Nucleosides and Nucleotides
Nucleosides are compounds formed by a nitrogenous base linked to a sugar (ribose or deoxyribose). When a phosphate group is added to the nucleoside, a nucleotide is formed. These compounds are essential in cellular biology, as nucleotides are the fundamental building blocks of DNA and RNA, responsible for storing and transmitting genetic information. Nucleosides have applications in the treatment of viral diseases, acting as inhibitors of viral replication. Nucleotides, besides their structural role in nucleic acids, are involved in energy processes, such as ATP synthesis.
At CymitQuimica, we offer a wide range of nucleosides and nucleotides essential for research in molecular biology, virology, and pharmacology.
Found 3427 products of "Nucleosides and Nucleotides"
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Emtricitabine Tenofovir Monosoproxil
Controlled Product<p>Stability Hygrscopic<br>Applications Emtricitabine Tenofovir Monosoproxil is a derivative of Emtricitabine (E525000). Emtricitabine is a reverse transcriptase inhibitor. It is an effective antiviral agent against HIV, HBV, and other viruses replicating in a similar manner.<br>References FASEB J., 13, 1511 (1999), Molina, J.-M., et al.: J. InfecSchinazi, R.F., et al.: Antimicrob. Ag. Chemother., 36, 2423 (1992), Shockeor, J.P., et al.: Xenobioica, 26, 189 (1996), Feng, J.Y., et al.: . Dis., 182, 599 (2000)<br></p>Formula:C23H32FN8O10PSColor and Shape:NeatMolecular weight:662.58Canagliflozin
CAS:Controlled Product<p>Applications Canagliflozin is a sodium/glucose cotransporter 2 (SGLT2) inhibitor. Canagliflozin has been shown to dose dependently reduce calculated renal threshold for glucose excretion and increase urinary glucose excretion. Canagliflozin is a candidate for the treatment of type 2 diabetes and obesity.<br>References Chao, E. et al.: Drug Fut., 36, 351 (2011); Sha, S. et al.: Diab. Obes. Metab., 13, 669 (2011); Kipnes, M.S.: Clin. Invest., 1, 145 (2011);<br></p>Formula:C24H25FO5SColor and Shape:ColourlessMolecular weight:444.52L-Valacyclovir Hydrochloride
CAS:Controlled Product<p>Applications Acyclovir (A192400) impurity. The L-Valine ester prodrug of Acyclovir.<br>References Beauchamp, L.M., et al.: Antiviral Chem. Chemother., 3, 157 (1992), Weller, S., et al.: Clin. Pharmacol. Ther., 54, 595 (1996), Lowance, D., et al.: N. Engl. J. Med., 340, 1462 (1999),<br></p>Formula:C13H20N6O4·ClHColor and Shape:White To Off-WhiteMolecular weight:360.80Famciclovir-d4
CAS:Controlled Product<p>Applications A deuterated prodrug of Penciclovir (P221500), which is used as an antiviral.<br>References Hodge, V.R.A., et al.: Antimicrob. Ag. Chemother., 33, 1765 (1989),<br></p>Formula:C142H4H15N5O4Color and Shape:Off-White To Light BeigeMolecular weight:325.36N6-Isopentenyladenosine
CAS:<p>Applications N6-Isopentenyladenosine has antiproliferative activity on MCF-7 breast cancer cells.<br>References Rajabi, M. et al.; DNA Cell Biol.; 29, 687 (2010)<br></p>Formula:C15H21N5O4Color and Shape:NeatMolecular weight:335.365-Fluorodihydropyrimidine-2,4-dione-13C,15N2
CAS:Controlled Product<p>Applications A labelled metabolite of 5-Fluorouracil (F596000).<br>References Bocci, G., et al.: Eur. J. Clin. Pharmacol., 58, 593 (2002), Longley, D.B., Nature Rev. Cancer, 3, 330 (2003), Fischel, J., et al.: Anti-Cancer Drugs, 15, 969 (2004)<br></p>Formula:C313CH5F15N2O2Color and Shape:Off-White To Light BrownMolecular weight:135.071-α-Methyl Dapagliflozin
CAS:<p>Stability Hygroscopic<br>Applications 1α-Methyl Dapagliflozin is an antidiabetic agent and intermediate of Dapagliflozin (D226255]), a sodium-glucose transporter 2 inhibitor.<br>References Kasichayanula, S. et al.: Diabetes, Obesity and Metabolism 13, 47 (2011); Bernhardson, D. et al.: Org. Proc. Res. Dev., 18, 57 (2014);<br></p>Formula:C22H27ClO7Color and Shape:WhiteMolecular weight:438.90Dapagliflozin
CAS:<p>Stability Hygroscopic<br>Applications A sodium-glucose transporter 2 inhibitor.<br>References Kasichayanula, S. et al.: Diabetes, Obesity and Metabolism 13, 47 (2011)<br></p>Formula:C21H25ClO6Color and Shape:NeatMolecular weight:408.87Ribavirin 5’-Monophosphate Dilithium Salt (90%)
CAS:Controlled Product<p>Applications A metabolite of Ribavirin.<br>References Allen, L.B., et al.: J. Med. Chem., 21, 742 (1978), Zimmerman, T., et al.: Biochem. Pharmacol., 27, 709 (1978), Page, T., et al.: Int. J. Biochem., 22, 379 (1990), Lin, C., et al.: Antimicrob. Agents Chemother., 47, 1395 (2003),<br></p>Formula:C17H19N4O9P·2LiPurity:90%Color and Shape:Off-White To Light BeigeMolecular weight:468.21O6-Benzylguanine
CAS:Controlled Product<p>Applications An irreversible inhibitor of the mammalian DNA repair protein, O6-alkylguanine-DNA alkyltransferase. Assists in the protection against carcinogenic and therapeutic alkylating agents.<br>References Dolan, M.E., et al.: Proc. Natl. Acad. Sci. USA, 87, 5356 (1990), Goodtzova, K., et al.: Biochemistry, 33, 385 (1994), Elder, R.H., et al.: Biochem. J., 298, 231 (1994)<br></p>Formula:C12H11N5OColor and Shape:NeatMolecular weight:241.25α-Ribavirin (Ribavirin Impurity B)
CAS:Controlled ProductFormula:C8H12N4O5Color and Shape:NeatMolecular weight:244.20Methyl 2-Deoxy-D-ribofuranoside
CAS:Controlled ProductFormula:C6H12O4Color and Shape:NeatMolecular weight:148.16L-Alanine 2-Ethylbutyl Ester Hydrochloride
CAS:Controlled Product<p>Applications L-Alanine 2-Ethylbutyl Ester Hydrochloride is used in the synthesis of phosphoramidate prodrug of a pyrrolo[2,1-f][triazin-4-amino] adenine C-nucleoside (GS-5734) for the treatment of ebola and emerging viruses.<br>References Siegel, D., et al.: J. Med. Chem., 60, 1648-1661 (2017)<br></p>Formula:C9H19NO2·ClHColor and Shape:NeatMolecular weight:209.7136Methyl p-Toluate
CAS:Controlled Product<p>Stability Unstable in Solution<br>Applications Methyl p-toluate is an impurity of 3-Toluoyl Decitabine (T536260), which is an intermediate of decitabine (A796950 for β-Decitabine). It is used as cancer treatment, in particular to inhibit the growth of pancreatic endocrine tumor cell lines.<br>References Deng, T., et al.: Life Sci., 84, 311 (2009), Horne, H., et al.: Mol. Cancer Res., 7, 199 (2009), Zinner, R., et al.: Mol. Cancer Ther., 8, 521 (2009),<br></p>Formula:C9H10O2Color and Shape:NeatMolecular weight:150.17Adenine Hemisulfate
CAS:Controlled Product<p>Stability Hygroscopic<br>Applications Adenine Hemisulfate can be one of the factors that influence in vitro growth and shoot multiplication of pomegranate. It can be used in biological study along with varied levels of sucrose, light intensity, and MS medium hydrogen ion concentration where those factors can all significantly influence multiplication and growth of Punica granatum shoots.<br>References Singh, P., & Patel, R., M.: Bioscan, 9, 1031-1035 (2014)<br></p>Formula:C5H5N5·SO4H2Color and Shape:NeatMolecular weight:368.333'-Azido-3'-deoxythymidine β-D-glucuronide, Sodium Salt
CAS:Controlled Product<p>Stability Hygroscopic<br>Applications A metabolite of the potent and selective inhibitor of HIV-1 replication, AZT.<br></p>Formula:C16H20N5O10·NaColor and Shape:White To Light YellowMolecular weight:465.35Cabotegravir O-β-D-Glucuronide
CAS:Controlled Product<p>Applications Cabotegravir O-β-D-Glucuronide is a metabolite of Cabotegravir (C050100), a long acting HIV-1 integrase inhibitor with action against a broad range of HIV subtypes.<br>References Yoshinaga, T. et al.: Antimicrob, Agents Chemother., 59, 397 (2015); Andrews, C. et al.: Sci. Transl. Med., 7, 270 (2015)<br></p>Formula:C25H25F2N3O11Purity:>80%Color and Shape:NeatMolecular weight:581.48Acyclovir Formacetal Dimer (>90%)
<p>Impurity Aciclovir EP Impurity R<br>Applications Acyclovir Formacetal Dimer is a dimer impurity of Acyclovir (A192400); an orally active acyclic nucleoside with inhibitory activity towards several herpes viruses. Also antiviral. (Aciclovir EP Impurity R)<br>References Collins, P., et al.: J. Antimicrob. Chemother., 5, 431 (1979); Matsumoto, H., et al.: Chem. Pharm. Bull., 36, 1153 (1988); Whitley, R.J., et al.: N. Engl. J. Med., 327, 782 (1992)<br></p>Formula:C17H22N10O6Purity:>90%Color and Shape:NeatMolecular weight:462.422’-Deoxyadenosine
CAS:<p>Applications 2prime-Deoxyadenosine is a nucleoside adenosine derivative with mutagenic properties.<br></p>Formula:C10H13N5O3Color and Shape:White To Off-WhiteMolecular weight:251.242N,O-Diacetyllamivudine
CAS:Controlled ProductFormula:C12H15N3O5SColor and Shape:Off-WhiteMolecular weight:313.33N-Nitrosodiethylamine (100 ug/mL in Methanol)
CAS:Controlled ProductFormula:C4H10N2OColor and Shape:Single SolutionMolecular weight:102.14Famciclovir
CAS:Controlled Product<p>Applications Used as an antiviral. Prodrug of Penciclovir (P221500).<br>References Hodge, V.R.A., et al.: Antimicrob. Ag. Chemother., 33, 1765 (1989),<br></p>Formula:C14H19N5O4Color and Shape:Off-WhiteMolecular weight:321.33Oxiracetam
CAS:Controlled Product<p>Applications Nootropic. Analog of Piracetam with psychostimulant activity.<br>References Son, J., et al.: J. Pharm. Biomed. Anal., 36, 657 (2004), Hlinak, Z., et al.: Behaviour. Brain Res., 161, 213 (2005),<br></p>Formula:C6H10N2O3Color and Shape:NeatMolecular weight:158.16Melphalan Hydrochloride
CAS:Controlled Product<p>Stability Moisture Sensitive<br>Applications Melphalan Hydrochloride is used in combined intravitreal chemotherapy with topotecan hydrochloride for viable vitreous seeding from retinoblastoma. Also, it is an anti-cancer chemotherapy drug.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Ghassemi, F., et al.: JAMA Ophthalmol., 132, 936-941 (2014); Gao, L. P., et al.: Adv. Mater. Res., 781-784, 993-998 (2013);<br></p>Formula:C13H18Cl2N2O2·ClHColor and Shape:NeatMolecular weight:341.66Ribavirin-13C5
CAS:Controlled Product<p>Stability Hygroscopic<br>Applications Labelled Ribavirin (R414475). Purine nucleoside analog; inhibits inosine monophosphate dehydrogenase (IMPDH). Used as an antiviral agent.This compound is suitable for pyruvate dehydrogenase (PDH) related research.<br>References Fernandez, H., et al.: Eur. J. Epidemiol., 2, 1 (1986), Liao, H.J. and Stollar, V.: Antiviral Res., 22, 285 (1993), Honda, Y., et al.: Antimicrob. Agents Chemother., 38, 653 (1994), Reichard, O., et al.: Lancet, 351, 83 (1998)<br></p>Formula:C5C3H12N4O5Color and Shape:NeatMolecular weight:249.17Flavine Adenine Dinucleotide Disodium Salt
CAS:Controlled Product<p>Stability Hygroscopic<br>Applications The prosthetic group of certain flavoproteins including D-amino acid oxidase, glucose oxidase, glycine oxidase, fumaric hydrogenase, histaminase, and xanthine oxidase. Riboflavin kinase tumor necrosis factor receptor 1 NADPH oxidase.<br>References DeLuca, K., et al.: J. Biol. Chem., 223, 569 (1956), Yagi, K., et al.: Biochemistry, 19, 1553 (1980), Li, G., et al.: J. Phys. Chem., 112, 4573 (2008),<br></p>Formula:C27H31N9O15P2·2NaColor and Shape:NeatMolecular weight:829.516,6'-Thiobis-9H-purine
CAS:Controlled Product<p>Applications 6,6'-Thiobis-9H-purine is used in the study of the activity of topoisomerase IIα.<br>References Jensen, L.H., et al.: Molecular Pharmacology, 70, 1503 (2006);<br></p>Formula:C10H6N8SColor and Shape:NeatMolecular weight:270.27Adenosine-1'-13C
CAS:Controlled ProductFormula:CC9H13N5O4Color and Shape:White To Off-WhiteMolecular weight:268.234Adenosine 5'-Triphosphate Disodium Salt
CAS:<p>Stability Hygroscopic, Temperature Sensitive<br>Applications A metabolite of Adenosine (A280400), a multifunctional nucleoside triphosphate used in cells as a coenzyme of intracellular energy transfer. It transports chemical energy within cells for metabolism.<br>References Knowles, J., et al.: Annu. Rev. Biochem., 49, 877 (1980),<br></p>Formula:C10H14N5O13P3·2NaColor and Shape:NeatMolecular weight:569.16Ethoxy-5-fluoro-4(3H)-pyrimidinone
CAS:Controlled Product<p>Impurity Fluorouracil EP Impurity F<br>Applications Ethoxy-5-fluoro-4(3H)-pyrimidinone (Fluorouracil EP Impurity F) is a derivative of 5-fluorouracil (3C,15N2 labelled, F596002) which is a potent antineoplastic agent in clinical use.<br>References Rudy, B.C., et al.: Anal. Profiles Drug Subs., 2, 221 (1973), Miyashita, O., et al.: Chem. Pharm. Bull., 29, 3181 (1981), Hansen, R.M., et al.: Cancer Invest., 9, 637 (1991),<br></p>Formula:C6H7FN2O2Color and Shape:NeatMolecular weight:158.132’-Deoxy Cytidine-5,6-d2
CAS:Controlled ProductFormula:C9D2H11N3O4Color and Shape:NeatMolecular weight:229.23Hypoxanthine
CAS:Controlled Product<p>Applications A naturally occurring purine derivative. Pharmaceuticals, Intermediates & Fine Chemicals<br>References Jansen, R., et al.: Clin. Biochem., 38, 362 (2005), Vorst, O., et al.: Metabolomics, 1, 169 (2005), Want, E., et al.: ChemBioChem., 6, 1941 (2005), van der Werf, M., et al.: Anal. Biochem., 370, 17 (2007),<br></p>Formula:C5H4N4OColor and Shape:NeatMolecular weight:136.11Ademethionine 1,4-Butanedisulfonate
CAS:Controlled Product<p>Stability Hygroscopic<br>Applications Ademethionine 1,4-Butanedisulfonate is used in the synthesis of sulfonio-adenosyl-L-methionine (SAMe) salts.<br></p>Formula:C15H22N6O5S·3C4H10O6S2Color and Shape:NeatMolecular weight:1451.62epi-Canagliflozin
CAS:Controlled Product<p>Applications epi-Canagliflozin is an epimeric impurity of Canagliflozin which is a sodium/glucose cotransporter 2 (SGLT2) inhibitor and is used in the treatment of type 2 diabetes and obesity.<br>References Chao, E. et al.: Drug Fut., 36, 351 (2011); Sha, S. et al.: Diab. Obes. Metab., 13, 669 (2011); Kipnes, M.S.: Clin. Invest., 1, 145 (2011);<br></p>Formula:C24H25FO5SColor and Shape:NeatMolecular weight:444.52(1R,2R,5R)-2-Isopropyl-5-methylcyclohexanol
CAS:<p>Applications (1R,2R,5R)-2-Isopropyl-5-methylcyclohexanol is used in the tetrahydropyranylation of alcohols.<br>References Magyar, A. et al.: Catal. Lett., 145, 1876 (2015);<br></p>Formula:C10H20OColor and Shape:NeatMolecular weight:156.275-Chlorocytidine
CAS:Controlled ProductFormula:C9H12ClN3O5Color and Shape:NeatMolecular weight:277.66Creatinine-d3
CAS:Controlled Product<p>Applications Labelled Creatinine. The end product of creatine catabolism. Normal constituent of urine. Also found together with creatine in muscle tissues and blood. Occurs in all soils and in grain seeds and other vegetable matter. Has been found in certain fish and in crab meat extract.<br>References Folin, et al.: J. Biol. Chem., 17, 463 (1914),<br></p>Formula:C42H3H4N3OColor and Shape:Off-WhiteMolecular weight:116.14Acyclovir Monophosphate
CAS:<p>Stability Hygroscopic<br>Applications A nucleoside analog phosphates for topical use in the treatment of herpes virus infections. A topical treatment that seems to bypass a key mechanism responsible for resistance to Acyclovir.<br>References Furman, P., et al.: J. Virol., 32, 72 (1979), Darby, G., et al.: J. Gen. Virol., 48, 451 (1980),Prisbe, E., et al.: J. Med. Chem., 29, 671 (1986), Ellis, M., et al.: Antimicrob. Agents Chemother., 33, 304 (1989),<br></p>Formula:C8H12N5O6PColor and Shape:Off-WhiteMolecular weight:305.18Adenosine-3'-monophosphate
CAS:Controlled Product<p>Applications Adenosine-3'-monophosphate (cas# 84-21-9) is a useful research chemical.<br></p>Formula:C10H14N5O7PColor and Shape:NeatMolecular weight:347.22125-(Hydroxymethyl)-2’-deoxycytidine
CAS:Controlled Product<p>Applications 4-(Hydroxymethyl)-2’-deoxycytidine is a modified pyrimidine that is capable of producing interstrand cross-links in duplex DNA. 4-(Hydroxymethyl)-2’-deoxycytidine can be analyzed to quantify DNA hydroxymethylation levels in biological samples<br>References Peng, X. et al.: J. Am. Chem. Soc., 130, 10299 (2008); Berkner, K. et al.: J. Biol. Chem., 252, 3185 (1977); Le, T. et al.: Anal. Biochem., 412, 203 (2011);<br></p>Formula:C10H15N3O5Color and Shape:NeatMolecular weight:257.241’-epi-Entecavir
CAS:Controlled Product<p>Impurity Entecavir EP Impurity A<br>Applications An epimeric impurity of the antiviral drug Entecavir (E558900).<br></p>Formula:C12H15N5O3Color and Shape:NeatMolecular weight:277.279Emtricitabine S-Oxide (Mixture of Diastereomers)
CAS:Controlled Product<p>Applications A metabolite of (-)-Emtricitabine (E525000).<br>References Schinazi, R.F., et al.: Antimicrob. Ag. Chemother., 36, 2423 (1992); Shockeor, J.P., et al.: Xenobioica, 26, 189 (1996); Feng, J.Y., et al.: FASEB J., 13, 1511 (1999); Molina, J.-M., et al.: J. Infec. Dis., 182, 599 (2000);<br></p>Formula:C8H10FN3O4SColor and Shape:Off-WhiteMolecular weight:263.25Levomefolate Calcium
CAS:<p>Applications The calcium salt of L-5-methyltetrahydrofolic acid which belongs to the group of folate vitamins (Vitamin B9, Folacin). It is a coenzymated form of folic acid.<br>References Prinz-Langhebohi, R.: et al., Br. J. Pharmac., 158, 2014 (2009); Wright, A. et al.: Brit, J. Nutrit., 103, 724 (2010);<br></p>Formula:C20H23N7O6·CaColor and Shape:Off-WhiteMolecular weight:497.52D-Ribose
CAS:Controlled Product<p>Applications D-Ribose is produced by microorganism fermentation of glucose in a fermentation culture medium without adding calcium carbonate.<br>References Ostrowski, S., et al.: Science, 305, 71 (2004), Vavilin, D., et al.: Biochim. Biophys. Acta, 1708, 91 (2005), Fletcher, J., et al.: Anal. Chem., 79, 2199 (2007), Weissleder, R., et al.: Nature, 452, 580 (2008),<br></p>Formula:C5H10O5Color and Shape:NeatMolecular weight:150.132-Phenylamino Adenosine
CAS:Controlled Product<p>Applications A selective A2-adenosine receptor agonist. Coronary vasodilator, antihypertensive and antipsychotic following systemic administration in vivo.<br>References Martin, et al.: Pharmacol. Biochem. Behav., 45, 951 (1993<br></p>Formula:C16H18N6O4Color and Shape:NeatMolecular weight:358.35Adenosine 2’,3’-Cyclic Phosphate Triethylammonium Salt
CAS:<p>Applications A 2',3'-cyclic nucleotide phosphodiester.<br>References Voegtli, W., et al.: Biochemistry, 39, 15365 (2000), Bernstein, N., et al.: Mol. Cell, 17, 657 (2005), Blondal, T., et al.: J. Biol. Chem., 280, 5188 (2005), Shenoy, A., et al.: J. Mol. Biol., 365, 211 (2007),<br></p>Formula:C16H27N6O6PColor and Shape:NeatMolecular weight:430.48-Cyclopentyl-1,3-dipropylxanthine
CAS:Controlled Product<p>Applications DPCPX is a potent and very selective A1-adenosine receptor antagonist, with a Ki of 0.46 nM for A1 receptors in rat whole-brain membranes. Its 740-fold A1-selectivity is the highest reported for an adenosine antagonist.<br>References Gessi, S., et al.: Mol. Pharmacol., 67, 2137 (2005), Minor, T.R., et al.: Behav. Neurosci., 122, 1236 (2008), Gracia, E., et al.: J. Neurochem., 107, 161 (2008), Gessi, S., et al.: Biochem. Pharmacol., 75, 562 (2008),<br></p>Formula:C16H24N4O2Color and Shape:NeatMolecular weight:304.391-Chloro-2-[(4-ethoxyphenyl)methyl]benzene
CAS:Controlled ProductFormula:C15H15ClOColor and Shape:NeatMolecular weight:246.732Adenosine Monophosphate (mixture of 2'(3')-phosphate isomers)-13C5 Sodium Salt
CAS:Controlled Product<p>Applications Labelled AMP mixture<br>References Jackson, E.K. et al.: Hypertension, 56, 151 (2010); Jackson, E.K. et al: J. Bio. Chem., 284, 33097 (2009);<br></p>Formula:C513C5H14N5O7P•x(Na)Color and Shape:NeatMolecular weight:352.182299
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