Carboxylic Acids

<p>N-Acetylornithine is found in human blood plasma (avg. 1.1±0.4 μmol/L) and urine (~1 μmol/day).</p>

<p>DL-O-Phosphoserine (DL-SOP), a normal metabolite in human biofluid, is an ester of serine and phosphoric acid.</p>

<p>α-Lactose is the major sugar present in milk and the main source of energy supplied to the newborn mammalian in its mother's milk.</p>

<p>Phenylacetylglutamine (NSC 203800)is a normal constituent of human urine, but other mammals such as the dog, cat, rat, and horse do not excrete this compound.</p>

<p>DL-Pyroglutamic acid exhibited a strong inactivating effect on hepatitis B surface antigen. </p>

<p>N-acetyl-L-methionine equals L-methionine in diet &amp; metabolism, essential for growth and methyl group transfers.</p>

<p>Methylmalonic acid (Isosuccinic acid) is a dicarboxylic acid that can be derived from methylmalonyl-coenzyme A.</p>

<p>N-Acetyl-L-aspartic acid: second to glutamate in brain, from aspartate &amp; acetyl CoA, roles in osmoregulation, lipid synthesis, and energy.</p>

<p>3-(3-Methoxyphenyl)propionic acid (3-Methoxyhydrocinnamic acid) is a naturally occurring human metabolite, It is an organic acid and excreted in human urine.</p>

<p>Glycylglycine (Diglycine) is a dipeptide used in biochemical research. It is the simplest and is used as a starting template for more complex peptides.</p>

<p>NAcGlu, made from glutamic acid &amp; acetyl-CoA by NAGS, activates urea cycle enzyme. NAGS deficiency causes Type I hyperammonemia.</p>

<p>3-Ethoxy-3-oxopropanoic acid (Monoethyl malonic acid) belongs to the class of organic compounds known as dicarboxylic acids and derivatives.</p>

<p>DL-o-Tyrosine: metabolite of Phenylalanine, precursor to catecholamines, marker of protein damage in β-thalassemia.</p>

<p>Applications 4-Dodecylbenzenesulfonic acid<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications 2,2-Diphenylpentanoic Acid (cas# 841-32-7) is a compound useful in organic synthesis.<br></p>

<p>Applications Phenylglyoxylic Acid (cas# 611-73-4) is a compound useful in organic synthesis.<br></p>

<p>Applications 6-Bromo-2-napthoic Acid is used in the preparation of Adapalene, a synthetic aromatic retinoid with specificity for RARβ and RARγ receptors.<br>References Milanese, A. et al.: Bioorg, Chem., 39, 151 (2011);<br></p>

<p>Applications 3,3-Dimethylbutyric Acid is used in the synthesis of imidazo[4,5-c]pyridine derivatives as anitmicrobial agents.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Jose. G., et. al.: Eur. J. Med. Chem., 77, 288 (2014)<br></p>

<p>Applications Fendizoic Acid is a reagent in the synthesis of fluorinated polyphthalazinone ethers containing perfluorophenylene moieties.<br>References Lu, Z., et al.: J. Polym. Sci. A1, 42, 925 (2004)<br></p>

<p>Applications (E)-Cyano(methoxyimino)-acetic Acid is a degradation product of Cymoxanil (C988995), which is a fungicide applied as a seed treatment or as a foliar application to the plants to control late blight.<br>References Morrica, P., et al.: J. Agric. Food Chem. 52, 99 (2004); Dhingani, J. C., et al.: J. Pure. App. Microbiol., 6, 1683 (2012); Bakirici, G.T., et al.: Food. Chem., 135, 1901 (2012)<br></p>

<p>Applications Repaglinide intermediate.<br>References Wolfenbuttel, B., et al.: Eur. J. Clin. Pharmacol., 45, 113 (1993), Grell, W., et al.: J. Med. Chem., 41, 5219 (1998), Anon., et al.: Drugs Future, 24, 815 (1999),<br></p>

<p>Applications Dithiocarbamate complexes serve as hosts for the specific binding of various metal cations.<br>References Bourson, J., et al.: J. Phys. Chem., 97, 4552 (1993), Lai, S., et al.: Inorg. Chem., 38, 4262 (1999),<br></p>

<p>Applications 4-octylbenzoic acid (cas# 3575-31-3) is a useful research chemical.<br></p>

<p>Applications Maleic Acid Monomethyl Ester, is relative to Maleic Anhydride (M124400), which is a heterocyclic compound used in the manufacture of unsaturated polyester resins. Maleic Anhydride has a wide range of other applications; it can also be used in synthetic tensides, insecticides, herbicides and fungicides.<br>References Hanafi, W.Z.A. et al.: Plast. Rub. Comp. Proc. Appl., 19, 175 (1993); Noma, K. et al.: Shik. Kyok., 36, 225 (1963); Augustin, M. et al.: Wissen. Zeitsch., 25, 5 (1976); Jiang, Q. et al.: Nongyao, 49, 257 (2010);<br></p>

<p>Applications 3-(4-Hydroxy-3,5-dimethoxyphenyl)propanoic Acid (cas# 14897-78-0) is a useful research chemical.<br></p>

<p>Applications 1,1-Cyclohexanediacetic Acid (cas# 4355-11-7) is a compound useful in organic synthesis.<br></p>

<p>Applications 3,5-Di-tert-butyl-4-hydroxybenzoic acid hexadecyl ester<br></p>

<p>Applications 2,3-Dihydroxypropanoic acid(20% in water) (cas# 473-81-4) is a useful research chemical.<br></p>

<p>Applications m-Toluic acid is used as a reagent in the preparation of hybrid molecules containing oxadiazole and thiadiazole bearing Schiff base moiety as it has antitumor activities.<br>References Zhang, K., et al.; Bioorg. Med. Chem. Lett., 24, 5154 (2014);<br></p>

<p>Applications Glutaconic Acid is used in the synthesis of dialkyltin derivatives of dicarboxylic acids which display antitumor properties. Also used in the synthesis of novel tetracyclic compounds as peripheral benzodiazepine receptor ligands with potential use for CNS illness treatments.<br>References Gielen, M. et al.: Hetero. Chem., 3, 449 (1992); Okubo, T. et al.: Bioorg. Med. Chem. Lett., 12, 3569 (2004);<br></p>

<p>Applications 3-(2,2-Dichloroethenyl)-2,2-dimethylcyclopropanecarboxylic Acid is a reagent used in the preparation of hapten and immunogen for the production of polyclonal antibodies, specific to Cypermethrin (C989000).<br>References Lee, N. et al.: J. Agri. Food Chem., 46, 520 (1998); Hongsibsong, S. et al.: Int. J. Agri. Biol., 14, 246 (2012);<br></p>

<p>Applications Benzyl Acetate, is found naturally in many flowers, It has pleasant sweet aroma reminiscent of jasmine, and thus is used widely in perfumery industry, and also as a flavouring agent. It is also used as a solvent.<br>References Schiestl, F. P., et al.: J. Chem. Ecology, 29 (2004); Qian-qian, M., et al.: Jingxi Huagong, 30, 442 (2013);<br></p>

<p>Applications 2-Amino-2-phenylbutyric acid 96% (cas# 5438-07-3) is a useful research chemical.<br></p>

<p>Stability Hygroscopic<br>Applications 3-Sulfanylhexyl Acetate is a precursor of 3-mercaptohexan-1-ol (M225270) found in grape juice.<br>References Harsch, M.J., et al.: J. Agri. Food. Chem., 61, 3703 (2013); Makhotkina, O., et al.: Food. Chem., 135, 486 (2012);<br></p>

<p>Applications Z-2-Fluoro-3-(3-pyridyl)acrylic Acid (cas# 359435-42-0) is a compound useful in organic synthesis.<br></p>

<p>Applications Di-β,β'-Chloroethylphosphoric Acid, is a dialkyl hydrogen phosphates, that can undergo the electrophilic trifluor- omethylation to produce trifluoromethyl phosphates in order to increase the lipophilicity of functional groups.<br>References Santschi, N., et al.: J. Fluorine Chem., 135, 83 (2012);<br></p>

<p>Applications 3,4-Secocholest-5-ene-3,4-dioic Acid Dimethyl Ester is an intermediate used in the synthesis of 3,4-Seco-solanidine-3,4-dioic Acid (S682410), which is a derivative of Solanidine (S682410).<br></p>

<p>Applications 2-(7-Amino-2-oxo-2H-chromen-4-yl)acetic acid (cas# 85157-21-7) is a useful research chemical.<br></p>

<p>Applications 1,4-dibutyl benzene-1,4-dicarboxylate (cas# 1962-75-0) is a useful research chemical.<br></p>

<p>Applications butyl carbamate (cas# 592-35-8) is a useful research chemical.<br></p>

<p>Applications Nicotinic Acid 2-Diethylamino-Ethyl Ester (cas# 3099-52-3) is a useful research chemical.<br></p>

<p>Applications 5-Chloronicotinic Acid is used as reagent/reactant luminescence and hydrothermal preparation of cobalt/cadmium/lead chloronicotinate phenanthroline MOF.<br>References Gao, Z.Q., et al.: J. Solid State Chem., 241, 121-130 (2016)<br></p>

<p>Applications (-)-α-Kainic Acid Monohydrate is the monohydrated form of (-)-α-Kainic Acid (K135010); a naturally occurring neuroexcitatory chemical that is a selective agonist for a subtype of ionotropic glutamate receptor. Administration of (-)-α-Kainic Acid has been shown to increase production of reactive oxygen species, mitochondrial dysfunction, and apoptosis in neurons in many regions of the brain, particularly in the hippocampal subregions and in the hilus of dentate gyrus.<br>References Wacker, D.A., et al.: Synlett, 503 (1997); Dunleavy, M., et al.: J. Molec. Neurosci., 49, 202 (2013); Zhang, J., et al.: Neuron., 76, 1133 (2012); Yamada, J., et al.: Neurosci., 226, 119 (2012); Wang,Q., et al.: Mol. Neurobiol., 31, 3 (2005)<br></p>

<p>Impurity Sulfadimethoxine EP Impurity D/ Mesalazine EP Impurity O<br>Applications Sulfanilic Acid (Sulfadimethoxine EP Impurity D) is a toxic metabolite of Tartrazine (T007700). Used as Ehrlich’s reagent, for detecting of nitrites. Antibacterial.<br>References Collins, T., et al.: Food Chem. Toxic., 28, 821 (1990), Levine, W., et al.: Drug Metab. Rev., 23, 235 (1991), Sasaki, Y., et al.: Mutat. .Res., 519, 103 (2002),<br></p>

<p>Applications Reagent used in the synthesis of cyhalothric pesticides and fungicides.<br>References Sun, C., et al.: Bioorg. Med. Chem., 14, 8574 (2006),<br></p>

<p>Applications DL-CITRAMALIC ACID (cas# 2306-22-1) is a useful research chemical.<br></p>

<p>Impurity Orlistat USP Related Compound B<br>Applications Orlistat USP Related Compound B<br></p>

<p>Applications 3-(1-Cyanoethyl)benzoic Acid is an intermediate for the synthetic preparation of various pharmaceutical compounds. 3-(1-Cyanoethyl)benzoic Acid was used in studies examining the enantioselectivity of nitrile hydratases.<br>References Rzeznicka, K., et al.: App. Microbiol. Biotechnol., 85, 1417 (2010); Van Pelt. S., et al.: Org. Biomole. Chem., 9, 3011 (2011);<br></p>

<p>Applications 7H-Dodecafluoroheptanoic Acid is a derivative of Heptanoic Acid (H998455) which can be used as an organic building blocks for the synthesis of variety of chemical compounds. Heptanoic Acid is used in the synthesis of 17-epi-Testosterone Enanthate (T155095). It is used in the preparation of esters, such as ethyl heptanoate, which are used in fragrances and as artificial flavors. It is also one of many additives in cigarettes.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Anneken, D. et al.: Fatty Acids, Ullmann's Encyclopedia of Industrial Chemistry (2006); Wudy, S., et al.: Steroids, 66, 759 (2001); Kootstra, P., et al.: Anal. Chim. Acta., 586, 82 (2007); Sten, T., et al.: Drug Metab. Dispos., 37, 417 (2009)<br></p>

<p>Applications Levulinic Acid is derived from the degredation of cellulose and is a potential precursor to biofuels. Levulinic acid is also a photosensitizer for photodynamic therapy.<br>References Serrano-Ruiz, J.C., et al.: Catalysis., 195, 162 (2012); Liedtke, A.J. et al.: Tetrahedron., 68, 10049 (2012);<br></p>

<p>Applications 2,6-Diaminopimelic Acid is useful in biological studies involving amino acids and amino sugars as molecular indicators of the origins of organic matter in buried tephra soils.<br>References Hobara, S., et al.: Geoderma, 373, 114449 (2020)<br></p>

<p>Applications DL-3-phenyllactic acid had been identified as a urinary food intake biomarker for milk, cheese and soy-based drinks.<br>References Munger, L.H.; et al.: J. Proteome Res., 16, 3321 (2017)<br></p>

<p>Applications Reagent used for Horner-Emmons modification.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Hediger, M., et al.: Bioorg. Med. Chem., 12, 4995 (2004), Kim, J., et al.: Nat., 452, 239 (2008),<br></p>

<p>Applications 2,2-dimethyl-4-oxo-4-(propan-2-yloxy)butanoic acid (cas# 1803601-41-3) is a useful research chemical.<br></p>

<p>Applications A naturally occurring chelation agent.<br>References Boonme, P., et al.: J. Biomed. Nanotechnol., 5, 373 (2009), Noh, J., et al.: Bioorg. Med. Chem., Lett., 19, 5586 (2009), Gohil, V., et al.: Nat. Biotechnol., 28, 249 (2010),<br></p>

<p>Applications 4,4'-Dithiobisbenzoic Acid, Technical Grade (cas# 1155-51-7) is a compound useful in organic synthesis.<br></p>

<p>Applications 4-hydroxy-2-nitrobenzoic acid (cas# 74230-08-3) is a useful research chemical.<br></p>

<p>Stability Moisture Sensitive<br>Applications Phosphoric Acid Tributyl Ester is used as a solvent in the solvent-detergent method for production of immunoglobulin for inactivation of viruses with lipid envelope on the model of duck hepatitis B virus. It is also used as a ligand in the extraction of lanthanide ions from solid and liquid materials by supercritical CO2.This compound is a contaminant of emerging concern (CECs).<br>References Zubkova, N., et al.: Bull. Exp. Biol. Med., 155, 821 (2013); Lin, Y., et al.: Anal. Chem., 66, 1971(1994)<br></p>

<p>Applications 4-Pyridylthioacetic Acid (cas# 10351-19-6) is a compound useful in organic synthesis.<br></p>

<p>Applications DL-p-Hydroxyphenyllactic Acid is used as a reagent in the synthesis of 2-O-(4-coumaroyl)-3-(4-hydroxyphenyl)lactic acid, an important intermediate of rosmarinic acid biosynthesis.<br>References Matsuno, M., et al.: Chem. Pharm. Bull., 49, 1644 (2001)<br></p>

<p>Applications Pentafluorobenzoic acid (cas# 602-94-8) is a useful research chemical.<br></p>

<p>Applications 3-Hydroxymandelic Acid is used in the synthesis of an enzyme activity-based labeling molule.<br>References Komatsu, T. et al.: J. Am. Chem. Soc., 128, 15946 (2006);<br></p>

<p>Applications 2-(2-ethoxyethoxy)acetic acid (cas# 7743-94-4) is a useful research chemical.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications 5-(3,4-dihydroxyphenyl)pentanoic Acid (cas# 31129-94-9) is a useful research chemical.<br></p>

<p>Applications Butyl Acetate, can be used as a synthetic fruit flavoring in foods such as candy, ice cream, cheeses, and baked goods.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Ullman's encyclopedia of industrial chemistry, 6th Ed., 1, 170 (2003);<br></p>

<p>Applications Sebacic Acid is a urinary metabolite that has been identified as an anti-fatigue biomarker.<br>References Ma, C. et. al.: J. Pharmaceut. Biomed. Anal. 105, 84 (2015)<br></p>

<p>Applications Ethyl 4-Phenylacetoacetate is a useful synthetic intermediate. It is used to prepare pyrazolone derivatives as antiprion compounds. It is also used to prepare pyrrolinylaminopyrimidine analogs as inhibitors of AP-1 and NF-κB mediated gene expression.<br>References Kimata, A., et al.: J. Med. Chem., 50, 5053 (2007); Palanki, M., et al.: Bioorg. Med. Chme. Lett., 12, 2573 (2002)<br></p>

<p>Applications (cas# 526-83-0) is a useful research chemical.<br></p>

<p>Applications Acetylpyruvic acid is a derivative of pyruvic acid (P998900) which is an intermediate in sugar metabolism and in enzymatic carbohydrate degradation (alcoholic fermentation) where it is converted to acetaldehyde and CO2 by carboxylase. In muscle, Pyruvic acid (derived from glycogen) is reduced to lactic acid during exertion, which is reoxidized and partially retransformed to glycogen during rest. The liver can convert Pyruvic acid to alanine by amination. A diagnostic agent for Parkinson disease.<br>References Wenzel, A., et al.: J. Neurosci., 21, 53 (2001), Martinez., et al.: Development, 6, 851 (2002), Nakayama, K., et al.: J. Biochem., 146, 757 (2009), Tanaka, T., et al.: J. Pharmacol. Sci., 109, 24 (2009),<br></p>

<p>Stability Light Sensitive<br>Applications TRANS-2-OCTENOIC ACID (cas# 1871-67-6) is a useful research chemical.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications PERFLUORO-3,6-DIOXAHEPTANOIC ACID (cas# 151772-58-6) is a useful research chemical.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications 3-(4-tert-Butylbenzene)propionic Acid (cas# 1208-64-6) is a compound useful in organic synthesis.<br></p>

<p>Applications Polymaleic acid (cas# 26099-09-2) is a useful research chemical.<br></p>

<p>Applications 17-Hydroxy-3,11-dioxo-androsta-1,4-diene-17β-carboxylic Acid is an intermediate used to prepare (11β,​17α)​-17-​[(Ethoxycarbonyl)​oxy]​-​11-​hydroxy-​3-​oxo-​androsta-​1,​4-​diene-​17-​carboxylic acid (E890570) which is a derivative of Loteprednol Etabonate (L471400), an ophthalmic corticosteroid.<br>References Alberth, M., et al.: J. Biopharm.Sci., 2, 115 (1991), Bodor, N., et al.: Pharm. Res., 9, 1275 (1992), Bartlett, J.D., et al.: J. Ocul. Pharmacol., 9, 157 (1993)<br></p>

<p>Applications Ethyl difluoroacetate<br></p>

<p>Applications 4-Morpholineethanesulfonic Acid is used in the synthesis of nanotechnology and nanoparticles, as potential therapy towards Alzheimer’s.<br>References Liu, G. et al.: Methods. Mol. Biol., 610, 123 (2010); Neugart, F. et al.: Nano. Lett., 7, 3588 (2007)<br></p>

<p>Applications A benzoic acid derivative used in photolysis reactions and biomaterial studies.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Wetzels, G.M. et al.: Biomaterials., 20, 1879 (1999); Mao, C. et al.: Adv. Coll. Int. Sci., 110, 5 (2004);<br></p>

<p>Applications 2-(4-((1-(Methoxycarbonyl)-2-oxocyclopentyl)methyl)phenyl)propanoic Acid is a reagent used in the preparation of Loxoprofen Sodium<br>References Liu, Q., et al.: Faming Zhuanli Shenqing (2016), CN 105218351 A 20160106<br></p>

<p>Applications Butylboronic Acid is a boronic acid derivative that can be used as a transport carriers in membrane-based sugar separations. Butylboronic Acid is used as an analytical reagent in the determination of serum glucose.<br>References Smith, B.D. et al.: ACS Symp. Ser., 642, 194 (1996); Prendergast, J.L. et al.: Anal. Bional. Chem., 397, 1779 (2010);<br></p>

<p>Applications Mesitoic acid can be used for its antioxidant.<br>References Thomas, P.S., et.al.: Medicines, 4, 1-7, (2017);<br></p>

<p>Applications Reagent used in labelled pyrimidine and purine synthesis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Das, S., et al.: J. Med. Chem., 52, 5937 (2009), Kim, K., et al.: Bioorg. Med. Chem. Lett., 19, 5225 (2009),<br></p>

<p>Applications 2-Ethoxybenzoic Acid is a component of dental cement. Low concentrations of 2-Ethoxybenzoic Acid in combination with Eugenol (E938640), gives a stabilizing effect to liposomes to lower damages to cells.<br>References Fujisawa, S., et al.: J. Dent. Res., 82, 43(2003); Brauer, G.M., et al.: J. Dent. Res., 62, 366 (1983); Brauer, G.M., et al.: J. Dent. Res., 63, 137 (1984); Fujisawa, S., et al.: J. Biomed. Mater. Res., 21, 89 (1987)<br></p>

<p>Applications 2-Oxohexanoic Acid (cas# 2492-75-3) has been useful in a biological study that investigated the impact of glutathione on wines oxidative stability.<br>References Nikolantonaki, M., et al.: Front. Chem. (Lausanne, Switzerland), 6, 182 (2018)<br></p>

<p>Stability Hygroscopic<br>Applications TAUROURSODEOXYCHOLIC ACID (cas# 14605-22-2) is a useful research chemical.<br></p>

<p>Applications Syringic Acid is used in biological studies for electron transfer from plant phenolates to carotenoid radical cations with antioxidant interaction entering the Marcus theory inverted region.<br>References Cheng, H., et al.: J. Agric. Food Chem., 62, 942 (2014)<br></p>

<p>Applications 18-(tert-Butoxy)-18-oxooctadecanoic Acid is used to engineer long-acting, potent exendin-4 based GLP-1 analog for microstructure-based transdermal delivery for glycemic control.<br>References Yang, P., et al.: Proc. Natl. Acad. Sci. USA, 113, 4140 (2016);<br></p>

<p>Applications 2,4-Dioxo-4-phenylbutanoic acid<br></p>

<p>Applications Iodic Acid is used in the synthesis of silybin derivatives showing antiradical and antioxidant activities. Also used in the iodination of compounds.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Gazak, R. et al.: Bioorg. Med. Chem., 12, 5677 (2004); Zangade, S. et al.: Eur. j. Chem., 3, 314 (2012);<br></p>

<p>Applications 3-Isopropoxybenzoic acid is a useful reagent for organic synthesis and other chemical processes.<br>References Chiong, H. A., et al.: J. Am. Chem. Soc., 129, 9879 (2007); Kingston, D. G. I., et al.: J. Med. Chem., 41, 3715 (1998)<br></p>

<p>Applications 7-Benzothiazolecarboxylic Acid is an intermediate used in the synthesis of pyrazole inhibitors of coactivator associated arginine methyltransferase 1 (CARM1). It is also used to prepare aminofuro-pyridine derivatives as inhibitors of TAK1.<br>References Huynh, T., et al.: Bioorg. Med. Chem. Lett., 19, 2924 (2009); Horneberger, K., et al.: Bioorg. Med. Chem. Lett., 23, 4517 (2013)<br></p>

<p>Applications 2-[(phenylsulfanyl)methyl]benzenecarboxylic acid (cas# 1699-03-2) is a useful research chemical.<br></p>