Nucleosides

5’-O-DMT-2’-b-C-methyladenosine is a modified nucleoside with antiviral and anticancer activity. It is an activator of DNA synthesis, and can be used as a precursor for phosphoramidites for the synthesis of oligonucleotides. The 5’-O-DMT group in this compound may be replaced with other activating groups to synthesize different modified nucleosides.

N2-Phenylacetyl-L-guanosine is a nucleoside that has been synthetically modified to have the desired properties of an anticancer agent. This compound inhibits DNA synthesis and is therefore cytotoxic to cells. It also inhibits RNA synthesis and is antiviral. N2-Phenylacetyl-L-guanosine has been found to be effective in preventing the growth of leukemia cells, breast cancer cells, prostate cancer cells, and ovarian cancer cells. N2-Phenylacetyl-L-guanosine is a nucleotide analogue that can be used as a building block for DNA or RNA synthesis. It can be used as a phosphate donor in phosphoramidite chemistry and can activate other nucleosides for use in chemical biology.

3'-O-Allylguanosine is a antiviral agent that belongs to the group of synthetic nucleosides. It is a monophosphate analog of guanosine and an activator of ribonucleotide reductase. 3'-O-Allylguanosine has been shown to be effective against cancer cells in vitro. It has also been shown to inhibit DNA synthesis and promote DNA degradation in human leukemia cells, suggesting its potential use for the treatment of leukemia.

2-Methylthioadenosine is a purine nucleoside which induces necrotic cell death. It is the first of its kind to be shown to have activity against squamous carcinoma cells, and is activated by nucleoside phosphorylase in order to produce its cytotoxic form. 2-Methylthioadenosine also inhibits the transcription-polymerase chain reaction and increases oxidative injury. This drug has been shown to have receptor activity in brain cells, as well as chemotactic activity for gland cells. 2-Methylthioadenosine has been used as a model organism for polymerase chain reactions, and has been shown to inhibit p2y receptors in the human colon cancer cell line HT29.

8-Bromoinosine is a potent chemical probe that can be used to study the molecular mechanism of cGMP-dependent protein kinase (PKG). 8-Bromoinosine reacts with the acceptor site in PKG, which is located at the base of the active site cleft. Electrons from hydrogen bond donor sites on 8-bromoadenosine are transferred to chloride ion and the resulting 8-bromoinosine chloride complex is an effective inhibitor of PKG. It has been shown that stereoselectivity plays a role in this reaction mechanism.

N6-Benzoyl-5'-O-DMT-2'-O-propynyladenosine 3'-CE phosphoramidite is a modified nucleoside, which is an important building block for DNA and RNA synthesis. It is synthesized by the condensation of 6-benzoyladenosine with 2'-O-propynyladenosin. The stability of this compound has been demonstrated by its resistance to hydrolysis and oxidation, while it can also be activated with a variety of activators, including NaBH4 or NaCNBH3. This novel nucleotide has shown anticancer activity in vivo and antiviral activity against HIV.

3'-O-Methylguanosine 5'-triphosphate lithium is a nucleotide that has been synthesized and characterized. It is a biochemical regulatory molecule that is involved in the synthesis of DNA, RNA, and proteins. 3'-O-Methylguanosine 5'-triphosphate lithium binds to the guanine nucleotide binding protein G, which acts as an allosteric activator of the enzyme ribonucleotide reductase. The reconstituted enzyme system containing 3'-O-methylguanosine 5'-triphosphate lithium has demonstrated a high level of fidelity in the replication of dna templates.

N6-Benzoyl-2'-O-tert-butyldimethylsilyl-5'-O-DMT-adenosine is a nucleoside that can be used in the synthesis of oligomers. It is a synthetic nucleoside with an absorption maximum at 410 nm and emission maximum at 522 nm. This compound has been shown to be efficient in the synthesis of phosphoramidites and ligands, as well as in rna synthesis and modifications. N6-Benzoyl-2'-O-tert-butyldimethylsilyl-5'-O-DMT-adenosine may inhibit bacterial growth by binding to the ribosome, preventing protein synthesis.

5’-Azido-5’-deoxy-2’-O-methyl-5-methyluridine is a novel nucleoside with the ability to activate ribonucleosides and phosphoramidites. It is a modified nucleoside that has been shown to have anticancer and antiviral properties. 5’-Azido-5’-deoxy-2’-O-methyl-5-methyluridine also inhibits the synthesis of viral RNA and DNA, which may result in its antiinflammatory properties. 5’-Azido-5’deoxy -2′O methyl -5′ methyl uridine has a CAS number of 187733–73–9.

6-Dimethylamino-9-(b-D-ribofuranosyl)purine (6-DMAP) is an analog of adenine that has been shown to have anticancer activity in human serum and tissue culture. 6-DMAP can inhibit the synthesis of ATP, leading to cell death by significantly inhibiting cellular processes such as glycolysis and DNA replication. 6-DMAP also has a significant cytotoxicity on various types of cancer cells and plant tissues. The mechanism of action for the anticancer activity of 6-DMAP is not yet known, but it may be due to its ability to interfere with purine metabolism or its ability to form covalent bonds with DNA.

3'-Azido-N4-benzoyl-2',3'-dideoxycytidine is a novel nucleoside analog with antiviral and anticancer activities. It is used for the treatment of HIV, hepatitis B and C, herpes, and influenza. 3'-Azido-N4-benzoyl-2',3'-dideoxycytidine has been shown to inhibit the proliferation of cells in culture and to induce apoptosis in various cancer cell lines.
The synthesis of 3'-azido-N4-benzoyl-2',3'-dideoxycytidine starts with the condensation of 4-(hydroxymethyl)phenylacetic acid (1) with 2,6-dichloroisonicotinic acid chloride (2) in the presence of triethylamine to give 4-(hydroxymethyl)phenylacetic acid chloride (3). The N4 benzoyl

2',3',5'-Tri-O-acetyl-2-fluoroadenosine is nucleoside analog of adenosine for use in research. The addition of a fluorine to an adenosine can change adenosine's properties such as its hydrogen bonding ability and how it interacts with water and other biological molecules. It can also increase the stability of adenosine and increase its half-life in biological systems.

1-(5-O-Acetyl-2,3-dideoxy-ß-L-glycero-pent-2-enofuranosyl)-5-fluorouracil is a modified nucleoside analog with structural alterations that enhance its biological properties and stability. The compound features 5-fluorouracil as the nucleobase, a fluorinated pyrimidine often used in chemotherapy due to its ability to interfere with DNA replication. The sugar component is 2,3-dideoxy-β-L-glycero-pent-2-enofuranose and has a specific glycerol and enol configuration, which alters its interactions with enzymes involved in nucleic acid metabolism. The compound includes a 5-O-acetyl protecting group at the 5'-position, which shields the hydroxyl group during synthesis.

2'-Deoxy-2'-fluoroguanosine is a modified nucleoside analog where the base is guanine, the sugar is deoxyribose, and a fluoro group is attached to the 2' position of the sugar ring. This modification potnetially enhances the stability and nuclease resistance of the nucleoside, making it a useful tool in molecular biology and drug development.

Adenosine 5′-phosphosulfate triethylammonium salt serves as a donor of sulfate groups in biochemical processes, such as in the synthesis of sulfate esters. The triethylammonium salt form improves the solubility and stability of the compound, making it useful in laboratory applications involving enzymatic assays and the synthesis of sulfated biomolecules.