Sulfonamides and Derivatives

Applications Labelled p-Phenetidine (P296300). A toxic metabolite of Phenacetin (P294580) which exhibits high renal toxicity. p-Phenetidine also reduced COX-1 and COX-2 expression in neutrophils.
References Green, C., et al.: Br. Med. J., 1, 162 (1969), Nelson, S., et al.: J. Med. Chem., 25, 753 (1982), Nicholls, A., et al.: Xenobiotica, 27, 1175 (1997),

Applications Labelled Sulfasalazine (S699084). An anti-inflammatory (gastrointestinal). Sulfasalazine has been used in granulomatous colitis.
References Schroder, H., et al.: Clin. Pharmacol. Ther.,13, 539 (1972), McDonnell, J.P., et al.: Anal. Profiles Drug Subs., 5, 515 (1976), Klotz, U., et al.: Clin. Pharmacokinet.,10, 285 (1985),

Impurity Brinzolamide O-Desmethyl Impurity
Applications O-Desmethyl Brinzolamide is a derivative of Brinzolamide (B677601), a carbonic anhydrase inhibitor that is used as an ocular topical treatment for patients experiencing intraocular pressure. Brinzolamide reduces pressure by reducing the rate of aqueous humour formation.
References Cvetkovic, R. & Perry, C.: Drugs & Aging, 20, 919 (2003); Ermis, S., et al.: Eye, 19, 303 (2005); Silver, L., et al.: Surv. Ophthalmol., 44, S147 (2000)

Applications An antibacterial used in the treatment of dermatitis herpetiformis.
References Francis, J., et al.: Br. J. Pharmacol., 5, 565 (1950), Uetrecht, J., et al.: Clin. Dermatol., 7, 111 (1989); Reszka, K., et al.: Chem. Res. Toxicol., 22, 1137 (2009), Santos, J., et al.: Bioorg. Med. Chem., 17, 3795 (2009), Varma, M., et al.: J. Med. Chem., 52, 4844 (2009),

Applications Antibacterial. This compound is a contaminant of emerging concern (CECs).
References Manius, G.J., et al.: Anal. Profiles Drug Subs., 7, 445 (1978), Roth, B., et al.: J. Med. Chem., 23, 379 (1980), Brogden, R.N., et al.: Drugs, 23, 405 (1982),

Applications A major active metabolite related to the adverse effects of Sulfasalazine in human serum.
References Stenson, W., et al.: J. Clin. Invest., 69, 494 (1982), Bissonnette, E., et al.: J. Immunol., 156, 218 (1996), Hirohata, S., et al.: J. Neurol. Sci., 67, 115 (1985), Pullar, T., et al.: Br. Med. J., 290, 1535 (1985), Ireland, A., et al.: Clin. Sci., 78, 119 (1990),

Impurity Furosemide EP Impurity A
Applications Iso Furosemide (Furosemide EP Impurity A) is a Furosemide (F865000) derivative which enhanced urinary excretion of active kallikrein.
References Kirk, K., et al.: J. Biol. Chem., 267, 23475 (1992), Kirk, K., et al.: Biochem. J., 311, 761 (1995), Egee, S., et al.: J. Physiol., 542, 795 ( 2002),

Applications 2-Methylindoline is an intermediate in the production of various indole derivatives
References Severino, B., et al.: Bioorg. Med. Chem., 16, 6009 (2008); Zlotos, D., et al.: J. Med. Chem., 52, 826 (2009);

Applications Non-steroidal anti-inflammatory with long half-life. Cyclooxygenase inhibitor. Clinically useful NSAID. Piroxicam may be useful for chemoprevention of solid cancers via inhibition of cyclooxygenase. Statins, which are used clinically for anti-inflammation, immunomodulation, neuroprotection, and im-provement of bone metabolism, have “remarkable efficiency…as individual drugs or assistant medicines that affect cell viability by inducing apoptosis….”
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Carty, T.J., et al.: Prostaglandins, 47, 55 (1980), Brogden, R.N., et al.: Drugs, 22, 165 (1981), Mihalic, M., et al.: Anal. Profiles Drug Subs., 15, 509 (1986), Laneauville., O., et al.: J. Pharmacol. Exp. Ther., 271, 927 (1994); AAPS Newsmagazine p.17, July 2016

Applications Labelled Etodolac (E933100). Anti-inflammatory; analgesic.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Humber, L.G., et al.: Med. Res. Rev., 7, 1 (1987), Balfour, J.A, et al.: Drugs, 42, 274 (1991),

Applications The isotopically labelled antibacterial drug Sulfamethoxazole (S699086). Sulfonamide antibiotic that blocks the synthesis of dihydrofolic acid by inhibiting the enzyme dihydropteroate synthase.
References Rudy, B.C., et al.: Anal. Profiles Drug Subs., 2, 467 (1973), Wormser, G.P., et al.: Drugs, 24, 459 (1982), Wharton, M., et al.: Ann. Intern. Med., 105, 37 (1986),

Applications Sulfamethoxazole-13C6 is the isotope labelled analog of Sulfamethoxazole (S699086). An antibacterial drug. Sulfonamide antibiotic that blocks the synthesis of dihydrofolic acid by inhibiting the enzyme dihydropteroate synthase.
References Rudy, B.C., et al.: Anal. Profiles Drug Subs., 2, 467 (1973), Wormser, G.P., et al.: Drugs, 24, 459 (1982), Wharton, M., et al.: Ann. Intern. Med., 105, 37 (1986),

Impurity Glipizide EP Impurity B
Applications Cyclohexylamine (Glipizide EP Impurity B) is a building block for pharmaceuticals that has been used for the preparation of paromomycin analogs to be used as aminogycoside antibiotics.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Rosenblum, I., Rosenblum, G.: Toxicol. Appl. Pharm., 12, 260 (1968); Hanessian, S., et. al.: J. Med. Chem., 50, 2352 (2007)

Applications Trichlormethiazide, is a diuretic, having similar properties as Hydrochlorothiazide (H714560). It is used for the treatment of oedema (including that which is associated with heart failure, hepatic cirrhosis and corticosteroid therapy) and hypertension.
References Imamura, T., et al.: International Heart J., 54(1), 48 (2013); Takahashi, Y., et al.: Cardiovas. Diabetology, 10(1), 45 (2011);

Impurity Salmeterol EP Impurity B
Applications A novel antibacterial analog of the antibacterial drug Sulfamethoxazole (S699086).

Stability Hygroscopic
Applications Carbonic anhydrase inhibitor. Diuretic.
References Vitale, R., et al.: J. Med. Chem., 52, 5990 (2009), Bell, H., et al.: Am. J. Physiol., 297, R370 (2009), Maresca, A., et al.: Bioorg. Med. Chem. Lett., 19, 4929 (2009), Liu, Y., et al.: Anal. Bioanal. Chem., 395, 591 (2009),