Carboxylic Acids

<p>Applications Vinblastine N'b-Oxide Maleic Acid Salt is an analog of vinca alkaloid n-oxide that is used for the treatment of hyperproliferative diseases.<br></p>

<p>Applications N-(4-bromo-2-thienyl)-carbamic Acid 1,1-Dimethylethyl Ester, is an intermediate for the synthesis of bicyclic inhibitors of ROCK protein kinsae.<br>References Hahmann, C. et al.: Cell. Mol. Life Sci., 67, 171 (2010);<br></p>

<p>Applications 3-Acetamidophenyl acetate<br></p>

<p>Applications 2-[(Dipropylamino)sulfonyl]benzoic Acid, is a building block used in various chemical synthesis.<br></p>

<p>Applications Tricosanoic Acid 1,2,3-Propanetriyl Ester, can be used for the manufacture of cosmetics, and perfumes.<br>References Oro, L., et al.: Acta Pharmacol. Toxicol., 18, 141 (1961),<br></p>

<p>Applications Trithiocyanuric acid (cas# 638-16-4) is a useful research chemical.<br></p>

<p>Applications 2-benzylcyclopropane-1-carboxylic acid (cas# 103986-55-6) is a useful research chemical.<br></p>

<p>Applications 1-Cyclopentenecarboxylic Acid can be used for enantioselective 1,3-dipolar cycloadditions of diazoacetates and solid-phase synthesis of substituted indolines. It can also be used to develop antagonists for A1- and A2-adenosine receptors.<br>References Sibi, M. P., et al.: Org Lett. 9, 1553 (2007); Nicolaou, K. C., et al.: J. Am. Chem. Soc. 122, 2966 (2000); Jacobson, K. A., et al.: Biochem. Pharmacol. 37, 3653 (1988)<br></p>

<p>Applications N-Caproic Acid Isopropyl Ester (cas# 2311-46-8) is a useful research chemical.<br></p>

<p>Applications 3-((E)-(2,4-Dimethylphenyl)diazenyl)-2,4-dihydroxy-5-((4-sulfophenyl)diazenyl)benzoic Acid is an intermediate in the synthesis of Acid Orange 24 (A189835), which is used in trickling biofilters for wastewater treatment. Acid Orange 24 is used in suncare compositions. It also serves as a raw material for cosmetics. Mutagenicity test for dye compositions in cosmetics.<br>References Garzon-Zuniga, M. A., et al.: Water Environ. Res., 83, 107 (2011); Anon.: IP.com Journal, 11, 5 (2011); Muzzall, J. M., et al.: Mutat. Res., Genet. Toxicol. Testing, 67, 1 (1979)<br></p>

<p>Applications 3,5-Dinitro-o-toluic Acid is used to gather data for partition coefficients of solutes and vapors into anhydrous THF and 1,4-dioxane using Abraham model.<br>References Saifullah, M., et al.: J. Solution Chem., 40, 2082 (2011);<br></p>

<p>Applications Racecadotril intermediate. A β-thiopropionyl-amino acid derivative used as β-lactamase inhibitor.<br>References Sanger, F., et al.: Biochem. J., 39, 507 (1945), Dawson, P., et al.: Science, 266, 776 (1994),<br></p>

<p>Applications (±)-2-Acetoxybutyric Acid is an intermediate in synthesizing 2-Hydroxy-N-(pyridin-4-yl)butanamide (H953495). It is a is a useful synthetic intermediate.<br></p>

<p>Applications p-Cyanobenzoic Acid Trimer is used in the synthetic preparation of Terbium Triazinetribenzoate Formate Metal Organic Framework (MOF).<br>References Han, Y., et al.: J. Mater. Chem. A Mater. Energy Sustain., 3, 24525 (2015)<br></p>

<p>Applications tert-Butyl (Trimethylsilyl)acetate is used to prepare lithium enolates, and is also a useful synthetic intermediate.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Rathke, M. &amp; Elghanian, R. tert-Butyl Trimethylsilylacetate In Handbook of Reagents for Organic Synthesis: Reagents for Silicon-Mediated Organic Synthesis; Fuchs, P.; Wiley, 2011; 147-148<br></p>

<p>Applications 3-Cyanobenzoic Acid, is a building block used for the synthesis of a variety of 3,5-disubstituted 1,2,4-oxadiazoles from carboxylic acids, that can be used for the synthesis of a metabotropic glutamate subtype 5 (mGlu5) receptor antagonist.<br>References Ramu, T., et al.: Chem. Lett., 42, 722 (2013);<br></p>

<p>Applications 3-Hydroxyhomophthalic acid (cas# 42421-12-5) is a useful research chemical.<br></p>

<p>Applications 2-Cyclohexylideneacetic acid (cas# 1552-91-6) is a useful research chemical.<br></p>

<p>Applications Furan-2-boronic acid<br></p>

<p>Applications Ethyl 2-(2,6-Dichlorophenyl)acetate (cas# 90793-64-9) is a useful research chemical.<br></p>

<p>Applications tert-butyl 2-ethynylmorpholine-4-carboxylate (cas# 1416229-07-6) is a useful research chemical.<br></p>

<p>Stability Light Sensitive<br>Applications 1-Oxo-1H-isochromene-4-carboxylic acid (cas# 15868-29-8) is a useful research chemical.<br></p>

<p>Applications 3-Trimethylstannyl Benzoic Acid (cas# 161767-56-2) is a compound useful in organic synthesis.<br></p>

<p>Applications tert-Butyl Bromoacetate is a halogenated t-butyl acetate commonly used as an alkylating agent. tert-Butyl Bromoacetate is used in the synthesis of collagenase inhibitors.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Steinman, D.H. et al.: Bioorg. Med. Chem. Lett., 8, 2087 (1998); Fray, M.J. et al.: J. Med. Chem., 46, 3514 (2003): Neri, P. et al.: J. Org. Chem., 59, 3880 (1994);<br></p>

<p>Applications 6-Chloronicotinic Acid, is an organic building block used for the synthesis of various biologically active compounds, including inhibitors. It is an intermediate for the synthesis of N-(thiophen-2-yl) benzamide derivatives as BRAFV600E inhibitors, and novel DNA-gyrase B inhibitors.<br>References Xie, Y., et al.: Bioorg. Med. Chem. Lett., 23, 2306 (2013); Shiroya, U., et al.: Med. Chem. Res., 22, 5227 (2013);<br></p>

<p>Applications Quinazoline-7-carboxylic Acid is a derivative of Quinazoline (Q670100) which is used to study the electrochemical behaviour of quinazoline using modern polarographic and voltammetric methods. Quinazoline is the basic structural unit of pharmaceuticals and plays an important role in modern synthesis of antitumor drugs.<br>References Hladikova, J., et al.: Sensing in Electroanal., 3, 165 (2008); Kurogi, Y., et al.: J. Med. Chem., 39, 1433 (1996)<br></p>

<p>Applications Ethyl 3,4-dihydro-2H-pyran-2-carboxylate (cas# 83568-11-0) is a useful research chemical.<br></p>

<p>Applications 2-(Methoxyimino)-3-oxo-butanoic Acid 1,1-Dimethylethyl Ester is an intermediate used in the synthesis of Cefotaxime Bromoacetyl Analogue (C242940), which is an impurity of Cefotaxime (C242950), a broad spectrum third generation cephalosporin antibiotic.<br>References Wise, R., et al.: Antimicrob. Agents Chemother., 14, 807 (1978), Muhtadi, F.J., et al.: Anal. Profiles Drug Subs., 11, 139 (1982),<br></p>

<p>Stability Light Sensitive, Temperature Sensitive<br>Applications 4-(2-Aminophenyl)-4-oxo-2-butenoic Acid is a novel human lens metabolite from normal and cataractous human lenses. A UV filter.<br>References Mizdrak, J., et al.: Tetrahedron, 63, 4990 (2007); Taylor, L. M., et al.: Exp. Eye Res., 75, 165 (2002)<br></p>

<p>Applications 5-carbamoylpentanoic acid (cas# 334-25-8) is a useful research chemical.<br></p>

<p>Applications (2E,​4E)​-2,​4-​Tetradecadienoic acid is used as a reactant in polymerization reactions such as the syntheses of monoacylglycerol and 1,​2-​diacyl-​sn-​glycerol.<br>References Matsumoto, A., et al.: Polym. J., 35, 652-61 (2003); Srisiri, W., et al.: J. Org. Chem. 61, 5911-15 (1996)<br></p>

<p>Applications Hexacosanoic Acid (cas# 506-46-7) is a compound useful in organic synthesis.<br></p>

<p>Applications 4'-Hydroxyazobenzene-4-carboxylic acid hydrate<br></p>

<p>Applications 3-[5-(2-thienyl)-2-furyl]propanoic Acid (cas# 24090-38-8) is a useful research chemical.<br></p>

<p>Stability Moisture Sensitive<br>Applications Tripropyl phosphate is an organophosphorus flame retardant and plasticizer.<br>References Bacaloni, A., et al.: Environ. Sci. Technol., 42, 1898 (2008)<br></p>

<p>Applications Used for preparation of Terfenadine (T114500) analogs.<br>References Uchida., et al.: Chem. Pharm. Bull., 37, 958 (1989),<br></p>

<p>Applications Methyl 5-Chloro-3-(Chlorosulfonyl)Thiophene-2-Carboxylate (cas# 126910-68-7) is a useful research chemical.<br></p>

<p>Applications Ethyl 4-Oxo-5-hexanoic Acid Ester is used in the synthesis of analogs of 5-aminolevulinic acid (ALA), which are potential inhibitors of ALA dehydratase (porphobilinogen synthase), an early enzyme of tetrapyrrole biosynthesis;Also, it is an intermediate of 4-Oxo-6-(2-oxo-5-vinylpyrrolidin-1-yl)hexanoic Acid (O858780), which is derived from Ethyl Succinoyl Chloride (E818230), which is used in the synthesis of bivalent ligands for D2/D3 dopamine receptors. Also used in the preparation of antimicrobial pyrrolo-isoquinolinones. Vigabatrin Impurity 2<br>References Appleton, D., et al.: J. Chem. Soc., Perkin Trans., 89-101 (1998); Gogoi, S. et al.: ACS Med. Chem. Lett., 3, 991 (2012)<br></p>

<p>Applications Allylboronic acid pinacol ester<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications Intermediate in the synthesis of angiotensin and fosinopril. Impurity in the preparation of Fosinopril Sodium.<br>References Anderson, N. et al.; Org. Proc Res. and Develop 1, 315 (1997)<br></p>

<p>Applications 8,13(15)-Abietadienoic Acid is a derivative of Methyl Abietate (M271910) and has cytotoxic, antimycotic, and antiviral activites.<br>References Gonzalez, Miguel A., et al.: Eur. J. Med. Chem., 44(6), 2468-2472 (2009); Agudelo-Gomez, Lee Solbay., et al.: Pharmacologyonline, 1, 36-42 (2012)<br></p>

<p>Applications 3-(2-Oxo-cyclohexyl)-propionic Acid is an intermediate in the synthesis of Hexahydrocoumarin (H293905), a derivative of Coumarin (C755380) that is used as a fragrance ingredient.<br>References Letizia, C. S., et al.: Food and Chemical Toxicology, 38, S115 (2000);<br></p>

<p>Applications Amino(3-​chlorophenyl)​acetic Acid functions as intermediate useful in the preparation of synthetic penicillins, also used in the structure-activity relationship examination of several drugs containing the benzyl moiety, their roles in biochemical and pharmacological processes.<br>References Hansch, C., et al.: J. Med. Chem., 13, 957 (1970); Holdrege, C. T., et al.: Can. (1975), CA 966853 A2 19750429;<br></p>

<p>Applications 4-Acetylphenylboronic acid4-Acetylphenylboronic Acid is used in several metal catalyzed cross-coupling reaction studies.<br>References Saito, S., et al.: J. Org. Chem., 2, 8024 (1997); Sakai, M., et al.: Organomet., 16, 4229 (1997); Molander, G., et al.: J. Org. Chem., 68, 4302 (2003);<br></p>

<p>Applications Intermediate in the preparation of nitro substituted quinazolones.<br>References Sirisoma, N., et al.: J. Med. Chem., 52, 2341 (2009), Zeng, X., et al.: Bioorg. Med. Chem. Lett., 20, 6282 (2010),<br></p>

<p>Applications 6-Bromo-2-chloronicotinic acid<br></p>

<p>Applications 3-Aminomethylbenzoic acid<br></p>

<p>Applications Methyl 2-Chloro-1-cyclopentenecarboxylate is a versatile reactant that can be synthesized from Methyl 2-Cyclopentanonecarboxylate (M294705), which is used in the preparation of functionalized ketones.<br>References Mashima, K. et al.: J. Org. Chem., 59, 3064 (1994); Hamashima, Y. et al.: J. Am. Chem. Soc., 124, 11240 (2002);<br></p>

<p>Applications 3-{4-[(furan-2-ylmethyl)sulfamoyl]phenyl}prop-2-enoic acid (cas# 391229-93-9) is a useful research chemical.<br></p>

<p>Applications Diethyl Iminodiacetate<br></p>

<p>Applications 3-​[[[3-​(Aminomethyl)​-​5-​methyl-​1-​oxohexyl]​amino]​methyl]​-​5-​methyl-hexanoic Acid is an intermediate in synthesizing 4,9-Diisobutyl-1,6-diazecane-2,7-dione (D456300), an impurity of rac-Pregabalin (P704800) which is a GABA analogue used as an anticonvulsant.<br>References Taylor, C.P., at al.: Epilepsy Res., 14, 11 (1993), Field, M.J., et al.: Pain, 80, 391 (1999)<br></p>

<p>Stability Air Sensitive<br>Applications Ethyl 2-Mercapto-1-cyclohexenecarboxylate is a reagent used in the synthesis of anti-inflammatory compounds,<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Lloret, G. et al.: J. Phys. Org. Chem., 22, 1188 (2009);<br></p>

<p>Applications Substituted cinnamic and dihydrocinnamic acids show anti-inflammatory and analgesic activity, with cinnamic acids being more biologically active.<br>References Runwal, L. et al.: Eastern Pharmacist 38, 141 (1995)<br></p>

<p>Applications Methyl (1R,4S)-4-[[(1,1-Dimethylethoxy)carbonyl]amino]-2-cyclopentene-1-carboxylic Acid Ester is used in the discovery of a potent, selective and orally bioavailable dual CCR2 and CCR5 antagonist.<br>References Zheng, C., et al.: Bioorg. Med. Chem. Lett., 21, 1442-1446 (2011)<br></p>

<p>Applications 2-amino-6-hydroxybenzoic acid (cas# 567-62-4) is a useful research chemical.<br></p>