Monosaccharides

<p>Glucose 6-phosphatase substrate</p>

<p>1-Octylamino-1-deoxy-D-glucitol is a natural product that is extracted from the bark of the tree Streptomyces griseorubens. It has been shown to have a diastereomeric ratio of 97:3 and an optical purity of 98%. The thermodynamic properties of this compound are determined by the reaction time, which can vary from 1 to 24 hours. The enantiomers are separated by chromatography or crystallization, and the solubility data is determined at 25°C.</p>

<p>Low-calorie sweetener; additive in detergents, cosmetics, and pharmaceuticals</p>

<p>Intermediate for the anomeric modification of Fuc, including fucosylation</p>

<p>Starting material for chiral-pool based synthesis of modified nucleosides</p>

<p>D-Mannose-6-phosphate disodium salt hydrate (DMDSP) is an endogenous pentose phosphate metabolite that is found in the human body. DMDSP is generated from the metabolism of mannose and glucose and functions as a regulator of metabolic intermediates. It has also been shown to inhibit bacterial growth and function as a competitive inhibitor of bacterial DNA gyrase, an enzyme that maintains the integrity of bacterial DNA. Genetic polymorphism in the DMDP gene may be associated with changes in response to DMDSP. The reductive amination reaction can be used to synthesize this compound from L-aspartic acid, malic enzyme, and nicotinamide adenine dinucleotide phosphate.</p>

N-Acetyl D-mannosamine (ManNAc) is an aldohexose (2-acetamido-2-deoxymannose) in which the axial hydroxyl group at position 2 is replaced by a N-acetyl group (Collins, 2006). It has been reported that N-acetyl D-mannosamine supplementation, may provide novel means to break the link between obesity and hypertension (Peng, 2019). N-Acetyl-D-mannosamine and N-acetyl-D-glucosamine are the essential precursors of sialic acid, the specific monomer of polysialic acid, a bacterial pathogenic determinant, for example, Escherichia coli K1 uses both amino sugars as carbon sources. Glycoproteins normally have some level of glycan sialylation, but incomplete sialylation can reduce their therapeutic effect when produced recombinantly. To improve performance, cell lines and culture media can be adjusted. The GNE enzyme controls the efficiency of sialylation in human cell lines, making it crucial for producing effective recombinant glycoprotein drugs. Adding ManNAc and other supplements to culture media improves sialylation, which boosts drug yield, increases stability and half-life, and lowers immune reactions by reducing antibody formation.It has also been reported that ManNAc can be used as a treatment for hereditary inclusion body myopathy, an adult-onset, progressive neuromuscular disorder and also for renal disorders involving proteinuria and hematuria due to podocytopathy and/or segmental splitting of the glomerular basement membrane (Galeano, 2007).

<p>1,3,4,6-Tetra-O-acetyl-a-D-glucopyranose is a synthon that is used as a synthetic intermediate for the synthesis of other compounds. It is also a reactive compound that can be used to synthesize carboxylic acids and hydroxy ketones by reaction with water or alcohols. 1,3,4,6-Tetra-O-acetyl-a-D-glucopyranose can also be converted into esters by reaction with alcohols.</p>

<p>4-Acetamidophenyl b-D-glucuronide sodium salt is a pharmaceutical drug that is a metabolite of acetaminophen. It can be detected in the urine by biochips, which are microarrays that contain immobilized binding sites for specific analytes. The analysis of 4-acetamidophenyl b-D-glucuronide sodium salt in urine is used to screen for the use of acetaminophen and to identify cytochrome P450 2C19 (CYP2C19) activity. This drug can also be detected by spectrometric methods using biochemical assays on plates or hepatocytes and mass spectrometric detection methods using liquid chromatography/mass spectrometry (LC/MS). Acetaminophen has been shown to have toxic effects on the liver, kidneys, and lungs in humans, as well as on diode photoluminescence.</p>

<p>Propyl b-D-glucuronide is a synthetic compound that belongs to the family of carbohydrates. It has a fluorinated hydroxyl group at the C3 position and an esterified carboxylic acid at the C1 position. This compound can be used as a building block for oligosaccharides and polysaccharides, which are complex carbohydrates. Propyl b-D-glucuronide is soluble in water and has a molecular weight of 176.</p>

<p>Quinovosamine hydrochloride (QNH) is a fatty acid that belongs to the group of galacturonic acid. It has been shown to be biologically active in wild-type strains and in some bacterial strains, including Pseudomonas aeruginosa. QNH has also been used for preparation of monoclonal antibodies directed against receptor activity, which are activated by QNH.</p>

<p>Resource for the synthesis of Clofarabine and other bioactive arabinosides</p>

<p>b-D-Xylopyranosyl azide is a device that records multimedia. It has been found that b-D-Xylopyranosyl azide can record audio, video, and data recordings by automated means. The renaming of multimedia files is also possible with b-D-Xylopyranosyl azide.</p>

<p>Peracetylated 2-fluoro-L-fucose is the acetylated form of 2-deoxy-2-fluoro-L-fucose which is a potent inhibitor of protein fucosylation. It exhibits improved cell permeability and is rapidly deacetylated into its active form, inside the cell. It is metabolised inside the cell into a corresponding donor substrate analogue of GDP-fucose or GDP-2FF, via the salvage pathway. GDP-2FF accumulates in the cell causing a shutdown of de novo pathway which leads to the desired fucosylation inhibition. The addition of 100 uM peracetylated-2-fluoro-L-fucose to plants severely inhibits root growth by 95% compared to an untreated plant, and is more potent compared to 2-fluoro-L-fucose.  The material is soluble in DMSO at 10mg/ml.</p>

<p>4-Methylphenyl 2,3,4,6-tetra-O-acetyl-b-D-thioglucopyranoside is an antibiotic that is used to treat infections caused by a wide range of pathogens. This drug is active against Gram-negative and Gram-positive bacteria, including some resistant strains. 4MPTGA inhibits the growth of bacteria by binding to their ribosomes and preventing protein synthesis. It has been shown to have antimicrobial activity against E. coli and other Enterobacteriaceae species as well as other Gram negative bacteria such as Salmonella typhi and Proteus mirabilis. 4MPTGA has also been shown to be effective against the common animal health pathogen Staphylococcus aureus</p>

<p>L-Rhamnose diethyl mercaptal is an antiperspirant and deodorant that is used in combination with other ingredients to reduce or eliminate body odor. It is a supplement, often found in combinations with other compounds such as neodymium and radium. This compound works by preventing the formation of sweat from the apocrine glands, which reduces underarm wetness and body odor. L-Rhamnose diethyl mercaptal also has antimicrobial properties that help prevent bacterial growth on the skin surface.</p>

<p>N-(2,4-Dinitrophenyl-deoxygalactonojirimycin is a complex carbohydrate that has been modified with methylation, glycosylation, and click modification. It has an Oligosaccharide chain and a CAS number of 888315-21-2. N-(2,4-Dinitrophenyl-deoxygalactonojirimycin is a high purity product that is available in the form of a white solid.</p>

<p>Methyl 4,6-O-benzylidene-a-D-mannopyranoside is a hexadecanoic acid that is mediated by the target cell. It has been shown to inhibit the growth of bacteria and cancer cells in vitro. Methyl 4,6-O-benzylidene-a-D-mannopyranoside also possesses an antibacterial activity with a low mammalian toxicity. This compound is hydrolyzed by esterases or glucuronidases, oxidized by cytochrome P450 enzymes, reduced by glutathione reductase, or conjugated with glucuronic acid. The residue of this compound has been shown to be carcinogenic in vivo and in vitro. Anticancer activity of this compound may be due to its ability to disrupt DNA synthesis and induce apoptosis of cancer cells.</p>

<p>N-Acetyl-L-xylosamine is a custom synthesis of a glycosylation product that contains an acetyl group and a xylosamine. It is used as a building block for the synthesis of complex carbohydrates. N-Acetyl-L-xylosamine can be modified with fluorination, saccharide, modification, sugar, or oligosaccharide to create custom products.</p>

<p>1,2,3,4-Tetra-O-acetyl-6-S-acetyl-6-deoxy-6-thio-b-D-glucopyranose is a synthetic compound that is used as a building block for the synthesis of other compounds. It is an acetylated oligosaccharide that can be modified with fluorine atoms to form 1,2,3,4-tetra-[F]fluoro-[F]deoxy-[F]thio-[F]hexose. This product has high purity and can be used in glycosylation reactions.</p>