Carboxylic Acids

<p>Applications 3,4-Epoxycyclohexanecarboxylate Methyl Ester is a useful reagent for organic synthesis.<br></p>

<p>Applications An intermediate in the preparation of Digallic Acid<br></p>

<p>Applications Ethyl 4,4-Difluoroacetoacetate is an intermediate used for the synthesis of pharmaceuticals such as potassium channel activators and β-alanine derived GABA-T antagonists.<br>References Qi, J.L., et al.: Euro. J. Medn. Chem., 46, 934 (2011); Schirlin, D., et al.: J. Enzymes. Inhibition., 1, 243 (1987);<br></p>

<p>Applications 3-(Diethylphosphono)propanoic acid<br></p>

<p>Applications Dibromoisocyanuric acid is a bromine compound with a superior bactericidal activity.<br>References Gottardi, W., et al.: J. Appl. Microbiol., 116, 1427 (2014)<br></p>

<p>Applications Ethyl 5-amino-1-benzofuran-2-carboxylate is used as an synthetic intermediate in the preparation of indolebutylpiperazines, a class of dual 5-HT1A receptor agonists and serotonin reuptake inhibitors. Ethyl 5-amino-1-benzofuran-2-carboxylate was also used as a potential radiolabelled analog for melanoma imaging and targeted radiotherapy.<br>References Chezal, J.M., et al.: J. Medn. Chem., 51, 3133 (2008); Heinrich, T., et al.: J. Medn. Chem., 47, 4684 (2004);<br></p>

<p>Applications 4-tert-Butoxyphenylboronic Acid is a compound used in the preparation of nitrophenylphenol via cross-coupling reaction of nitrohalobenzenes with phenylboronic acids and deprotection.<br>References Kumamoto, N., et al.: Preparation of nitrophenylphenol, JP 2001055360 (2001);<br></p>

<p>Applications Quinazoline-7-carboxylic Acid is a derivative of Quinazoline (Q670100) which is used to study the electrochemical behaviour of quinazoline using modern polarographic and voltammetric methods. Quinazoline is the basic structural unit of pharmaceuticals and plays an important role in modern synthesis of antitumor drugs.<br>References Hladikova, J., et al.: Sensing in Electroanal., 3, 165 (2008); Kurogi, Y., et al.: J. Med. Chem., 39, 1433 (1996)<br></p>

<p>Applications Clavulanic Acid 2-Amino-2,4,4-trimethylpentane Salt is an intermediate in the synthesis of Clavulanic Acid Potassium Salt (C563750), a β-lactamase inhibitor, typically added to amoxicillin to increase its effectiveness.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Reading, C. and Cole, M.: Antimicrob. Ag. Chemother., 11, 852 (1977); Ball, A.P., et al.: Lancet, 1, 620 (1980); Brogden, R.N., et al. Drugs, 22, 337 (1981)<br></p>

<p>Applications Ethyl 3,4-dihydro-2H-pyran-2-carboxylate (cas# 83568-11-0) is a useful research chemical.<br></p>

<p>Applications 3,4-Dihydro-2H-1,4-benzoxazine-7-boronic acid pinacol ester is a useful intermediate for the synthesis of naphthamides which functions as VEGFR-2 kinase inhibitors for cancer treatment.<br>References Lv, Y., et al.: ACS Med. Chem. Lett., 5, 592 (2014)<br></p>

<p>Applications 2-Isopropoxy-2-phenylacetic acid<br></p>

<p>Applications 2-(Methoxyimino)-3-oxo-butanoic Acid 1,1-Dimethylethyl Ester is an intermediate used in the synthesis of Cefotaxime Bromoacetyl Analogue (C242940), which is an impurity of Cefotaxime (C242950), a broad spectrum third generation cephalosporin antibiotic.<br>References Wise, R., et al.: Antimicrob. Agents Chemother., 14, 807 (1978), Muhtadi, F.J., et al.: Anal. Profiles Drug Subs., 11, 139 (1982),<br></p>

<p>Applications 2-amino-6-hydroxybenzoic acid (cas# 567-62-4) is a useful research chemical.<br></p>

<p>Applications 5-carbamoylpentanoic acid (cas# 334-25-8) is a useful research chemical.<br></p>

<p>Applications Benzothiophene-5-boronic acid<br></p>

<p>Applications 3-Furoic Acid, is metabolized by Corynebacterium fascians from soil, limonoid metabolism based on a biological studies.<br>References Hasegawa, S., et al.: J. Arg. Food Chem., 31, 807 (1983)<br></p>

<p>Applications Methylboronic Acid is a methylated derivative of boronic acid, a building block towards various intermediates in suzuki coupling.<br>References Baker, J. O., et al.: Biochem.. 22, 2098 (1983); Garner, C.W., et al.: J. Biol. Chem., 255, 5064 (1980)<br></p>

<p>Applications 3-Amino-4-hydroxybenzoic acid (cas# 1571-72-8) is a useful research chemical.<br></p>

<p>Applications (2S)-2-acetamido-5-(diaminomethylideneamino)pentanoic Acid (cas# 155-84-0) is a useful research chemical.<br></p>

<p>Applications N-M-Tolylphthalamic Acid is used to prevent premature drop an anti shock treatment for pants. On ingestion is hydrolyzed to produce m-toluidine<br>References Pawar, G., et al.: Synth. Comm., 32, 1929-1936 (2002)<br></p>

<p>Applications methyl amino(2-bromophenyl)acetate hydrochloride (cas# 1219408-44-2) is a useful research chemical.<br></p>

<p>Applications A useful synthetic intermediate.<br>References Li, A., et al.: J. Med. Chem., 42, 706 (1999), Low, E., et al.: Bioorg. Med. Chem. Lett., 19, 196 (2009),<br></p>

<p>Applications (2E,​4E)​-2,​4-​Tetradecadienoic acid is used as a reactant in polymerization reactions such as the syntheses of monoacylglycerol and 1,​2-​diacyl-​sn-​glycerol.<br>References Matsumoto, A., et al.: Polym. J., 35, 652-61 (2003); Srisiri, W., et al.: J. Org. Chem. 61, 5911-15 (1996)<br></p>

<p>Applications 3-Oxo-1,2,3,4-tetrahydroquinoxaline-6-carboxylic acid (cas# 702669-54-3) is a useful research chemical.<br></p>

<p>Applications Ethyl 2-Benzylacetoacetate (cas# 620-79-1) is a compound useful in organic synthesis.<br></p>

<p>Applications 5-Ethyl-6-hydroxyhexanoic Acid is an intermediate in the synthesis of metabolites of Bis(2-ethylhexyl) Phthalate (DEHP) (B433850).<br>References Kaulen, J., et al.: Tetrahedron., 38, 3299 (1982);<br></p>

<p>Applications Diethyl 1,1-Cyclopropanedicarboxylate (cas# 1559-02-0) is a compound useful in organic synthesis.<br></p>

<p>Applications 4-(dimethylamino)-3-nitrobenzoic Acid (cas# 28096-56-2) is a useful research chemical.<br></p>

<p>Applications 2,2-Dimethylbutyrate (DMB) is a potential treatment for thalassemia and hemoglobinopathies.<br>References Yeh, K., et al.: J. Pharmacokinet. Biopharm., 6, 79 (1978), Cunningham, M., et al.: Blood, 104, 34 (2004), Rund, D., et al.: N. Engl. J. Med., 353, 1135 (2005),<br></p>

<p>Stability Hygroscopic<br>Applications Diphenylphosphinodithioic acid is used in the extraction of rhodium from nitrate media using phosphinic acids. It also functions as a new materials for microelectronic and molecular electronic devices.<br>References Samuels, A. C., et al.: Solvent Extraction and Ion Exchange, 33, 418 (2015)<br></p>

<p>Applications 3-(3-THIENYL)ACRYLIC ACID (cas# 102696-71-9) is a useful research chemical.<br></p>

<p>Applications 5-Hydroxy-3-phenylbenzoic Acid can be used in biological study of preparation and identification of hydroxybenzoic acids as lactate receptor agonists and antilipolytics. It can also be used in discovery of new series of BRD4(1) inhibitors using protein-ligand docking and structure-guided design.<br>References Duffy, B. C., et al.: Bioorg Med Chem Lett, 25, 2818 (2015), Dvorak, C. A., et al.: ACS Med Chem Lett, 3, 637 (2012)<br></p>

<p>Applications Thiazol-4-ylboronic acid (cas# 1016642-07-1) is a useful research chemical.<br></p>

<p>Applications 3-[5-(2-thienyl)-2-furyl]propanoic Acid (cas# 24090-38-8) is a useful research chemical.<br></p>

<p>Applications Ethyl (7Z)-4-Oxo-7-decanoic Acid Ester is an intermediate used in the synthesis of (Z)-γ-Jasmolactone (J210470), which is a compound that has a fruity, flowery and sweet taste and is commonly used as a fruit flavouring agent to enhance the peach flavour in a variety of food items.<br>References Clososki, G., et al.: Synth. Comm., 34, 817 (2004); Coelho, G., et al.: Hand. Fruit Veg. Flav., No vol. given, 211 (2010); Missio, L. &amp; Comasseto, J.: Tetrahedron: Asymm., 11, 4609 (2000); Wamhoffa, H. &amp; Gribbleb, G.: Adv. Hetero. Chem., 106, 185 (2012)<br></p>

<p>Applications Ethyl trans-2-(4-aminocyclohexyl)acetate, HCl<br></p>

<p>Applications 2-(chroman-4-yl)acetic acid (cas# 5655-26-5) is a useful research chemical.<br></p>

<p>Applications (R)-2-(Tetrahydropyranyloxy)propionic Acid can be employed to synthesize lactic acid oligomers, depsides, and depsipeptides on solid phase.<br>References Kuisle, O., et al.: Tetrahedron Lett. 40, 1203 (1999); Kim, S. et al. tetrahedron asymmetry 22, 1499 (2011)<br></p>

<p>Applications 2-Pyridylphosphonic Acid is used as ligand in the hydrothermal preparation of copper(II)-lanthanide(III) and zinc(II)-lanthanide(III) pyridylphosphonate coordination polymers.<br>References Ma, Y., et al.: Chem. Eur. J., 13, 4759 (2007);<br></p>

<p>Applications Ethyl (1S,3R,4R)-3-(tert-butoxycarbonylamino)-4-hydroxycyclohexane-1-carboxylate, is a building block used in various chemicla synthesis. It can be used for the preparation of six stereoisomers of diaminocyclohexane carboxamide as key intermediates for synthesis of factor Xa inhibitors.<br>References Wang, X. et al.: Tetrahedron, Vol.73, Iss.11, P1381-1388 (2017);<br></p>

<p>Applications (S)-(+)-Z-4-Amino-2-hydroxybutyric Acid is used in the synthesis of aminoglycoside antibiotics.<br>References Rai, R. et al.: Org. Lett., 8, 887 (2006); Li, Jie. et al.: J. org. Chem., 72, 4055 (2007);<br></p>

<p>Stability Hygroscopic<br>Applications 2,​2-​Bis(hydroxymethyl)​propionic Acid is a reagent used in the synthesis of disulfide monomers for cross-linked poly(urethane-urea) coatings.<br>References Nevejans, S. et al.: Polym., 166, 229 (2019);<br></p>

<p>Applications S-Acetylthioacetic Acid (cas# 1190-93-8) is a compound useful in organic synthesis.<br>References Fox, M., et al.: J. Microbiol. Methods, 56, 221 (2004),<br></p>

<p>Applications Phenylmethyl ester N-[(3aS,4R,6S,6aR)-tetrahydro-6-hydroxy-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-yl]-Carbamic acid is a useful chiral building block. It has been used in the synthesis of all-cis carbocyclic precursor of ticagrelor via oxidation/stereoselective reduction sequences.<br>References Wlodarczyk, J.; et al.: Tet. Lett., 56, 6093 (2015).<br></p>

<p>Applications cis-10-Pentadecenoic Acid is a monounsaturated fatty acid, that can inhibits IFN-γ-induced production of kynurenine in Thp-1 cells by 16%.<br>References Costabile M. et al.: Prostaglandins Leukot. Essent. Fatty Acids 122, 7-15 (2017).;<br></p>

<p>Applications N-​Methylaniline Trifluoroacetate is regent used in organic synthesis, functioning as an α-methylating agent for ketones and activates internucleodecoupling upon removal.<br>References Nikolaev, V. et al.: E-Eros. Encyc. Reag. Org. Synth, 1, (2001); Wallace, D. et al.: Tetrahedron Lett., 54, 4425 (2013);<br></p>

<p>Applications 4-Hydroxy-3-nitrobenzoic acid<br></p>

<p>Applications 2,4,5-TRIMETHOXYBENZOIC ACID (cas# 490-64-2) is a useful research chemical.<br></p>

<p>Applications 4-Carboxyphenylboronic acid is a reagent used in suzuki coupling reactions.<br>References Hu, Z., et al.: Wuji Huaxue Xuebao, 34, 387 (2018); Ibrahim, M., et al.: J. Organomet. Chem., 859, 44 (2018); Erami, R. S., et al.: Catalysts, 7, 76 (2017)<br></p>

<p>Applications 1,2,4-Benzenetricarboxylic acid 1,2-Dihexyl Ester is a useful reagent for organic synthesis.<br></p>

<p>Applications 5-Formylfuran-2-boronic Acid Neopentyl Glycol Ester is a useful reagent in lapatinib synthesis.<br>References Radl, S., et al.: PCT Int. Appl. (2014), WO 2014059956 A1<br></p>

<p>Applications 5-[2-(Trifluoromethyl)phenyl]-2-furoic Acid is a chemical reagent used in the preparation of novel TRPV1 antagonists. Also used in the preparation of potent inhibitors of FeII and MnII E, coli Methionine Aminopeptidase as antibacterial agents.<br>References Huguet, F. et al.: ChemMedChem. 7, 1020 (2012); Kim, N. et al.: Chem. Asian J., 8, 400 (2013);<br></p>

<p>Applications 2-(Phenylamino)nicotinic Acid (cas# 16344-24-4) is a useful research chemical.<br></p>

<p>Applications Substituted cinnamic and dihydrocinnamic acids show anti-inflammatory and analgesic activity, with cinnamic acids being more biologically active.<br>References Runwal, L. et al.: Eastern Pharmacist 38, 141 (1995)<br></p>

<p>Stability Store in Freezer<br>Applications A useful synthetic intermediate for the preparation of novel antiinflammatory agents.<br></p>

<p>Applications Dibenzothiophene-2-boronic acid is a useful reagent for organic synthesis and other chemical processes.<br>References Duncton, M. A. J., et al.: Org. Lett., 10, 3259 (2008)<br></p>

<p>Applications m-Tolylacetic acid is used as a reactant in the diastereoselective preparation of arylmethylene-isoindolinones.<br>References Anamimoghadam, Ommid, et al.: Beilstein J. of Org. Chem., 13, 2833-2841 (2017)<br></p>

<p>Applications Used in the synthesis of anti-tumor compounds comprising of hydroxyisovalerylshikonin analogs. Furthermore, the compound is a reagent in the synthesis of class II c-Met inhibitors, in the treatment of c-Met dependant tumors.<br>References Rao, Z. et al.: Eur. J. Med. Chem., 46, 3934 (2011); Liu, L. et al.: J. Med. Chem., 55, 1868 (2012);<br></p>

<p>Applications 5-Hydroxytoluene-2,4-disulfonic Acid acts as a synthetic reagent in the sulfonation of 2 and 3-Methylphenol.<br>References Strandlund, G., et al.: Acta Chem. Scand., 33, 261 (1979)<br></p>

<p>Applications 2,2-Dimethyl-3-(4-mercaptophenyl)propionic Acid (cas# 887354-80-5) is a compound useful in organic synthesis.<br></p>

<p>Applications 2,2-Diethylhexanoic Acid is a pollutant that is found in anaerobic environment of river sediments,<br>References Chau, H., et al.: Appl. Biochem. Biotechnol., 70, 853 (1998); McInerney, M., et al.: Appl. Env. Microbiol., 41, 1029 (1981)<br></p>

<p>Applications A caged, photolabile Nitric Oxide donor that is useful for delivering nitric oxide into intracellular compartments in microsecond time scale without any cytotoxic effects.<br>References Namiki, S., et al.: Bioorg. Med. Chem., 7, 1695 (1999),<br></p>

<p>Applications Used for production of peptide thioester.<br>References Gaeta, A., et al.: Bioorg. Med. Chem. Lett., 20, 4649 (2010),<br></p>

<p>Applications 5-Chlorohexanoic acid CAS#: 112176-22-4 is a building block used in organic synthesis.<br>References Liang, S., et al., Green Chemistry., 20, 680 (2018)<br></p>

<p>Applications 3-Formylphenylboronic Acid is a reactant in the synthesis of I-BET726 (GSK1324726A), a potent tetrahydroquinoline ApoA1 up-regulator and selective BET bromodomain inhibitor.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Gosmini, R., et. al.: J. Med. Chem., 57, 8111 (2014)<br></p>

<p>Applications 2-hydroxy-5-[2-(4-hydroxyphenyl)propan-2-yl]benzoic acid (cas# 101949-49-9) is a useful research chemical.<br></p>

<p>Applications tert-Butyl 2-(3-Aminophenyl)acetate can be used as anti-heparanase to treat diseases and disorders associated with heparanase activity.<br>References Giannini, G., et.al.: PCT Int. Appl., 103, (2018);<br></p>