Carboxylic Acids

<p>4-Bromomandelic acid is a chemical with the molecular formula CHBrO. It is an acid that can be found in the form of a solution at room temperature. It is soluble in water and alcohols, but not in ether or chloroform. 4-Bromomandelic acid is used as a reagent for the identification of carbohydrates and other organic compounds by phase chromatography. 4-Bromomandelic acid can be recycled from triticum aestivum (wheat) straw by washing with hydrochloric acid to remove impurities. The purified product can then be crystallized from trifluoroacetic acid or acetic anhydride, followed by backpressure to remove excess solvent. It has been shown that binding constants for metal ions are increased in the presence of p-hydroxybenzoic acid or biphenyl, which has led to its use as a catalyst for reactions involving these substances.</p>

<p>(S)-(+)-2-Phenylpropionic acid is an organic solvent that is catalyzed by a hydroxy group. It has been shown to be active against bacterial strains in the presence of borohydride reduction and immobilized on polystyrene beads. The enzyme activities were stereoselectively inhibited in the presence of (R)-(-)2-phenylpropionic acid, which is an enantiomer of (S)-(+)2-phenylpropionic acid. This inhibition may be due to the ability of this compound to form a more stable radical coupling with fatty acids such as oleic acid. The reaction temperature can affect the stereoselectivity, with higher temperatures favoring (R)-(-)2-phenylpropionic acid.</p>

<p>1-Methyl-L-histidine (3-(1-Methylimidazol-4-yl)-L-alanine) is a natural but non-proteinogenic amino acid; employed as index of muscle protein breakdown.</p>

<p>Applications 2-[(1,3-Dihydro-1,3-dioxo-2H-isoindol-2-yl)acetyl]-butanedioic Acid Diethyl Ester is an intermediate in the synthesis of 5-Aminolevulinic Acid-3-13C Hydrochloride which is a naturally occurring amino acid; precursor of tetrapyrroles in the biosynthesis of chlorophyll and heme. Antineoplastic (photosensitizer).<br>References Sisler, E.C., et al.: Physiol. Plant., 16, 315 (1963), Herdeis, C., et al.: Arch. Pharm., 317, 304 (1984), Peng, Q., et al.: Cancer, 79, 2282(1997),<br></p>

<p>Applications Phthalamic Acid is a reactant in the synthesis of phthalimide derivatives with analgesic activity.<br>References Gajare, S.P., Mahajan, S.S.: Int. J. Pharmaceut. Phytopharmacol. Res., 1, 357 (2012)<br></p>

<p>Applications trans-3-Hexenedioic Acid is used as a starting material in the synthesis of Adipic Acid (A291590) which is primarily used in the synthesis of nylon.<br>References Kim, Y. et al.: Ind. Eng. Chem. Res., 51, 15801 (2012); Li, C., et al.: Electrochim. Acta, 56, 1529 (2010)<br></p>

<p>Applications METHYL 2-(4-OXOCYCLOHEXYL)ACETATE (cas# 66405-41-2) is a useful research chemical.<br></p>

<p>Applications 1,1-Cyclopentanediacetic Anhydride is used to prepare betulin carboxyalkanoate derivatives as anti-HIV agents.<br>References Sun, I., et al.: J. Med. Chem., 41, 4648 (1998); Zhu, Y., et al.: Bioorg. Med. Chem. Lett., 11, 3115 (2001)<br></p>

<p>Applications tert-Butyl (Triphenylphosphoranylidene)carbamate is used in the preparation of ketimines.<br>References Yan, W., et. al.: Organic Lett., 14, 2512 (2012)<br></p>

<p>Applications Used in the preparation of Isoxazole derivatives.<br>References Silverman, R.: J. Heterocyc. Chem. 15, 1519 (1978)<br></p>

<p>Applications (E,E)-8-Oxogeranyl Acetate is an intermediate in the synthesis of rac-Rossinone B, an bioactive meroterpenoids from the Antarctic Ascidian.<br>References Appleton, D.R., et al.: J. Org. Chem., 23, 9195 (2009); Zhang, Z., et al.: Org. Lett., 12, 5554 (2010);<br></p>

<p>Applications 5-Amino-2-chlorobenzoic Acid is a reagent in the preparation of potent and selective benzothiazole hydrazone inhibitors of Bcl-XL.<br>References Sleebs, B.E., et al.: J. Med. Chem., 56, 5514, (2013)<br></p>

<p>Applications 2-(((10-(Benzyloxy)-10-oxodecan-2-yl)oxy)carbonyl)benzoic Acid is an intermediate in the synthesis of Monocarboxyisodecyl Phthalate (M525575), a metabolite of Dibutyl phthalate (DBP) (D429495), which is found widely in consumer products.<br></p>

<p>Applications ISOPROPYL TRIFLUOROACETATE (cas# 400-38-4) is a useful research chemical.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications A benzoic acid derivative used in the preparation of potent, selective, orally bioavailable matrix metalloproteinase inhibitors.<br>References Wada, C. et al.: J. Med. Chem., 45, 219 (2002)<br></p>

<p>Applications 4-Benzyloxybenzoic Acid is a chemical reagent in the preparation of anticancer leads such as quinolin-4-one derivatives.<br>References Cheng, Y. et al.: Bioorg. Med. Chem. Lett., 23, 5223 (2013);<br></p>

<p>Applications Ethyl 2-(1,3-dioxoisoindol-2-yl)acetate<br></p>

<p>Applications α-Hydroxy-3,4-bis(phenylmethoxy)benzeneacetic Acid Phenylmethyl Ester is an protected intermediate in the synthesis of metabolites of Catecholamines.<br></p>

<p>Applications 9-Hydroxydecanoic Acid Benzyl Ester is an intermediate in the synthesis of Monocarboxyisodecyl Phthalate (M525575), a metabolite of Dibutyl phthalate (DBP) (D429495), which is found widely in consumer products.<br>References Weber, A. E., et al.: J. Med. Chem., 35, 3755 (1992);<br></p>

<p>Applications Methyl 2-[2-[(2,5-Dimethylphenoxy)methyl]phenyl]-2-(hydroxy)acetic Acid Ester is an intermediate used in the synthesis of Mandestrobin (M162555), which is a novel fungicide having a methoxyacetamid structure. Mandestrobin also shows safer profiles for human health and the environment.<br>References Hirotomi, D., &amp; Kiguchi, S.: PCT Int. Appl., WO 2017026526 A1 20170216 (2017)<br></p>

<p>Applications Methyl 4-Bromofuran-2-carboxylate is used to prepare pyrimidinamines and pyridinamines as adenosine receptor modulators for treatment of CNS disorders.<br>References Borroni, E., et al.; PCT Int. Appl., WO 2001062233 A2 20010830 (2001)<br></p>

<p>Applications Methyl α-bromophenylacetate is used in synthetic chemistry as an initiator for polymerization reactions (such as the polymerization of methyl methacrylate). Methyl α-bromophenylacetate is also used as a reagent to synthesize compounds that act as selective Serotonin (HCl: S274980) reuptake inhibitors (SSRI). SSRIs are used to modulate symptoms in autistic patients.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Fors, B. &amp; Hawker, C.: Angew. Chem. Int. Edit., 51, 8850 (2012); Ghoneim, O., et al.: Bioorgan. Med. Chem. Lett., 21, 6714 (2011); O’Reilly, R., et al.: Macromolecules, 40, 7441 (2007)<br></p>

<p>Applications Isobutyl Acetoacetate is a building block that has been used as a reactant in the preparation of b-annulated 1,4-dihydropyridine derivatives as TGFβ signaling inhibitors.<br>References Schade, D., et. al.: J. Med. Chem., 55, 9946 (2012)<br></p>

<p>Applications Dimethylarsinothioic Acid Anhydrosulfide is an intermediate in the synthesis of standards for arsenic inspection. It is used as an aid to help in determining the level of toxicity in humans. Metabolite in mammals.<br></p>

<p>Applications 2-(Carboxymethylamino) Nicotinic Acid Diethyl Ester (cas# 1178176-00-5) is a compound useful in organic synthesis.<br></p>

<p>Applications Acetylenedicarboxylic Acid is used as an electrolyte in the fabrication of anodic nanoporous alumina. It is also used as a reagent in the synthesis of several organic compounds including that of derivatives of metronodazole (antibiotic and antiprotozoal medication) which display increased antimicrobial and antiparasitic properties.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Kikuchi, T., et al.: Electrochem. Lett., 3, C25 (2014); Al-Masoudi, N., et al.: Monatsh. Chem., 147, 383 (2016);<br></p>

<p>Applications (2S)-2-[[(phenylmethoxy)carbonyl]amino]-4-Pentenoic acid is a useful building block, and has been used in the regioselective preparation of nonracemic silylated amino acids.<br>References Marchand, D.; et al.: Eur. J. Org. Chem., 18, 3107 (2008).<br></p>

<p>Applications 4-Oxocyclohexanecarboxylic Acid is used in the preparation of Indomethacin (I641000) analogues used in the treatment of prostate cancer. In addition it is used in the synthesis of β-alanine derivatives as glucagon receptor antagonists.<br>References Liedtke, A. et al.: J. Med. Chem., 56, 2429 (2013); Lau, J. et al.: J. Med. Chem., 50, 113 (2007);<br></p>

<p>Applications 4-(Benzyloxy)-2-hydroxy-5-(sulfooxy)benzoic Acid is an intermediate used in the synthesis of 4-Hydroxy Flecainide (H942485), which is an analogue of Flecainide (F390000).<br>References Blom, Y., et al.: J. Chromatogr., 653, 138 (1993),<br></p>

<p>Applications Ethyl 2-Aminothiophene-3-carboxylate (cas# 31891-06-2) is a compound useful in organic synthesis.<br></p>

<p>Applications 4-(3-Acetoxypropyl)phenyl Acetate is an intermediate used in biological studies for biodistribution and elimination of xenoestrogen nonylphenol in Wistar rats.<br>References Oriyama, T., et al.: Synlett., 6, 701 (1997);<br></p>

<p>Applications Intermediate in the production of DMEQ-TAD<br>References Shimizu, M., et al.: Anal. Biochem., 194, 77 (1991),<br></p>

<p>Applications N-(2-N’,N’-Dimethylaminoethyl)maleamic Acid (cas# 116503-79-8) is a compound useful in organic synthesis.<br></p>

<p>Applications rac-Trifluorolactic Acid is a derivative of DL-Lactic Acid (L113490) which occurs in small quantities in the blood and muscle fluid of man and animals. The lactic acid concentration increases in muscle and blood after vigorous activity.<br>References He, W. et al.: Comp. Biochem. Phys. Part A: Mol. Int. Phys., 166, 308 (2013)<br></p>

<p>Applications benzyl (2s)-4-oxoazetidine-2-carboxylate, is a building block used for various chemical synthesis such as for the synthesis of NMDA receptor antagonists, 3-alkyl-L-aspartic acids, and orally active β-lactam inhibitors.<br>References Baldwin, J.E. et al. Tetrahedron 51, 11581-11581, (1995); Hanessian, S. et al. Synlett , 33-33, (1992)<br></p>

<p>Applications Ethyl [(tert-Butyldimethylsilyl)oxy]acetate (cas# 67226-78-2) is a compound useful in organic synthesis.<br></p>

<p>Applications 1,1-Dimethyl 2-Ethenylcyclopropane-1,1-dicarboxylate is a useful chemical in organic synthesis.<br>References Laugeois, Maxime, et al.: Org. Let., 19(9), 2266-2269 (2017);Zhu, Haipan, et al.: Beilstein J. of Org. Chem., 12, 1340-1347 (2016)<br></p>

<p>Applications DI-Tert-Butyl Hydrazodicarboxylate (cas# 16466-61-8) is a useful research chemical.<br></p>

<p>Applications Intermediate in the preparation of alkoxycarbonylthiazolethione derivatives.<br></p>

<p>Applications N,N’-Di-Boc (R)-1-Azido-3-[[3-fluoro-4-(morpholin-4-yl)phenyl]amino]propan-2-yl Acetate is an intermediate used in the synthesis of N-Desacetyl-N,O-descarbonyl O-Acetyl Linezolid (D288280), which is an impurity of Linezolid (L466500); an oxazolidinone antimicrobial that inhibits bacterial mRNA translation.<br>References Brickner, S.J., et al.: J. Med. Chem., 39, 673 (1996); Ford, C.W., et al.: Antimicrob. Agents Chemother., 40, 1508 (1996); Rybak, M.J., et al.: Pharmacotherapy, 18, 456 (1998); Stevens, D.L., et al.: Clin. Infect. Dis., 34, 1481 (2002)<br></p>

<p>Applications 3-(4-Aminophenyl)propionic acid (cas# 2393-17-1) is a useful research chemical.<br></p>

<p>Applications 8-Bromooctanoic Acid (cas# 17696-11-6) is a compound useful in organic synthesis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications rac (Aminomethyl)ethylenediaminetetraacetic Acid tetra-(t-Butyl Ester) (cas# 1391052-55-3) is a compound useful in organic synthesis.<br></p>

<p>Applications Allenylboronic acid pinacol ester<br></p>

<p>Applications (2R,3R)-2,3-Bis(acetyloxy)butanedioic Acid Mono[(10S)-5-(aminocarbonyl)-10,11-dihydro-5H-dibenz[b,f]azepin-10-yl] Ester is an intermediate in the synthesis of Eslicarbazepine (M546510), a novel central nervous system drug.<br>References Duncan, J., et al.: Br. J. Clin. Pharmacol., 53, 123 (2002), Almeida, L., et al.: J. Clin. Pharmacol., 45, 1062 (2005), Coppola, G., et al.: CNS Drugs, 18, 133 (2004),<br></p>

<p>Applications Diisopropyl Azodicarboxylate is an azodicarboxylic acid derivative used as a reagent in the production of many organic compounds. Diisopropyl Azodicarboxylate is commonly used as an oxidizer in Mitsunobu reactions and can also serve as a selective deprotectant of N-benzyl groups in the presence of other protecting groups.<br>References Pichika, R. et al.: Nuc. Med. Biol., 38, 1183 (2011); Kroutil, J. et al.: Synthesis, 3, 446 (2004); Hughes, D.L. et al.: Org. React., 42, 335 (1992);<br></p>

<p>Stability Hygroscopic, Moisture sensitive<br>Applications Isotope labelled Acetic Acid is a common chemical reagent used in a multitude of organic reactions. It is the primary constituent of vinegar, contributing to its distinct taste and odor. It is used in the synthesis of dye-sensitized solar cells.<br>References Hara, K. et al.: J. Phys. Chem. 109, 15476 (2005); Nakayama, T. et al.: J. Biochem., 46, 1217 (1959);<br></p>

<p>Applications 4-Benzoylbenzoic acid is a reagent that is used in the synthesis of BzATP Triethylammonium Salt, which is a selective P2X purinergic agonist. It is more potent than ATP at homodimeric P2X7 receptors.<br>References Cole, D., Yount, R.: J. Biol. Chem., 265, 22537 (1990); Atarashi, K., et al.: Nature, 455, 808 (2008)<br></p>

<p>Applications Ethyl (2’-Hydroxy-3’-benzyloxybenzoyl)acetate is an intermediate used in the preparation of 8-Hydroxy Warfarin (H996140).<br></p>

<p>Applications 2,2-Dimethylpropanoic Acid 1,1'-[[1-Ethyl-2-(4-hydroxyphenyl)-1,2-ethenediyl]di-4,1-phenylene] Ester is an intermediate in the synthesis of ferrocenyl tamoxifen derivatives with modified side chains.<br>References Nguyen, A., et al.: Chem. Eur. J., 15, 684 (2009);<br></p>

<p>Stability Store in a Cool Dry Area.<br>Applications A metabolite of 1,4-diethenylbenzene.<br>References Linhart, I., et al.: Xenobiotica, 19, 645 (1989),<br></p>

<p>Applications 2,2-Dimethyl-1,3-dioxane-5,5-dicarboxylic Acid Dimethyl Ester (cas# 111934-93-1) is a compound useful in organic synthesis.<br></p>

<p>Applications 6-Quinoxalinecarboxylic Acid is an intermediate used in the production of antiprotozoal agents.<br>References Kim, D., et al.: Eur. J. Med. Chem., 44, 568 (2009), Lyne, P., et al.: Bioorg. Med. Chem. Lett., 19, 1026 (2009),<br></p>

<p>Applications Ethyl 2-(ethoxymethylene)acetoacetate<br></p>

<p>Applications 5-Amino-2-chloro-4-fluorobenzoic Acid is an intermediate in the synthesis of Saflufenacil-d7 (S081802). Saflufenacil-d7 is the labeled version of Saflufenacil (S081800), which is a herbicide of the pyrimidinedione chemical class used for the preplant burndown and selective preemergence dicot weed control in different field crops. It was found to inhibit protoporphyrinogen IX oxidase (PPO) enzyme.<br>References Knezevic, S., et al.: Crop Prot., 29, 148 (2010); Grossmann, K., et al.: Weed Sci., 58, 1 (2010)<br></p>

<p>Applications Homophthalic acid (cas# 89-51-0) is a useful research chemical.<br></p>

<p>Applications (R)-5-Oxotetrahydrofuran-2-carboxylic Acid is an intermediate used to synthesize 2',3'-dideoxy-4'-selenonucleosides as potential antiviral agents.<br>References Jeong, L., et al.: Bioorg. Med. Chem., 16, 9891 (2008)<br></p>

<p>Applications 10,12-TRICOSADIYNOIC ACID (cas# 66990-30-5) is a useful research chemical.<br></p>

<p>Applications 2-Butynoic Acid is used as a reagent in the synthesis of BMS 911543 (B596075); a potent JAK2 inhibitor used as a potential treatment for myeloproliferative disorders. 2-Butynoic Acid is also used in the preparation of chirally pure 1,2,3,4-tetrahydroisoquinoline analogs as anti-cancer agents.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Fitzgerald, M.A., et al.: J. Org. Chem., 80, 6001 (2015); Ramanivas, T., et al.: Eur. J. Med. Chem., 92, 608 (2015)<br></p>

<p>Applications 2-(Furan-2-yl)-2-(methoxyimino)acetic Acid is an intermediate in the synthesis of Cephalosporin derivatives.<br>References Ger. Offen. (1978), DE 2731724 A1 19780119.<br></p>

<p>Applications 9-Oxo-9H-fluorene-4-carboxylic acid (cas# 6223-83-2) is a useful research chemical.<br></p>

<p>Applications (2,2-Dimethyl-1,3-dioxolan-4-yl)methyl Dibenzyl Carbamate Phosphate is an intermediate used in the synthesis of Glycerol 3-Phosphoethanolamine (G601595), which is the product of a alcoholysis reaction with phosphatidylcholine and phosphatidylethanolamine.<br>References Meng, Z., et al.: Zhongguo Youzhi, 38, 32 (2013)<br></p>

<p>Applications 2-(4-Pyridyl)ethanesulfonic acid is the sulfonated substrate for alkanesulfonate monooxygenase. It is also used in the preparation of benzyldimethyltetradecyl ammoniumchloride dihydrate solution.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Kasahara, I., et al.: Anal. Sci., 17, i1233 (2001); Eichhorn, E., et al.: J. Biol. Chem., 274, 26639 (1999)<br></p>

<p>Applications Dimethyl cyclopropane-1,1-dicarboxylate (cas# 6914-71-2) is a useful research chemical.<br></p>

<p>Applications Ethyl-[4-(thienylketo)-2,3-dichloro-phenoxy]acetate (cas# 66883-42-9) is a compound useful in organic synthesis.<br></p>

<p>Applications Methyl 1,4-Benzodioxan-2-carboxylate is an intermediate used to prepare 2,3-dihydrobenzo[b|[1,4|dioxin- and indolealkylamine derivatives as potential antidepressants.<br>References Wang, S., et al.: Archiv der Pharmazie (Weinheim, Germany), 347, 32 (2014); Wang, S., et al.: Bioorg. Med. Chem. Lettt., 24, 1766 (2014)<br></p>

<p>Applications Propyl Acetoacetate is used as a reagent in the synthesis of 3,4-dihydropyrimidin-2(1H)-ones as a novel class of potent and selective A2B adenosine receptor antagonists.<br>References Crespo, A., et al.: ACS Med. Chem. Lett., 4, 1031 (2013)<br></p>

<p>Applications Intermediate in the preparation of Benzoxazines.<br></p>

<p>Applications 3-[(Carboxymethyl)thio]propionic Acid Dimethyl Ester (cas# 7400-45-5) is a compound useful in organic synthesis.<br></p>

<p>Applications 2-(Cyclopropylmethoxy)-acetic Acid (cas# 246869-08-9) is a compound useful in organic synthesis.<br></p>

<p>Applications Trichloroacetic Anhydride is used in organometallic reactions as well as oxadiazole containing 5-lipoxygenase activating protein inhibitors.<br>References Takahashi, H. et al.: J. Med. Chem., 58, 1669 (2015);<br></p>

<p>Applications 3-Thiophenecarboxylic Acid was used as a lading compound for the development of a clinic useful D-amino acid inhibitor and have the potential to sever as active site proves to elucidate the structure-function relationships of D-amino acids.<br>References Katane, M., et al.: J. Med. Chem., 56, 1894 (2013)<br></p>

<p>Applications is a building block used in various chemial synthesis such in the preparation of 6-(carboxymethylureido)-(±)-nicotine (CMUNic), nicotine immunogen, and  imidazo[1,2-c]-quinazoline-2,5-(3H,6H)dione.<br>References Y Hieda et. al,: The Journal of pharmacology and experimental therapeutics, 283(3), undefined (1998-2-12); Papadopoulos EP.Journal of Heterocyclic Chemistry 18(3), 515-518,<br></p>

<p>Applications 2-(Cyclopropylmethoxy)-acetic Acid 1,1-Dimethyl-2-[4-(methylsulfonyl)phenyl]-2-oxoethyl Ester is a useful research chemical for organic synthesis and other chemical processes.<br>References Leblanc, Y., et al.: Bioorg. Med. Chem. Lett., 9, 2207 (1999)<br></p>

<p>Applications An intermediate in the preparation of Digallic Acid<br></p>

<p>Applications Methyl 2-benzylhydrazinecarboxylate is an intermediate for the synthesis of CFM 1571 Hydrochloride (C291720), which acts as a soluble guanylyl cyclase (sGC) activator while ignoring adenylyl cyclase. Inhibits collagen-stimulated platelet aggregation in vitro.<br>References Kotzki, S. et al.: J. Pharm. Exp. Ther., 346, 424 (2013); Selwood, D&gt; et al.: J. Med. CHem., 44, 78 (2001)<br></p>

<p>Applications Diethyl N,N-(3’-Pyridylmethylene)bis(carbamate) (cas# 2744-17-4) is a compound useful in organic synthesis.<br></p>

<p>Applications (Z)-2-(Methoxyimino)-3-oxo-butanoic Acid is an intermediate used in the synthesis of Cefotaxime Bromoacetyl Analogue (C242940), which is an impurity of Cefotaxime (C242950), a broad spectrum third generation cephalosporin antibiotic<br>References Wise, R., et al.: Antimicrob. Agents Chemother., 14, 807 (1978), Muhtadi, F.J., et al.: Anal. Profiles Drug Subs., 11, 139 (1982),<br></p>

<p>Applications P,P'-[(1,2-Phenylene)bis(methylene)]bisphosphonic Acid P,P,P',P'-Tetraethyl Ester also used in claisen condensations. Also used in the synthesis of styrylbenzenes as β-amyloid binding ligands as well as free radical scavengers.<br>References Gavara, L. et al.: Tetrahedron Lett., 54, 817 (2013); Flaherty, D. et al.: J. Med. CHem., 53, 7992 (2010);<br></p>

<p>Applications Dibenzyl azodicarboxylate is a reagent used in the synthesis of Minocycline-d6 (M344797). Minocycline-d6 is a labeled second generation tetracycline antibiotic. Antibacterial.<br>References Zbinovsky, V., et al.: Anal. Profiles Drug Subs., 6, 323 (1977); Oringer, R.J., et al.: J. Periodontol., 73, 835 (2002)<br></p>

<p>Applications Tetradeca-1,13-dien-3-yl Acetate in synthesizing 3-Hydroxydodecanedioic Acid (H939615), which is used in studies of fatty acid metabolic disorders such as ketoacidosis where enzyme deficiencies are believed to be present.<br>References Chickos, J. et al.: J. Clin. Lab. Anal., 16, 115 (2002); Greter, J. et al.: Clin. Chem., 26, 281 (1960);<br></p>

<p>Applications Protected ε-Aminocaproic Acid (A603015). Used in the preparatiom of esters of 6-aminohexanoic acid as antibacterial agents. EACA is reported to inhibit chymotrypsin, Factor VIIa, lysine carboxy peptidase, plasmin, and plasminogen activator.<br>References Dolezal, P., et al.: Pharm. Res., 10, 1015 (1993), Vavrova, K., et al.: Curr. Med. Chem., 12, 2273 (2005), Holas, T., et al.: Bioorg. Med. Chem., 14, 7671 (2006),<br></p>

<p>Applications Hydrofluoric Acid is a common chemical reagent used as a precursor to most pharmaceutical and high volume fluoride compounds as well as in the oil refinery process. Hydrofluoric acid causes skin burns if contact with skin.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Yamashita M. et al.; Crit. Care. Med., 29, 1575 (2001); Stahl, K. et al.: Ind. Eng. Chem., 7, 56 (1915);<br></p>

<p>Applications 3,3-Diphenylpropionic Acid is used in the preparation of steroid 5α-reductase inhibiting acylpiperidines. It can also be used in the preparation of calpain-inhibitory piptidyl α-ketoacids and esters.<br>References Picard, F. et al.: J. Med. Chem., 45, 3406 (2002); Donkor, I. et al.: J. Med. Chem., 51, 4346 (2008);<br></p>

<p>Applications Allyl Acetate is an intermediate in synthesizing Cabergoline-d5 (C050002), a labelled dopamine D2-receptor agonist.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Brambilla, E., et al.: Eur. J. Med. Chem., 24, 421 (1989); Ferrari, C., et al.: J. Clin. Endocrinol. Metab., 68, 1201 (1989); Hutton, J.T., et al.: Neurology, 46, 1062 (1996)<br></p>

<p>Applications Propane-1,3-diylbis((3-acetamidopropyl)carbamic Acid) di-tert-Butyl Ester is an intermediate in the synthesis of derivatives of Spermine (S680510) which is a biogenic polyamine formed from Spermidine (S680400) that occurs in almost all tissues.<br>References Theoharides, T.C., et al.: Life Sci., 27, 703 (1980); Horn, Y., et al.: Cancer Res., 42, 3248 (1982)<br></p>

<p>Applications Methyl Cyanoacetate is often used as a nucleophile in the electrochemical oxidation of catechols. Methyl Cyanoacetate is also a reagent in the synthesis of Methyl 2-Amino-4-trifluoromethylthiophene-3-carboxylate (M287290); a compound used in the synthesis of DPP-IV inhibitors for treating type 2 diabetes.<br>References Rafiee, M., et al.: J. Electroanal. Chem., 626, 36 (2009); Deng, J., et al.: Eur. J. Med. Chem., 46, 71 (2010)<br></p>