6-membered Rings

<p>Applications 1-(1-phenylcyclobutanecarbonyl)piperidine-4-carboxylic acid (cas# 1099048-69-7) is a useful research chemical.<br></p>

<p>Applications BENZYL CYANOMETHYLCARBAMATE (cas# 3589-41-1) is a useful research chemical.<br></p>

<p>Applications 5-Phenyl-1,2,5-thiadiazolidin-3-one 1,1-Dioxide is used in the structure-based design of protein tyrosine phosphatase-1B inhibitors.<br>References Black, E. et al.: Bioorg. Med. Chem. Lett., 15, 2503 (2005);<br></p>

<p>Applications Ethyl 3,5-dichloro-4-hydroxybenzoate (cas# 17302-82-8) is a useful research chemical.<br></p>

<p>Applications A compound used in anti-corrosive coating material for the prevention of corrosion in metals.<br>References Weng, C. et al.: Chem. Mat., 22, 2075 (2011);<br></p>

<p>Applications 5-(Diphenylphosphinyl)pentanoic Acid, can be used for the preparation of praseodymium coordination polymers with diphenylphosphorylvalerate ligand. It is also a by product in the preparation of prostaglandin analogs.<br>References Spichal, Z., et al.: Polyhedron, 48, 99 (2012); Zhao Y. et al.: PCT Int. Appl. 43pp.Patent, 2016<br></p>

<p>Applications 4,4'-Dimethoxydiphenylamine is a diphenylamine derivative used as a chemical additive for cured rubber. 4,4'-Dimethoxydiphenylamine is highly toxic and may potentially induce chromosome abberation.<br>References Kel'man, G.Y. et al.: Kauch. Rez., 26, 28 (1967); Sofuni, T. et al.: Mutat. res. Gen. Toxicol. Test., 24, 175 (1990);<br></p>

<p>Applications (R)-2-(Tetrahydropyranyloxy)propionic Acid can be employed to synthesize lactic acid oligomers, depsides, and depsipeptides on solid phase.<br>References Kuisle, O., et al.: Tetrahedron Lett. 40, 1203 (1999); Kim, S. et al. tetrahedron asymmetry 22, 1499 (2011)<br></p>

<p>Applications 1,2,3-Trimethoxybenzene can be used for RSM-optimised slow pyrolysis of rice husk for bio-oil production.<br>References Das, S., et.al.: Energy, 225, 120161, (2021);<br></p>

<p>Applications (1R,2R,4R)-rel-1,2,4-Trimethylcyclohexane is present in jet fuel-derived liquids light fractions.<br>References Xie, G. et al.: Env. Sci. Tech., 37, 4751 (2003); Gentner, D. et al.: Env. Sci. Tech., 47, 11837 (2013);<br></p>

<p>Applications 4-[[[(1,1-Dimethylethyl)diphenylsilyl]oxy]methyl]-2,2-dimethyl-1,3-dioxolane is an intermediate in the synthesis of 1,2-Dioleoyl-rac-glycerol (D482175), which is an analog of 1,3-Dioleoylglycerol (D484210) which is used in the synthesis of amphiphilic gadolinium complexes as MRI contrast agents.<br>References Accardo, A., et. al.: J. Mater. Chem. B., 1, 617 (2013)<br></p>

<p>Applications 2,2-Dimethyl-3-(4-mercaptophenyl)propionic Acid (cas# 887354-80-5) is a compound useful in organic synthesis.<br></p>

<p>Applications Ethyl (1S,3R,4R)-3-(tert-butoxycarbonylamino)-4-hydroxycyclohexane-1-carboxylate, is a building block used in various chemicla synthesis. It can be used for the preparation of six stereoisomers of diaminocyclohexane carboxamide as key intermediates for synthesis of factor Xa inhibitors.<br>References Wang, X. et al.: Tetrahedron, Vol.73, Iss.11, P1381-1388 (2017);<br></p>

<p>Applications 1,3-Dimethyl-2-nitrobenzene is an aromatic compound that is present as a contaminant in agricultural water sources. 1,3-Dimethyl-2-nitrobenzene is also a derivative of Xylene (X749400), an aromatic hydrocarbon that is widely used in the petrochemical industry.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Chen, C., et al.: J. Air Was. Manag. Ass., 55, 1487 (2005); Li, P.,e t al.: Bull. Env. Cont. Toxicol., 69, 59 (2002)<br></p>

<p>Applications [(Methoxy)methyl]triphenylphosphonium Chloride is used in the synthesis of Cephalotaxine (C261050), an antiviral and antitumor agent. Also used in the synthesis of Taxol A fragment.<br>References Sells, M., et al.: J. Virol., 62, 2836 (1988), Kaneko, S., et al.: J. Clin. Microbiol., 27, 1930 (1989), Baba, Y., et al.: Bioorg. Med. Chem., 13, 5164 (2005), Romero, M., et al.: Antiviral Res., 68, 75 (2005); Hirai, S. et al.: Tetrahedron Lett., 54, 1888 (2013); Xing, P. et al.: Synth., 45, 596 (2013);<br></p>

<p>Applications 2-PHENYLNICOTINIC ACID (cas# 33421-39-5) is a useful research chemical.<br></p>

<p>Applications Phenyl[2-phenylthio)phenyl]carbamate is an intermediate utilized for the synthesis of Quetiapine Hemifumarate (Q510000), an atypical antipsychotic agent used for the treatment of patients with schizophrenia, biopolar disorder and to treat major depressive disorder.<br>References Niphade, N.C., et al.: Org. Proc. Rsch. Dev., 13, 792 (2009); Stolarczyk, E.U., et al.: Pharm. Dev. Tech., 14, 27 (2009);<br></p>

<p>Applications 4-Ethylbenzoic acid<br></p>

<p>Applications N-(4-Bromo-2-picolinoylphenyl)-2-chloroacetamide is a derivative of 2-(2-Amino-5-bromobenzoyl)pyridine (A601785); an intermediate in the preparation of Bromazepam (B678500).<br>References Panderi, I., et al.: J. Pharm. Biomed. Anal., 17, 327 (1998); El-Haj, B., et al.: J. Anal. Toxicol., 25, 316 (2001); Hansen, S., et al.: J. Pharm. Biomed. Anal., 39, 322 (2005)<br></p>

<p>Applications Methyl 4-Acetylbenzoate is used in the preparation of trisubstituted pyrazoles as novel hepatitis C virus entry inhibitors.<br>References Hwang, J.Y., et al.: Bioorg. Med. Chem. Lett., 23, 6467 (2013); Simmonds, P., et al.: Hepatology, 42, 962 (2005)<br></p>

<p>Applications 4-​tert-​Butylbenzoic Acid is a general chemical reactant/reagent used in the synthesis of Arylboronic Acids as dual-action FAAH and TRPV1 ligands. As well, used in the preparation of cellular chemical probes targetting PRC1 (polycomb repressive complex 1) for prostate cancer cells.<br>References Morera, E. et al.: Bioorg. Med. Chem. Lett., 26, 1401 (2016); Stuckey, J. et al.: Nat. Chem. Biol., 12, 180 (2016);<br></p>

<p>Applications 2-(5-formylfuran-2-yl)benzoic Acid (cas# 88460-72-4) is a useful research chemical.<br></p>

<p>Applications 1,4-Dimethoxybenzene is a useful chemical in organic synthesis.<br>References Digwal, Chander S., et al.: Asian J. of Org. Chem., 7(5), 865-869 (2018);Cai, Zhi-Bin, et al.: RSC Advances, 6(52), 46853-46863 (2016);Lin, Qi, et al.: Soft Matter, 13(39), 7222-7226 (2017)<br></p>

<p>Applications 4-Benzyloxyphenylacetonitrile is an intermediate in the preparation of Desmethylvenlafaxine, an antidepressant and also in the preparation of RAGE antagonist for the treatment of Alzheimer's disease.<br>References Zhao, J., et al.: Zhongguo Yiyao Gongye Zazhi, 45, 601 (2014); Lee, Y. S., et al.: Bioorg. Med. Chem. Lett., 22, 7555 (2012)<br></p>

<p>Applications 4-Hydroxy-3-nitrobenzoic acid<br></p>

<p>Applications (S)​-​(-​)​-​1-​Phenyl-​1-​propanol is a building block used in the synthesis of inhibitors of steroid 11-β hydroxylation in the adrenal cortex related to androgen production in the fetus.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Zolle, I. et al.: J. med. Chem., 51, 2244 (2008);<br></p>

<p>Applications [4-[3-[[(Methylamino)methylene]amino]phenyl]-2-thiazolyl] Guanidine is a guanidino heterocyclic phenylamidines with pharmaceutical properties.<br>References Bietti, G., et al.: Eur. Pat. Appl. (1983), EP 89730 A2 19830928<br></p>

<p>Applications 1-[2-Hydroxy-4,6-bis(ethoxymethoxy)phenyl]ethanone (cas# 128837-25-2) is a compound useful in organic synthesis.<br></p>

<p>Applications Dicyclohexyl(2,4,6-triisopropylphenyl)phosphine (cas# 303111-96-8) is a useful research chemical.<br></p>

<p>Applications α-Ethyl-benzeneacetyl Chloride is used in the synthesis of mild and neutral system for selective reduction of organic functional groups. Also used in the preparation of phenothiazine derivatives for the reversible inhibition of human butyrylcholinesterase.<br>References Sarmah, B. et al.: Tetrahedron, 47, 8587 (1991); Darvesh, S. et al.: Bioorg. Med. Chem., 15, 6367 (2007);<br></p>

<p>Applications N-[3-(4-Aminophenyl)propyl]-N,N-dimethylamine<br></p>

<p>Applications 7-Chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-1,1-dioxide is used in the preparation of antihypertensive agents.<br>References Topliss, J. G., et al.: Journal of Medicinal Chemistry, 6, 122 (1963);<br></p>

<p>Applications (3aR,7R,7aR)-Ethyl 2,2-Diethyl-7-((methylsulfonyl)oxy)-3a,4,7,7a-tetrahydrobenzo[d][1,3]dioxole-5-carboxylate is a useful synthesis intermediate.<br></p>

<p>Applications 1,2-Dimethylcyclohexane is used in the preparation of rhodium nanoparticles as recyclable catalysts.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Stratton, S.A., et. al.: Catalysis Today, 183, 96 (2012)<br></p>

<p>Applications Methyl 5-Chloro-2-[(4-ethoxy-4-oxobutyl)amino]benzoate is a reactant in the synthesis of 7-chloro-5-oxo-2,3,4,5-tetrahydro-1H-1-benzoazepin, an intermediate in synthesis of Tolvaptan (T536650).<br>References Liu, Dengke, et al.: Tianjin Institute of Pharmaceutical Research, CN 103012265 A 20130403(2013);<br></p>

<p>Applications Methyl 2-Acetamido-3-(3,4-diacetoxyphenyl)-2-propenoate (cas# 170699-07-7) is a compound useful in organic synthesis.<br></p>

<p>Applications O-(2-Bromo-6-chlorophenyl) O-Ethyl S-Propyl Phosphorothioate is a useful intermediate.<br></p>

<p>Applications 6,6-Dimethyl-3-(Methylthio)-4-Oxo-4,5,6,7-Tetrahydrobenzo[C]Thiophene-1-Carbonitrile (cas# 175202-50-3) is a useful research chemical.<br></p>

<p>Applications o-Carbomethoxybenzyl Sulfonamide is a useful reactant in organic synthesis.<br>References Jiang, Lin, et al.: Youji Huaxue, 26(2), 203-206 (2006)<br></p>

<p>Applications 5-PHENYL-1,2,4-TRIAZIN-3-AMINE (cas# 942-60-9) is a useful research chemical.<br></p>

<p>Applications Methoxy4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-3-benzenemethanol, is prepared synthetically from vanillin (V097500) with an intermediate of methoxy-4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-3-benzaldehyde (M269710).<br>References Gowravarm, S. et al.: Adv. Synth. Catal., 343, 169 (2001)<br></p>

<p>Applications 5-(Benzyloxy)-2-Hydroxybenzoic Acid (cas# 16094-44-3) is a useful research chemical.<br></p>

<p>Applications A more base-stable alternative to Ellman’s reagent for the quantification of thiol contents and enzymatic assays under basic pH conditions. . It reacts with free thiols similar to Ellman’s reagent but has dramatically improved stability under alkaline conditions, making it an excellent alternative to Ellman’s reagent.<br>References Zhang, H., et al.: Bioorg. Chem., 26, 356 (1998), Chen, Y., et al.: Biochem., 43, 11491 (2004),<br></p>

<p>Applications 1,3-Diphenylpropane (cas# 1081-75-0) is a useful research chemical.<br></p>

<p>Applications Substituted cinnamic and dihydrocinnamic acids show anti-inflammatory and analgesic activity, with cinnamic acids being more biologically active.<br>References Runwal, L. et al.: Eastern Pharmacist 38, 141 (1995)<br></p>

<p>Stability Moisture Sensitive<br>Applications Benzeneacetyl Chloride is used in the synthesis of aromatic inhibitors of HIV-1 integrase. Also used in the preparation of napthalenic ligands with high affinity for melatonin receptor.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Burke, T. et al.: J. Med. Chem., 38, 4171 (1995); Yous, S. et al.: J. Med. Chem., 35, 1484 (1992);<br></p>

<p>Applications Thiane, is a organic sulfide, that has shown to have antioxidant activity.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Chao, Q., et al.: Thermochimica Acta, 447 (2006);<br></p>

<p>Applications 3-Hydroxy-4-phenylbenzoic Acid is a useful reagent for the preparation of spiro[3,4-dihydro-2H-pyrrolo[1,2-a]pyrazine-1,4'-piperidine] derivatives as modulators of sodium ion channel.<br>References Hadida Ruah, S. S., et al.: U.S. Pat. Appl. Publ. (2012), US 20120196869 A1<br></p>

<p>Applications Methyl 4-amino-2-fluorobenzoate<br></p>

<p>Applications Methyl 4-amino-2,3,5,6-tetrafluorobenzoate (cas# 715-37-7) is a useful research chemical.<br></p>

<p>Applications 9,9-Dimethyl-N-phenyl-9H-fluoren-2-amine is useful for the synthetic preparation of secondary amines.<br>References Yao, W., et al.: Catal. Sci., 9, 3874 (2019)<br></p>

<p>Applications 3,5-Dimethoxybenzyl Alcohol is used in the synthesis of Resveratrol (R150000).<br></p>

<p>Applications N-​(3-​Dibenzofuranyl)-​5-​nitro-2-​furancarboxamide is synthesized from Dibenzo[b,d]furan-3-amine (D418205), which is a building block used as a reactant in the preparation of dibenzofuryl(phosphonomethyl)alanines as endothelin converting enzyme inhibitors.<br>References De Lombaert, S., et al.: J. Med. Chem., 43, 488 (2000);<br></p>

<p>Applications 5,6,8,9-Tetrahydro-7H-dibenzo[c,g]carbazole (cas# 117766-87-7) is a compound useful in organic synthesis.<br></p>

<p>Applications 4-Isopropylphenylacetic acid (cas# 4476-28-2) is a useful research chemical.<br></p>

<p>Applications Triethylene Glycol Monobenzyl Ether is used in the preparation of self-assembled monolayers with multiple binding sites and biocompatible imprinted cavities for biosensor application. Also used in the synthesis of novel ethoxylated inositol surfactants.<br>References Zhang, X. et al.: J. Am. Chem. Soc., 135, 9248 (2013); Catanoiu, G. et al.: J. Colloid. Inter. Sci., 371, 82 (2012);<br></p>

<p>Applications 4-Ethynyltetrahydro-2H-pyran is useful in the synthesis of preparation of aminopyrazine derivatives useful as PI3k-γ inhibitors.<br>References Douty, B., et al.: U.S. Pat. Appl. Publ., 132 (2020)<br></p>