Pharmaceutical and Veterinary Compounds and Metabolites

<p>Cortisone Acetate is a synthetic or semisynthetic analog of the naturally occurring cortisone hormone produced by the adrenal glands with anti-inflammatory and</p>

<p>Vitamin K1 (Phylloquinone) a fat-soluble, naturally occurring vitamin with antihemorrhagic and prothrombogenic activity.</p>

<p>Flavone (2-Phenyl-4-chromone) have effects on CYP (P450) activity which are enzymes that metabolize most drugs in the body.</p>

<p>Oleoylethanolamide (N-Oleoylethanolamide) is a high affinity endogenous agonist of PPAR-α.</p>

<p>Sucralose (Trichlorosucrose), an artificial sweetener, is not degraded by the body, so it is noncaloric.</p>

<p>L-Glutathione reduced (Glutathione) is a naturally occurring tripeptide found in cells as an endogenous antioxidant that scavenges oxygen free radicals.</p>

<p>5-Cholestene-26-oic acid-3β-ol is a cholesterol catabolite [1] .</p>

<p>Suberylglycine is an acyl glycine that is a normally minor metabolite of fatty acid.</p>

<p>Arylsulfatase, a type I sulfatase enzyme found in both prokaryotes and eukaryotes, is frequently utilized in biochemical research [1].</p>

<p>GlcNAc kinase (EcNagK), ATP-dependent, phosphorylates C-6 hydroxyl on GlcNAc, producing GlcNAc-6-P.</p>

<p>ent-Prostaglandin F2α is the enantiomer of PGF2α and is found in urine.</p>

<p>ScHEX1, a glycolytic hexokinase, is blocked by n-acetylglucosamine, detaching from the mitochondrial membrane and activating NLRP3 inflammasome.</p>

<p>PGK is an enzyme that catalyzes phosphate transfer between 1,3-BPG and ADP, vital in glycolysis and gluconeogenesis.</p>

<p>GyK, a bacterial sugar kinase, initiates glycerol metabolism by converting it into G3P, key for cell uptake.</p>

<p>Nuclease P1 cleaves single-stranded nucleic acids into 5'-mononucleotides; key in molecular biology, pharmaceuticals, and food.</p>

<p>Alpha-2-3,6-sialidase (BiNanH2) is a sialyltransferase for biochemical studies, transferring sialic acid to galactosides.</p>

<p>Dihydrozeatin riboside is a cytokinin that can be isolated from Phaseolus vulgaris L.</p>

<p>13-cis-Retinyl acetate: active 13-cis isomer of Retinyl acetate, metabolite of vitamin A.</p>

<p>substrate of IMP dehydrogenase (IMPDH)</p>

<p>Glycerol phosphate dehydrogenase catalyzes the conversion of dihydroxyacetone phosphate to α-glycerol phosphate [1] .</p>

<p>alpha-1,3/4-Fucosyltransferase (α1,3/4FucT) (Hp3/4FT) can be found in Helicobacter pylori .</p>

<p>H-Arg-Lys-OH TFA is a dipeptide formed from L-arginyl and L-lysine residues [1] .</p>

<p>Trichodecenin I is a peptaibol isolated from Trichoderma viride.</p>

<p>ATP ditromethamine is key for energy storage, metabolism, and acts as a coenzyme and signaling molecule in immunity and inflammation.</p>

<p>Sodium valproate is an anti-epileptic, boosting brain GABA levels and possibly affecting potassium channels for membrane stability.</p>

<p>TPI, a glycolytic enzyme, swiftly converts dihydroxyacetone phosphate to D-glyceraldehyde-3-phosphate at its dimer interface.</p>

<p>CESs are enzymes in mammalian liver hydrolyzing esters and other substrates in biochemical studies.</p>

<p>Cholesterol esterase breaks down cholesterol ester into cholesterol and free fatty acids, aiding absorption.</p>

<p>Avellanin B is a fungal metabolite.</p>

<p>Neo-Inositol, a stable, polar compound, is a rare natural inositol stereoisomer.</p>

<p>Hydroxypyruvic acid lithium hydrate is a metabolic intermediate for serine, glycine, threonine, and a substrate for specific aminotransferases.</p>

<p>Uricase catalyzes uric acid to allantoin in many mammals' peroxisomes, used in biochemistry.</p>

<p>Cholesteryl arachidonate is a human endogenous metabolite.</p>

<p>Neohydroxyaspergillic acid, a fungal product from A. sclerotiorum, combats various bacteria and fungi with MICs ranging from 125-700 μg/ml.</p>

<p>EGCase I is a glycosidase used in biochemistry to transfer GSL sugars to 1-alkanols' primary hydroxyl groups.</p>

<p>7-Hydroxydichloromethotrexate is a methotrexate metabolite.</p>

<p>C17 Sphingomyelin is a synthetic derivative of sphingomyelin that has been used as an internal standard for the quantification of sphingomyelin.</p>

<p>TDC, a PLP-dependent enzyme, removes carboxyl groups from tyrosine, producing tyramine and CO2, found in plants, insects, and microbes.</p>

<p>Phytin has a wide range of applications in life science related research.</p>

<p>a1,3GalT (GGTA1) synthesizes α-gal glycan by adding galactose from UDP to glycoproteins.</p>

<p>P-orlandin, a fungal compound, blocks FREP1, halting P. falciparum's mosquito infection.</p>

<p>Berninamycin D, a cyclic peptide derived from Streptomyces bernensis through fermentation, is recognized as a fungal metabolite [1].</p>

<p>4-Phytase is a phosphohydrolase of inositol hexaphosphate [1] .</p>

<p>16α-Hydroxydehydroepiandrosterone-d5 (16α-Hydroxy-DHEA-d5) is the deuterated form of 16α-Hydroxydehydroepiandrosterone.</p>

<p>Glycodeoxycholic acid monohydrate is a nuclear receptor ligand.</p>

<p>Cortisol sulfate sodium, a Cortisol metabolite, binds specifically to intracellular transcortin.</p>

<p>13,14-dihydro PGE1, a metabolite of PGE1, inhibits platelet aggregation and activates adenylate cyclase with IC50 of 31/21 nM and Kact 668 nM.</p>

<p>ω-Muricholic acid (ω-MCA) is a murine-specific secondary bile acid.</p>

<p>3-Hydroxysebacic acid, an endogenous metabolite found in urine, is utilized in the study of Medium Chain Acyl-CoA Dehydrogenase Deficiency (MCADD) [1] [2].</p>

<p>Gliorosein is a biohcemical.</p>

<p>D-Glyceric acid, found in urine, aids in Primary hyperoxaluria I &amp; Glutaric Acidemia II research.</p>

<p>L-Glutamic acid ammonium is an excitatory neurotransmitter.</p>

<p>Kallikrein is capable of forming the kallikrenase kalinin system (KKS) in plasma and tissues, producing bradykinin and kalin peptides , respectively [1] .</p>

<p>GPI, also PGI or PHI, is a conserved dimeric glycolytic enzyme, catalyzing glucose-6-phosphate to fructose-6-phosphate isomerization.</p>

<p>1,2-Dilinoleoyl-sn-glycerol, a DAG with two linoleic acids, is in rat liver, spinach membranes, and indicates preeclampsia risk in pregnancy.</p>

<p>Homocarnosine TFA: brain-exclusive GABA-histidine dipeptide, neuronal, anticonvulsant, antioxidant, anti-inflammatory.</p>

<p>4-Hydroxytryptamine creatinine sulfate, a derivative of tryptamine, acts as an agonist for neurotransmitters.</p>

<p>cGAMP disodium, a bacterial CDN, boosts interferon production and activates STING, enhancing immune responses as a sublingual adjuvant.</p>

<p>Glutamic protease, a proteolytic enzyme characterized by the presence of a glutamic acid residue [1], is exclusive to fungi.</p>

<p>IAGNH, a glycosidase, breaks N-glycosidic bonds in nucleosides, recycling nucleobases and ribose.</p>

<p>Sarcophine is a natural cembranoid from the Red Sea soft coral Sarcophyton glaucum.</p>

<p>Succinic acid tromethamine is an oral anxiolytic, TCA cycle intermediate, and key precursor in various industries.</p>

<p>Atrazine mercapturate, a major atrazine metabolite from glutathione, is detectable in urine and linked to cancer, reproductive, and endocrine issues.</p>

<p>Cellulose, an excipient, aids stability, solubility, and processing of drugs and affects their ADME.</p>

<p>1, 4-butanediamine is an aliphatic diamine compound that can be used as an analytical reagent to assist in precise detection experiments and also as a dye intermediate to facilitate the synthesis of various functional dyes.</p>

<p>ACS activates fatty acids for lipid metabolism and the TCA cycle.</p>

<p>Estriol-3-glucuronide, a natural compound found in urine, is also present in amniotic fluid during normal pregnancy [1][2].</p>

<p>12(S)-HETE, from arachidonic acid via 12-lipoxygenase, is found in platelets and leukocytes, aids tumor cell adhesion, with a derivative used in research.</p>

<p>10-Formyldihydrofolate is a Methotrexate metabolite. It inhibits thymidylate synthetase and glycinamide ribotide transformylase.</p>

<p>L-Amino acid oxidase catalyzes the oxidative deamination of L-amino acids, which have local oxidative effects as well as potent antimicrobial effects.</p>

<p>Clostripain is a protease from Clostridium with esterase, amidase activities, targeting arginine.</p>

<p>Epicoccamide is a marine fungal metabolite originally isolated from E. purpurascens.</p>

<p>Sodium 18:0,22:6 phosphatidylserine (PS) is a lipid found within synaptic vesicles alongside cholesterol, utilized in metabolic research [1].</p>

<p>Di-O-demethylcurcumin (Bisdemethylcurcumin) is an intestinal metabolite of curcumin known for its neuroprotective properties.</p>

<p>2,8-Dihydroxyadenine causes urinary crystals, kidney stones, and helps diagnose APRT deficiency.</p>

<p>Cystocholic acid is a metabolite of bile acids, possessing antimicrobial potential.</p>

<p>D-Sedoheptulose-7-phosphate: Key in pentose phosphate path, carbon fixation, and compound biosynthesis.</p>

<p>BlUSP enzyme turns Glc-1-P into UDP-Glucose, transferring uridyl from UTP and producing PPi.</p>

<p>18-Oxocortisol, a naturally occurring mineralocorticoid and adrenal biomarker, is produced by CYP11B2.</p>

<p>Diaphorase from anaerobic sludge catalyzes RDX biotransformation via denitrification.</p>

<p>1-Methyladenosine-d3 hydrochloride is the hydrochloride salt form of deuterium-labeled 1-Methyladenosine. This compound is a modification of RNA that serves as a biomarker for tumors, with elevated levels in the body linked to cancer development. Upon methylation, 1-Methyladenosine upregulates the expression of PPARδ, regulates cholesterol metabolism, and activates the Hedgehog signaling pathway, thereby driving the onset of liver tumors.</p>

<p>3α-Hydroxysteroid dehydrogenase (3α-HSD), encoded by the AKR1C4 gene, is responsible for catalyzing the transformation of 3-ketosteroids into 3α-hydroxy</p>

<p>5-Aminolevulinic acid: heme synthesis intermediate, photosensitizer, antineoplastic, prodrug, treats actinic keratosis with blue light.</p>

<p>Estriol 16α-(β-D-glucuronide), an endogenous metabolite found in urine, is utilized in pregnancy research [1] [2].</p>

<p>18-Hydroxycorticosterone is a corticosteroid and corticosterone derivative, which can lead to serious electrolyte imbalances.</p>

<p>ADR-925 has the ability to protect neonatal rat cardiomyocytes from doxorubicin-induced injury.Cost-effective and quality-assured.</p>

<p>9(S)-HpOTrE, a product of 5-LO on α-linolenic acid, transforms into colnelenic acid and 9,16-dihydroperoxy acid; it inactivates LOs through epoxide formation.</p>

<p>Uric Acid (Lithic acid) is an oxidation product of oxypurines. Uric Acid is the final oxidation product of purine catabolism in humans and primates.</p>

<p>D-Fructose 1-phosphate disodium salt, a derivative of fructose, serves as a crucial intermediate in glucose metabolism.</p>

<p>9(S)-HOTrE is a plant metabolite and octadecatrienoic acid produced by the action of 5-lipoxygenase (5-LO) on α-linolenic acid.</p>

<p>13-cis-Retinyl palmitate in corn flakes is 75% as active as all-trans form.</p>

<p>TMC-205: natural antiproliferative fungal metabolite; boosts SV40 promoter transcription.</p>

<p>Tetranor-PGEM, the primary urinary byproduct of PGE1 and PGE2, marks PGE2 production; humans excrete 7-40 μg daily.</p>

<p>Phenolic acid is an endogenous metabolite.</p>

<p>Pyrindolol, a S. alboverticillatus metabolite, inhibits bovine β-galactosidase at 2 μg/ml in acid; not effective on other species' enzymes.</p>

<p>N-β-Alanyldopamine hydrochloride (NBAD hydrochloride) represents the primary dopamine derivative found in haemolymph [1].</p>

<p>Mevalonic acid 5-pyrophosphate (also known as 5-Diphosphomevalonic acid) tetralithium is an endogenous metabolite involved in the mevalonate pathway.</p>

<p>1-Palmitoyl LPA: a palmitic acid-containing LPA analog, targets GPCRs, affects cell responses, and boosts β-lactam antibiotics against Pseudomonas aeruginosa.</p>

<p>AtGlcAK: GHMP-kinase family, specific for D-glucuronic acid, Km 0.7 mM, converts it with ATP to D-glucuronic-1-phosphate and ADP.</p>

<p>D-myo-Inositol 4-mono-phos-phate is a biochemical reagent that can be used as a biological material or organic compound for life science related research.</p>

<p>Aspercolorin is a fungal metabolite produced by Aspergillus.</p>

<p>6-Ethyl-2,7-dimethoxyjuglone is a metabolite isolated from freshwater fungi [1] .</p>

<p>N-Formyl-2-aminophenol (N-(2-hydroxyphenyl)methanamide) is a bacterial secondary metabolite found in P. chrysogenum and exhibits antioxidant properties.</p>

<p>Aldose 1-epimerase facilitates the conversion of α- to β-sugars like glucose, crucial for carbohydrate processing.</p>

<p>B4GALT1 (LgtB) is key in biochemical research, bonding UDP-galactose and N-acetylglucosamine to form Galβ1-4GlcNAc.</p>

<p>Poly(4-vinylphenol) is an endogenous metabolite.</p>

<p>Carboxypeptidase B degrades peptides from C-terminal, freeing amino acids, and targets basic residues.</p>