Amines

<p>4,6-Diamino-2-thiopyrimidine is a glycosidic bond that has been shown to inhibit the growth of bacteria in cell culture. It has also been shown to have an anticoagulant effect on human serum. The molecular weight of heparin is typically between 5000 and 15000 Da. In this study 4,6-Diamino-2-thiopyrimidine was found to be the most potent inhibitor of heparinase I activity with an IC50 of 1.5 mM. This compound is a trifluoroacetate salt that has a neutral pH and low solubility in water. It can be detected by electrochemical impedance spectroscopy (EIS). Hydrolysis by hydrochloric acid yields 4,6-diamino-2-thiopyrimidine trifluoroacetic acid as the only product. The chemical name for this substance is 4,6 diamino 2 thiop</p>

<p>Fluorescent probe for AMC-based labelling of oligosaccharides or peptides</p>

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<p>Histamine (H1) antagonist; used to treat allergies</p>

<p>3-Noradamantaneamine hydrochloride is a thioamide that has inhibitory activities on biological processes, such as the production of tumor necrosis factor-α (TNF-α). 3-Noradamantaneamine hydrochloride also inhibits angiogenesis and the proliferation of endothelial cells. The drug was shown to be neuroprotective in animal models and to have anti-angiogenic properties. The mechanism of action is not yet clear, but may involve nitric oxide synthase inhibition or nitration of the drug.</p>

<p>4-Aminobenzotrifluoride is a chemical compound that belongs to the group of nitroso compounds. It has been shown to have antiproliferation activity in vitro and in vivo. 4-Aminobenzotrifluoride is synthesized by reacting sodium nitrite with p-hydroxybenzoic acid in the presence of an organic acid, such as acetic acid or formic acid, to produce diazonium salt. The diazonium salt is then reacted with an inorganic acid, such as hydrochloric acid or sulfuric acid. This reaction produces 4-aminobenzotrifluoride and water.</p>

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<p>Tryptamine hydrochloride is a tryptamine that is used in the synthesis of various drugs with antiinflammatory properties. It has been shown to be a potent and selective antagonist of 5-HT2 receptors, with a pKi value of 7.4. Tryptamine hydrochloride has also been found to have an inhibitory effect on mitochondrial membrane potential and to decrease human serum 5-HT levels at physiological doses. This drug is structurally related to serotonin, which is believed to be a cause for its antiinflammatory activity.</p>

<p>Monofluoroamine is a chemical substance with the chemical formula NH2F. It is a colorless liquid that is stable to both acidic and basic environments, but reacts with fluorine gas to form hydrofluoric acid. Monofluoroamine is used in the synthesis of pharmaceuticals, pesticides, and other organic compounds. This compound can be prepared by reacting ammonia with hydrogen fluoride at low temperature or by reacting ammonia with hydrogen fluoride at high pressure. The Friedel-Crafts reaction of monofluoroamine with an amide produces the corresponding amine. Monofluoroamine has been used as a conditioning agent in NMR spectroscopy experiments to remove the water signal from complex NMR spectra. In addition, this compound has been shown to have antiviral effects against HIV infection through its ability to inhibit protein synthesis.</p>

<p>3-Aminopyrazole is a redox potential small molecule drug that has been shown to have tuberculostatic activity. It binds to the 5-HT2 receptor on the surface of tumor cells, which causes an increase in intracellular calcium levels and cell death. 3-Aminopyrazole also inhibits growth factor production, and this may be a part of its mechanism of action. 3-Aminopyrazole has been shown to be active against gram positive bacteria such as staphylococcus aureus and streptococcus pneumoniae. It also shows antimicrobial activity against gram negative bacteria such as pseudomonas aeruginosa, e.g., in vitro assays.</p>

<p>1-(2-Furyl)ethanamine is a chiral compound that can be synthesized from readily available feedstocks. This synthetic method was developed to allow for the preparation of 1-(2-furyl)ethanamine in high yields and with good selectivity. The strategy involves the transfer of an ethyl group from an alcohol to a carbonyl group, which is catalyzed by gold nanoparticles. This process has been shown to be sustainable and provides an alternative for the use of more hazardous chemicals in the synthesis of this compound.</p>

<p>Trolamine salicylate is a polymer film-forming drug that contains methyl anthranilate and trolamine. It is used in the treatment of skin cancer, as well as for the prevention of radiation-induced erythema. Trolamine salicylate has been shown to be effective in reducing the incidence of skin cancer caused by exposure to ultraviolet light at wavelengths below 320 nm. Trolamine salicylate forms a polymeric matrix on the surface of skin cells and acts as an anti-inflammatory agent. When applied topically, it undergoes chemical reactions with water vapor in the air and can be degraded by enzymes in human serum. The elimination rate of trolamine salicylate from body is about 1% per day and its half-life is about 20 days.<br>Trolamine salicylate is also used to treat acute dermatitis caused by contact with industrial chemicals such as phenols, amines, and ketones. It</p>

<p>N,N-Dimethyl-(tetrahydro-3,3 diphenyl-2-furilidine)ammonium bromide is a synthetic opioid analgesic and is used in the treatment of severe pain. It has been shown to cause life-threatening cardiac effects, supratherapeutic concentrations, or fatalities in humans and animals. N,N-Dimethyl-(tetrahydro-3,3 diphenyl-2-furilidine)ammonium bromide has also been shown to cause gastrointestinal inflammation in animal models. This drug acts as an agonist at opioid receptors and can be fatal at high doses.</p>

<p>Difluoroamine is a chemical compound that is used in the production of organic compounds. It has been shown to have high stability and detection sensitivity, which is attributed to its hydrogen bond forming ability. Difluoroamine also reacts with trifluoroacetic acid and hydrogen fluoride, both of which are strong acids. The reaction mechanism of difluoroamine involves the protonation of nitrogen atoms on the molecule followed by a nucleophilic attack on the electrophilic carbon atom that results in the formation of an amine group. This reaction can be carried out in a flow system as well as in a batch process. Difluoramine is an intermediate product during this process and can be converted into glycol ethers or nitrobenzene.</p>

<p>Simvastatin is a hydrated, acylated statin that is used as a lipid-lowering drug. It inhibits HMG-CoA reductase, an enzyme that plays a central role in cholesterol biosynthesis. The reaction solution can be activated by mixing with an acyltransferase and the desired acyl group. Simvastatin has a toxicity profile that includes myopathy, rhabdomyolysis, and liver failure. Simvastatin also inhibits lipoprotein lipase and prevents the hydrolysis of triglycerides to fatty acids and glycerol. This leads to reduced levels of low-density lipoproteins (LDLs) and increased levels of high-density lipoproteins (HDLs). Simvastatin is converted into an amide form by enzymatic cleavage, which may lead to metabolic inhibition.</p>

<p>Cianopramine is a potent, selective inhibitor of the uptake of 5-hydroxytryptamine (5-HT) at 5-HT2 receptors. It has been shown to be effective in vivo models for chronic schizophrenia and has shown promising results in clinical trials with drug-naive patients. Cianopramine also inhibits the binding of drugs such as clomipramine and other tricyclic antidepressants to their receptor sites. In addition, cianopramine is a bicyclic heterocycle that binds to the human serum albumin with high affinity and specificity.</p>

<p>3-(Boc-amino)propyl bromide is an antimicrobial agent that has been shown to be a potent inhibitor of cancer cell growth in vitro. The mechanism of action of 3-(Boc-amino)propyl bromide is not yet known, but it may be due to its ability to inhibit the uptake of radiotracers by mda-mb-231 cells. 3-(Boc-amino)propyl bromide has also been shown to have a high affinity for proteins and is able to hydrogen bond with them. This property may explain the high salt requirement for its solubility, as well as its toxicity towards bacteria and other microorganisms.</p>

<p>(R)-Amino carnitine is a pancreatic enzyme that is used as an experimental treatment for fatty liver disease. It has been shown to inhibit the synthesis of fatty acids, which are the main components of triglycerides. The inhibition of this enzyme leads to a decrease in the production of triglycerides and their accumulation in the liver, thereby reducing hepatic steatosis. (R)-Amino carnitine also has an inhibitory effect on protein synthesis, which is important for the conversion of amino acids into proteins essential for cell division and growth. This mechanism may explain its beneficial effects on insulin resistance, obesity, and diabetes.</p>

<p>1-Heptylamine is a chiral dinucleotide phosphate. It has been shown to have a high affinity for the nicotinic acetylcholine receptors in the human body, where it acts as an agonist. This compound also has a variety of other reactions that are not yet fully understood. 1-Heptylamine is found naturally in the human body and can be detected in wastewater treatment plants.<br>1-Heptylamine has been used in analytical methods such as titration calorimetry and laser ablation to measure nitrogen atoms or chiral compounds respectively. The compound is also used as an amide or alkanoic acid, although its role in these reactions is unknown.</p>

<p>1-(4-Amino-3,5-dichloro-phenyl)-2-ethanone is a beta-adrenergic agent. It has been used as a stable isotope label for the study of the pharmacokinetics and metabolism of drugs in humans. In addition, it has been shown to have a good stability profile in acidic solutions and can be easily converted to other derivatives by simple chemical methods. The compound's UV spectrum is linear with respect to concentration over the range from 0.1 to 1 mg/mL, with maxima at 227 nm and 254 nm. This compound has been characterized using analytical methods such as diffraction, spectroscopy, and chromatography.</p>

<p>4-Octyloxybenzylamine is a fine chemical that is used as a building block in research or as a reagent in the synthesis of other compounds. It has CAS No. 37806-64-7 and can be used in organic synthesis as a speciality chemical or as an intermediate or scaffold for complex organic molecules. 4-Octyloxybenzylamine has many uses, including being a versatile building block for synthesizing other compounds, such as polymers and polyesters, which are useful for commercial applications, such as textiles and plastics.</p>

<p>4-(Dimethylamino)benzylamine dihydrochloride (DMAA) is an inhibitor of the enzyme form of acetylcholinesterase. It has been used as a reagent in the biochemical, analytical and chromatographic detection of acetylcholine. DMAA can be used to measure acetylcholine levels in human serum, and has a kinetic time range of 0.5-2 hours. This chemical has potent inhibition against cytosolic but not plasma cholinesterase activity, which may be due to its binding to the active site of the enzyme. DMAA also inhibits lymphocytic leukemia cell growth by inducing chemiluminescence, which is a reaction that produces light from a chemical reaction in the absence of oxygen.</p>

<p>Ammonium hexafluorotitanate(IV) is a fine chemical that can be used as a reagent, building block, or intermediate in the synthesis of other chemicals. It is a versatile building block and reacts with other compounds to form complex compounds. Ammonium hexafluorotitanate(IV) is also an intermediate for the production of ammonium hexafluorophosphate (III), which is used in the manufacture of fertilizers. Ammonium hexafluorotitanate(IV) can be used as a reactant to produce titanium metal, which has many industrial applications.</p>

<p>Dimethylbenzylamine is a colorless, volatile liquid with a low boiling point. It has been shown to be an effective biocide in the form of its copper complex, which may be used in detergent compositions for the inhibition of microbial growth on surfaces. Dimethylbenzylamine is also used as a standard reagent for determining redox potentials and has been studied extensively in kinetic and analytical chemistry. The reaction mechanism of dimethylbenzylamine has been determined to be similar to that of benzalkonium chloride and other quaternary ammonium salts. Dimethylbenzylamine is also used as a ligand in coordination geometry, transfer reactions, and salt metathesis.</p>

<p>Tetraoctyl ammoniumchloride is an inexpensive chemical that has a high affinity for membranes. It is a cationic surfactant with a structure of four octyl chains, each containing an amine group. Tetraoctyl ammoniumchloride has been used to study the kinetics of ion transport in membranes and has been shown to be able to inhibit nitrate uptake by plant roots. This chemical also has light resistance properties and can be used to protect gold nanoparticles from degradation by light.</p>

<p>4'-Amino-N-methylacetanilide is a chemical reagent that can be used as a building block for the synthesis of other chemicals. It has been shown to have a high quality and is useful in the research field. It has been used as an intermediate in the production of pharmaceuticals and pesticides, such as acetaminophen, chloramphenicol, and nitrofurantoin. 4'-Amino-N-methylacetanilide has also been used as a versatile building block for the synthesis of various complex compounds, including dyes and polymers.</p>

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<p>Applications Ethyl 3-(Butanoylamino)-2-oxobutanoate s a reactant used to prepare Vardenafil (V098001, 2HCl salt) which is a selective phosphodiesterase type 5 (PDE5) inhibitor.<br>References Bischoff, E., et al.: J. Urol., 165, 1316 (2001), Kim, N.N., et al.: Life Sci., 69, 2249 (2001), Kendirci, M., et al.: Expert Opin. Pharmacother., 5, 923 (2004)<br></p>

<p>Ammonium metavanadate is a compound with the chemical formula NH4VO3. It is an oxidizing agent that can be used in wastewater treatment to remove organic and inorganic contaminants from wastewater streams. The product has been shown to be a strong catalyst for the oxidation of ammonium, water vapor, and sulphur dioxide at ambient temperature. Ammonium metavanadate has been studied extensively as a catalyst for the removal of volatile organic substances (VOS) from gas streams, and is considered to be one of the most efficient catalysts currently available. Ammonium metavanadate also increases cytosolic calcium levels in human cells by promoting its release from intracellular stores.</p>

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<p>Ammonium tetrafluoroborate is a salt of the organic compound tetrafluoroborate and ammonium. It is a colorless solid that can be used as a chemical reagent. Ammonium tetrafluoroborate has a higher chemical stability than other salts of tetrafluoroborate, such as ammonium hexafluorophosphate and ammonium hexafluoroarsenate. Ammonium tetrafluoroborate is used to make the dinucleotide phosphate, which is an important component in DNA synthesis. In a redox potential test, ammonium tetrafluoroborate showed no electrochemical activity in water vapor at pH 7. Ammonium tetrafluoroborate reacts with trifluoroacetic acid to produce hydrogen fluoride and ammonium chloride. This reaction is reversible, which means that it can be used for the synthesis of ammonia gas from hydrogen and nitrogen gases or for the</p>

<p>Ammonium iron(III) sulfate dodecahydrate is a water-soluble inorganic salt that can be used as an oxidizing agent to reduce the color of stains. It has been shown to have good growth kinetics and is easy to use. Ammonium iron(III) sulfate dodecahydrate is an inorganic acid that can be used as a reagent for extractions. It has been found to have good extraction yield and particle size, which makes it ideal for use in polymer films. Ammonium iron(III) sulfate dodecahydrate reacts with hydroxyl groups and forms p-hydroxybenzoic acid, which can be used in clinical pathology tests.</p>

<p>Ammonium hydroxide is a chemical compound that is used to remove sodium salts from water in the treatment of wastewater. Ammonium hydroxide is also an analytical reagent for the determination of ammonium ions by titration, and is used as a polymerization catalyst. It can be used to produce glycol ethers, which are solvents with low toxicity and high boiling points. The reaction mechanism involves the conversion of hydrogen fluoride (HF) to hydrofluoric acid (HF), which reacts with ammonia to form ammonium fluoride (NH4F). This reaction produces heat and gives off water vapor. Ammonium hydroxide is a weak base, so it will react with any strong acid, such as hydrochloric acid or sulfuric acid, but not with weak acids such as acetic acid or phosphoric acid.</p>

<p>Ammonium hexafluoroniobate is an organosilicon compound that does not react with water and is used as a solvent for other organics. It can be activated to form a reactive surface by treatment with a metal such as copper or aluminum, which can then be used in the treatment of metals. Ammonium hexafluoroniobate has been used as a diagnostic agent and diagnostic reagent in various reactions at different temperatures. It has also been used as the photoreceptor in electrophotographic printing processes, where it is exposed to light-sensitive material and then developed using organic solvents.</p>

<p>Bis(hydroxyethyl)methylamine is a chemical compound that is used in wastewater treatment. It is a strong base that can be used to remove nitrogen compounds, such as ammonia and nitrite, from wastewater. The process optimization of the thermal expansion of Bis(hydroxyethyl)methylamine has been studied. This chemical has been found to inhibit the growth of bacteria and fungi, which may be due to its ability to disrupt protein synthesis by interfering with the enzyme fatty acid synthase.</p>

<p>Tetrahydro-a-(1-naphthalenylmethyl)-2-furanpropanoic Acid 2-(Diethylamino)ethyl Ester is a fatty acid analog that has antimicrobial properties. It is used in the treatment of bone cancer, and can be used to diagnose and treat other diseases such as glomerular filtration rate, receptor binding, and malonic acid. Tetrahydro-a-(1-naphthalenylmethyl)-2-furanpropanoic Acid 2-(Diethylamino)ethyl Ester binds to receptors on cells, which leads to an increase in the amount of monoamine neurotransmitters released by the cells.</p>

<p>2-Diethylamino)ethanol hydrochloride is a chemical compound that is used in analytical chemistry as a stationary phase for thin layer chromatography. Sephadex G-100 was developed by Pharmacia &amp; Upjohn Company and marketed in the 1970s. It has been shown to be useful in plasma mass spectrometry experiments, which measure the molecular weight of proteins and other compounds. The solubility of 2-diethylamino)ethanol hydrochloride has been studied using experimental solubility data, electrochemical impedance spectroscopy, and amines. The reaction mechanism of 2-diethylamino)ethanol hydrochloride is not well understood but it appears to involve potassium dichromate, hydrochloric acid, fluoroacetic acid, benzalkonium chloride and other chemicals.</p>

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<p>Ammonium bromide is a chemical compound used in wastewater treatment. It is the active ingredient in a number of water purification methods, including those used to remove nitrates and heavy metals. Ammonium bromide also has inhibitory properties on the release of neurotransmitters from nerve cells. This inhibition of neurotransmitter release may be due to its ability to inhibit the action of neurokinin-1 receptor (NK-1) at the synapse. Ammonium bromide has been shown to have some toxic effects on the heart, although it does not appear to be toxic to other organs or tissues. Experimental solubility data shows that this solution is soluble in water, but insoluble in ethanol and ether. 4-Hydroxycinnamic acid, which can be found in coffee beans, has been shown to increase ammonium bromide solubility in water solutions by forming an inclusion complex with ammonium bromide.</p>

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<p>3-(1-Piperidin-1-ylcyclohexyl)phenyl]amine hydrochloride is a ligand that binds to the acetylcholine receptor. 3-(1-Piperidin-1-ylcyclohexyl)phenyl]amine hydrochloride is an active analogue and has a high binding affinity for the cholinergic receptor. It has been shown to have a kinetic effect on the excitatory system, enhancing excitatory effects of acetylcholine without affecting inhibitory effects. 3-(1-Piperidin-1-ylcyclohexyl)phenyl]amine hydrochloride also has an antagonistic effect on modifiers of acetylcholine activity such as amantadine, but enhances the effects of other drugs, such as clonidine.</p>

<p>21-Amino-17-hydroxyprogesteroneHydrochloride is a synthetic corticosteroid that is used to suppress the immune system in patients with severe allergies and those who have had an organ transplant. It binds to receptors on the surface of lymphocytes, preventing them from producing antibodies. It also inhibits the production of white blood cells by interfering with DNA synthesis and protein synthesis. 21-Amino-17-hydroxyprogesteroneHydrochloride is used to treat conditions such as sepsis, rheumatoid arthritis, lupus erythematosus, and myasthenia gravis. The medication is administered by injection into muscle or vein.</p>

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<p>4-Aminoquinoline-2-one is a nonsteroidal anti-inflammatory drug that has tuberculostatic activity. It binds to the nitrogen atoms of the enzyme dihydropteroate synthase, which is involved in the synthesis of folic acid and DNA. This leads to an increase in reactive oxygen species and inflammation, which causes disease activity. 4-Aminoquinoline-2-one has been shown to be synergistic with monoclonal antibodies when used as a treatment for inflammatory diseases. In order for 4-aminoquinoline-2-one to be taken up by cells, it must bind to cellular uptake proteins through hydrogen bonds or disulfide bonds.</p>

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<p>Triethanolamine hydrochloride, widely known as TEA-HCl, is a buffer used in biochemistry to maintain a stable pH in the range of 7.3 to 8.3 during processes like protein extraction and purification. They are also used in enzyme assays.</p>

<p>Ammonium sulphate is a white, crystalline solid that is used as a fertilizer and in the manufacture of paper. Ammonium sulphate is an ammonium salt of sulfuric acid with the chemical formula NH4HSO4. It is most often used as a fertilizer, although it has many other uses. Ammonium sulfate enhances the absorption of water vapor by plants, which increases their ability to grow. The optimum concentration for ammonium sulfate is from 20-40 g/L. Ammonium sulfate also increases the rate of synthesis of RNA and proteins in cells. This may be because it provides sulfur for enzymes involved in energy metabolism and protein synthesis. Ammonium sulfate has been shown to have synergistic effects with zirconium oxide, allowing more rapid dissolution in water than would be expected from its solubility alone. Ammonium sulfate reacts with bowel disease causing inflammation and ulceration due to its effect on bowel flora (e</p>

<p>4,4'-Diaminostilbene is a chemical compound that is stable in the presence of alkali metals. It also has been shown to be titrated with sodium salts and to have a cavity that can be analyzed by fluorescence. 4,4'-Diaminostilbene has been used for the detection of beta-cyclodextrin and sodium ion in analytical methods. The intensity of its fluorescence depends on the concentration of aniline and protonated amines. This compound has been used as a reagent for nmr spectroscopy analysis.</p>

<p>Diammonium hydrogenphosphate is a monoammonium or diammonium phosphate salt of the phosphoric acid. It is used as a fertilizer and in analytical chemistry. Diammonium hydrogenphosphate is often used in wastewater treatment, because it has high solubility and low toxicity. Diammonium hydrogenphosphate can be synthesized by the reaction of ammonium phosphate with magnesium and ammonium hydroxide. This compound has synergic effects with magnesium, which may be due to its ability to reduce enzyme activities in the cell membrane. Diammonium hydrogenphosphate also has an effect on calcium-protein binding and phosphorus pentoxide crystallization.</p>

<p>1,2-Distearoyl-sn-glycero-3-phosphoethanolamine-N-[amino(polyethylene glycol) 2000] (ammonium salt) is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. 1,2-Distearoyl-sn-glycero-3-phosphoethanolamine-N-[amino(polyethylene glycol) 2000] (ammonium salt) is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.</p>

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<p>Ammonium sulfite is a chemical compound that is used as an additive in wastewater treatment and as a reagent in organic synthesis. The reaction solution contains ammonium sulfite, sodium carbonate, and water. It has been shown to be toxic to animals when administered at high doses. Ammonium sulfite does not react with hydrogen fluoride or water and it is not soluble in anhydrous sodium. The polymerase chain reaction (PCR) technique has been used to study the reaction mechanism of ammonium sulfite. The reactions are catalysed by metal hydroxides such as magnesium hydroxide and aluminium hydroxide, which are present at the surface of the solid phase.</p>

<p>2,4,5,6-Tetraaminopyrimidine sulphate is a chemical compound that is used for the treatment of leukemic mice. It has shown to have anti-inflammatory and anti-cancer properties. This drug binds to the enzyme p-hydroxybenzoic acid that is involved in the synthesis of collagen and elastin. It also suppresses the production of inflammatory cytokines such as TNF-α and IL-1β. 2,4,5,6-Tetraaminopyrimidine sulphate has been used in clinical trials for the treatment of autoimmune diseases and inflammatory diseases such as psoriasis. The drug is currently being researched for use in cancer treatments due to its ability to inhibit cell division and induce apoptosis. 2,4,5,6-Tetraaminopyrimidine sulphate has also been shown to be effective when applied topically on skin as a cosmetic agent or when administered orally as a supplement for</p>

<p>6-Aminopicolinamide is a metabolite of nicotinamide, which can be found in the urine of humans and animals. 6-Aminopicolinamide has been shown to have anti-leukemic activity against experimental leukemias in animals. The mechanism of action is not well understood but may involve inhibition of nucleotide synthesis or the inhibition of dehydrogenase activity. Clinical trials are underway to determine its efficacy as an anti-tumor agent.</p>

<p>2-Dimethylaminoethanol (+)-bitartrate salt is a potent, reversible inhibitor of protein synthesis that binds reversibly to the 50S ribosomal subunit. It is used in regulatory toxicology and clinical pathology as a positive control for the study of chronic toxicity and long-term effects. 2-Dimethylaminoethanol (+)-bitartrate salt has shown no treatment effect on ovary weight or estrous cycle length in female Sprague-Dawley rats after chronic exposure and long-term exposure at doses up to 1,000 mg/kg/day. This drug has also shown no effect on rat fertility or reproductive performance, indicating it does not cause reproductive toxicity.</p>