Carboxylic Acids

<p>Applications tert-Butyl Methylcarbamate is an substituent in the synthetic preparation of PF-06463922, a macrocyclic inhibitor of Anaplastic Lymphoma Kinase (ALK) and c-ros Oncogene 1 (ROS1).<br>References Johnson, T. W., et al.: J. Med. Chem., 57, 4720 (2014);<br></p>

<p>Applications BENZYL CYANOMETHYLCARBAMATE (cas# 3589-41-1) is a useful research chemical.<br></p>

<p>Applications 4-Oxooctanoic Acid is one of mid-chain oxocarboxylic acids detected in Antarctic aerosols and possible precursors to the production of low molecular weight diacids such as succinic acid.Also, it is derived from 4-Octanolide (O239723), which is one of the fine organic aerosol emitted from meat cooking operations that was examined by high-resolution gas chromatography.<br>References Nishikiori, M., et al.: Chikyu Kagaku, 30, 27-34 (1996); Rogge, W., et al.: Environ. Sci. Technol., 25, 1112 (1992)<br></p>

<p>Applications 2-Ethylheptanoic Acid is used in the preparation of prostaglandin which is for for promoting bone growth<br>References Barrett, S., et al.: PCT Int. Appl., 331 (2015)<br></p>

<p>Applications Ethyl 2-Isopropylacetoacetate is a reactant in the preparation of nonracemic arylhydroxymethylpyrrolidinylmethylphenyl thiazoleacetamides and cyclopentathiazolecarboxamides as conformationally restricted β3-adrenoceptor agonists as a potential treatment for overactive bladder.<br>References Moyes, C.R., et. al.: J. Med. Chem., 57, 1437 (2014)<br></p>

<p>Applications Triacontanoic Acid has agricultural applications and is a useful compound in the removal of residual pesticides from fruit via ozone-microbubble treatment.<br>References Li, C., et al.: Food Control, 120, 107548 (2020)<br></p>

<p>Applications tert-Butyl (2-(methoxy(methyl)amino)-2-oxoethyl)carbamate has been used as a reactant in the preparation of potent and selective hydantoin inhibitors of aggrecanase-1 and aggrecanase-2 with potential use in osteoarthritis therapy.<br>References Durham, T.B., et. al.: J. Med. Chem., 57, 10476 (2014)<br></p>

<p>Applications [4-(2-hydroxyacetamido)phenyl]arsonic acid (cas# 144-87-6) is a useful research chemical.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications 3-(2-Oxo-cyclohexyl)-propionic Acid is an intermediate in the synthesis of Hexahydrocoumarin (H293905), a derivative of Coumarin (C755380) that is used as a fragrance ingredient.<br>References Letizia, C. S., et al.: Food and Chemical Toxicology, 38, S115 (2000);<br></p>

<p>Applications tert-Butyl carbamate is used to prepare N-Boc-protected anilines. It is also used in the synthesis of tetrasubstituted pyrroles, functionalized with ester or ketone groups at C-3 position.<br>References Bhagwanth, S., et al.: J. Org. Chem., 74, 4634 (2009); Cadierno, V., et al.: J. Heterocycl. Chem., 47, 233 (2010)<br></p>

<p>Applications 4-Nitrobenzyl Acetoacetate acts as a reagent in the preparation of panipenem via esterification of nitrobenzyl alcohol followed by substitution, cyclizations and hydrogenation. Panipenem I is a new carbapenem antibiotic for the treatment of inflammation.<br>References Fang, H., et al.: hongguo Yaowu Huaxue Zazhi, 21, 216 (2011)<br></p>

<p>Applications Phenethyl Carbamate is an impurity in the synthesis of Felbamate (F231000), an antiepileptic, structurally similar to meprobamate.<br>References Swinyard, E.A., et al.: Epilepsia, 27, 27 (1986), Remmel, R.P., et al.: Ther. Drug Monit., 12, 90 (1990), Sofia, R.D., et al.: Epilepsy Res. Suppl., 3, 103 (1991),<br></p>

<p>Applications Azidoacetic acid NHS ester (cas# 824426-32-6) is a useful research chemical.<br></p>

<p>Applications 1,2,4,5-BENZENETETRACARBOXYLIC ACID (cas# 89-05-4) is a useful research chemical.<br></p>

<p>Applications 3,5-Dinitro-o-toluic Acid is used to gather data for partition coefficients of solutes and vapors into anhydrous THF and 1,4-dioxane using Abraham model.<br>References Saifullah, M., et al.: J. Solution Chem., 40, 2082 (2011);<br></p>

<p>Applications o-Bromophenoxyacetic acid<br></p>

<p>Applications 2,2-Dimethyl-3-(4-mercaptophenyl)propionic Acid (cas# 887354-80-5) is a compound useful in organic synthesis.<br></p>

<p>Applications 1,2,3,4-Cyclobutanetetracarboxylic Acid is a reagent used in the preparation of cobalt cyclobutanetetracarboxylate polymer.<br>References Diaz-Gallifa, P., et al.: Inorg.Chem., 53, 5674 (2014)<br></p>

<p>Applications 2-Acetylthioisobutyric Acid (cas# 135937-96-1) is a compound useful in organic synthesis.<br>References Souers, A., et al.: Bioorg. Med. Chem. Lett., 8, 2297 (1998), Deaton, D., et al.: Bioorg. Med. Chem. Lett., 18, 732 (2008),<br></p>

<p>Applications 4,4'-Dithiobisbenzoic Acid Dimethyl Ester (cas# 35190-68-2) is a compound useful in organic synthesis.<br></p>

<p>Applications 6-Fluoronicotinic acid<br></p>

<p>Applications Ethyl 4-Chloroacetoacetate (cas# 638-07-3) is a compound useful in organic synthesis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications 3-((E)-(2,4-Dimethylphenyl)diazenyl)-2,4-dihydroxy-5-((4-sulfophenyl)diazenyl)benzoic Acid is an intermediate in the synthesis of Acid Orange 24 (A189835), which is used in trickling biofilters for wastewater treatment. Acid Orange 24 is used in suncare compositions. It also serves as a raw material for cosmetics. Mutagenicity test for dye compositions in cosmetics.<br>References Garzon-Zuniga, M. A., et al.: Water Environ. Res., 83, 107 (2011); Anon.: IP.com Journal, 11, 5 (2011); Muzzall, J. M., et al.: Mutat. Res., Genet. Toxicol. Testing, 67, 1 (1979)<br></p>

<p>Applications 1-Butenylboronic Acid is a reagent used in the synthesis of polyene natural products.<br>References Lee, S. J., et al.: J. Am. Chem. Soc., 130, 466-468 (2008)<br></p>

<p>Stability Moisture Sensitive<br>Applications Methyl 3-Phenyloxirane-2-carboxylate (cas# 37161-74-3) is a useful research chemical.<br></p>

<p>Applications Ethyl Isobutyrylacetate is used in the synthesis of piperazine derivatives as possible multireceptor atypical antipsychotics, affecting dopamine and serotonin receptor properties . Also used in the synthesis of pyrazinecarboxamide DGAT1 (diacylglycerol acyltransferase 1) inhibitors used in the treatment of obesity.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Chen, Y. et al.: J. Med. Chem., 56, 4671 (2013); J. Med. Chem., 55, 10610 (2012);<br></p>

<p>Applications tert-Butyl (3-(2-(2-(3-Aminopropoxy)ethoxy)ethoxy)propyl)carbamate is used as a reactant in the synthesis of gallium-labeled PET imaging agents for CXCR4 for potential cancer diagnosis.<br>References Poty, Sophie, et al.: Bioconjugate Chem., 27(3), 752-761 (2016)<br></p>

<p>Applications Dibenzo[b,d]furan-2-sulfonic acid (cas# 83863-63-2) is a useful research chemical.<br></p>

<p>Applications 2-CYCLOPENTYL-2-PHENYLACETIC ACID (cas# 3900-93-4) is a useful research chemical.<br></p>

<p>Applications 2-(Diphenylphosphino)benzoic Acid is used in small molecule control of protein function through staudinger reduction.<br>References Luo, J., et al.: Nat. Chem., 8, 1027 (2016)<br></p>

<p>Applications N-Caproic Acid Isopropyl Ester (cas# 2311-46-8) is a useful research chemical.<br></p>

<p>Applications Hydroxyacetic Acid Hydrazide (cas# 3530-14-1) is a compound useful in organic synthesis.<br></p>

<p>Applications Ethyl 4-Oxo-5-hexanoic Acid Ester is used in the synthesis of analogs of 5-aminolevulinic acid (ALA), which are potential inhibitors of ALA dehydratase (porphobilinogen synthase), an early enzyme of tetrapyrrole biosynthesis;Also, it is an intermediate of 4-Oxo-6-(2-oxo-5-vinylpyrrolidin-1-yl)hexanoic Acid (O858780), which is derived from Ethyl Succinoyl Chloride (E818230), which is used in the synthesis of bivalent ligands for D2/D3 dopamine receptors. Also used in the preparation of antimicrobial pyrrolo-isoquinolinones. Vigabatrin Impurity 2<br>References Appleton, D., et al.: J. Chem. Soc., Perkin Trans., 89-101 (1998); Gogoi, S. et al.: ACS Med. Chem. Lett., 3, 991 (2012)<br></p>

<p>Applications 4-Carboxymethylphenylboronic acid<br></p>

<p>Applications 1-Cyclopentenecarboxylic Acid can be used for enantioselective 1,3-dipolar cycloadditions of diazoacetates and solid-phase synthesis of substituted indolines. It can also be used to develop antagonists for A1- and A2-adenosine receptors.<br>References Sibi, M. P., et al.: Org Lett. 9, 1553 (2007); Nicolaou, K. C., et al.: J. Am. Chem. Soc. 122, 2966 (2000); Jacobson, K. A., et al.: Biochem. Pharmacol. 37, 3653 (1988)<br></p>

<p>Applications 3-​Hydroxypivalic Acid is a general reagent used in the synthesis of AZD8835, a potent and selective inhibitor of PI3K and PI3Kδ in the treatment of cancers.<br>References Barlaam, B. et al.: Bioorg. Med. Chem. Lett., 25, 5155 (2015);<br></p>

<p>Applications Dimethyl cyclopentane-1,3-dicarboxylate (cas# 2435-36-1) is a useful research chemical.<br></p>

<p>Applications N-M-Tolylphthalamic Acid is used to prevent premature drop an anti shock treatment for pants. On ingestion is hydrolyzed to produce m-toluidine<br>References Pawar, G., et al.: Synth. Comm., 32, 1929-1936 (2002)<br></p>

<p>Applications Methyl 2-Aminothiazole-5-carboxylate (cas# 6633-61-0) is a compound useful in organic synthesis.<br></p>

<p>Applications 4-Biphenylcarboxylic acid (cas# 92-92-2) is a useful research chemical.<br></p>

<p>Applications 6-Cyclohexylhexanoic Acid (cas# 4354-56-7) is useful for the preparation of N-​Acylethanolamine Acid Amidase (NAAA) inhibitors, which exhibit anti-inflammatory and analgesic activities.<br>References Ren, J., et al.: RSC Advances, 7, 12455 (2017)<br></p>

<p>Applications 2,5-Furandicarboxylic Acid Diethyl Ester (cas# 53662-83-2) is a compound useful in organic synthesis.<br></p>

<p>Applications Trimethyl Bromoorthoacetate is an intermediate in the synthesis of 3,6-Bis(2-hydroxyethyl)-2-pyrazinepropanoic Acid (B444100), an impurity of Clavulanic Acid (C563750).<br>References Zupke, C., et al.: Biotechnol. Prog., 10, 489 (1994), Finlay, J., et al.: J .Antimicrob. Chemother., 52, 18 (2003),<br></p>

<p>Applications 1,2,2-Trimethylcyclopropyl Boronic Acid is the boronic acid analogue of 1,2,2-Trimethylcyclopropane. Boronic acid derivatives are widely used in several applications in organic synthesis.<br></p>

<p>Applications methyl amino(2-bromophenyl)acetate hydrochloride (cas# 1219408-44-2) is a useful research chemical.<br></p>

<p>Applications N-Pentylboronic Acid is used in the synthesis of (-)-Δ8-THC and (-)-Δ9-THC. Also it aids in the synthesis of boronic acid inhibitors of endothelial lipase.<br>References O'Connell, D. et al.: Bioorg. Med. Chem. Lett., 22, 1397 (2012); Cheng, L. et al.: Org. Lett., 15, 764 (2013);<br></p>

<p>Stability Light Sensitive<br>Applications Azobenzene-4,4'-dicarboxylic Acid (cas# 586-91-4) is a useful research chemical.<br></p>

<p>Applications Tricosanoic Acid 1,2,3-Propanetriyl Ester, can be used for the manufacture of cosmetics, and perfumes.<br>References Oro, L., et al.: Acta Pharmacol. Toxicol., 18, 141 (1961),<br></p>

<p>Applications 6-Chloro-1-benzofuran-2-carboxylic Acid is used to prepare cis-diaminocyclohexane derivatives as factor Xa inhibitors. It is also used to synthesize tachykinin NK2 receptor antagonists.<br>References Bioorg. Med. Chem., 17, 8206 (2009); Gensini, M., et al.: ChemMedChem, 5, 65 (2010)<br></p>

<p>Applications 4-Oxo-3,4-dihydroquinazoline-7-carboxylic acid (cas# 202197-73-7) is a useful research chemical for organic synthesis and other chemical processes.<br>References Bogert, M. T., et al.: J. Am. Chem. Soc., 29, 82 (1907); Baker, B. R., et al.: J. Org. Chem., 17, 141 (1952)<br></p>

<p>Applications 3-(3-THIENYL)ACRYLIC ACID (cas# 102696-71-9) is a useful research chemical.<br></p>

<p>Applications (2R)-4-(1,1-Dimethylethyl) Ester 2,4-Morpholinedicarboxylic Acid is used in the preparation of renin inhibitors.<br>References Yuan, J. et al.: Bioorg. Med. Chem. Lett., 21, 4836 (2011); Fish, P. et al.: Tetra. Lett., 50, 389 (2009);<br></p>

<p>Applications 4-(Cyclopropylcarbonyl)-α,α-dimethylbenzeneacetic Acid is used for the preparation of Terfenadine ((T114500) analogs.<br>References Uchida., et al.: Chem. Pharm. Bull., 37, 958 (1989),<br></p>

<p>Applications methyl 2,4-dichlorothiazole-5-carboxylate (cas# 861708-66-9) is a useful research chemical.<br></p>

<p>Applications Bis[2-​(1-​methylethyl)​phenyl] Ester Phosphorochloridic Acid is an intermediate in the synthesis of Bis(2-isopropylphenyl) Phenyl Phosphate (B451445), which is a triaryl phosphate used as plasticizers in polyvinyl chloride (PVC) as well as a flame retardant. Studies show that Bis(2-isopropylphenyl) Phenyl Phosphate inhibits the human androgen receptor.<br>References Duke, A.J.: Chimia, 32, 457 (1978); Honkakoski, P. et al.: Biochem. Pharmacol., 67, 97 (2004); Nobile, E.R. et al.: Bull. Environ. Contam. Toxicol., 25, 755 (1980);<br></p>

<p>Applications Substituted cinnamic and dihydrocinnamic acids show anti-inflammatory and analgesic activity, with cinnamic acids being more biologically active.<br>References Runwal, L. et al.: Eastern Pharmacist 38, 141 (1995)<br></p>

<p>Applications Hexahydro-4-oxo-1(2H)-azocinecarboxylic Acid 1,1-Dimethylethyl Ester is a chemical reagent used in organic synthesis.<br></p>

<p>Applications 10-Undecynoic Acid is a fatty acid used in the synthesis of copolyesters.<br>References Beyazkilic, Z. et al.: Polym., 79, 290 (2015);<br></p>

<p>Applications (+)-Dibenzoyl-D-Tartaric Acid Monohydrate (cas# 80822-15-7) is a useful research chemical.<br></p>

<p>Applications tert-Butyl (5-Chloro-2-fluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)carbamate is used as a reactant in the synthesis of BRAF-kinase inhibitors.<br>References Repik, Alexey E., et al.: PCT Int. Appl., WO 2017146604 A1 20170831 (2017)<br></p>

<p>Applications 5-Hydroxytoluene-2,4-disulfonic Acid acts as a synthetic reagent in the sulfonation of 2 and 3-Methylphenol.<br>References Strandlund, G., et al.: Acta Chem. Scand., 33, 261 (1979)<br></p>

<p>Applications Methyl (1R,4S)-4-Amino-2-cyclopentene-1-carboxylate (2S,3S)-2,3-Dihydroxybutanedioic Acid is an intermediate used in the synthesis of ent-Abacavir (A105015), which is an enatiomer of Abacavir (A105000). Abacavir is a carbocyclic 2'-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively.<br></p>

<p>Applications O-Acetyl Mandelic Acid is a useful reagent for the synthesis of hindered triazolopyridinone derivatives.<br>References Ye, Z., et al.: Nat. Commun., 11, 3628 (2020)<br></p>

<p>Applications Phosphoric acid diethyl octyl ester is part of a group of phosphate derivatives that enhance drug penetration through the skin. Phosphoric acid diethyl octyl ester is also used as a reagent to prepare trialkyl phosphate and phosphorothiolate anticholinesterases.<br>References Aoyagi, T., et al.: Drug Des. Discovery, 8, 47 (1991); Bracha, P. &amp; O’Brien, R.: Biochemistry, 7, 1555 (1968)<br></p>

<p>Applications γ-Isodurylic Acid is an intermediate in the synthesis of Ketoprofen (K200800) related compounds.<br>References Colomina, M., et al.: J. Chem. Thermodynamics., 19, 1139 (1987);<br></p>

<p>Applications Ethyl 4-bromoacetoacetate<br></p>

<p>Impurity Ketoprofen EP Impurity G<br>Applications 3-​(2-Hydroxyethyl)​benzoic Acid (Ketoprofen EP Impurity G) is an impurity in the synthesis of Ketoprofen (K200800), anti-inflammatory (1,2); analgesic.<br>References 1. Ueno, K. et al.: J Med Chem. 1976 Jul;19(7):941-6. 2. Jamali, F. et al.: Clin Pharmacokinet. 1990 Sep;19(3):197-217.<br></p>