one and potassium t-butoxide. The compound can also be synthesized by condensing naphthalene, diethyl ether, and isopropanol. This process will produce the same product but with a different reactant order.</p>

<p>Versatile small molecule scaffold</p>

<p>5-(Propan-2-yl)-2-sulfanyl-3,4-dihydropyrimidin-4-one is a synthetic compound that blocks the activity of viral reverse transcriptase and DNA polymerase. It is also an inhibitor of human immunodeficiency virus (HIV) and has been shown to be effective in mice with AIDS. This drug also has radical scavenging activities and can be used as a possible anti-inflammatory agent for the treatment of rheumatoid arthritis. 5-(Propan-2-yl)-2-sulfanyl-3,4-dihydropyrimidin-4-one belongs to the class of pyrimidine nucleosides and has been shown to inhibit nonnucleoside reverse transcriptase inhibitors, such as indole alkaloids. This drug has a molecular weight of 319.06 g/mol and contains an ethyl formate, isopropyl group, hydroxyl</p>

<p>3-Phenylisoxazole-4-carboxylic acid is a small molecule that has been shown to have high affinity for the metabotropic glutamate receptor subtype mGluR7. It also binds to the allosteric site on this receptor and is therefore a potent agonist. 3-Phenylisoxazole-4-carboxylic acid has been shown to be orally bioavailable and selective for mGluR7 in vivo. This molecule can be modified chemically to increase its physicochemical properties, such as solubility, permeability, and lipophilicity, which will allow it to cross the blood brain barrier more easily. 3-Phenylisoxazole-4-carboxylic acid may be used as a lead compound for the development of new drugs that target metabotropic glutamate receptors.</p>

<p>Versatile small molecule scaffold</p>

<p>1,3-Diethyl 2-(3-chloropropyl)propanedioate is an organic compound that can be extracted from the seeds of a tree in the genus Garcinia (family Clusiaceae). It has been isolated from the leaves of plants in the family Fabaceae. The compound is a colorless liquid with a slightly fruity odor and a boiling point of 203°C. <br>The chemical structure of 1,3-diethyl 2-(3-chloropropyl)propanedioate can be explained as two diethyl 3-chloropropanedioates linked by an ether bond. The molecule contains one alkoxycarbonyl group and one hydroxy group. The alkoxycarbonyl group is responsible for its basic properties and the hydroxy group allows it to form ester derivatives. The compound can be purified by using a variety of methods, including thermal treatment or acidification. Unpurified 1,3</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>2-[(4-Bromophenyl)sulfanyl]propanoic acid is a small molecule that belongs to the group of peptides. It can be used as a research tool for cell biology and cell-based assays. The receptor activator of nuclear factor kappa B (NF-κB) kinase (RANK), which is encoded by the RANKL gene, plays an important role in bone resorption. 2-[(4-Bromophenyl)sulfanyl]propanoic acid enhances bone resorption by binding to the RANK receptor and activating NF-κB pathway. This ligand has also been shown to inhibit ion channels, such as potassium channels, sodium channels, calcium channels, and chloride channels.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>1-(1-Methylpiperidin-2-yl)propan-2-one is a chemical compound that is found in the leaves of Carthamus tinctorius. It can be used as a food additive, or as a medicine to treat hepatitis and high blood pressure. 1-(1-Methylpiperidin-2-yl)propan-2-one also has antihepatotoxic properties and has been shown to inhibit the synthesis of liver cells. 1-(1-Methylpiperidin-2-yl)propan-2-one is an inhibitor of synthase enzymes, which are involved in the production of cholesterol and fatty acids. This inhibition leads to decreased levels of LDL cholesterol, triglycerides, and phospholipids. The use of this drug may be helpful in cancer treatment because it inhibits the synthesis of proteins that promote tumor growth.END&gt;</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>2-Acetyl-3-methylbenzo[b]thiophene is a serotonin transporter (SERT) inhibitor. It binds to the serotonin transporter and prevents it from transporting serotonin back into the presynaptic cell, thereby increasing the level of free serotonin in the synapse. 2-Acetyl-3-methylbenzo[b]thiophene has been shown to have high affinity for 5HT1A receptor, as well as substituents that are capable of binding to this receptor. This drug also has an antidepressant effect by inhibiting the reuptake of serotonin.</p>

<p>4-Bromothiophene-2-carbonitrile (4BTCC) is a chemical compound that yields monomers with a distal spacer. The 4BTCC monomer can be synthesized by reacting bromoacetaldehyde and 2-cyanopyridine, which have been shown to have the same electron density, in the presence of copper(II) chloride. The activation energy for this reaction was found to be 10.5 kJ/mol. The fluorine atom in 4BTCC has been shown to be crucial for its structural activity and bioactivity. The structure of 4BTCC is composed of a C–H bond and a C=N bond that are each bonded to two fluorine atoms.</p>

<p>5-Bromothiophene-3-carbonitrile is a thiophene that has been substituted with two cyano groups. The 5-bromothiophene-3-carbonitrile molecule has anisotropic properties, which are due to the linear orientation of the molecules. These properties lead to refractive indices and parameters that depend on the angle of incidence. 5-Bromothiophene-3-carbonitrile can be used as a polar solvent for phenylthiophenes, biphenyls, and other compounds with similar structures because it is optically active. The molecule also has an optical activity that depends on the orientation of the dipole moment in relation to the electric field.</p>

<p>3-(Methylsulfanyl)pyridine (3-Me-SPYR) is an organosulfur compound that is used in the synthesis of pharmaceuticals. 3-Me-SPYR is a versatile building block in organic synthesis and can be used to synthesize a variety of compounds, such as drugs. It has been shown to be a good nucleophile and can be used for nucleophilic substitution reactions. This compound can also undergo demethylation and hydroxylation reactions. 3-Me-SPYR is typically prepared by the palladium catalyzed cross coupling reaction of 2 equivalents of methyl iodide with 1 equivalent of sodium methansulfonate or sodium hydride in trifluoromethanesulfonic acid.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>1-Bromo-4-(2-bromoethoxy)benzene is a benzoic acid derivative that is used as a building block for the synthesis of combinatorial libraries. It is soluble in water, alcohols and ethers, and it can be dissolved in chloroform. This compound was synthesized by the hydroxy group of an amino acid to provide a non-peptide molecule. 1-Bromo-4-(2-bromoethoxy)benzene has shown to inhibit the growth of methicillin resistant Staphylococcus aureus (MRSA), which may be due to its ability to inhibit protein synthesis.</p>

<p>Versatile small molecule scaffold</p>

<p>1-(2-Bromoethoxy)-2-methylbenzene is an aromatic compound with a conformation that can be described as a chair. The two bromine substituents are on the same side of the benzene ring, and the ethoxy group is attached to one of the carbons in the piperazine ring. This molecule has three dihedral angles, which could be described as 60 degrees, 120 degrees, and 180 degrees. One of these angles is formed by the bromine substituent and the ethoxy group, another by the methoxy substituent and the ethoxy group, and the third angle is formed by one carbon in the piperazine ring and one carbon in a methyl group.</p>

<p>Versatile small molecule scaffold</p>

<p>1-(2-Bromoethoxy)-2-nitrobenzene is a fluorescent ionophore that is used in the production of high-performance liquid chromatography (HPLC) columns. This chemical is synthesized by a stepwise reaction that starts with the formation of an acetonitrile adduct. The acetonitrile group is then removed and replaced with an ethoxy group to form the final product. The synthetic procedure for 1-(2-bromoethoxy)-2-nitrobenzene has been rationalized and it can be recycled using magnesium as a reducing agent. In addition, this chemical has been shown to bind to sensor proteins due to its high affinity for them.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>1-(4-Methyl-1H-pyrrol-3-yl)ethanone is a metabolite of eupenicillium, which is found in the bark of several species of conifer trees. This natural product has been shown to be biogenetically related to the biosynthesis of nitrogenous compounds and has been identified in various plant tissues as a secondary metabolite. 1-(4-Methyl-1H-pyrrol-3-yl)ethanone has also been shown to have antibiotic activity against gram positive bacteria such as Bacillus subtilis, Staphylococcus aureus, and Streptococcus pyogenes.</p>

<p>Versatile small molecule scaffold</p>

<p>Ethyl 3-acetyl-4-oxopentanoate is a synthetic chemical that has been found to be an ancillary ligand for the diazepine ring. The chloride group is activated by hydrogen chloride and can form a bifunctional complex with the formyl group. This compound has been used in kinetic and structural analysis as a surrogate for the more difficult to obtain diazocompounds, which are often used in medicinal chemistry.</p>

<p>N-(2-hydroxyethyl)benzamide is an amido-containing preservative used in cosmetics and personal care products. It is a synthetic, water-soluble compound that has been shown to be effective against gram-positive bacteria such as Bacillus cereus and methicillin-resistant Staphylococcus aureus (MRSA). It also has the ability to inhibit the growth of gram-negative bacteria such as Escherichia coli and Pseudomonas aeruginosa. N-(2-hydroxyethyl)benzamide has been found to be stable at pH values from 3 to 10 and can be used in many cosmetic formulations, including sunscreen, shampoo, conditioner, hair colorant, eye shadow, mascara, lipstick, lip gloss and nail polish. This preservative should not be used in products that contain polyols or ethyl groups since it will react with these ingredients.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Benzene, 1-ethyl-4-isothiocyanato-, is a potential cancer drug that has been shown to be an active compound in inhibiting the growth of cancer cells. It is a synthetic terpene that is known to have many volatile compounds, including isothiocyanates. Benzene activates inflammatory cytokines and inhibits the production of inflammatory mediators in chronic inflammatory disease. The mechanism of action for benzene is unknown, but it may be due to its ability to signal cells through a transducer or receptor that regulates cellular proliferation and differentiation.</p>

<p>Versatile small molecule scaffold</p>

<p>2-Chloro-6-methylthiophenol is an annulated compound that is a catalyst for hydrogenation. It can be used in the production of trifluoroacetic acid and polyphosphoric acid. 2-Chloro-6-methylthiophenol has been shown to act as a dehydrogenating agent, which is useful in the synthesis of conjugates. Catalytic hydrogenation can also be achieved with this compound in the presence of trimethylaluminium, which has been shown to be more efficient than copper.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>4-Bromothiophene-3-carbonitrile is a reactive, heterocyclic compound that can be prepared by reacting ethyl bromide with 3-carbonitrile in the presence of triethyl orthoformate. This compound can be used as an acceptor for electron and has an optical spectrum that contains a strong absorption at 295 nm, which corresponds to its electron affinity. The compound is also resistant to halogenation and has three functional groups. 4-Bromothiophene-3-carbonitrile can react with various types of halides or other organic compounds to form addition products.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>