Quinazoline and Quinoline Derivatives
Quinazolines and quinolines are nitrogen-containing heterocyclic compounds with aromatic structures that play a key role in the synthesis of drugs with anticancer, antimicrobial, and anti-inflammatory activity. Their derivatives feature structural modifications that optimise bioavailability and selectivity, enabling the development of new active ingredients for various therapeutic applications. These compounds are used in the manufacture of APIs for the treatment of cancer, infections, neurodegenerative diseases, and cardiovascular conditions. Additionally, quinazoline and quinoline derivatives are essential in the research of enzyme inhibitors and the design of innovative bioactive molecules.
At CymitQuimica, we offer high-purity quinazoline and quinoline derivatives for applications in chemical synthesis, pharmaceutical development, and biotechnology.
Found 65941 products of "Quinazoline and Quinoline Derivatives"
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Clonidine
CAS:Controlled Product<p>Applications Clonidine is an α2-Adrenergic agonist. Antihypertensive; analgesic for neuropathic pain.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Roach, A.G., et al.: J. Pharmacol. Exp. Ther., 227, 421 (1983); Glassman, A.H., et al.: Science, 226, 864 (1984); Abounassif, A.M., et al.: Anal. Profiles Drug Subs. Excip., 21, 109 (1992);<br></p>Formula:C9H9Cl2N3Color and Shape:NeatMolecular weight:230.09Dasatinib Carboxylic Acid
CAS:Controlled Product<p>Applications An oxidative metabolite of Dasatinib (M6 metabolite); used in the treatment of cancers and immune diseases. It is a COVID19-related research product.<br>References Jaworski, T., et al.: Xenobiotica, 21, 1451 (1991), Shah, N., et al.: Science, 305, 399 (2004), O'Hare, T., et al.: Cancer Res., 65, 4500 (2005), Das, J., et al.: J. Med. Chem., 49, 6819 (2006), Christopher, L., et al.: Drug Metab. Dispos., 36, 1341 (2008),<br></p>Formula:C22H24ClN7O3SColor and Shape:Light YellowMolecular weight:501.993-Chlorobenzyl Cyanide
CAS:Controlled Product<p>Applications 3-Chlorobenzyl Cyanide is a useful synthetic intermediate. It was used to design EGFR Tyrosine Kinase Inhibitors. It can also be used to synthesize imidoyl thioureas as non-nucleoside reverse transcriptase inhibitors.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Traxler, P., et al.: J. Med. Chem., 42, 1018 (1999); Ludovici, D., et al.: Bioorg. Med. Chem. Lett., 11, 2225 (2001)<br></p>Formula:C8H6ClNColor and Shape:NeatMolecular weight:151.59(1S,2R)-2-(2-Benzylamino-1-hydroxyethyl)-6-fluorochromane
CAS:Controlled Product<p>Applications (-)-Nebivolol intermediate.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>Formula:C18H20FNO2Color and Shape:WhiteMolecular weight:301.36rac Methyl Efavirenz (Mixture of Diastereomers)
CAS:Controlled Product<p>Applications Efavirenz (E425000) potential synthetic impurity and degradation product.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Phelan, P., et al.: J. Chromatogr. Sci., 19, 13 (1981), Mangia, A., et al.: Anal. Chim. Acta., 149, 349 (1983), Careri, M., et al.: J. Chromatogr., 647, 79 (1993), van Beek, T., et al.: Phytochem. Anal., 6, 1 (1995),<br></p>Formula:C15H11ClF3NO2Color and Shape:NeatMolecular weight:329.70N-Benzyl Epinephrine-d3
CAS:Controlled Product<p>Applications Labelled analogue of N-Benzyl Epinephrine, an impurity of Epinephrine (E588580).<br></p>Formula:C16H16D3NO3Color and Shape:NeatMolecular weight:276.35S-Desethylpiperidino S-[2-Carboxyl-2-oxo-ethyl-(2-aminoethyl)amino] Vardenafil
CAS:Controlled Product<p>Applications S-Desethylpiperidino S-[2-Carboxyl-2-oxo-ethyl-(2-aminoethyl)amino] Vardenafil is an impurity of Vardenafil (V098001, 2HCl); a selective phosphodiesterase type 5 (PDE5) inhibitor.<br>References Bischoff, E., et al.: J. Urol., 165, 1316 (2001); Kim, N.N., et al.: Life Sci., 69, 2249 (2001); Kendirci, M., et al.: Expert Opin. Pharmacother., 5, 923 (2004)<br></p>Formula:C21H26N6O7SColor and Shape:Off White SolidMolecular weight:506.53Riociguat Nitroso Impurity 1
Controlled ProductFormula:C18H16FN9OColor and Shape:NeatMolecular weight:393.15Efavirenz Penteneyne
Controlled Product<p>Applications Efavirenz penteneyne is an analog of Efavirenz (E425000), a nonnucleoside HIV-1 reverse transcriptase inhibitor and antiviral agent.<br>References Young, S.D., et al.: Antimicrob. Ag. Chemother., 39, 2602 (1995)<br></p>Formula:C14H9ClF3NO2Color and Shape:NeatMolecular weight:315.67N-Nitrosomorpholine-13C4
CAS:Controlled ProductFormula:C4H8N2O2Color and Shape:NeatMolecular weight:120.09O-Desmorpholinopropyl-O-methyl-gefitinib
CAS:Controlled Product<p>Applications O-Desmorpholinopropyl-O-methyl-gefitinib is a anilinoquinazoline derivative of which acts as an inhibitor of tyrosine kinases and found to be allosteric inhibitors of the enzyme frutose 1,6-bisphosphatase. It serves as a lead to further drug design.<br>References Wright, S. W., Bioorganic & Medicinal Chemistry Letters, 11, 17-21, (2000)<br></p>Formula:C16H13ClFN3O2Color and Shape:White To Off-WhiteMolecular weight:333.74Dehydro Silodosin
CAS:Controlled Product<p>Applications Dehydro Silodosin is an impurity of Silodosin (S465000).<br>References Moriyama., et al.: Eur. J. Pharmacol., 331, 39 (1997), Zhu, J., et al.: Br. J. Pharmacol., 131, 546 (2000),<br></p>Formula:C25H30F3N3O4Color and Shape:NeatMolecular weight:493.52(R)-(+)-Felodipine
CAS:Controlled Product<p>Applications A dihydropyridine calcium channel blocker. Enantiomer R of Felodipine.<br>References Berntsson, P.B., et al.: Acta Pharm. Suec., 18, 221 (1981), Kratochwil, N., et al.: Biochem. Pharmacol., 64, 1355 (2002), O'Brien, S., et al.: J. Med. Chem., 48, 1287 (2005), Castilho, M., et al.: Bioorg. Med. Chem., 14, 516 (2006),<br></p>Formula:C18H19Cl2NO4Color and Shape:NeatMolecular weight:384.25Prochlorperazine Sulfoxide
CAS:Controlled Product<p>Applications A metabolite of Prochlorperazine.<br>References Finn, A., et al.: J. Clin. Pharmacol., 45, 1383 (2005),<br></p>Formula:C20H24ClN3OSColor and Shape:NeatMolecular weight:389.94Indomethacin Ethyl Ester
CAS:Controlled ProductFormula:C21H20ClNO4Color and Shape:Off-WhiteMolecular weight:385.84(S)-5-Chloro Naproxen
CAS:Controlled ProductFormula:C14H13ClO3Color and Shape:NeatMolecular weight:264.70Rotigotine Hydrochloride
CAS:<p>Applications It is a non-ergot dopamine agonist drug and is indicated for the treatment of Parkinson’s disease.<br>References Loschmann, P., et al.: Eur. J. Pharmacol., 166, 373 (1989), Edgar, D., et al.: J. Pharmacol. Exp. Ther., 283, 757 (1997), Ferreira, J., et al.: Lancet, 355, 1333 (2000), Arnulf, I., et al.: Neurology, 58, 1019 (2002), Wisor, J., et al.: Neuroscience, 132, 1027 (2005),<br></p>Formula:C19H25NOS·ClHColor and Shape:White To Off-WhiteMolecular weight:351.934-Chloro Perphenazine
CAS:Controlled Product<p>Applications 4-Chloro Perphenazine is an impurity of Perphenazine (P291100), an D2 dopamine receptor antagonist; α-adrenergic receptor antagonist and σ-receptor agonist; phenothiazine antipsychotic.<br>References Briggs, K., et al.: Toxicology, 231, 113 (2007), Toga, T., et al.: J. Pharmacol. Sci., 105, 207 (2007),<br></p>Formula:C21H26ClN3OSColor and Shape:NeatMolecular weight:403.97(E/Z)-Chlorprothixene-d6 Hydrochloride(Mixture)
CAS:Controlled Product<p>Applications Labelled cis/trans-Chlorprothixene (C424850). Antipsychotic.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Rudy, B.C., et al.: Anal. Profiles Drug Subs., 2, 63 (1973), Bagli, M., et al.: Arzneim.-Forsch., 46, 247 (1996),<br></p>Formula:C18H13D6Cl2NSColor and Shape:NeatMolecular weight:358.362’-Des(1-hydroxy-1-methylethyl)-2’-methycarboxy Montelukast Hydrochloride
CAS:Controlled Product<p>Applications 2’-Des(1-hydroxy-1-methylethyl)-2’-methycarboxy Montelukast Hydrochloride is an impurity of Montelukast (M568000), a selective leukotriene D4-receptor antagonist.<br>References Kumar, I.V. et al.: Asian J. Chem., 23, 4536 (2011)<br></p>Formula:C34H33Cl2NO4SColor and Shape:NeatMolecular weight:622.65'-Hydroxyphenyl Carvedilol-d5
CAS:Controlled Product<p>Applications A Labelled metabolite of Carvedilol which is a multiple-action, neurohormonal antagonist that is used in the treatment of hypertension.<br>References Schaefer, W.H., et al.: Drug Metab. Dispos., 26, 958 (1998).<br></p>Formula:C24H21D5N2O5Color and Shape:NeatMolecular weight:427.5Ipidacrine-d9 (Major)
CAS:Controlled Product<p>Applications Ipidacrine-d9 (Major) is an isotopic analog of ipidacrine, which is used in biological studies as a possible treatment of toxic cognitive disorders.<br>References Fateev, I V., et al.: B. Exp. Biol. Med., 156, 353 (2014);<br></p>Formula:C12H8D9N2Color and Shape:NeatMolecular weight:198.33Vilazodone Carboxylic Acid
CAS:Controlled Product<p>Stability Hygroscopic<br>Applications Vilazodone Carboxylic Acid is the carboxylic acid impurity and an intermediate in the preparation of the antidepressant Vilazodone (V265000).<br>References Heinrich, T. et al.: J. Med. Chem., 47, 4684 (2004); Hu, B. et al.: Org. Proc. Res. Dev., 16, 1552 (2012);<br></p>Formula:C26H26N4O3Color and Shape:NeatMolecular weight:442.51(S)-4-(4-(5-(Aminomethyl)-2-oxooxazolidin-3-yl)phenyl)morpholin-3-one
CAS:Controlled Product<p>Applications (S)-4-(4-(5-(AMINOMETHYL)-2-OXOOXAZOLIDIN-3-YL)PHENYL)MORPHOLIN-3-ONE (cas# 446292-10-0) is a useful research chemical.<br></p>Formula:C14H17N3O4Color and Shape:White To Off-WhiteMolecular weight:291.304-(2-Pyridinyl)benzaldehyde
CAS:Controlled Product<p>Impurity Atazanavir Impurity (Pyridinyl Benzaldehyde)<br>Applications Reactive metabolite of atazanavir. Atazanavir Impurity; Pyridinyl Benzaldehyde impurity<br>References F. Li et al., Drug Metabolism and Disposition 39, 294 (2011)<br></p>Formula:C12H9NOColor and Shape:NeatMolecular weight:183.21(2S,4S)-Argatroban
CAS:Controlled Product<p>Applications Synthetic thrombin inhibitor. Antithrombotic.<br>References Abiko, Y., et al.: Thromb. Res., 24, 285 (1981), Kikumoto, R., et al.: Biochemistry, 23, 85 (1984),<br></p>Formula:C23H36N6O5SColor and Shape:NeatMolecular weight:508.63N-Desmethyl Prochlorperazine-d8 Dimaleate
CAS:Controlled ProductFormula:C27H22D8ClN3O8SColor and Shape:NeatMolecular weight:600.11N-(4-Amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidineamine
CAS:Controlled Product<p>Applications Intermediate in the preparation of Imatinib impurities. It is a COVID19-related research product.<br></p>Formula:C16H15N5Color and Shape:NeatMolecular weight:277.32(S)-Hydroxy Timolol
CAS:Controlled Product<p>Applications (S)-(-)-Hydroxy Timolol is a metabolite of the non-selective beta-adrenergic receptor blocker, Timolol (T443710).<br>References Volotinen, M. et al.: Basic Clin. Pharmacol. Toxicol., 106, 302 (2010);<br></p>Formula:C13H24N4O4SColor and Shape:NeatMolecular weight:332.42Dronedarone-d6 Hydrochloride
CAS:Controlled Product<p>Stability Hygroscopic<br>Applications A drug used for the treatment of atrial fibrillation and atrial flutter in patients who have suffered cardiac arrhythmias.<br>References Singh, B., et al.: J. Cardiovas. Pharmacol., 52, 300 (2008), Hoy, S., et al.: Drugs, 69, 1647 (2009), Hohnloser, S., et al.: New Eng. J. Med., 360, 668 (2009),<br></p>Formula:C31H39D6ClN2O5SColor and Shape:NeatMolecular weight:599.25Desalkyl Ebastine-d5
CAS:Controlled Product<p>Applications A labelled metabolite of Ebastine.<br>References Wiseman, L., et al.: Drugs, 51, 260 (1996), Takanori, H., et al.: Drug Metab. Dispos., 26, 566 (1998), Moss, A., et al.: Clin. Exp. Allergy 1999, 29, 200 (1999), Simons, F., et al.: Clin. Pharmacokinet., 36, 329 (1999), Hashizume, T., et al.: J. Pharmacol. Exp. Theor., 300, 298 (2002),<br></p>Formula:C18H16D5NOColor and Shape:NeatMolecular weight:272.4Furagin-13C3
Controlled Product<p>Applications Furagin-13C3 is the isotope labelled analogue of the antibacterial Furagin (F863000).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Agace, W., et al.: J. Clin. Invest., 92, 780 (1993); Lawrenson, R., et al.: J. Antimicrob. Chemother., 48, 895 (2001); Dalhoff, A., et al.: Lancet Infect. Dis., 3, 359 (2003); Thumbikat, P., et al.: J. Immunol., 176, 3080 (2006);<br></p>Formula:C713C3H8N4O5Color and Shape:NeatMolecular weight:267.173-[2-[4-(6-Fluoro-2-benzoxazolyl)-1-piperidinyl]ethyl]-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one (Risperidone Impurity)
CAS:Controlled ProductFormula:C23H27FN4O2Color and Shape:NeatMolecular weight:410.48Lodoxamide
CAS:Controlled Product<p>Stability Hygroscopic<br>Applications Lodoxamide is an antiallergic drug that acts as a mast cell stabilizer. It is effective in the treatment of allergic conjunctivitis and in decreasing vascular permeability.<br>References Ciprandi, G., et al.: Allergy, 51(12), 946-951 (1996); Bayer, Atilla., et al.: Ophthalmologica, 217(2), 119-123 (2003)<br></p>Formula:C11H6ClN3O6Color and Shape:NeatMolecular weight:311.63Ethionamide Sulfoxide-D3
CAS:Controlled ProductFormula:C8D3H7N2OSColor and Shape:NeatMolecular weight:185.266-Hydroxy-7-methoxy-4(1H)-quinazolinone
CAS:Controlled Product<p>Applications 6-Hydroxy-7-methoxy-4(1H)-quinazolinone is a reactant used in the preparation of 4-anilinoquinazoline derivatives that have shown antitumor activities. 6-Hydroxy-7-methoxy-4(1H)-quinazolinone was also used as a reactant in the synthetic preparation of 2-arylbenzothiazoles as kinase inhibitors.<br>References Chandregowda, V., et al.: Eur. J. Med. Chem., 44, 3046 (2009); Tasler, S., et al.: Bioorg. Med. Chem. Lett., 17, 6728 (2009);<br></p>Formula:C9H8N2O3Color and Shape:BeigeMolecular weight:192.17Nifekalant Hydrochloride
CAS:<p>Applications Nifekalant Hydrochloride is a class III antiarrhythmic agent. Nifekalant Hydrochloride is used in the treatment of patients with extensive anterior infarction and severe ventricular dysfunction.<br>References Takenaka, K. Jap. Circ. J., 65, 60 (2001); Igawa, M. et al.: J. Cardio. Pharmacol., 40, 735 (2002); Washizuka, T. et al.: Circ. J., 69, 1508 (2005);<br></p>Formula:C19H27N5O5·ClHColor and Shape:Light Yellow SolidMolecular weight:441.9091CP-690550 N-Hydroxyl
CAS:Controlled Product<p>Impurity CP-690550 Impurity<br>Applications CP-690550 N-Hydroxyl is an impurity of CP-690550 (C781350), a pyrrolo[2,3-d]pyrimidine derivative, as Janus kinase inhibitor for treatment of rheumatoid arthritis.<br>References Sheiner, L., et al.: Clin. Pharmacol. Ther., 25, 358 (1979); Dayneka, N., et al.: J. Pharmacokin. Biopharm., 21, 457 (1993); Changelian, P., et al.: Science, 302, 875 (2003); Lee, H., et al.: Clin. Pharmacol. Ther., 73, 348 (2003); Hutmacher, M., et al.: J. Clin. Pharmacol., 47, 238 (2007)<br></p>Formula:C16H20N6O2Color and Shape:NeatMolecular weight:328.369N-Nitrosodabigatran Etexilate-d11
Controlled ProductFormula:C35H33D11N8O9SColor and Shape:NeatMolecular weight:763.91N-Triphenylmethyl-5-[4'-methylbiphenyl-2-yl]tetrazole
CAS:Controlled Product<p>Applications An intermediate in the preparation of Candesartan. Also used in the synthesis of novel biphenyltetrazole derivatives.<br>References Chao, S. et al.: J. Chin. Chem. Soc., 52, 539 (235);<br></p>Formula:C33H26N4Color and Shape:NeatMolecular weight:478.59N-Desmethyl N-Nitroso Olopatadine-d3
Controlled ProductFormula:C20D3H17N2O4Color and Shape:NeatMolecular weight:355.402Levomepromazine-D3 Sulfoxide
CAS:Controlled ProductFormula:C19D3H21N2O2SColor and Shape:NeatMolecular weight:347.49(S,S)-Dihydro Bupropion β-D-Glucuronide
Controlled Product<p>Applications (S,S)-Dihydro Bupropion β-D-Glucuronide is a glucuronide metabolite of the drug Bupropion (B689625, HCl salt). Bupropion is a selective inhibitor of dopamine uptake.<br>References Soroko, F., et al.: J. Pharm. Pharmacol., 29, 769 (1977), Tucker, W.E., J. Clin. Psychiatry, 44, 60 (1983), Hsyu, P-H., et al.: J. Clin. Pharmacol., 37, 737 (1997), West, R., et al.: Expert Opin. Pharmacother., 4, 533 (2003),<br></p>Formula:C19H28ClNO7Color and Shape:NeatMolecular weight:417.881-Bromo-2-(bromomethyl)-4,5-dimethoxybenzene
CAS:Controlled Product<p>Applications 1-Bromo-2-(bromomethyl)-4,5-dimethoxybenzene is used in the synthesis of novel histone deacetylase 1 inhibitors (HDAC 1). Also used in the synthesis of antibacterial gemifloxacin derivatives.<br>References Sun, Q. et al.L: Bioorg. Med. Chem. Lett., 23, 3295 (2013); Feng, L. et al. Eur. J. Med. Chem., 55, 125 (2012);<br></p>Formula:C9H10Br2O2Color and Shape:NeatMolecular weight:309.98rac N-Methyl Epinephrine-d6 Hydrochloride (>90%)
CAS:Controlled Product<p>Applications Labelled N-Methylepinephrine, the N-methylated analogue of the sympathomimetic hormone Epinephrine (E588585). Recent studies suggest that N-Methylepinephrine may be synthesized from Epinephrine by phenylethanolamine N-methyltransferase present in the brain.<br>References Kajita, M. et al.: Nip. Iyo Masu Sup. Gak. Kon., 19, 107 (1994); Plummer, C.J. et al.: Eur. J. Med. Chem., 148, 481 (1988);<br></p>Formula:C10H9D6NO3•HClPurity:>90%Color and Shape:Off-White To Light GreenMolecular weight:203.2736461,4-bis(7-Chloroquinolin-4-yl)piperazine
CAS:Controlled ProductFormula:C22H18Cl2N4Color and Shape:NeatMolecular weight:409.31Lumateperone-d4
CAS:Controlled ProductFormula:C24D4H24FN3OColor and Shape:NeatMolecular weight:397.522N-Desethyl N-Methyl Rivastigmine
CAS:Controlled Product<p>Impurity Rivastigmine EP Impurity B<br>Applications N-Desethyl N-Methyl Rivastigmine (Rivastigmine EP Impurity B) is an impurity of Rivastigmine (R541000), a brain selective acetylcholinesterase inhibitor. Nootropic.<br>References Rosler, M., et al.: Brit. Med. J., 318, 633 (1999), Enz, A., et al.: Prog. Brain Res., 98, 431 (1993),<br></p>Formula:C13H20N2O2Color and Shape:NeatMolecular weight:236.32N-(2-Methyl-4-nitrophenyl)-4-(3-pyridinyl)-2-pyrimidinamine
CAS:Controlled Product<p>Applications Intermediate in the preparation of Imatinib impurities. It is a COVID19-related research product.<br>References Zimmermann., A., et al.: Bioorg. Med. Chem. Lett., 7, 187 (1997),<br></p>Formula:C16H13N5O2Color and Shape:LightMolecular weight:307.31Paliperidone N-Oxide
CAS:Controlled Product<p>Impurity Paliperidone USP Related Compound D<br>Applications One of the major degradation product of Risperidone in bulk drug and pharmaceutical dosage forms. Paliperidone USP Related Compound D.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Leysen, J., et al.: J. Pharmacol. Exp. Ther., 247, 661 (1988), Huang, M., et al.: Pharm. Drug Dispos., 54, 257 (1993), Smyth, W., et al.: Anal. Bioanal. Chem., 378, 1305 (2004),<br></p>Formula:C23H27FN4O4Color and Shape:NeatMolecular weight:442.48(R)-Propranolol-d7 Hydrochloride
CAS:Controlled Product<p>Applications The labelled R-enantiomer of Propranolol (P831800). β−Adrenergic blocker. Antihypertensive; antianginal; antiarrhythmic (class II).<br>References Bond, et al.: Nature, 213, 721 (1967), Hansteen, V., et al.: Br. Med. J., 284, 155 (1982), Diamond, S., et al.: J. Clin. Pharmacol., 28, 193 (1988),<br></p>Formula:C16H15D7ClNO2Color and Shape:NeatMolecular weight:302.85a,a,a-Trifluorotoluene
CAS:Controlled Product<p>Applications α,α,α-Trifluorotoluene, is used as a specialty solvent in organic synthesis and an intermediate in the production of pesticides and pharmaceuticals.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Skelly, P. D., et al.: Handbook for Critical Cleaning, 1, 191 (2011);<br></p>Formula:C7H5F3Color and Shape:ColourlessMolecular weight:146.11N-[2(4-(-Octylphenyl))butanoic Acid] Fingolimod
CAS:Controlled Product<p>Applications N-[2(4-(-Octylphenyl))butanoic Acid] Fingolimod, is an impurity of Fingolimod (F805000, HCl salt). Fingolimod is a novel immune modulator that prolongs allograft transplant survival in numerous models by inhibiting lymphocyte emigration from lymphoid organs.<br>References Brinkmann, V., et al.: Transplantation, 72, 764 (2001), Brinkmann, et al.: J. Biol. Chem., 277, 24, 21453 (2002), Mtaloubian, M., et al.: Nature, 427, 355 (2004),<br></p>Formula:C37H59NO4Color and Shape:NeatMolecular weight:581.87O-Desbromo-pyrimidinyl Macitentan
CAS:Controlled ProductFormula:C15H19BrN4O4SColor and Shape:NeatMolecular weight:431.3Sitagliptin N-Sulfate Sodium Salt
CAS:Controlled Product<p>Applications A metabolite of Sitagliptin.<br>References Beconi, M.G. , et al.: Drug Metab. Dispos., 35, 525 (2007),<br></p>Formula:C16H15F6NaN5O4SColor and Shape:NeatMolecular weight:509.36Apatinib-d8 25-N-Oxide Dihydrochloride
CAS:Controlled Product<p>Applications Labelled Apatinib 25-N-Oxide (A726160). Apatinib 25-N-Oxide is a metabolite of the antiangiogenic agent and selective VEGFR2 inhibitor Apatinib (A726150).<br>References Ding, J, et al.: J. Chrom B Anal. Technol. Biomed. Life Sci., 895, 108 (2012);<br></p>Formula:C24H15D8N5O2•2HClColor and Shape:NeatMolecular weight:421.52236465-[(2-Chloroethyl)(2-hydroxyethyl)amino]-1-methyl-1H-benzimidazole-2-butanoic Acid Ethyl Ester
CAS:Controlled Product<p>Stability Hygroscopic<br>Applications Bendamustine (B132500) impurity.<br></p>Formula:C18H26ClN3O3Color and Shape:NeatMolecular weight:367.87(E,Z)-Tamoxifen-d5 N-β-D-Glucuronide (~90%)
CAS:Controlled Product<p>Applications Α labelled metabolite of Tamoxifen (T006000).<br>References Sun, D., et al.: Breast Cancer Res., 8(4), (2006), Zheng, Y., et al.: Drug Metab. Dispos., 35, 1942 (2007),<br></p>Formula:C32H33D5NO7Purity:~90%Color and Shape:NeatMolecular weight:553.68Dimenhydrinate
CAS:Controlled Product<p>Stability Hygroscopic<br>Applications An antihistamine with antiemetic properties used to prevent nausea and motion sicknes composed of two drugs 8-Chlorotheophylline (C411440) and Diphenhydramine (D486900).<br>References Sibel, K. et al.: Arzneim.-Forsch. , 52, 529 (2002); Pytel, J. et al.: Clin. Therap., 29, 84 (2007); Scholtz, A.W. et al.: Clin. Therap., 26, 866 (2004);<br></p>Formula:C17H21NO·C7H7ClN4O2Color and Shape:NeatMolecular weight:469.96N-[(2R)-2-Hydroxy-2-(3-hydroxyphenyl)ethyl]-N-methyl-glycine Sodium Salt
CAS:Controlled Product<p>Applications N-[(2R)-2-Hydroxy-2-(3-hydroxyphenyl)ethyl]-N-methyl-glycine Sodium salt is the sodium salt of H943135, which is an impurity of Phenylephrine (P320640), an α-Adrenergic agonist. Mydriatic; decongestant.<br>References Warren, M.R., et al.: J. Pharmacol. Exp. Ther., 86, 284 (1946), Gaglia, C.A., et al.: Anal. Profiles Drug Subs., 3, 483 (1974)<br></p>Formula:C11H14NNaO4Color and Shape:NeatMolecular weight:247.22rac N-Nitroso-N-Desmethyl Dapoxetine-D3
Controlled ProductFormula:C20D3H17N2O2Color and Shape:NeatMolecular weight:323.4042-Acetylbenzothiophene
CAS:Controlled Product<p>Applications A novel anti-osteoporosis agent, by enhansing expression of the BMP-2 gene.<br>References Horiguchi, Y., et al.: Chem. Pharm. Bull., 52, 214 (2004), Joshi, E., et al.: Chem. Res. Toxicol., 17, 137 (2004), Liu, Z., et al.: Bioorg. Med. Chem. Lett., 19, 4167 (2009),<br></p>Formula:C10H8OSColor and Shape:NeatMolecular weight:176.23N-Nitrosopendimethalin-d4
Controlled ProductFormula:C13H14D4N4O5Color and Shape:NeatMolecular weight:337.367(4-Methyl-1H-imidazol-5-yl)methanol Hydrochloride
CAS:Controlled Product<p>Applications (4-Methyl-1H-imidazol-5-yl)methanol hydrochloride (cas# 38585-62-5) is a useful research chemical.<br></p>Formula:C5H8N2O·ClHColor and Shape:NeatMolecular weight:148.59Phenylbutazone(diphenyl-d10)
CAS:Controlled Product<p>Applications Phenylbutazone(diphenyl-d10) is the isotope labelled analog of Phenylbutazone (P319570); a non-steroidal anti-inflammatory compound and an inhibitor of cyclooxygenase that is also a substrate for peroxidation by cyclooxygenase.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Ali, S.L., Anal. Profiles Drug Subs., 11, 483 (1982); Hughes, M.F., et al.: Mol. Pharmacol., 34, 186 (1988)<br></p>Formula:C192H10H10N2O2Color and Shape:Off White CrystallineMolecular weight:318.44Nilotinib 3-Imidazolyl N-oxide
CAS:Controlled Product<p>Applications 4-Methyl-3-(4-pyridin-3-yl)pyrimidin-2-yl]amino-N-(5-(3-oxo-4-methyl-1H-imidazol-1-yl)-3-(trifluoromethyl)phenyl)benzamine is an impurity compound of Nilotinib (N465300), useful in the treatment of chronic myelogenous leukemia. It is a COVID19-related research product.<br>References Wei-Sheng H., et al.: Synthesis, 14, 2121 (2007); Corbin, A., et al.: J. Biol. Chem., 277, 32214(2002), Golemovic, M., et al.: Clin. Cancer Res., 11, 4941 (2005), Gleixner, K., et al.: Blood, 107, 752 (2006), Nicolini, F., et al.: Leukemia, 20, 1061 (2006),<br></p>Formula:C28H22F3N7O2Color and Shape:NeatMolecular weight:545.522-Amino-3-hydroxypyridine
CAS:Controlled Product<p>Applications 2-Amino-3-hydroxypyridine (cas# 16867-03-1) is a compound useful in organic synthesis.<br></p>Formula:C5H6N2OColor and Shape:NeatMolecular weight:110.11Nintedanib Demethyl-O-glucuronic Acid
CAS:Formula:C36H39N5O10Color and Shape:NeatMolecular weight:701.72Triciribine
CAS:Controlled Product<p>Applications Triciribine is an antitumor tricyclic nucleoside. Triciribine acts as a potent, small-molecule inhibitor of AKT phosphorylation in subjects with solid tumors contining activated AKT. Triciribine is also a selective inhibitor of HIV-1 and HIV-2, including strains known to be resistant to AZT or TIBO.<br>References Garrett, C.R. et al.: Invest. New Drugs, 29, 1381 (2011); Ptak, R.G. et al.: AIDS Res. Human Retrovir., 14, 1315 (1998); Bennett, L.L. et al.: BIochem. Pharmacol., 27, 233 (1978);<br></p>Formula:C13H16N6O4Color and Shape:NeatMolecular weight:320.30(R)-1-Methyl-3-pyrrolidinol
CAS:Controlled Product<p>Applications (R)-1-Methyl-3-pyrrolidinol is a useful synthetic intermediate. It is used for asymmetric synthesis of constrained (-)-S-adenosyl-L-homocysteine (SAH) analogs as DNA methyltransferase inhibitors.<br>References Isakovic, L., et al.: Bioorg. Med. Chem. Lett., 19, 2742 (2009); Gobbini, M., et al.:J. Med. Chem., 51, 4601 (2008)<br></p>Formula:C5H11NOColor and Shape:NeatMolecular weight:101.152',6'-Dichloroacetanilide
CAS:Controlled ProductFormula:C8H7Cl2NOColor and Shape:NeatMolecular weight:204.05[3-(9H-Carbazol-4-yloxy)-2-hydroxy]propyl Carvedilol
CAS:Controlled ProductFormula:C39H39N3O6Color and Shape:NeatMolecular weight:645.74N-[[4-(3-Methoxypropoxy)-3-methyl-2-pyridinyl]methyl] Rabeprazole Sulfide
CAS:Controlled Product<p>Applications Rabeprazole (R070500) N-aralkyl impurity.<br>References Fujisaki, H., et al.: Biochem. Pharmacol., 42, 321 (1991), Morri, M., et al.: J. Biol. Chem., 268, 21553 (1993), Pingili, R., et al.: Pharmazie, 60, 814 (2005),<br></p>Formula:C29H36N4O4SColor and Shape:NeatMolecular weight:536.696-Amino-1-methyl-5-nitrosouracil
CAS:Controlled Product<p>Stability Light and temperature sensitive<br>Applications 6-Amino-1-methyl-5-nitrosouracil is known to exhibit anitmicrobial activity and form complexation with platinum (II).<br>References Gaballa, A.S., et al.: Molec. Biomolec. Spectro. 75A, 146 (2010);<br></p>Formula:C5H6N4O3Color and Shape:NeatMolecular weight:170.134,6-Dichloro-5-nitro-2-(propylthio)pyrimidine
CAS:<p>Stability Unstable in DMSO Solution<br>Applications 4,6-Dichloro-5-nitro-2-(propylthio)pyrimidine is used as a reactnat in the synthesis of carba-nucleosides as potent antagonists of ADP purinergic receptor P2Y12 on human platelets.<br>References Ye, H., et al.: ChemMedChem, 3, 732 (2008);<br></p>Formula:C7H7Cl2N3O2SColor and Shape:NeatMolecular weight:268.120Iguratimod
CAS:Controlled Product<p>Applications Iguratimod acts as an anti-inflammatory agent, used primarily in the treatment of rheumatoid arthritis.<br>References Estellat, C. et al.: Arch. Int. Med., 172, 237 (2012); Du, F. et al.: Arth. Res. Ther., 10 (2008); Tanaka, K. et al.: Rheumatol. Rep., 1, 11 (2009);<br></p>Formula:C17H14N2O6SColor and Shape:NeatMolecular weight:374.37N-[1,1-Bis[(acetyloxy)methyl]-3-(4-octylphenyl)propyl]acetamide
CAS:Controlled Product<p>Applications N-[1,1-Bis[(acetyloxy)methyl]-3-(4-octylphenyl)propyl]acetamide is derived from Diethyl 2-Acetamidomalonate (D443130), which is a versatile building block used for the synthesis of various pharmaceutical and biologically active compounds. It is an intermediate for the preparation of Novobiocin (N888500) analogues as potential heat shock protein 90 inhibitors.<br>References Gunaherath, G. M., et al.: Bioorg. Med. Chem., 21, 5118 (2013);<br></p>Formula:C25H39NO5Color and Shape:NeatMolecular weight:433.583-Ethyl Haloperidol
CAS:Controlled ProductFormula:C23H27ClFNO2Color and Shape:NeatMolecular weight:403.92Leflunomide 3-Isomer
CAS:Controlled Product<p>Impurity Leflunomide EP Impurity C/ Leflunomide BP Impurity C<br>Applications Leflunomide 3-Isomer (Leflunomide EP Impurity C) is a Leflunomide analogue, with potential antiinflammatory and anti-viral activity. Leflunomide (L322750) Impurity E.<br>References Bertolini, G., et al.: J. Med. Chem., 40, 2011 (1997), Huang, W., et al.: Chem. Pharm. Bull., 51, 313 (2003),<br></p>Formula:C12H9F3N2O2Color and Shape:White To Off-WhiteMolecular weight:270.21Moclobemide N-Oxide
CAS:<p>Applications Moclobemide N-Oxide is a metabolite of Moclobemide (M481000), a reversible monoamine oxidase inhibitor.<br>References Plenis, A., et. al.: Biomed. Chrom., 21, 958 (2007); Rakic, A., et. al.: J. Pharmaceut. Biomed. Anal., 43, 1416 (2007); Wiesel, F.A., et al.: Eur. J. Clin. Pharmacol., 28, 89 (1985), Burkard, W.P., et al.: J. Pharmacol. Exp. Ther., 248, 391 (1989)<br></p>Formula:C13H17ClN2O3Color and Shape:NeatMolecular weight:284.74N-Methylthiophene-2-carboxamide
CAS:Controlled ProductFormula:C6H7NOSColor and Shape:NeatMolecular weight:141.19(S)-N-[2-[2,3-Dihydro-6-hydroxy-7-(2-hydroxyethyl)-1H-inden-1-yl]ethyl]propanamide
CAS:Controlled Product<p>Applications Intermediate in the production of Ramelteon.<br>References Uchikawa, O., et al.: J. Med. Chem., 45, 4222 (2002),<br></p>Formula:C16H23NO3Color and Shape:NeatMolecular weight:277.36Ticagrelor TCG Sulfonate
<p>Applications Ticagrelor TCG Sulfonate is an impurity of Ticagrelor (T437700), the first reversible oral P2Y12 receptor antagonist, provides faster, greater, and more consistent ADP-receptor inhibition than Clopidogrel. Used in the treatment of acute coronary syndromes (ACS).<br>References Matetzky, S., et al.: Circulation, 109, 3171 (2004), Bassand, J., et al.: Eur. Heart J., 28, 1598 (2007), Jakubowski, J., et al.: Cardiovasc. Drug Rev., 25, 357 (2007),<br></p>Formula:C23H28F2N6O7S2Color and Shape:NeatMolecular weight:602.63(E)-Thiothixene
CAS:Controlled Product<p>Applications (E)-Thiothixene is an antipsychotic agent used in the treatment of psychological disorders.<br>References Andorn, A. et al.: Brain Res., 971, 66 (2003); Seeman, P. et al.: Mol. Pharmacol. 28, 391 (1985);<br></p>Formula:C23H29N3O2S2Color and Shape:NeatMolecular weight:443.635-Methyl-1,3-benzenediacetonitrile
CAS:<p>Impurity Anastrozole 1,3-Dicyanomethyl Impurity<br>Applications 5-Methyl-1,3-benzenediacetonitrile is an Anastrozole intermediate. Anastrozole 1,3-Dicyanomethyl Impurity. Anastrozole is an aromatase inhibitor and used as an antineoplastic.<br>References Plourde, P.V., et al.: Breast Cancer Res. Treat., 30, 103 (1994), Buzdar, A.U., et al.: Cancer, 79, 730 (1997)<br></p>Formula:C11H10N2Color and Shape:NeatMolecular weight:170.21Telmisartan Amide
CAS:<p>Impurity Telmisartan EP Impurity F / Telmisartan Amide<br>Applications An amide impurity of Temisartan (D294250).<br>References Xu, G. et al.: Zhong. Yiyao Gong. Zaz., 40, 714 (2009);<br></p>Formula:C33H31N5OColor and Shape:NeatMolecular weight:513.63OPC 14714
CAS:Controlled Product<p>Impurity Aripiprazole Impurity<br>Applications A novel antipsychotic agents with dopamine autoreceptor agonist properties. Aripiprazole Impurity<br>References Simpson, G., et al.: Drugs, 1981, 21, 138 (1981), Banno, K., et al.: Chem. Pharm. Bull., 36, 4377 (1988), Momiyama, T., et al.: Life Sci., 47, 761 (1990), Caprathe, B., et al.: J. Med. Chem., 34, 2736 (1991),<br></p>Formula:C23H28BrN3O2Color and Shape:White To Off-WhiteMolecular weight:458.394-Hydroxy Propranolol β-D-Glucuronide (Mixture of Diastereomers)
CAS:Controlled Product<p>Applications A metabolite of 4-Hydroxy propranolol. Antihypertensive; antianginal; antiarrhythmic (class II).<br>References Walle, T., et al.: Clin. Pharmacol. Ther., 46, 257 (1989), Christ, D.D., et al.: Drug Metab. Dispos., 18, 1 (1990),<br></p>Formula:C22H29NO9Color and Shape:NeatMolecular weight:451.47(R)-Ofloxacin-d3
CAS:Controlled Product<p>Applications A labelled fluorinated quinolone antibacterial. An enantiomer of Levofloxacin (L360000).<br>References Hwangbo, H.J. et al.: Eur. J. Pharmac. Sci., 18, 197 (203); Gascon, A.R. et al.: J. Clin. Pharmacol, 40, 869 (2000); Monk, J.P., et al.: Drugs, 33, 346 (1987); Drlica, K., Curr. Opin. Microbiol. 2, 504 (1990);<br></p>Formula:C182H3H17FN3O4Color and Shape:NeatMolecular weight:364.39Hydroxy Celecoxib
CAS:Controlled Product<p>Applications A metabolite of Celecoxib (C251000).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Penning, T., et al.: J. Med. Chem., 40, 1347 (1997), Paulson, S., et al.: Drug Metab. Dispos., 28, 308 (2000), Kirchheiner, J., et al.: Clin. Pharmacol. Ther., 71, 286 (2002),<br></p>Formula:C17H14F3N3O3SColor and Shape:NeatMolecular weight:397.37N’-Benzylidene-2-ethoxybenzimidohydrazide Hydroiodide
Controlled ProductFormula:C16H17N3O·HIColor and Shape:Off-WhiteMolecular weight:395.2383-Ethynylaniline
CAS:Controlled Product<p>Stability Light Sensitive<br>Applications Reagent in the preparation of a metabolite of Erlotinib (E625000).<br></p>Formula:C8H7NColor and Shape:Colourless To Dark RedMolecular weight:117.15Dasatinib-d8 N-Oxide
CAS:Controlled Product<p>Applications The labelled oxidative metabolite of Dasatinib (M5 metabolite). It is a COVID19-related research product.<br>References Cashman, J.R., et al.: Chem. Res. Toxicol., 8, 165 (1995), Aasmoe, L., et al.: Toxicol. Appl. Pharmacol., 150, 86 (1998), Galetin, A., et al.: J. Pharmacol. Exp. Ther., 314, 180 (2005), Christopher, L.J., et al.: Drug Metab. Dispos., 36, 1357 (2008),<br></p>Formula:C22H18D8ClN7O3SColor and Shape:NeatMolecular weight:512.052,3-Bis[(acetyloxy)methyl]-1-oxoquinoxalin-1-ium-4(1H)-olate
CAS:Controlled Product<p>Applications 2,3-Bis[(acetyloxy)methyl]-1-oxoquinoxalin-1-ium-4(1H)-olate is an antibiotic.<br>References Marrero-Ponce, Yovani, et al.: Bioorg. & Med. Chem., 13(8), 2881-2899 (2005)<br></p>Formula:C14H14N2O6Color and Shape:NeatMolecular weight:306.27Argatroban
CAS:Controlled Product<p>Applications Synthetic thrombin inhibitor. Antithrombotic.<br>References Abiko, Y., et al.: Thromb. Res., 24, 285 (1981), Kikumoto, R., et al.: Biochemistry, 23, 85 (1984),<br></p>Formula:C23H36N6O5SColor and Shape:White PowderMolecular weight:508.63Tafamidis Meglumine
CAS:Formula:C14H7Cl2NO3·C7H17NO5Color and Shape:NeatMolecular weight:308.11 + 195.222-(6-Methoxy-2-naphthyl)acetonitrile
CAS:Controlled Product<p>Applications 2-(6-Methoxy-2-naphthyl)acetonitrile (cas# 71056-96-7) is a compound useful in organic synthesis.<br></p>Formula:C13H11NOColor and Shape:NeatMolecular weight:197.235-Ethoxy-2-pyrrolidone
CAS:Controlled Product<p>Applications 5-Ethoxy-2-pyrrolidone is an intermediate in the synthesis of rac-Vigabatrin (V253005), a novel antiepileptic drug. Antidepressant; antipsychotic; anxiolytic.<br>References Vajda, F., et al.: Clin. Neurosci., 7, 88 (2000), Beghi, E., et al.: Lancet. Neurol., 3, 618 (2004), Sagirli, O., et al.: J. Pharmaceut. Biomed., 42, 618 (2006),<br></p>Formula:C6H11NO2Purity:>90%Color and Shape:NeatMolecular weight:129.165-(Chloromethyl)-α1,α1,α3,α3-tetramethyl-1,3-benzenediacetonitrile
CAS:Controlled ProductFormula:C15H17ClN2Color and Shape:NeatMolecular weight:260.762-Fluoro-4-desfluoro Bicalutamide
CAS:Controlled Product<p>Impurity Bicalutamide EP Impurity B<br>Applications Bicalutamide impurity. Bicalutamide derivative.<br>References Tucker, H., et al.: J. Med. Chem., 31, 954 (1988),<br></p>Formula:C18H14F4N2O4SColor and Shape:NeatMolecular weight:430.3734Ofloxacin N-Oxide Hydrochloride
CAS:Controlled ProductFormula:C18H20FN3O5·ClHColor and Shape:Off-WhiteMolecular weight:413.83(R)-Naproxen
CAS:Controlled ProductFormula:C14H14O3Color and Shape:White To Off-WhiteMolecular weight:230.26ent-Rotigotine
CAS:<p>Applications It is a non-ergot dopamine agonist drug and is indicated for the treatment of Parkinson’s disease.<br>References Loschmann, P., et al.: Eur. J. Pharmacol., 166, 373 (1989), Edgar, D., et al.: J. Pharmacol. Exp. Ther., 283, 757 (1997), Ferreira, J., et al.: Lancet, 355, 1333 (2000), Arnulf, I., et al.: Neurology, 58, 1019 (2002), Wisor, J., et al.: Neuroscience, 132, 1027 (2005),<br></p>Formula:C19H25NOSColor and Shape:Brown OilyMolecular weight:315.47rac O-Acetyl Pseudoephedrine Hydrochloride
CAS:Controlled Product<p>Applications rac O-Acetyl Pseudoephedrine is a racemic O-acetylated analogue of the non-selective adrenergic agonist Pseudoephedrine (P839350).<br>References Snopek, J. et al.: J. Chrom., 438, 211 (1988);<br></p>Formula:C12H17NO2·ClHColor and Shape:WhiteMolecular weight:243.732,4-Difluorobenzoic Acid
CAS:Controlled Product<p>Applications 2,4-Difluorobenzoic Acid (cas# 1583-58-0) is a compound useful in organic synthesis.<br></p>Formula:C7H4F2O2Color and Shape:NeatMolecular weight:158.10Iproniazid
CAS:Controlled Product<p>Applications Iproniazid is a hydrazine based drug used as an antidepressant. Iproniazid acts as an irreversible and nonselective monoamine oxidase inhibitor.<br>References Fagervall, I. et al.: Biochem. Pharmacol., 35, 1381 (1986); Horita, A.: Princ. Psychopharmacol., 279 (1970); O'Donnell, J.M. et al.: Psychopharmacology, 78, 214 (1982);<br></p>Formula:C9H13N3OColor and Shape:White SolidMolecular weight:179.22rac 6-Chloro-1,4-dihydro-4-(1-pentynyl)-4-(trifluoromethyl)-2H-3,1-benzoxazin-2-one
CAS:Controlled Product<p>Applications An Efavirenz (E425000) impurity.<br></p>Formula:C14H11ClF3NO2Color and Shape:Off White SolidMolecular weight:317.69Afatinib-des(4-dimethylamino-2-en-1-oxo)butyl (Contained ~8.5% Ethanol)
CAS:Formula:C18H16ClFN4O2Color and Shape:NeatMolecular weight:374.8N-Methyl Omeprazole-d3 (Mixture of isomers with the methylated nitrogens of imidazole)
CAS:Controlled Product<p>Applications Labelled Omeprazole (O635000) impurity.<br>References Allenmark, S., et al.: Anal. Biochem., 136, 293 (1984), Besancon, M., et al.: J. Biol. Chem., 272, 22438 (1997),<br></p>Formula:C18H18D3N3O3SColor and Shape:NeatMolecular weight:362.463-Deschloro-3,4-difluoro Gefitinib
CAS:<p>Applications 3-Deschloro-3,4-difluoro gefitinib, is an impurity of Gefitinib (G304000), an antineoplastic.<br>References Anderson, N.G., et al.: Int. J. Cancer, 94, 774 (2001), Hirata, A., et al.: Cancer Res., 62, 2554 (2002), Kris, M.G., et al.: J. Am. Med. Assoc., 290, 2149 (2003), Tamura, K., et al.: Expert Opin. Pharmacother., 6, 985 (2005),<br></p>Formula:C22H24F2N4O3Color and Shape:Off-White To Light YellowMolecular weight:430.4484-Isobutylamino-3-aminoquinoline
CAS:Controlled Product<p>Applications 4-Isobutylamino-3-aminoquinoline is a pharmacologically active compound related to Imiquimod (I475000), an immune response modifier. It stimulates the production of Interferon-a.<br>References Megyeri, K., et al.: Mol. Cell Biol., 15, 2207, (1995), Witt, P.L., et al.: Cancer Res., 53, 5176 (1993), Edwards, L., et al.: Arch. Dermatol., 134, 25 (1998); Gerster, J. et al.: J. Med. Chem., 48, 3481 (2005);<br></p>Formula:C13H17N3Color and Shape:NeatMolecular weight:215.29N-[(2Z)-Piperazin-2-ylidene]-2,2,2-trifluoroacetohydrazide
CAS:Controlled Product<p>Applications Sitagliptin intermediate.<br>References Sarges, R, et al.: J. Med. Chem., 33, 2240 (1990),<br></p>Formula:C6H9F3N4OColor and Shape:NeatMolecular weight:210.16Nintedanib Demethyl-O-glucuronic Acid-d3
CAS:Controlled Product<p>Applications Nintedanib Demethyl-O-glucuronic Acid-d3 is an isotopic analog of Nintedanib Demethyl-O-glucuronic Acid (N478295), a metabolite of the drug Nintedanib (N478290).<br>References Sun, L., et al.: J. Med. Chem., 41, 2588 (1998); Xie, H., et al.: J. Med. Chem., 50, 4898 (2007); Hilberg, F., et al.: Cancer Res., 68, 4774 (2008); Roth, G., et al.: J. Med. Chem., 58, 1053 (2015)<br></p>Formula:C36H36D3N5O10Color and Shape:NeatMolecular weight:704.74Leflunomide EP Impurity G
CAS:Controlled ProductFormula:C12H12N2O2Color and Shape:NeatMolecular weight:216.24Efavirenz 3-Desoxy
CAS:<p>Applications Efavirenz 3-Desoxy is an analog of Efavirenz (E425000), a nonnucleoside HIV-1 reverse transcriptase inhibitor. Antiviral.<br>References Young, S.D., et al.: Antimicrob. Ag. Chemother., 39, 2602 (1995)<br></p>Formula:C15H11ClF3NOColor and Shape:Off White SolidMolecular weight:313.70Loratadine Impurity F
CAS:Controlled Product<p>Impurity Loratadine EP Impurity F; Loratadine USP Related Compound G Impurity<br>Applications Loratadine Impurity F (Loratadine EP Impurity F; Loratadine USP Related Compound G Impurity) is a fluorinated analog of Loratadine (L469575), which is a nonsedating-type histamine H1-receptor.<br>References Bruttmann, G., et al.: J. Allergy Clin. Immunol., 83, 411 (1989), Haria, M., et al.: Drugs, 48, 617 (1994)<br></p>Formula:C22H24ClFN2O2Color and Shape:White To Off-WhiteMolecular weight:402.892-Methyl-5-nitroaniline
CAS:Controlled Product<p>Applications 2-Methyl-5-nitroaniline is used as a reagent in the synthesis of imatinib base derivatives which show antibacterial and antifungal activity. Also used as a reagent in the synthesis of pyrimidinylaminobenzene derivatives which exhibit antiproliferative activity against melanoma. Dyes and metabolites, Environmental Testing. It is a COVID19-related research product.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Patoliya, M.J., et al.: J. Chem., no vol., no pp. (2013); Kim, H.J., et al.: B. Korean Chem. Soc., 34, 2311 (2013)<br></p>Formula:C7H8N2O2Color and Shape:YellowMolecular weight:152.15O-Desmethylsulpiride
CAS:Controlled ProductFormula:C14H21N3O4SColor and Shape:NeatMolecular weight:327.40Pazufloxacin Mesylate
CAS:Controlled Product<p>Applications A fluorinated quinolone antibiotic. Antibacterial.<br>References Fukuoka,Y., et al.: Antimicrob. Ag. Chemother., 37, 384 (1993), Todo, Y., et al.: Chem. Pharm. Bull., 42, 2569 (1994)<br></p>Formula:C16H15FN2O4·CH4O3SColor and Shape:NeatMolecular weight:414.41(3-Methyl-4-(2,2,2-trifluoroethoxy)pyridin-2-yl)methyl Acetate
CAS:Controlled Product<p>Impurity Lansoprazole<br>Applications (3-Methyl-4-(2,2,2-trifluoroethoxy)pyridin-2-yl)methyl Acetate is an impurity of Lansoprazole (L175000). Lansoprazole is used as a gastric proton pump inhibitor and an antiulcerative. It May limit the severity of tuberculosis.<br>References Figgitt, D., et al.: Drugs, 60, 925 (2000); Katsuki, H., et al.: Eur. J. Clin. Pharmacol., 57, 709 (2001); Barradell, L.B., et al.: Drugs, 44, 225 (1992); Kim, K., et al.: Clin. Pharmacol. Ther., 72, 90 (2002); Niioka, T., et al.: Ther. Drug Monit., 28, 321 (2006); Chem. and Eng. News. p. 28 July 20 (2018)<br></p>Formula:C11H12F3NO3Color and Shape:NeatMolecular weight:263.213Dapoxetine N-Oxide (90%)
CAS:Controlled Product<p>Applications The N-oxide impurity of the selective serotonin reuptake inhibitor Dapoxetine (D185700).<br></p>Formula:C21H23NO2Purity:90%Color and Shape:NeatMolecular weight:321.412-Chloro Loratadine
CAS:Controlled Product<p>Applications 2-Chloro Loratadine is an impurity of Loratadine (L469575), a nonsedating-type histamine H1-Receptor blocker.<br>References U.S. (1998), US 5719148 A 19980217. PCT Int. Appl. (1995), WO 9510515 A1 19950420.<br></p>Formula:C22H22Cl2N2O2Color and Shape:NeatMolecular weight:417.33rac Felodipine-d3
CAS:Controlled Product<p>Applications A labelled dihydropyridine calcium channel blocker.<br>References Berntsson, P.B., et al.: Acta Pharm. Suec., 18, 221 (1981), Kratochwil, N., et al.: Biochem. Pharmacol., 64, 1355 (2002), O'Brien, S., et al.: J. Med. Chem., 48, 1287 (2005), Castilho, M., et al.: Bioorg. Med. Chem., 14, 516 (2006),<br></p>Formula:C182H3H16Cl2NO4Color and Shape:NeatMolecular weight:387.273-Methylxanthine
CAS:Controlled Product<p>Impurity Pentoxifylline EP Impurity B<br>Applications 3-Methylxanthine (Pentoxifylline EP Impurity B) is a metabolite of Theophylline (58-55-9), which is a Xanthine (X499950) derivative with diuretic, cardiac stimulant and smooth muscle relaxant activities; isomeric with theobromine.They can also act as Bronchodilator.<br>References Cohen, J.L., et al.: Anal. Profiles Drug Subs., 4, 466 (1975); Svedmyr, K., et al.: Allergy, 37, 111 (1982);<br></p>Formula:C6H6N4O2Color and Shape:BeigeMolecular weight:166.14Dimethylamine (40% aq.)
CAS:Controlled Product<p>Applications Dimethylamine (40% aq.) is a compound often used in industry as a precursor to Nitrosodimethylamine (N525625), a potent carcinogen that is produced during disinfection of wastewater effluent, and is also present in trace amounts in food and polluted air. Dimethylamine is also present in human urine and can be indicative of certain disorders.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Gereke, A. & Sedlak, D.: Env. Sci. Tech., 37, 1331 (2003); Mitch, W., et al.: Env. Eng. Sci., 20, 389 (2003); Tsikas, D., et al.: J. Chromatogr. B, 851, 229 (2007)<br></p>Formula:C2H7NColor and Shape:NeatMolecular weight:45.081-Benzo[b]thien-4-yl-piperazine
CAS:Controlled Product<p>Applications is an intermediate in synthesizing Brexpiprazole 5-1H-Quinolin-2-one (B677428), an impurity of Brexpiprazole (B677385), which is a drug candidate useful in treatment and prevention of mental disorders including CNS disorders.<br>References Yamashita, H., et al.: PCT Int. Appl., WO 2006112464 A1 20061026 (2006)<br></p>Formula:C12H14N2SColor and Shape:NeatMolecular weight:218.32Acalabrutinib-d3
CAS:Controlled ProductFormula:C26D3H20N7O2Color and Shape:NeatMolecular weight:468.525Atazanavir-d9
CAS:Controlled Product<p>Applications Atazanavir-d9 is the deuterated analog of Atazanavir (A790051), a azapeptide HIV protease inhibitor derivative. Atazanavir have been investigated as potential treatment of human immunodeficiency virus (HIV) and for anticancer purposes.<br>References Musial, B.L., et al.: Am. J. Health Syst. Pharm., 61, 1365 (2004), Wood, R., et al.: J. Acquir. Immune Defic. Syndr., 36, 684 (2004),<br></p>Formula:C382H15H37N6O7Color and Shape:NeatMolecular weight:719.95Eltenac-13C,d3
CAS:Controlled Product<p>Applications Labelled Eltenac (E507000). A nonsteroidal anti-inflammatory drug.<br>References Allen, A., et al.: Gut, 21, 249 (1980), Tobin, T., et al.: J. Vet. Pharmacol. Therap., 9, 1 (1986),<br></p>Formula:CC11H7Cl2D2NO2SColor and Shape:NeatMolecular weight:302.18N-[4-Cyano-3-(trifluoromethyl)phenyl]-2,3-dihydroxy-2-methylpropanamide
CAS:Controlled Product<p>Applications N-[4-Cyano-3-(trifluoromethyl)phenyl]-2,3-dihydroxy-2-methylpropanamide is used as a reagent in the preparation of bicalutamide by coupling with sodium p-fluorobenzenesulfinate.<br>References Thijs, L., et al.: U.S. Pat. Appl. Publ. 23pp. (2004)<br></p>Formula:C12H11F3N2O3Color and Shape:NeatMolecular weight:288.22Levofloxacin Hydrochloride
CAS:Formula:C18H20FN3O4·(HCl)Color and Shape:White To Light BeigeMolecular weight:361.37 + (36.46)Sulcotrione-d7
CAS:Controlled ProductFormula:C14D7H6ClO5SColor and Shape:Light Yellow SolidMolecular weight:335.81Omeprazole Sodium Salt
CAS:Controlled Product<p>Stability Hygroscopic<br>Applications Omeprazole Sodium Salt is the salt analogue of Omeprazole (O635000), which binds covalently to proton pump. It inhibits gastric secretion. Used as an anttiulcerative.<br>References Muller, P., et al.: Arzneimittel-Forsch., 33, 1685 (1983); Wallmark, B., et al.: Biochim. Biophys. Acta., 778, 549 (1984); Morii, M., et al.: J. Biol. chem., 268, 21553 (1993); Ritter, M., et al.: Br. J. Pharmacol., 124, 627 (1998)<br></p>Formula:C17H18N3O3S·Na·H2OColor and Shape:Off-WhiteMolecular weight:385.41N,O-Diacetyl Pseudoephedrine
CAS:Controlled Product<p>Applications N,O-Diacetyl Pseudoephedrine is the diacetylated analogue of the non-selective adrenergic agonist Pseudoephedrine (P839350).<br></p>Formula:C14H19NO3Color and Shape:NeatMolecular weight:249.31Quetiapine Dimer Impurity-d8
CAS:Controlled Product<p>Applications An impurity of labelled Quetiapine.<br>References Xu, H., et al.: J. Pharm. Biomed. Anal., 47, 658 (2008), Stolarczyk, E., et al.: Pharm. Develop. Technol., 14, 27 (2009),<br></p>Formula:C30H16D8N4S2Color and Shape:NeatMolecular weight:512.72(S)-5-Chloro-a-(cyclopropylethynyl)-2-[[(4-methoxyphenyl)methyl]amino]-a-(trifluoromethyl)benzenemethanol
CAS:Controlled Product<p>Applications (S)-5-Chloro-α-(cyclopropylethynyl)-2-[[(4-methoxyphenyl)methyl]amino]-α-(trifluoromethyl)benzenemethanol is the S enantiomer of rac-5-Chloro-α-(cyclopropylethynyl)-2-[[(4-methoxyphenyl)methyl]amino]-α-(trifluoromethyl)benzenemethanol (C365145). (S)-5-Chloro-α-(cyclopropylethynyl)-2-[[(4-methoxyphenyl)methyl]amino]-α-(trifluoromethyl)benzenemethanol is also an impurity of Efavirenz (E425000), an HIV-1 reverse transcriptase inhibitor.<br>References Pierce, M., et al.: J. Org. Chem., 63, 8536 (1998)<br></p>Formula:C21H19ClF3NO2Color and Shape:NeatMolecular weight:409.832-(2,6-Dioxo-3-piperidinyl)-4-fluoro-1H-isoindole-1,3(2H)-dione
CAS:Formula:C13H9FN2O4Color and Shape:Off White PowderMolecular weight:276.22p-Nitrophenyl 2-(Furfurylsulfinyl)acetate
CAS:Controlled Product<p>Stability Moisture Sensitive<br>Applications p-Nitrophenyl 2-(Furfurylsulfinyl)acetate is a furfurylsulfinyl derivative with gastroprotective activity. p-Nitrophenyl 2-(Furfurylsulfinyl)acetate is used in the preparation of histamine H2-receptor antagonist.<br>References Hirakawa, N. et al.: Chem. Pharmac. Bull., 46, 616 (1998); Zhu, R. et al.: Hef. Gong. Dax. Xue. Zir. Kex., 28, 1346 (2005);<br></p>Formula:C13H11NO6SColor and Shape:BeigeMolecular weight:309.29Nintedanib Acetyl Impurity
CAS:Controlled Product<p>Applications An impurity of Nintedanib, which is an antifibrotic drug.<br>References Holdsworth, G.; et al.: Scientific Reports, 7, 1 (2017)<br></p>Formula:C26H23N3O4Color and Shape:NeatMolecular weight:441.49Perphenazine-d8 Dihydrochloride Salt (1.0 mg/mL in Methanol)
CAS:Formula:C21H18D8ClN3OS·2HClColor and Shape:ColourlessMolecular weight:484.93Nicoboxil
CAS:Controlled Product<p>Applications Nicoboxil is a medication used in the treatment of acute non-specific low back pains.<br>References Gaubitz, M., et al.: Eur. J. Pain , 20, 263 (2016),<br></p>Formula:C12H17NO3Color and Shape:ColourlessMolecular weight:223.27(3Z)-2,3-Dihydro-3-[[[4-(methylamino)phenyl]amino]phenylmethylene]-2-oxo-1H-Indole-6-carboxylic Acid Methyl Ester
CAS:Controlled ProductFormula:C24H21N3O3Color and Shape:NeatMolecular weight:399.44Afatinib Impurity AFT-8
CAS:Controlled Product<p>Applications Afatinib Impurity AFT-8 is an impurity of its parent compound Afatinib (A355300), which is an aminocrotonylamino-substituted quinazoline derivative used for treating cancer and diseases of the respiratory tract, lungs, gastrointestinal tract, bile duct, and gallbladder.<br></p>Formula:C24H27ClFN5O4Color and Shape:NeatMolecular weight:503.954(6S)-N6-[3-[[(6S)-2-Amino-4,5,6,7-tetrahydro-6-benzothiazolyl]amino]-1-ethyl-2-methylpropyl]-4,5,6,7-tetrahydro-2,6-benzothiazolediamine
CAS:<p>Stability Hygroscopic<br>Applications (6S)-N6-[3-[[(6S)-2-Amino-4,5,6,7-tetrahydro-6-benzothiazolyl]amino]-1-ethyl-2-methylpropyl]-4,5,6,7-tetrahydro-2,6-benzothiazolediamine can be obtained from (-)-2-Amino-6-propionamido-tetrahydrobenzothiazole (A628150) and is the byproduct of process for the preparation of pramipexole and salts thereof by reductive amination of (diamino)tetrahydrobenzothiazole with propanal. It is also a Pramaxo Impurity C.<br>References Deo, K., et al.: Indian Pat. Appl. (2015), IN 2013MU02843 A<br></p>Formula:C20H32N6S2Purity:>80%Color and Shape:NeatMolecular weight:420.6383Hydroxy Ebastine-d5
CAS:Controlled Product<p>Applications A labelled metabolite of Ebastine.<br>References Hashizume, T., et al.: Drug Metab. Dispos., 29, 798 (2001), Hashizume, T., et al.: J. Pharmacol. Exp. Ther., 300, 298 (2002), Matsumoto, S., et al.: Xenobiotica, 33, 615 (2003), Chaikin, P., et al.: Br. J. Clin. Pharmacol., 59, 346 (2005),<br></p>Formula:C32H34D5NO3Color and Shape:NeatMolecular weight:490.69N-Desethyl Sunitinib-d4 Maleate
CAS:Controlled Product<p>Applications N-Desethyl Sunitinib-d4 Maleate, is the labeled analogue of N-Desethyl Sunitinib (D289650), a metabolite of Sunitinib (S820000).<br>References Sun, L., et al.: J. Med. Chem., 46, 1116 (2003), Mendel, D.B., et al.: Clin. Cancer Res., 9, 327 (2003), Sistla, A., et al.: Drug Dev. Ind. Pharm., 30, 19 (2004), Sakamoto, K.M., et al.: Curr. Opin. Invest. Drugs, 5. 1329 (2004),<br></p>Formula:C20H19D4FN4O2•C4H4O4Color and Shape:NeatMolecular weight:347.45116077-Ethyl-10-(4-amino-1-piperidino)carbonyloxycamptothecin
CAS:<p>Stability Light Sensitive, Moisture Sensitive, Temperature Sensitive<br>Applications A major metabolite of Irinotecan.<br>References Canal, P., et al.: J. Clin. Oncol., 14, 2688 (1996), Haaz, M., et al.: Cancer Res., 58, 468 (1998), Kehrer, D., et al.: Clin. Cancer Res., 6, 3451 (2000), Hanioka, N., et al.: Xenobiotica, 31, 687 (2001), Satoh, T., et al.: Drug Metab. Dispos., 30, 488 (2002),<br></p>Formula:C28H30N4O6Color and Shape:NeatMolecular weight:518.562-Nitroso Riluzole
Controlled Product<p>Applications 2-Nitroso Riluzole is an impurity of Riluzole (R510000); is a neuroprotective agent. Modulates glutamatergic transmission. A glutamate release inhibitor. An anticonvulsant. Neuroprotective agent.<br>References Mizoule, J., et al.: Neuropharmacology, 24, 767 (1985), Wahl, F., et al.: Eur. J. Pharmacol., 230, 209 (1993) Bensimon, G., et al.: N. Engl. J. Med., 330, 585 (1994)<br></p>Formula:C8H3F3N2O2SColor and Shape:Dark GreenMolecular weight:248.182Despropylrotigotine
CAS:Controlled ProductFormula:C16H19NOSColor and Shape:NeatMolecular weight:273.39(R,R)-Dihydro Bupropion β-D-Glucuronide
<p>Applications (R,R)-Dihydro Bupropion β-D-Glucuronide is a glucuronide metabolite of the drug Bupropion (B689625, HCl salt). Bupropion is a selective inhibitor of dopamine uptake.<br>References Soroko, F., et al.: J. Pharm. Pharmacol., 29, 769 (1977), Tucker, W.E., J. Clin. Psychiatry, 44, 60 (1983), Hsyu, P-H., et al.: J. Clin. Pharmacol., 37, 737 (1997), West, R., et al.: Expert Opin. Pharmacother., 4, 533 (2003),<br></p>Formula:C19H28ClNO7Color and Shape:NeatMolecular weight:417.882-Cyano-3-(3-chlorophenylethyl)pyridine
CAS:Controlled ProductFormula:C14H11ClN2Color and Shape:NeatMolecular weight:242.704-Desmethoxypropoxyl-4-chloro Rabeprazole Sulfide
CAS:Controlled Product<p>Applications A process impurity of Rabeprazole (R070500).<br>References Pingili, R.R., et al.: Pharmazie, 60, 814 (2005),<br></p>Formula:C14H12ClN3SColor and Shape:NeatMolecular weight:289.782-Des(5-methyl-1,3,4-oxadiazole-2-carboxamide) 2-(2-(2-Acetylhydrazinyl)-2-oxoacetamide) Raltegravir
CAS:<p>Applications 2-Des(5-methyl-1,3,4-oxadiazole-2-carboxamide) 2-(2-(2-Acetylhydrazinyl)-2-oxoacetamide) Raltegravir is an impurity of a potent human immunodeficiency virus (HIV) integrase inhibitor. A novel anti-AIDS drug.<br>References Wade, K., et al.: J. Pharmacol. Biomed. Anal., 8, 401 (1990), Hazuda, D., et al.: Science, 287, 646 (2000), Williams, J., et al.: Drug Metab. Dispos., 32, 1201 (2004), Duckett, C., et al.: Xenobiotica, 36, 59 (2006), Miners, J., et al.: Biochem. Pharmacol., 71, 1531 (2006), Summa, V., et al.: J. Med. Chem., 49, 6646 (2006),<br></p>Formula:C20H23FN6O6Color and Shape:Off-WhiteMolecular weight:462.433-Des(2-methoxyethyl) 3-(1-Methylethyl) Ester Nimodipine
CAS:Controlled Product<p>Impurity Nimodipine EP Impurity B<br>Applications 3-Des(2-methoxyethyl) 3-(1-Methylethyl) Ester Nimodipine (Nimodipine EP Impurity B) can be used in synthetic preparation of dihydropyridinedicarboxylic acid esters by methylimidazolium trifluoroacetate-catalyzed Hantzsch cyclocondensation reaction of oxo-carboxylic acid esters with aldehydes and ammonium acetate. It can also be used as an analyte for analytical study in developing and optimizing a validated isocratic reversed-phase high-performance liquid chromatograhy separation of nimodipine and impurities in tablets using experimental. design methodology. It is an impurity of the drug Nimodipine (N478200).<br>References Avalani, J. R., et al.: J. Chem. Sci., 124, 1091-1096 (2012); Barmpalexis, P., et al.: J. Pharmaceut. Biomed., 49, 1192-1202 (2009)<br></p>Formula:C21H26N2O6Color and Shape:NeatMolecular weight:402.442-Hydroxy Imipramine-d6
CAS:Controlled Product<p>Applications A labelled metabolite of Imipramine.<br>References De Jongh, G.D., et al.: Drug Metab. Dispos., 2, 48 (1981), Suckow, R.F., et al.: J. Pharm. Sci., 73, 1745 (1984), Fraser, A.D., et al.: J. Anal. Toxicol., 11,168 (1987),<br></p>Formula:C19H18D6N2OColor and Shape:NeatMolecular weight:302.441-(4-Carboxybutyl)-3,7-dimethylxanthine
CAS:Controlled ProductFormula:C12H16N4O4Color and Shape:White To Off-WhiteMolecular weight:280.2810-Methoxy-5H-dibenz[b,f]azepine-5-carbonyl chloride
CAS:Controlled ProductFormula:C16H12ClNO2Color and Shape:NeatMolecular weight:286.004-{[(p-Fluorophenyl)imino]methyl}phenol
CAS:Controlled Product<p>Applications 4-{[(p-Fluorophenyl)imino]methyl}phenol is used in the preparation of benzylacetones which promote anti-fungal activity.<br>References Sandhar, R. et al.: J. Ind. Council Chem., 22, 32 (2005);<br></p>Formula:C13H10FNOColor and Shape:NeatMolecular weight:215.22(alphaS)-N,N,α-Trimethyl-3-(4-nitrophenoxy)benzenemethanamine
CAS:Controlled Product<p>Applications (αS)-N,N,α-Trimethyl-3-(4-nitrophenoxy)benzenemethanamine is an impurity of Rivastigmine Tartrate (R541000). Rivastigmine Tartrate is a brain selective acetylcholinesterase inhibitor.<br>References Rosler, M., et al.: Brit. Med. J., 318, 633 (1999); Enz, A., et al.: Prog. Brain Res., 98, 431 (1993)<br></p>Formula:C16H18N2O3Color and Shape:OrangeMolecular weight:286.33Fluphenazine β-D-Glucuronide
CAS:Controlled ProductFormula:C28H34F3N3O7SColor and Shape:NeatMolecular weight:613.652-Des(5-methyl-1,3,4-oxadiazole-2-carboxamide) (E)-2-(N,N-Dimethylformimidamide) Raltegravir
CAS:Controlled Product<p>Applications 2-Des(5-methyl-1,3,4-oxadiazole-2-carboxamide) (E)-2-(N,N-Dimethylformimidamide) Raltegravir is an impurity of Raltegravir (R100300), a potent human immunodeficiency virus (HIV) integrase inhibitor. A novel anti-AIDS drug.<br>References Wade, K., et al.: J. Pharmacol. Biomed. Anal., 8, 401 (1990), Hazuda, D., et al.: Science, 287, 646 (2000), Williams, J., et al.: Drug Metab. Dispos., 32, 1201 (2004), Duckett, C., et al.: Xenobiotica, 36, 59 (2006), Miners, J., et al.: Biochem. Pharmacol., 71, 1531 (2006), Summa, V., et al.: J. Med. Chem., 49, 6646 (2006),<br></p>Formula:C19H24FN5O3Color and Shape:NeatMolecular weight:389.42Olanzapine-d3 (1 mg/ml in Acetonitrile)
CAS:Controlled ProductFormula:C172H3H17N4SColor and Shape:ColourlessMolecular weight:315.452-[[(3aR,4S,6R,6aS)-6-[[5-Amino-6-chloro-2-(propylthio)-4-pyrimidinyl]amino]tetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-yl]oxy]ethanol
CAS:Controlled Product<p>Applications 2-[[(3aR,4S,6R,6aS)-6-[[5-Amino-6-chloro-2-(propylthio)-4-pyrimidinyl]amino]tetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-yl]oxy]ethanol is used as a reagent in the synthesis of Ticagrelor (T437700) derivatives as antiplatelet agents.<br>References Zhang, H., et al.: Bioorg. Med. Chem. Lett., 22, 3598 (2012)<br></p>Formula:C17H27ClN4O4SColor and Shape:NeatMolecular weight:418.946-Fluoro-3-(1-nitrosopiperidin-4-yl)benzo[d]isoxazole
CAS:Controlled ProductFormula:C12H12FN3O2Color and Shape:NeatMolecular weight:249.241Anastrozole Diacid
CAS:Controlled Product<p>Impurity Anastrozole Diacid Impurity<br>Applications Anastroloze Diacid is a derivative of Anastrozole (A637425), an aromatase inhibitor. Used as an antineoplastic. Anastrozole Diacid Imp<br>References Plourde, P.V., et al.: Breast Cancer Res. Treat., 30, 103 (1994), Buzdar, A.U., et al.: Cancer, 79, 730 (1997)<br></p>Formula:C17H21N3O4Color and Shape:WhiteMolecular weight:331.373-Hydroxy Anagrelide-13C3 (~80%)
CAS:Controlled Product<p>Applications 3-Hydroxy Anagrelide-13C3 is a major labelled metabolite of Anagrelide, an antithrombotic.<br>References Fleming, J., et al.: Thromb. Res., 15, 373 (1979), Gillespie, E., et al.: Biochem. Pharmacol., 37, 2866 (1988), Mazur, E., et al.: Blood, 79, 1931 (1992), Wang, G., et al.: Br. J. Pharmacol., 146, 324 (2005), Wagstaff, A., et al.: Drugs, 66, 111 (2006),<br></p>Formula:C713C3H7Cl2N3O2Purity:~80%Color and Shape:NeatMolecular weight:275.07Ethyl 4-(8-chloro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)piperidine-1-carboxylate
CAS:Controlled Product<p>Applications Ethyl 4-(8-chloro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)piperidine-1-carboxylate is an impurity of loratadine (L469575), which is a nonsedating-type histamine H1-receptor.<br>References Bruttmann, G., et al.: J. Allergy Clin. Immunol., 83, 411 (1989), Haria, M., et al.: Drugs, 48, 617 (1994)<br></p>Formula:C22H21ClN2O2Color and Shape:NeatMolecular weight:380.87Niclosamide Piperazinesalt
CAS:Controlled ProductFormula:C13H8Cl2N2O4·C4H10N2Color and Shape:NeatMolecular weight:413.265,7-Difluorochroman-4-one
CAS:Controlled ProductFormula:C9H6F2O2Color and Shape:NeatMolecular weight:184.14Tipiracil Hydrochloride
CAS:Controlled Product<p>Applications Tipiracil Hydrochloride serves as a treatment for metastatic colorectal cancer (mCRC). A thymidine phosphorylase inhibitor.<br>References Sugita, K., et al.: Oncol., 91, 224-230 (2016); van der Velden, D. L., et al.: Clin. Cancer Res., 22, 2835-2839 (2016)<br></p>Formula:C9H11ClN4O2·(HCl)Color and Shape:White To Off-WhiteMolecular weight:242.66 + (36.46)5-Acetyl-2-propyl-1H-Imidazole-4-carboxylic Acid Ethyl Ester
CAS:Controlled Product<p>Applications 5-Acetyl-2-propyl-1H-Imidazole-4-carboxylic Acid Ethyl Ester is used in the synthetic preparation of imidazole-5-carboxylic acids bearing alkyl, alkenyl, and hydroxyalkyl substituents at the 4-position and their related compounds.<br>References Yanagisawa, H., et al.: J. Med. Chem., 39, 323 (1996);<br></p>Formula:C11H16N2O3Color and Shape:NeatMolecular weight:224.26N-Nitroso Amodiaquine
Controlled ProductFormula:C20H21ClN4O2Color and Shape:NeatMolecular weight:384.859Zosuquidar Trihydrochloride
CAS:Controlled Product<p>Applications Multi-drug resistance (MDR) modulator; selective inhibitor of P-glycoprotein (P-gp). Antineoplastic adjunct (chemosensitizer).<br>References Green, L.J., et al.: Biochem. Pharmacol., 61, 1393 (2001), Shepard, R.L., et al.: Int. J. Cancer, 103, 121 (2003),<br></p>Formula:C32H31F2N3O2·3ClHColor and Shape:NeatMolecular weight:636.993-(Dibenzo[b,e]oxepin-11(6H)yl)-N,N-dimethylpropan-1-amine Hydrochloride
CAS:Controlled Product<p>Applications 3-(Dibenzo[b,e]oxepin-11(6H)yl)-N,N-dimethylpropan-1-amine Hydrochloride is an impurity of Doxepin (D550000), which is used clinically to treat anxiety and depression and is classified as an antidepressant.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Ribbentrop, A., et al.: Arzneim.-Forsch., 15, 863 (1965); Hobbs, D.C., et al.: Biochem. Pharmacol., 18, 1941 (1969); Pinder, R.M., et al.: Drugs, 13, 161 (1977); Shrivastava, R.K., et al.: Clin. Ther., 7, 181 (1985)<br></p>Formula:C19H23NO•(HCl)Color and Shape:NeatMolecular weight:281.393646Fenpropimorph
CAS:Controlled Product<p>Applications Systemic fungicide for control of powdery mildew, rust in cereal crops.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Baloch, R.I., et al.: Phytochemistry, 23, 2219 (1984), Pommer, E.-H., et al.: Pestic. Sci., 15, 285 (1984),<br></p>Formula:C20H33NOColor and Shape:ColourlessMolecular weight:303.485’-Hydroxyphenyl Carvedilol
CAS:<p>Applications A metabolite of Carvedilol (C184625). It is used in the treatment of hypertension.<br>References Sponer, G., et al.: J. Cardiovasc. Pharmacol., 9, 317 (1987), Fujimaki, M., ET AL.: Xenobiotica, 20, 1025 (1990), Ruffolo, R., et al.: Eur. J. Clin. Pharmacol., 38, S82 (1990), Schaefer, W.H., et al.: Drug Metab. Dispos., 26, 10, 958 (1998),<br></p>Formula:C24H26N2O5Color and Shape:NeatMolecular weight:422.471-Nitroso-4-phenylpiperazine
CAS:Controlled Product<p>Applications Metabolite of N-Phenylpiperazine (P336040) found in wastewater treatment facilities.<br>References Jung, C. et al., Appl. Environ. Microb., 74, 6147 (2008)<br></p>Formula:C10H13N3OColor and Shape:NeatMolecular weight:191.23Levofloxacin Hydroxy Acid
CAS:Controlled Product<p>Applications Levofloxacin Hydroxy Acid is found in the synthesis of Levofloxacin (L360000), S-(-)-form of Ofloxacin. An antibiotic used against gram-negative organisms.<br>References Kato, M., et al.: Arzneim.-Forsch., 42, 365 (1992), North, D.S., et al.: Pharmacotherapy, 18, 915 (1998), Hwang, D.G., et al.: Br. J. Ophthalmol., 87, 1004 (2003),<br></p>Formula:C18H21F2N3O4Color and Shape:Light YellowMolecular weight:381.3738Safinamide-d4
CAS:Controlled Product<p>Applications Safinamide-d4 is a labelled analogue of Safinamide. Safinamide is a potent and selective MAO-B inhibitor, and is used as an add-on treatment to treat Parkinson’s disease.<br>References Finberg, J.P.M., et al.: Front Pharmacol., 7, 340-54 (2016);<br></p>Formula:C17D4H15FN2O2Color and Shape:NeatMolecular weight:306.368Quetiapine Carboxylate Impurity
CAS:Controlled Product<p>Applications Quetiapine Carboxylate is an impurity of Quetiapine Hemifumarate (Q510000), an atypical antipsychotic agent used for the treatment of patients with schizophrenia, biopolar disorder and to treat major depressive disorder.<br>References Wetzel, H., et al.: Psychopharmacol., 119, 231 (1995); Bharathi, C., et al.: Pharmazie., 63, 14 (2008);<br></p>Formula:C22H25N3O4SColor and Shape:Light Orange ColourMolecular weight:427.52cis-Hydroxy Solifenacin N-Oxide(Mixture of Diastereomers)
Controlled Product<p>Applications Solifenacin (S676700) metabolite.<br></p>Formula:C23H26N2O4Color and Shape:NeatMolecular weight:394.464-Methyl Irinotecan
Controlled Product<p>Applications 4-Methyl Irinotecan, is an impurity of Irinotecan (I767500), a DNA topoisomerase inhibitor.<br>References Kunimoto, T., et al.: Cancer Res., 47, 5944 (1987), Shimada, Y., et al.: J. Clin. Oncol., 11, 909 (1993)<br></p>Formula:C34H40N4O6Color and Shape:NeatMolecular weight:600.70(S)-Propyl Pramipexole
CAS:Controlled Product<p>Applications (S)- Propyl Pramipexole is (S)-Pramipexole (P700750) analogue. (S)-Pramipexole (P700750) is a dopamine-D2-receptor agonist. Antiparkinsonian. Pramipexole (Mirapex, Mirapexin, Sifrol) is a non-ergoline dopamine agonist indicated for treating early-stage Parkinson's disease (PD) and restless legs syndrome (RLS).[1] It is also sometimes used off-label as a treatment for cluster headache and to counteract the problems with sexual dysfunction experienced by some users of the selective serotonin reuptake inhibitor (SSRI) antidepressants.<br>References Mierau, J., et al.: J. Med. Chem., 30, 494 (1987);Schilling, J.C., et al.: Clin. Pharmacol. Ther., 51, 541 (1992);Kieburtz, K., et al.: J. Am. Med. Assoc., 278, 125 (1997);<br></p>Formula:C13H23N3SColor and Shape:NeatMolecular weight:253.412-(1-aminocyclohexyl)acetic acid
CAS:Controlled ProductFormula:C8H15NO2Color and Shape:NeatMolecular weight:157.21Manidipine
CAS:Controlled Product<p>Applications A dihydropyridine calcium channel blocker. Antihypertensive.<br>References Meguro, K., et al.: Chem. Pharm. Bull., 33, 3787 (1985), Mizuno, K., et al.: Curr. Ther. Res., 52, 248 (1992)<br></p>Formula:C35H38N4O6Color and Shape:Off White PowderMolecular weight:610.705-Methyl-5-propyl-2-dioxanone (80%)
CAS:Controlled Product<p>Stability Moisture Sensitive<br>Applications An intermediate in the synthesis of Carisoprodol.<br></p>Formula:C8H14O3Purity:80%Color and Shape:NeatMolecular weight:158.193,3'-Sulfonylbis(N-(4-cyano-3-(trifluoromethyl)phenyl)-2-hydroxy-2-methylpropanamide)(Mixture of Diastereomers)
CAS:Controlled Product<p>Impurity Bicalutamide EP Impurity K / Bicalutamide EP Impurity L<br>Applications 3,3'-Sulfonylbis(N-(4-cyano-3-(trifluoromethyl)phenyl)-2-hydroxy-2-methylpropanamide) is an impurity of Bicalutamide (B382000); a non-steroidal peripherally active antiandrogen. Also used as an antineoplastic (hormonal).<br>References Tucker, H., et al.: J. Med. Chem., 31, 954 (1988); Cockshott, I.D., et al.: Eur. Urol., 18, Suppl. 3, 10 (1990); Cockshott, I., et al.: Br. J. Clin. Pharm., 36, 339 (1993); McKillop, D., et al.: Xenobiotica, 25, 623 (1995)<br></p>Formula:C24H20F6N4O6SColor and Shape:NeatMolecular weight:606.494-(1-Methylethenyl)-2-propyl-1H-imidazole-5-carboxylic Acid Ethyl Ester
CAS:Controlled Product<p>Applications Olmesartan intermediate.<br>References Yanagisawa, H., et al.: J. Med. Chem., 39, 323 (1996),<br></p>Formula:C12H18N2O2Color and Shape:NeatMolecular weight:222.28Mosapride-d5
CAS:Controlled Product<p>Applications A labelled selective 5-HT4 receptor agonist. Gastroprokinetic.<br>References Yoshida, N., et al.: Arch. Int. Pharmacodyn. Ther., 300, 51 (1989), Yatera, S., et al.: Japan. Pharmacol. Ther., 21, 21 (1993), Ruth, M., et al.: Aliment Pharmacol. Ther., 12, 35 (1998),<br></p>Formula:C21H20D5ClFN3O3Color and Shape:NeatMolecular weight:426.923-Hexyl Chloroformate (>80%)
CAS:<p>Stability Air Sensitive, Moisture Sensitive<br>Applications 3-Hexyl Chloroformate is a potential impurity in the synthesis of Dabigatran Etexilate Mesylate (D100150); a nonpeptide and direct thrombin inhibitor. Antithrombotic.<br>References Zheng, Y., et al.: Org. Process Res. Dev., 18, 744 (2014); Hauel, N., et al.: J. Med. Chem., 45, 1757 (2002); Mungall, D., et al.: Curr. Opin. Invest. Drugs, 3, 095 (2002); Stangier, J., et al.: J. Clin. Pharmacol., 45, 555 (2005)<br></p>Formula:C7H13ClO2Purity:>80%Color and Shape:NeatMolecular weight:164.632-((3-Fluoro-4-(methylcarbamoyl)phenyl)amino)-2-methylpropanoic acid
CAS:Controlled Product<p>Applications 2-((3-Fluoro-4-(methylcarbamoyl)phenyl)amino)-2-methylpropanoic acid (cas# 1289942-66-0) is a useful research chemical.<br></p>Formula:C12H15FN2O3Color and Shape:NeatMolecular weight:254.26rac-Rupatadine Pyridinium Fumarate Adduct Inner
CAS:Controlled ProductFormula:C30H30ClN3O4Color and Shape:NeatMolecular weight:532.03S-(s)-Verapamil-D6
CAS:Controlled Product<p>Applications Labelled S-Verapamil (V124991). Both isomers inhibit the p-glycoprotein efflux pump in multidrug resistant tumor cells.<br>References Peroutka, S., et al.: J. Ann. Neurol, 23, 500 (1988), Eliason, J.F., et al.: Int. J. Cancer, 46, 113 (1990),<br></p>Formula:C27H33D6ClN2O4Color and Shape:NeatMolecular weight:497.1
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