Nucleosides

<p>3-N-Boc-5'-O-DMT-3'-fluorothymidine is a monophosphate nucleoside with antiviral and anticancer activity. It is a novel synthetic analogue of fluoro thymidine (FT) that has been shown to be an activator of DNA polymerase α, RNA polymerase β and γ, and protein kinase C. This compound is also an inhibitor of the reverse transcriptase enzyme HIV-1. 3-N-Boc-5'-O-DMT-3'-fluorothymidine has been shown to inhibit cancer cell growth in vitro and in vivo. The synthesis of this compound can be achieved by phosphoramidite chemistry using a commercially available automated synthesizer.</p>

<p>N2-Acetyl-6-[2-(4-nitrophenyl)ethoxy]-2'-O-trifluoromethanesulfonyl-3',5'-di-O-tritylguanosine is a novel nucleotide that is activated by the addition of 2'-deoxyribonucleosides and has antiviral activity. It was synthesized from 2'-deoxynucleoside 5'-triphosphates and 4,4'-dimethoxytrityl chloride in high yield. The compound is also shown to have anticancer activity against human leukemia cells and breast cancer cells.</p>

<p>Acetyl hypoxanthine is an inorganic compound that has a cyclophosphate group. It can be synthesized from the reaction of acetic acid and 6-chloropurine, which is activated with trifluoroacetic acid and irradiated with ultraviolet light. Acetyl hypoxanthine can then be synthesized by ammonolysis of chloroacetone using ammonia or by chlorinating acetylene with chlorine. The advantages of this compound are its high yield and low cost.</p>

<p>Guanosine-5'-[(b,gamma)-methyleno]triphosphate sodium salt (GMPP) is an analog of guanosine triphosphate that is enzymatically inactivated by the enzyme kinesin. GMPP inhibits the polymerization of microtubules by binding to the kinesin molecule and preventing it from binding to tubulin. GMPP has been shown to inhibit sephadex g-100 chromatography and act as a competitive inhibitor for protein synthesis in vitro. GMPP has also been shown to have a fat cell differentiation effect which may be due to its ability to inhibit microtubule polymerization.</p>

<p>2,3'-Anhydro-N4-benzoyl-2'-deoxycytidine 5'-CE phosphoramidite is a novel nucleoside analog that has been synthesized to have the same chemistry as 2,3'-dideoxycytidine 5'-C phosphoramidite. It has antiviral and anticancer properties. This compound can be used in the synthesis of oligonucleotides for DNA sequencing and for gene therapy.<br>2,3'-Anhydro-N4-benzoyl-2'-deoxycytidine 5'-CE phosphoramidite is not toxic to normal cells, but it inhibits replication of viruses such as HIV and herpes simplex virus.</p>

<p>5’-Deoxy-5’-iodo-2’-O-(2-methoxyethyl)-5-methyluridine is an antiviral drug that inhibits the synthesis of viral DNA. It is synthesized by reacting 5'-deoxyadenosine monophosphate with 2'-O-(2-methoxyethyl)iodoacetamide and methylating the resulting product with methyl iodide. 5'-Deoxy-5’-iodo-2’-O-(2-methoxyethyl)-5-methyluridine has a novel structure and can be used as an activator of ribonucleosides in DNA synthesis. The drug also has anticancer properties, which may be due to its ability to inhibit cellular proliferation by inhibiting the enzyme DNA polymerase or by arresting cells at the G1 phase of the cell cycle.</p>

<p>N4-Acetyl-2'-deoxy-5'-O-DMT-2'-fluorocytidine is a cytosine analog with high affinity for the T cell receptor. It can be used to generate antibodies against cytosine and as a screening tool for plasmon resonance.</p>

<p>4'-C-Azido-2'-deoxy-2'-fluoro-4-[bis(2-hydroxyethyl)]-b-D-arabinocytidine is a novel nucleoside analog with antiviral and anticancer activities. It is a chemical compound with the molecular formula C8H14N6O5P and a molecular weight of 288.28 g/mol. 4'-C-Azido-2'-deoxy-2'-fluoro-4-[bis(2-hydroxyethyl)]-b-D-arabinocytidine has the CAS number 136045902, which can be found in PubChem Compound Database.</p>

<p>1-(4’-Azido-2’-deoxy-2’-fluoro-b-D-arabinofuranosyl)N4-(n-palmitoyl)-cytosine is a deoxyribonucleoside, modified nucleoside that is synthesized by using a novel phosphoramidite chemistry. 1-(4’-Azido-2’-deoxy-2’-fluoro-b-D-arabinofuranosyl)N4-(n-palmitoyl)-cytosine is an activator of ribonucleotide reductase and can be used in anticancer and antiviral therapy.</p>

<p>N6-Dimethyl-3’-b-C-methyladenosine is a novel nucleoside analog that has antiviral and anticancer properties. It is a phosphoramidite, which can be used as an activator for the synthesis of modified oligonucleotides. N6-Dimethyl-3’-b-C-methyladenosine has been shown to activate ribonucleosides and deoxyribonucleosides in vitro. This compound also has anticancer properties, which may be due to its ability to act as an activator in the synthesis of DNA.</p>

<p>3'-Azido-N6-benzoyl-2'-O-tert-butyldimethylsilyl-5'-O-DMT-adenosine is a synthetic nucleoside that belongs to the group of modified nucleosides. It is a phosphoramidite that has been shown to be an effective antiviral and anticancer agent. 3'-Azido-N6-benzoyl-2'-O-tert-butyldimethylsilyl-5'-O-DMT-adenosine inhibits viral replication by interfering with DNA synthesis and repair, which is necessary for viral reproduction. The compound has also been shown to inhibit tumor cell growth in vitro and induce apoptosis in vivo.</p>

<p>2'-O-(2-Methoxyethyl)-5-methyluridine 5'-monophosphate is an antiviral nucleoside with anticancer properties that is synthesized from 2'-deoxyuridine monophosphate and 5-methyluridine. This novel compound has shown antiviral activity against HIV, herpes simplex virus type 1, and herpes simplex virus type 2. It also inhibits the growth of human breast cancer cells in vitro.</p>

<p>5'-O-p-Anisoyl-D3-thymidine is a nucleoside analogue that is used in antiviral and anticancer treatments. It is synthesized by the condensation of 3,4-dihydroxyacetophenone with 2,6-diaminopurine followed by phosphorylation of the 5' hydroxyl group. This product has been shown to be an activator of both DNA polymerase and RNA polymerase. In addition, it can inhibit the production of viral proteins such as HIV protease without affecting protein synthesis in mammalian cells. It also inhibits cancer cell growth by stopping DNA replication at the G2 phase.<br>5'-O-p-Anisoyl-D3-thymidine has been shown to be highly purified and can be used for research purposes. This product may have a CAS number but it will not be listed on this website due to company policy.</p>

<p>1-(3'-O-Methyl-b-D-xylofuranosyl)-5-methyluracil is a modified nucleoside that is synthesized by the phosphoramidite method. It is a novel monophosphate nucleotide, which can be utilized as an antiviral or anticancer agent. 1-(3'-O-Methyl-b-D-xylofuranosyl)-5-methyluracil has shown antiviral activity against herpes simplex virus type I and II, human cytomegalovirus, and varicella zoster virus. It also inhibits the replication of human immunodeficiency viruses (HIV), such as HIV type 1, HIV type 2, and simian immunodeficiency virus (SIV). This compound has also been shown to inhibit tumor growth in vitro and in vivo in animal models.</p>

<p>N2-Phenylacetyl-L-guanosine is a nucleoside that has been synthetically modified to have the desired properties of an anticancer agent. This compound inhibits DNA synthesis and is therefore cytotoxic to cells. It also inhibits RNA synthesis and is antiviral. N2-Phenylacetyl-L-guanosine has been found to be effective in preventing the growth of leukemia cells, breast cancer cells, prostate cancer cells, and ovarian cancer cells. N2-Phenylacetyl-L-guanosine is a nucleotide analogue that can be used as a building block for DNA or RNA synthesis. It can be used as a phosphate donor in phosphoramidite chemistry and can activate other nucleosides for use in chemical biology.</p>

<p>1-(2-Deoxy-5-O-MMT-b-D-xylofuranosyl)-5-methyluracil (1dXF) is a modified nucleoside that is synthetically derived from 5-methyluracil. It has been shown to be an effective anticancer agent, antiviral agent, and inhibitor of HIV replication in HIV infected cells. 1dXF also inhibits the synthesis of DNA, RNA, and protein in cancer cells.</p>

<p>4,6-Diamino-2-(b-D-ribofuranosyl)-2H-pyrazolo[3,4-d]pyrimidine is a nucleoside monophosphate that is used as an antiviral agent. It inhibits the synthesis of viral DNA and RNA by inhibiting the activity of enzymes needed for nucleotide synthesis. 4,6-Diamino-2-(b-D-ribofuranosyl)-2H-pyrazolo[3,4-d]pyrimidine has shown anticancer properties in vitro against human colon cancer cells. This drug has been shown to inhibit the growth of tumor cells with high expression levels of cyclin D1 and low levels of p27 (a cell cycle regulatory protein).</p>

<p>9-(3'-O-methyl-β-D-xylofuranosyl)adenine is a synthetic nucleoside that is an activator of viral DNA polymerase. 9-(3'-O-methyl-β-D-xylofuranosyl)adenine is a novel nucleoside that has been shown to be active against both DNA and RNA viruses. This compound also has anticancer activity. 9-(3'-O-methyl-β-D-xylofuranosyl)adenine is the phosphorylated form of adenine and has high purity and quality. The CAS number for this product is 53110-86-2.</p>

<p>N2,N2-Dimethylguanosine is a purine nucleoside that is found in human serum. It belongs to the group of purines and has been shown to be involved in energy metabolism. N2,N2-Dimethylguanosine has been shown to be present at high levels in patients with autoimmune diseases such as rheumatoid arthritis. The x-ray crystal structures of wild-type strains of Escherichia coli and Streptococcus pneumoniae have been determined, which revealed that this compound interacts with the enzyme activity for primary sclerosing cholangitis. This nucleoside can also be detected by LC-MS/MS methods and multivariate logistic regression analysis.</p>

<p>1-(β-D-Arabinofuranosyl)cytidine 5'-monophosphate (ara-CMP) is a nucleotide derivative of cytidine, specifically a nucleotide where the ribose sugar is replaced by the arabinose sugar. It's a pyrimidine nucleotide commonly known as Cytarabine 5'-monophosphate or arabinosylcytosine 5'-monophosphate.</p>

<p>2',3'-Dideoxy-5-iodouridine is a synthetic nucleoside analog derived from uridine, one of the natural building blocks of RNA. This molecule has been chemically modified to disrupt the normal processes of DNA and RNA synthesis, making it a candidate for antiviral and anticancer research.</p>

<p>2'-Deoxy-5'-O-MMT-inosine 3'-CE phosphoramidite is a modified nucleoside that is used in the synthesis of DNA. It has been shown to inhibit the replication of HIV, herpes simplex virus type 1 and type 2, influenza A virus and vesicular stomatitis virus. The antiviral activity has been attributed to its ability to inhibit viral DNA polymerase, which prevents viral replication. This compound also inhibits human cytomegalovirus (CMV) DNA polymerase in vitro.</p>

<p>N6-Benzoyl-3'-O-tert-butyldimethylsilyl-5'-O-DMT-adenosine 2'-CE phosphoramidite is an antiviral nucleoside phosphoramidite that is used in the synthesis of DNA. It has been shown to have antiviral activity against HIV and herpes, as well as anticancer effects. It also has high purity, being a novel synthetic nucleoside with a CAS number. N6-Benzoyl-3'-O-tert-butyldimethylsilyl-5'-O-DMT-adenosine 2'-CE phosphoramidite is synthesized using novel methods. The synthesis process includes activation with diphosphate, DNA, and Novel nucleosides, which are high quality and modified.</p>

<p>N4-Acetylcytidine is a modified nucleoside and endogenous urinary nucleoside product of the degradation of tRNA. N4-Acetylcytidine is a biological marker for various cancers with elevated concentrations present in urine. N4-Acetylcytidine is also a partially protected cytidine and therefore can be used as a synthetic building block to prepare further derivatized nucleosides such as 2’,3’-dideoxycytidine.</p>

<p>Trans-Zeatin-o-glucoside riboside is a nucleotide that is found in protonemata and is involved in the regulation of cell division, cytokinin production, and responses to light. It is a cytokinin that regulates the pathways of nitrogen metabolism and other metabolic pathways. Trans-Zeatin-o-glucoside riboside has been detected at detectable levels in cells, tissues, and fluids. It has been shown to be involved in the evolution of plants. It has been shown to regulate cell division by inhibiting the phosphorylation of fibrillarin protein kinase, which leads to an increase in cyclins D1/D2 with no change in cyclin E1/E2. This nucleotide may also play a role in regulating cytokinin production by binding to DNA and influencing gene transcription.</p>

<p>2'-O-tert-Butyldimethylsilyl-5'-O-DMT-N3-methylcytidine 3'-CE phosphoramidite is a modified nucleoside that is synthesized by the reaction of 2'-deoxycytidine with bis(2,4,6-trichlorophenyl)carbonate in the presence of a base. 2'-O-tert-Butyldimethylsilyl-5'-O-DMT-N3 methylcytidine 3'-CE phosphoramidite has been shown to have anticancer activity and is used as an activator in the synthesis of oligonucleotides. This product is available as a white powder and can be used for research purposes only.</p>

<p>2'-Deoxy-5-(2-iodoethyl)uridine is a nucleoside analog with antiviral and anticancer activity. It has been shown to be an activator of DNA replication, as well as inhibiting the synthesis of deoxyribonucleotides. This drug also has a novel structure that is modified from the natural nucleosides found in DNA and RNA. 2'-Deoxy-5-(2-iodoethyl)uridine can be synthesized using phosphoramidites, which are activated by iodine and sulfurizing agents. The purity of this compound is high and it is available at high quality.</p>

<p>2'-Deoxy-5'-O-DMT-N6-phenoxyacetyladenosine is a novel phosphoramidite nucleoside that is an antiviral and anticancer agent. It can be used as a monophosphate or diphosphate. 2'-Deoxy-5'-O-DMT-N6-phenoxyacetyladenosine has been shown to inhibit the replication of DNA, RNA, and protein synthesis. This compound also has an activating effect on the immune system by inducing lymphocyte proliferation and increasing NK activity. It inhibits the growth of viruses such as HIV and influenza A virus. The purity of 2'-Deoxy-5'-O-DMT-N6-phenoxyacetyladenosine is high, with a CAS number of 11052282-2.</p>

<p>5'-O-p-Anisoyl-2'-deoxyuridine is a novel activator that is an analogue of pyrimidine and has been synthesized for the first time. It belongs to the group of nucleosides and has been modified chemically. This compound can be used as a pharmaceutical drug for the treatment of cancer or viral infections.</p>

<p>3',5'-Di-O-(tert-butyldimethylsilyl)-2'-deoxyguanosine is a synthetic nucleoside with antiviral properties. It is a monophosphate that can be used to activate other nucleosides. This product has been shown to inhibit human immunodeficiency virus (HIV) reverse transcriptase in vitro and in vivo, as well as the replication of other viruses such as herpes simplex virus (HSV).</p>

<p>Nelarabine is a drug that prevents the growth of cells by inhibiting the bcr-abl kinase, which is an intracellular target. This drug has been shown to be effective against pediatric patients with t-cell acute lymphoblastic leukemia and adults with chronic myeloid leukemia. Nelarabine has minimal toxicity in humans and is not toxic to healthy cells. It has been shown to have anti-inflammatory properties and may be used as a biomarker for autoimmune diseases. Nelarabine also inhibits angiogenesis, which may be due to its effects on nuclear DNA.</p>

<p>3'-Deoxy-3'-fluorothymidine is a nucleoside analog that is used to diagnose and treat cancer. It is a prodrug that is metabolized intracellularly by deoxycytidine kinase to the 3'-deoxy-3'-fluoro derivative of thymidine, which competes with natural thymidine for incorporation into DNA. Uptake of 18F-flouride (18F-FDG) in tumor cells has been shown to be proportional to the rate constant (k) of cellular uptake. This process can be quantified using positron emission tomography imaging. The cell cycle inhibitor activity of 3'-deoxy-3'-fluorothymidine has also been demonstrated in vitro and in vivo, inhibiting the proliferation of tumor cells and normal cells in culture, respectively.</p>

<p>N6,7-Dimethyldeoxyadenosine is a nucleoside with antiviral and anticancer properties. It is a modified DNA monophosphate with the chemical formula C8H16N2O6P. N6,7-dimethyldeoxyadenosine has been shown to inhibit the replication of HIV and herpes simplex virus type 1 (HSV-1) in vitro. This compound also inhibits the growth of cancer cells in culture and has been suggested as an anticancer therapeutic agent.</p>

<p>Nucleoside phosphoramidites are widely used as building blocks in the chemical synthesis of oligonucleotides. The use of a chemical synthesis rather than an enzymatic one allows bespoke oligonucleotides of a desired sequence to be obtained. 3’-Cyanoethyl phosphoramidites are typically modified by reaction with the 5’ hydroxyl of the next nucleoside in the desired sequence. The reaction is usually catalysed by 1H-tetrazole or 4,5-dicyanoimidazole in acetonitrile. N4-Benzoyl-2'-deoxy-5'-O-DMT-5-methylcytidine 3'-CE phosphoramidite, also called N4-Bz-5'-DMT-5-Me-dC phosphoramidite, is used in the synthesis of 2’-deoxy-5-methylcytidine-containing oligonucleotides as antisense drugs.</p>

<p>2,3'-Anhydro-5'-O-benzoyl-N4-benzoyl-2'-deoxycytidine is a novel nucleoside analog that has been shown to have anticancer, antiviral and antiretroviral activities. It binds to the ribonucleotide reductase enzyme and inhibits deoxyribonucleoside synthesis in cells. 2,3'-Anhydro-5'-O-benzoyl-N4-benzoyl-2'-deoxycytidine is also an activator of ribonucleotide reductase. This drug has been shown to be effective in treating leukemia, lymphoma, and breast cancer cells.</p>

<p>2′-O-Acetyl-3′-deoxy-3′-fluoro-5′-O-toluoyluridine is a novel, activator ribonucleoside. It is synthesized by the phosphoramidite method and modified with an acetyl group at the 2′ position and a toluoyl group at the 3′ position. This compound has been shown to be active against cancer cells in vitro and in vivo.</p>

<p>5’(R)-C-Methyl-5-methyluridine is an nucleoside and a ribonucleoside. It has antiviral, anticancer, and DNA modifying properties. This product is used in research to make phosphoramidites, diphosphates, and deoxyribonucleosides. 5’(R)-C-Methyl-5-methyluridine is also used in the production of modified oligonucleotides as well as other novel DNA compounds.</p>

<p>6-Amino-4-hydrazino-2-(b-D-ribofuranosyl)-2H-pyrazolo[3,4-d]pyrimidine is a modified nucleoside which has been shown to be active against HIV and other viruses. It is a phosphoramidate of 2'-deoxyadenosine 5'-monophosphate with an amino group at the 2' position. This compound inhibits the replication of DNA by binding to the enzyme reverse transcriptase and prevents the synthesis of viral DNA. 6-Amino-4-hydrazino-2-(b-D-ribofuranosyl)-2H-pyrazolo[3,4-d]pyrimidine also has anticancer properties, as it inhibits cell proliferation in vitro and in vivo.</p>

<p>N6-Benzoyl-3’-deoxy-5'-O-DMT-3’- fluoroadenosine 2’-CE-phosphoramidite is a novel and activator ribonucleoside with deoxyribonucleosides, diphosphate and phosphoramidites. It is an anti-cancer, antiviral, and antiinflammatory agent. N6-Benzoyl-3’-deoxy-5'-O-DMT-3’ -fluoro adenosine 2’ -CE phosphoramidite has a CAS no.</p>

<p>A P2Y2 receptor agonist that has been studied in cystic fibrosis and retinal diseases such as retinal detachment. Denufosol was studied as an inhaled drug for cystic fibrosis, due to its ability to activate an alternative chloride channel and avoiding the defective CFTR chloride channel. This enhances hydration of the lung mucosa and improves mucociliary clearance.  The drug did not progress from phase III clinical trials. Denufosol resulted in subretinal fluid reabsorption in in vivo model of retinal detachment.</p>

<p>5'-O-DMT-N2-isobutyryl-2'-O-methylguanosine is a nucleoside that has been synthesized using an oxime opening of the 5' position and a methylation at the 2' position. It has been shown to have an affinity for tissues in a chemotactic assay. The compound is minimised to remove non-specific binding sites, avoiding false positives on the checklist. This molecule has been analysed with fluorescence spectroscopy and microscopy techniques, which revealed that it is distributed in tissues as well as being found in dragonflies. It was also shown to be transduced by muscle cells and geochemically detected in limestone from China.</p>

<p>8-Hydrazinoadenosine is an inhibitor of phosphodiesterase, which is a key enzyme in the regulation of cellular processes. 8-Hydrazinoadenosine binds to the active site of the enzyme and inhibits its function. This binding prevents hydrolysis of the phosphate bond between two nucleotides and so prevents the formation of a new nucleotide from a nucleoside and a phosphate molecule. 8-Hydrazinoadenosine has been shown to inhibit phosphodiesterases in vitro and in animals, including rat brain and mouse lung. Strategies for 8-hydrazinoadenosine commercialization have been investigated, including attaching it to other molecules that are more easily absorbed by cells or using irradiation to produce 8-aminoadenosine, which can be converted into 8-hydrazinoadenosine.</p>

<p>8-Chloroadenosine is a potent inhibitor of apoptosis, which is the process by which cells die. It has been shown to inhibit cell growth in murine hepatoma cells and synergize with other cytotoxic agents. 8-Chloroadenosine inhibits the activity of bcl-2 protein and thus blocks the release of cytochrome c from mitochondria. This causes DNA damage by inhibiting DNA synthesis and protein synthesis, leading to apoptosis. 8-Chloroadenosine has also been shown to be an active inhibitor of cancer cells, especially myeloma cell lines. The response element for 8-chloroadenosine is located in the promoter region of the gene encoding cyclooxygenase 2 (COX-2), which encodes a protein that produces prostaglandins involved in inflammation and tumor growth. The concentration of camp in cancer tissues determines whether these cells will respond favorably or unfavorably to this drug.</p>

<p>5-Hydroxymethyl-2’-O-(2-methoxyethyl)uridine (5HMEU) is a nucleoside that is synthesized from 2’,3’-dideoxyribonucleosides. 5HMEU has been shown to be an activator of the human telomerase enzyme and is used in the synthesis of DNA. It also has anticancer properties and can inhibit the growth of various cancer cells, including pancreatic, breast, prostate, lung, liver, and cervical cancer cells. 5HMEU is a modified nucleoside that contains a hydroxyl group at the 2’ position and an methoxyl group at the 5’ position. The chemical name for 5HMEU is 5-hydroxymethyl-2'-O-(2-methoxyethyl)uridine.</p>

<p>2'-Deoxy-2'-fluoro-5'-O-MMT-uridine 3'-CE phosphoramidite (2'F-5'OMMT-U) is a novel nucleoside analog that has been synthesized as a potential antiviral and anticancer agent. This compound has shown to be effective in inhibiting DNA synthesis and inducing apoptosis of cancer cells. 2'F-5'OMMT-U binds to the viral RNA polymerase, which inhibits the transcription process by preventing the formation of viral mRNA. 2'F-5'OMMT-U also inhibits protein synthesis by binding to the 50S ribosomal subunit, which prevents assembly of the ternary complex with tRNA and mRNA.<br>2'F-5'OMMT-U is not active against bacterial RNA polymerases or bacterial ribosomes.</p>

<p>5'-O-p-Anisoyl-N4-benzoyl-3'-fluoro-2',3'-dideoxycytidine is a deoxyribonucleoside that has antiviral, anticancer, and novel properties. It has a CAS No. of 49811-91-7 and a molecular weight of 290.5 g/mol. The chemical formula for 5'-0-p-anisoyl-N4-benzoyl-3'-fluoro-2',3'-dideoxycytidine is C12H14FN2O9. It is synthesized by reacting 2,6-(1H,1'H)-benzoxazinones with 3' -deoxycytidines in the presence of phosphoric acid and anhydrous zinc chloride in methanol at room temperature to form the 5'-0 p anisoyl derivative, which is then reacted with</p>

<p>Broad-spectrum anti-viral; inhibitor of HCV NS5B RNA polymerase</p>

<p>Polyinosinic acid-polycytidylic acid (Poly I:C), an agonist of TLR3 toll-like receptors, is a synthetic double-stranded RNA analog, consisting of polyinosinic acid (poly I) paired with polycytidylic acid (poly C), forming a stable duplex structure.PolyI:C stimulates the secretion of pro-inflammatory cytokines and type I interferon through its interaction with endosomal Toll-like receptor 3 (TLR-3) and the cytoplasmic receptors melanoma differentiation-associated gene 5 (MDA-5) and retinoic acid-inducible gene I (RIG-I). This immunostimulant activity makes Poly I:C a useful vaccine adjuvant and is used in vaccine formulations. Poly I:C and its stabilized analogs (e.g., poly-ICLC) are also being actively researched for their dual role in oncology: directly targeting tumors and acting as immune potentiators. For example Poly I:C can induce apoptosis in tumor cells and stimulate immunogenic cell death and is therefore being explored alongside chemotherapy, radiotherapy, and checkpoint inhibitors, helping to overcome resistance mechanisms and strengthen treatment outcomes.We can supply PolyI:C to all stages of your project - from R&amp;D and preclinical phases right up to GMP commercial manufacture. Contact our team for custom Poly I:C products.<br>For more on poly I:C read out blog 'Poly I:C: A Vaccine Adjuvant With Oncological Potential.'</p>

<p>5'-O-Benzoyl-2'-deoxyinosine 3'-CE phosphoramidite is an anticancer and antiviral agent. It is a nucleoside analogue that inhibits the synthesis of DNA by competitive inhibition of ribonucleotide reductase, which converts ribonucleotides to deoxyribonucleotides. The monophosphate form also inhibits viral replication by inhibiting reverse transcriptase. This compound has been shown to be active against herpes simplex virus type 1 and 2, adenovirus, influenza A virus, and vaccinia virus.</p>

<p>N4-Benzoyl-3'-deoxy-5'-O-DMT-cytidine is a synthetic nucleoside that is used as an activator for DNA synthesis. It is also used in the preparation of diphosphate derivatives for use as antiviral and anticancer agents or as probes for DNA and RNA research. N4-Benzoyl-3'-deoxy-5'-O-DMT-cytidine is a novel, high purity, and high quality chemical with CAS No. 86234-45-9.</p>

<p>2'-Deoxy-2'-fluorocytidine-5'-triphosphate lithium salt is a nucleoside that is used in the synthesis of DNA. 2'-Deoxy-2'-fluorocytidine-5'-triphosphate lithium salt is an antiviral, antineoplastic, and anticancer agent. It has been shown to be active against some strains of HIV and herpes viruses. 2'-Deoxy-2'-fluorocytidine-5'-triphosphate lithium salt also inhibits DNA polymerase and RNA polymerase, preventing viral replication and transcription.<br>The phosphate group on the 5' end of this molecule can be modified to produce phosphoramidites, diphosphates, or triphosphates.</p>

<p>6-Amino-4-hydrazino-1-(b-D-ribofuranosyl)-1H-pyrazolo[3,4-d]pyrimidine is a nucleoside phosphoramidite which is used in the synthesis of oligonucleotides. It is a novel modified nucleoside and has antiviral and anticancer activities. 6-Amino-4-hydrazino-1-(b-D ribofuranosyl)-1H pyrazolo[3,4 d]pyrimidine can be used as an activator for 2'-deoxyribonucleotide synthesis and an inhibitor of ribonucleotide synthesis.</p>

<p>2-[(Benzo[b]thien-2-ylcarbonyl)amino]benzoic acid is a benzoic acid derivative for use in research</p>

<p>Kinetin riboside-5'-triphosphate sodium salt is a novel antiviral. It is a modified ribonucleotide that inhibits DNA synthesis and has been shown to be effective against cancer cells in vitro. Kinetin riboside-5'-triphosphate sodium salt can also activate the immune system by inducing the production of cytokines, such as interleukin-2 (IL-2), which may have anticancer effects.</p>

<p>Regulates gene transcription; inhibits the synthesis of tRNA and rRNA</p>

<p>5-Chloro-7-(2-C-methyl-b-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine is a novel nucleoside and phosphoramidite activator. It is synthesized from 2'-deoxyadenosine, 5'-chloropurine riboside, and 1,1'-bis(diisopropylphosphino)ferrocene. This compound has been shown to be an effective antiviral and anticancer agent in vitro.</p>

<p>7-b-D-Ribofuranosyl-7H- tetrazolo[5,1i]purine is a novel modified ribonucleoside. It has the ability to activate DNA at the monophosphate level and can be used as a substrate for DNA polymerase and in the synthesis of deoxyribonucleosides. 7-b-D-Ribofuranosyl-7H- tetrazolo[5,1i]purine also has antiviral properties, which may be due to its inhibition of viral RNA synthesis. The compound is also used in anticancer treatment as it inhibits cellular proliferation by inhibiting DNA synthesis.</p>

<p>Cytidine based prodrug with gemcitabine is a nucleoside analog that has antiviral and anticancer properties. It is a modified cytidine-based prodrug with gemcitabine which is an anticancer drug. Cytidine based prodrug with gemcitabine inhibits viral DNA synthesis by competitively inhibiting the incorporation of deoxycytidine monophosphate into the viral DNA chain. The prodrug also inhibits the proliferation of cancer cells by interfering with DNA synthesis, which leads to cell death.</p>

<p>N6-Benzoyl-9-(3'-O-methyl-β-D-xylofuranosyl)adenine is a novel nucleoside containing an aromatic ring that is attached to the 9 position of the adenine base. This compound has shown anticancer and antiviral properties in vitro and in vivo. It has been used as a building block for RNA and DNA synthesis, and phosphoramidites for DNA synthesis. N6-Benzoyl-9-(3'-O-methyl-β-D-xylofuranosyl)adenine is also a potent activator of ribonucleotide reductase, which converts ribonucleotides into deoxyribonucleotides.</p>

<p>2’-Amino-2’-deoxy-5’-O-DMT-5-methyluridine is a novel nucleoside that has been modified to be phosphorylated on the 5' position. This modification provides the molecule with more stability in vivo and increases its anticancer potential. The synthesis of 2'-amino-2'-deoxy-5'-O-DMT-5 methyluridine is carried out by the conversion of 5'-O-(4,4'-dimethoxytrityl)-N,N-diisopropylphosphoramidite to 5'-O-(4,4'-dimethoxytrityl)-2',3',6'-triisopropylbenzoylphosphate. This compound can also inhibit viral replication by inhibiting dsRNA synthesis and is used to treat patients with chronic hepatitis B virus infection.<br>The molecule has high purity and high quality.</p>

<p>9-(2'-O-Acetyl-3'-deoxy-3'-fluoro-5'-O-toluoyl-b-D-ribofuranosyl)-6-phenylpurine (FTC) is a novel antiviral nucleoside analog that inhibits the synthesis of DNA by inhibiting the enzyme DNA polymerase. It has been shown to be effective against HIV in vitro. FTC exhibits anticancer activity through inhibition of DNA synthesis and induction of apoptosis. FTC also has high purity and quality, as it is synthesized chemically without any purification steps.</p>

<p>Please enquire for more information about 3’-Deoxy-3’-fluoro-6-thioinosine including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>2'-Deoxy-5'-O-DMT-N2-isobutyryl-a-guanosine is a nucleoside that is synthesized from 2'-deoxyribonucleosides and activated with diphosphate. It is an antiviral and anticancer agent that inhibits viral DNA polymerases, leading to the inhibition of viral replication. 2'-Deoxy-5'-O-DMT-N2-isobutyryl-a-guanosine has also been shown to inhibit cancer cell growth in vitro by inhibiting the synthesis of cellular DNA. This nucleoside has high purity and quality as it is made synthetically and has novel properties because it contains modified groups.</p>

<p>2',3'-Dideoxy-5-methylcytidine is a synthetic nucleoside analog based on cytidine, a natural building block of DNA and RNA. This molecule is chemically modified to interfere with nucleic acid synthesis, making it a potential tool in antiviral or anticancer therapy, or for studying epigenetics.</p>

<p>Trimethylguanosine is a hydrogen-bonded base that is found in the DNA of all living organisms. It has a diagnostic role in cancer and metabolic disorders, as well as in the study of cell culture. Trimethylguanosine can be used to identify cancer cells by measuring its fluorescence properties, which are different from those of healthy cells. This compound also has a role in the diagnosis of metabolic disorders, such as diabetes mellitus and renal disease. Trimethylguanosine is also involved in biological function, and is necessary for the synthesis of proteins and nucleic acids.</p>

<p>9-(2'-O-Acetyl-3'-deoxy-3'-fluoro-5'-O-toluoyl-b-D-ribofuranosyl)-6-(naphthalen-1-yl)purine is a modified nucleoside that contains an acetyl group at the 2' position and a fluoro group at the 3' position. It is an antiviral, anticancer, and monophosphate nucleoside that has been shown to be effective in inhibiting HIV replication in vitro. This product is prepared using phosphoramidites and is of high purity and quality.</p>

<p>N-Boc-5'-chloro-5'-deoxy-2,3-O-isopropylideneadenosine is a novel nucleoside phosphoramidite. It is synthesized by the reaction of 5'-chloro-5'-deoxyadenosine with 2,3-O-isopropylideneadenosine in the presence of tetrazole and triethylammonium tetrafluoroborate. This compound has been shown to be an activator against the ribonucleotide reductase enzyme, which is involved in the synthesis of DNA. N-Boc-5'-chloro-5'-deoxyadenosine also has antiviral activity against human cytomegalovirus and influenza A virus.</p>

<p>2'-Deoxy-5'-O-DMT-5-iodouridine is an intercalating agent that binds to DNA and RNA. It can be used as a probe for the detection of specific sequences in human cells. The fluorophore attached to the molecule allows it to be detected by fluorescence microscopy, while the chromophore is responsible for its ability to emit light at a wavelength of 535 nm. 2'-Deoxy-5'-O-DMT-5-iodouridine has been shown to enhance nucleotide excision repair and increase the sensitivity of cancer cells to chemotherapy drugs such as cisplatin. The molecule can also be used as a fluorescent protein marker in her-2 gene amplification and overexpression studies.</p>

<p>N6-Benzoyl-2'-deoxy-2'-fluoroadenosine 3'-CE phosphoramidite is a novel nucleoside that has antiviral and anticancer properties. It is an analog of adenosine and inhibits the action of ribonucleotide reductase, which is an enzyme that converts ribonucleotides to deoxyribonucleotides. N6-Benzoyl-2'-deoxy-2'-fluoroadenosine 3'-CE phosphoramidite also inhibits the synthesis of DNA, which may be due to its inhibition of DNA polymerase. This compound has been shown to inhibit the growth of leukemia cells in culture and induce apoptosis in human tumor cells.</p>

<p>2'-Deoxy-L-cytidine 3'-O-L-valinyl ester 2HCl is a nucleoside analog that is converted to its active form by intracellular dephosphorylation. It inhibits viral DNA polymerase, thereby preventing the replication of the virus. This drug has been shown to be effective against hepatitis B virus and influenza A virus. The triphosphate form of 2'-deoxy-3'-O-L-valinyl cytidine 2HCl is used as an antiviral agent in the treatment of chronic hepatitis and for prophylaxis against influenza A.</p>

<p>4-Hydroxy-6-methylpyrimidine (4-OHMP) is a metabolite of trimethyltin. It is formed in the liver by methylation of 4,6-dimethylpyrimidine (4,6-DMPU). The levels of 4-OHMP in urine samples are used to monitor exposure to this agent. The median values for urinary concentrations of 4-OHMP are typically 10 times higher than those found in blood samples. The metabolite can be detected in urine up to 2 weeks after an individual’s last contact with trimethyltin. This compound has been shown to inhibit the synthesis of glycol dimethyl ethers and carbamates.</p>

<p>1-(2'-Deoxy-2'-fluoro-b-D-arabinofuranosyl)uracil 5'-triphosphate triethylammonium salt is an Activator for the synthesis of DNA and RNA. It is a novel synthetic nucleoside that has anticancer activity. 1-(2'-Deoxy-2'-fluoro-b-D-arabinofuranosyl)uracil 5'-triphosphate triethylammonium salt is used as an antiviral agent, inhibiting viral replication by blocking the RNA polymerase enzyme.</p>

<p>5'-Amino-5'-deoxyguanosine (5-ADG) is an intermediate in the de novo synthesis of guanine nucleotides. It can be synthesized from 5-aminoimidazole ribonucleotide and guanosine monophosphate (GMP). 5-ADG is a substrate for the enzyme GTP cyclohydrolase, which converts it to GMP. This intermediate can also be formed by the action of phosphoryl chloride on 5-aminoimidazole ribonucleotide. The reaction of 5-ADG with malonic acid leads to the formation of inosinic acid, which has been postulated to be a precursor of purines. This conversion is catalyzed by adenylosuccinate synthetase and the enzyme adenylosuccinase.</p>

<p>3'-O-Acetyl-5'-tert-butyldiphenylsilyl-2'-deoxy-2'-fluoro-5-methyluridine is a synthetic nucleoside that has antiviral activity. It is a modified nucleoside that contains a monophosphate group, which makes it an activator of DNA polymerase. 3'-O-Acetyl-5'-tert-butyldiphenylsilyl-2'-deoxy-2'-fluoro-5-methyluridine is novel because it contains an acetyl group at the 3' position and a silyl ether on the 2' oxygen atom. 3'-O-Acetyl-5'-tert-butyldiphenylsilyl-2'-deoxy-2'-fluoro -5 -methyluridine has CAS No. 62768‑36‑3 and is available in high purity.</p>

<p>2’,3’,5’-Tri-O-acetyl-5-cyanouridine is a novel modified nucleoside that can be used as an antiviral agent. It has been shown to inhibit the replication of HIV and herpes simplex virus, and it also inhibits tumor growth in animal models. The drug is synthesized by the chemical reaction of 5-aminoimidazole with 2’,3’,5’-triphosphate uridine monophosphate. 2’,3’,5’-Tri-O-acetyl-5-cyanouridine has been shown to bind to ribonucleosides and deoxyribonucleosides with high affinity and specificity. This drug may be useful for the treatment of cancer or for the prevention of viral infection.</p>

<p>Adenosine-5'-O-(1-thiotriphosphate) lithium salt is an inhibitor of the guanine nucleotide-binding protein that is reversibly inhibited by adenosine triphosphate. It has been shown to inhibit HIV infection by binding to the Ryanodine receptor and blocking the release of calcium ions from intracellular stores. This prevents the activation of caspases, which are enzymes that cause cell lysis. Adenosine-5'-O-(1-thiotriphosphate) lithium salt also blocks transcription and polymerase chain reactions, and may inhibit the growth of cancer cells by inhibiting epidermal growth factor receptors on the cell surface.</p>

<p>3'-Deoxy-3'-fluoro-2'-C-methylguanosine is a nucleoside analog that is used in the treatment of cancer. It is an activator of the anticancer drug 5-FU, which inhibits DNA synthesis and cell division. 3'-Deoxy-3'-fluoro-2'-C-methylguanosine may also be used as a starting material for the synthesis of other nucleosides, such as 2',3'-deoxyadenosine and 3',5' -deoxycytidine.</p>

<p>2,2'-Anhydrocytidine HCl is a nucleoside for use as a DNA synthesis inhibitor</p>

<p>3’-Azido-3’-deoxy-b-L-adenosine is a novel nucleoside that has been synthesized to be used as an antiviral agent. It is phosphorylated, which allows it to be activated by adenosine kinase, and is thus able to inhibit viral replication and spread. 3’-Azido-3’-deoxy-b-L-adenosine is effective against various viruses, including HIV, herpes simplex virus type 1 (HSV1), and hepatitis C virus (HCV). This nucleoside also has anticancer activity due to its ability to inhibit the synthesis of DNA and RNA. It has been modified from the natural nucleosides with the addition of a 2′,3′ azido group at the 3 position on the ribose sugar. The modification prevents viral resistance because it does not require activation by cellular kinases or phosphorylation in order to be active.</p>

<p>5'-O-tert-Butyldimethsilyl-2'-Deoxy-N2-isobutyrylguanosine 3'-CE phosphoramidite is a novel nucleoside analog with antiviral and anticancer properties. It is a modified nucleoside that is synthesized by reacting 5'-O-tert-butyldimethylsilyl guanosine with 2'-deoxyisobutyryl chloride in the presence of triethylamine. The resulting 5'-O-tert-butyldimethylsilyl-2'-deoxyisobutyrylguanosine 3'-CE phosphoramidite has been shown to be cytotoxic to tumor cells without affecting normal cells.</p>

<p>2’C-Methyl-2-thiouridine is a novel nucleoside phosphoramidite that has been synthesized to serve as an activator for DNA polymerases. 2’C-Methyl-2-thiouridine is a potent antiviral agent that inhibits the replication of the hepatitis C virus in vitro. It also has antiproliferative effects against certain cancer cells and can be used as an anticancer drug. 2’C-Methyl-2-thiouridine contains a methylated thiol group, which confers a high degree of resistance to degradation by thiols, including glutathione (GSH). This compound is stable to hydrolysis and may be used in the synthesis of deoxyribonucleosides or monophosphate nucleotides.</p>

<p>N1-Methylguanosine is a methylated nucleotide that is incorporated into the growing DNA chain during protein synthesis. The incorporation of N1-methylguanosine into the growing DNA chain can cause frameshifting, which creates an unusual amino acid sequence. This effect has been shown in model organisms, such as Saccharomyces cerevisiae and Escherichia coli. In these organisms, N1-methylguanosine has been shown to induce cancer when added to the growth medium. It is also found in urine samples from people with bladder cancer and has been used to identify urinary tract cancers. Titration calorimetry studies have shown that N1-methylguanosine binds to a chelate ligand and forms a disulfide bond with cysteine residues on proteins or peptides, which may lead to mitochondrial dysfunction by interfering with hydrogen bonding interactions. Messenger RNA studies show that N1-methylguanosine inhibits translation of mRNA by binding to</p>

<p>N4-Benzoyl-5'-O-DMT-2'-O-(2-methoxyethyl)cytidine 3'-O succinate TEA salt (BEDOT) is a novel nucleoside analogue that is a phosphoramidite for DNA synthesis. BEDOT has shown anticancer and antiviral activity in vitro.</p>

<p>N-Succinyl-5-aminoimidazole-4-carboxamide ribose disodium salt is a novel modified nucleoside with anticancer activity. The compound is a monophosphate, which activates DNA and RNA synthesis. This agent also has antiviral and antifungal effects. N-Succinyl-5-aminoimidazole-4-carboxamide ribose disodium salt is synthesized from diphosphate and deoxyribonucleosides. It was first patented in 1979 and has been approved by the US Food and Drug Administration (FDA) for use as a pharmaceutical agent. N-Succinyl-5-aminoimidazole-4-carboxamide ribose disodium salt can be used to produce phosphoramidites, which are synthetic DNA building blocks that are used in the production of DNA and RNA synthesis.</p>

<p>Please enquire for more information about 3’,5’-Di-O-acetyl-2’-azido-2’-deoxy-5-methyluridine including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>5-Iodo-2’-C-methylcytidine is a synthetic nucleoside that is an activator of DNA polymerases. It has been shown to be an anticancer agent and antiviral agent, with potential applications in the treatment of HIV and HBV infections. 5-Iodo-2’-C-methylcytidine is a novel monophosphate nucleoside that has been modified to improve its stability. This product is sold as a high purity, high quality, NMR grade material that can be used in research or in the manufacture of pharmaceuticals.</p>

<p>7-[3,5-Bis-O-[(-2,4-dichlorophenyl)methyl]-2-C-methyl-b-D-ribofuranosyl]-4-chloro-5-iodo-7H-pyrrolo[2,3-d]pyrimidine is a synthetic nucleoside that inhibits viral DNA synthesis by interfering with the viral enzyme polymerase. It has been shown to be active against HIV and HSV and may have potential therapeutic use in antiviral therapy. 7-[3,5-Bis-O-[(-2,4-dichlorophenyl)methyl]-2-C--methyl--b--D--ribofuranosyl]-4--chloro--5--iodo--7H--pyrrolo[2,3--d]pyrimidine has been synthesized for the first time by a novel process involving deoxyribonucleosides and phosphor</p>

<p>2',3'-Di-O-acetyl-D-uridine is a nucleoside for use in research applications</p>

<p>Uridine 5'-monophosphate (UMP) is a nucleotide that is synthesized from uridine. Uridine 5'-monophosphate has been shown to have anticancer activity in vitro and in vivo, as well as antiviral activity against herpes viruses. UMP has been shown to inhibit the protein synthesis of cells by inhibiting the enzyme activities of DNA polymerase and RNA polymerase. <br>It also inhibits the synthesis of p2y receptors, which are involved in cell proliferation and differentiation. Further studies suggest that UMP may be an effective anti-inflammatory agent due to its ability to decrease prostaglandin production.</p>

<p>2'-Deoxy-5-ethyluridine is a nucleoside analog that is used in cancer gene therapy. It is an analog of the natural pyrimidine base uracil and inhibits RNA synthesis by competing with natural nucleosides for incorporation into the growing RNA chain. 2'-Deoxy-5-ethyluridine is cytotoxic to cervical cancer cells, inhibiting cell growth and proliferation at inhibitory doses of 0.1 μM. This drug has also been shown to have synergistic effects with other drugs such as trifluoroacetic acid, monoclonal antibody, tissue culture, glycosidic bond, biological properties, cancer tissues, and polymerase chain reaction (PCR).</p>

<p>Treats herpes-associated keratitis and keratoconjunctivitis; antineoplastic</p>

<p>Coenzyme and regenerating electron donor in catabolic processes</p>

<p>2'-Deoxy-5-methylcytidine HCl is a cytidine derivative that is used in the synthesis of DNA. It has been shown to have anticancer and antiviral properties, as well as being a synthetic activator for RNA polymerase. The chemical name for 2'-deoxy-5-methylcytidine HCl is 5'-[(2-bromoacetyl)amino]-2'-deoxyuridine 5'-O-(1,3-dithiole-2-thiocarbonyl)-3',5' -diiodo-. It belongs to the class of deoxyribonucleosides. This product may be used in applications such as DNA synthesis, modification of DNA, and antiviral treatment.</p>

<p>2'-O-tert-Butyldimethylsilyl-N2-Isobutyryl-5'-O-tritylguanosine 3'-CE phosphoramidite is an anticancer nucleoside, which is used as a building block to synthesize DNA and RNA. The compound has been shown to be effective against HIV and herpes simplex virus. It also has antiviral effects against influenza A virus, cytomegalovirus, and Epstein Barr virus.</p>

<p>5’-Deoxy-5’-iodo-2’-O-methyl-5-methyluridine is a monophosphate nucleoside. It is an antiviral and anticancer agent that inhibits viral replication by inhibiting the synthesis of viral DNA. It also has been shown to have antitumor activity, but it can only be used in cancer treatments when combined with other drugs such as 5FU. The chemical formula for 5’-Deoxy-5’-iodo-2’O methyl -5 methyl uridine is C10H14N4O8P.</p>

<p>2'-Deoxyadenosine 3'-O-L-valinyl ester is a novel nucleoside phosphoramidite that is synthesized by activating the 2'-deoxyribose phosphate with an L-valyl chloride. This synthetic nucleoside analog can be used as a substitute for dATP in DNA synthesis and has antiviral as well as anticancer activities.</p>

<p>1-(b-L-Threonyl)uracil is a novel anticancer drug that has been synthesized with the aim of increasing the efficacy of DNA synthesis. The incorporation of this nucleoside in the DNA chain prevents the formation of ribonuclesides, which are inhibitory to DNA synthesis. It also inhibits viral replication and can be used as a treatment for HIV infection. 1-(b-L-Threonyl)uracil is synthesized by reacting b-L-threonyl chloride with uracil in the presence of a base and a catalytic amount of thiourea. This product is used in biotechnology as an activator for phosphoramidites and modified nucleosides.</p>

<p>5-Methyl-7-(2-C-methyl-b-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine is a synthetic nucleoside analog of 2'-deoxyadenosine. It is an activator of DNA synthesis and replication by virtue of its ability to inhibit the enzyme ribonucleotide reductase. The compound has antiviral and anticancer activities, as well as antitumor activity. 5-Methyl-7-(2-C-methyl-b-Dribofuranosyl)-7H-[1,2] pyrrolo[2,3]-d]pyrimidin--4--amine has shown good results in treating chronic myelogenous leukemia.</p>

<p>Coenzyme and regenerating electron donor in catabolic processes</p>

<p>3'-O-Allylguanosine is a antiviral agent that belongs to the group of synthetic nucleosides. It is a monophosphate analog of guanosine and an activator of ribonucleotide reductase. 3'-O-Allylguanosine has been shown to be effective against cancer cells in vitro. It has also been shown to inhibit DNA synthesis and promote DNA degradation in human leukemia cells, suggesting its potential use for the treatment of leukemia.</p>