Amino Acids (AA)

<p>Applications It is useful for solid phase synthesis of polyamides containing imidazole.<br></p>

<p>Applications 7-METHYLINDOLE-3-ACETIC ACID (cas# 5435-36-9) is a useful research chemical.<br></p>

<p>Impurity Bosentan USP Related Compound D<br>Applications Bosentan USP Related Compound D<br>References Morimoto, H., et al.: J. Med. Chem., 44, 3369 (2001),<br></p>

<p>Applications 4-methyl-3-nitrobenzoic acid (cas# 96-98-0) is a useful research chemical.<br></p>

<p>Applications Bisphenol C Mono-β-D-glucuronide is a metabolite of Bisphenol C (B519600), which is an analogue of Bisphenol A (B519495), a well known endocrine-disrupting chemical with estrogenic activity.<br>References Kitamura, S., et al.: Toxicol. Sci., 84, 249 (2005); Delfosse, V., et al.: P. Natl. Acad. Sci. USA, 109, 14930 (2012);<br></p>

<p>Applications Fmoc-D-propargylglycine<br></p>

<p>Applications 4’-Methylbiphenyl-2-carboxylic Acid is used in the synthesis of angiotensin II receptor antagonists used as potent orally active antihypertensives.<br>References Carini, D. et al.: J. Med. Chem/, 34, 2525 (1991); Ismail, M. et al.: J. Med. Chem., 49, 1526 (2006);<br></p>

<p>Applications trans-1-Methyl-2-propylcyclohexane, is one of the chemical components of in petroleum solvents.<br>References Hosoi, J., et al.: Tokyo-to Kankyo Kagaku Kenkyusho Nenpo, 135 (2007);<br></p>

<p>Applications Methyl Dl-2-(1-Boc-Piperidin-4-Yl)-Beta-Glycinate (cas# 362703-57-9) is a useful research chemical.<br></p>

<p>Applications 2-Bromo-3-methylthiophene is used to prepare pyrazolo[3,4-d]pyrimidine derivatives as inhibitors of human enterovirus, coxsackievirus, echovirus, influenza virus, herpes simplex virus and rhinovirus. It is also used in the synthesis of oral α7 nicotinic receptor agonists.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Chern, J., et al.: Bioorg. Med. Chem. Lett., 14, 2519 (2004); Tatsumi, R., et al.: J. Med. Chem., 48, 2678 (2005)<br></p>

<p>Applications A 2-substituted 2’-Deoxyadenosine (D231620). Used in the synthesis of oligonucleotides.<br>References Ishikawa, F., et al.: J. Mol. Biol., 70, 475 (1972), Hattori, M., et al.: Biochemistry, 13, 2754 (1974), Kazimierczuk, Z., et al.: J. Med. Chem., 33, 1683 (1990),<br></p>

<p>Applications N-Boc-4-(hydroxymethyl)-pyrrolidin-2-ol is a chemical reagent used in organic synthesis for pharmaceutically active compounds.<br>References Yohannes, D. et al.: Org. Lett., 10, 5353 (2008);<br></p>

<p>Applications N-Methyl-1,3-propanediamine is used as a reagent in the lipase-catalyzed synthesis of novel linear polyamidoamine oligomers.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Monsalve, L.N., et al.: Polymer, 51, 2998 (2010)<br></p>

<p>Applications Fmoc-Leu-OH-5,5,5-d3 is an isotope labelled compound of Fmoc-L-Leu-OH (F625015). Fmoc-L-Leu-OH is an amino acid derivative, used in peptide chemistry. It is also one of the novel PPARγ ligands that can activate PPARγ in different ways, that reduces osteoclasts differentiation, and thus are better therapeutic targets in diabetes than traditional antidiabetic drugs.<br>References Haochen, W., et al.: J. Cell. Biochem., 114, 1969 (2013)<br></p>

<p>Applications Intermediate in the production of T Epitope, Threonyl<br></p>

<p>Applications A labelled trans-4-Hydroxy-L-proline. A natural constituent of animal structural proteins such as collagen and elastin. Several microorganisms producing proline trans-4- and cis-3-hydroxylase were discovered and these enzymes were applied to the industrial production of trans-4- and cis-3-hydroxy-L-proline.<br>References Langmaier, F. et al.: Int. J. Cosm. Sci., 24, 273 (2002); Lawrence, C., et al.: Biochem. J., 313, 185 (1996); Mori, H., et al.: J. Bacteriol.; 179, 5677 (1997); Clifton, I., et al.: Eur. J. Biochem., 268, 6625 (2001);<br></p>

<p>Applications A useful synthetic intermediate.<br></p>

<p>Applications 5-Methyl-2-hexanol, is a component of essential oils from various plants. It is also used as the carbon-terminal fragment for the synthesis of 6,10,13-Trimethyl-1-tetradecanol having pheromonal activity.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Xu, F., et al.: 34 (12), 1887 (2011); Kochansky, J., et al.: J. Chem. Ecology, 15 (6), 1717 (1989);<br></p>

<p>Applications (S)-(+)-2-Chlorophenylglycine Methyl Ester Tartrate Salt acts as a reagent in the synthesis of biologically active metabolites of Clopidogrel (C587250), an antithrombotic.<br>References Shaw, S. et al.: J. Org. Chem., 80, 7019 (2015); Mills, D.C.B., et al.: Arterioscler. Thromb., 12, 430 (1992), Feuerstein, G., et al.: Exp. Opin. Invest. Drugs, 4, 425 (1995)<br></p>

<p>Applications 5-Bromo-2-iodo-3-methoxypyridine<br></p>

<p>Applications 1,2,3,4,5,6,7,8-Octahydro-1-[(4-methoxyphenyl)methyl]-isoquinoline is a useful synthetic compound.<br></p>

<p>Applications 2-Methyl-propanoic-3,3,3-d3 Acid is a useful labeled reagent.<br></p>

<p>Applications 6-methyl-4-oxo-1,4-dihydroquinoline-2-carboxylic acid (cas# 130064-09-4) is a useful research chemical.<br></p>

<p>Stability Unstable in Acidic Solution<br>Applications 4-Methyl-5-oxyethyl Thiazol Diphosphate Ammonium Salt is a useful reagent in the enzymic synthesis of thiamine. An Inhibitor of carboxylase.<br>References Nose, Y., et al.: Biochimica et Biophysica Acta, 34, 277 (1959), Nose, Y., et al.: J. Vitaminol., 7, 98 (1961), Buchman, E. R., et al.: Proc. Natl. Acad. Sci. USA, 26, 561 (1940)<br></p>

<p>Applications H-ALA-ALA-ALA-ALA-ALA-OH (cas# 10183-34-3) is a useful research chemical.<br></p>

<p>Applications L-Phenyl-d5-alanine-N-FMOC (CAS# 225918-67-2) is a useful isotopically labeled research compound.<br></p>

<p>Applications N-Acetyl-D-serine is the modified amino acid D-Serine (S270975). D-Serine is a neurotransmitter that is concentrated in the mammalian brain, and is one of the very few amino acids that occur in the D- and L-configurations in significant amounts. D-Serine is an potent agonist of the N-methyl-D-aspartate (NMDA) receptor in the brain, which is associated with schizophrenia. Use of D-Serine has been considered as an additional therapy for refractory schizophrenic patients.<br>References Heresco-Levy, U., et al.: Biol. Psych., 57, 577 (2005); Mothet, J., et al.: Proc. Nat. Acad. Sci., 97, 4926 (2000); Snyder, S. &amp; Kim, P.: Neurochem. Res., 25, 553 (2000); Tsai, G., et al.: Biol. Psych., 44, 1081 (1998)<br></p>

<p>Applications 2-Methyl-d3-3-butyn-1,1,1-d3-2-ol (CAS# 57444-27-6) is a useful isotopically labeled research compound.<br></p>

<p>Applications L-Valine-d8-N-FMOC (CAS# 1007834-06-1) is a useful isotopically labeled research compound.<br></p>

<p>Applications 5-Chloro-2-methoxy-4-methylaminobenzoic Acid (cas# 61694-98-2) is a compound useful in organic synthesis.<br></p>

<p>Applications 3-(4-Chloro-2-fluoro-5-methylphenyl)-1-methyl-5-(trifluoromethyl)-1H-pyrazole is an intermediate in the synthesis of Fluazolate (F407500), the active ingredient in the preparation of agrochemicals and drugs in amorphous form.<br>References Foster, R. S., et al.: Org. Lett., 14, 4858 (2012);<br></p>

<p>Stability Light and temperature sensitive<br>Applications 4-Chloro-2-methyl-1-pentene is the derivative of 3-Chloro-2-methyl-1-propene (C368130), which has been used in the synthesis of 2-S-substituted pyrimidines as antimetabolites of nucleic acid precursors for cancer therapy.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Kaldrikyan, M.A., Melik-Ohanjanyan, R.G.: Hayastani Kimiakan Handes, 67, 321 (2014)<br></p>

<p>Applications 4-Chloro-2-fluoro-N-methylbenzamide<br></p>

<p>Stability Hygroscopic<br>Applications 4-Hydroxy-3-methyoxybenzyl Alcohol is used in the anti-asthmatic activity of phenolic compounds from the roots of Gastrodia elata Bl. Chemical composition, antioxidant and antibacterial activities of lemon peel essential oil.<br>References Jang, Y. W., et al.: Int. Immunopharmacol., 10, 147 (2010); Zhang, B., et al.: Shipin Gongye Keji, 36, 126 (2015)<br></p>

<p>Applications Methyl 2-diethoxyphosphoryl-2-methoxyacetate is a reagent in a Wittig reaction.<br>References Ribereau, P., et al.: Can. J. Chem., 61, 334 (1983);<br></p>

<p>Applications Fmoc-(4-carboxymethyl)piperazine<br></p>

<p>Applications 4-methanesulfinylbutanenitrile (cas# 61121-65-1) is a useful research chemical.<br></p>

<p>Applications 3-CHLOROMETHYL-1-METHYLPIPERIDINE HYDROCHLORIDE (cas# 66496-82-0) is a useful research chemical.<br></p>

<p>Applications 2-Methyl-propanoic acid 3-Hydroxy-2,2,4-trimethylpentyl Ester is a plasticizer. It can also be used to synthesize hard and flexible nanocomposite coatings.<br>References Dieckmann, D., et al.:J. Vinyl Addit. Technol., 12, 217 (1990); Fogelstroem, L., et al.: ACS Appl. Mater. Interfaces, 2, 1679 (2010)<br></p>

<p>Applications methyl 2-methoxy-2-methylpropanoate (cas# 17860-39-8) is a useful research chemical.<br></p>

<p>Stability Hygroscopic<br>Applications L-3-(4-Hydroxy-3-methoxy-d3-phenyl)alanine (CAS# 586954-09-8) is a useful isotopically labeled research compound.<br></p>

<p>Applications 3-Methyl α-Carboline is used in the synthesis of carbolines by photostimulated cyclization of anilinohalopyridines.<br>References Cao, R., et al.: Curr. Med. Chem., 14, 479 (2007), Kumar, E., et al.: Mini. Rev. Med. Chem., 8, 538 (2008),<br></p>

<p>Applications 2,5-dimethoxy-N-methylaniline (cas# 10224-66-5) is a useful research chemical.<br></p>

<p>Applications 2-Methoxy-3-methylnaphthalene (cas# 61873-80-1) is a useful research chemical.<br></p>

<p>Applications 2'-Methoxy-3'-nitro-[1,1'-biphenyl]-3-carboxylic Acid is a reagent which can be used for preparation of pyrazolone derivatives useful in thrombocytopenia treatment<br>References Duffy, K., et al.: U.S. Pat. Appl. Publ. (2011), US 20110212054 A1 20110901;Deng, B., et al.: Faming Zhuanli Shenqing (2010), CN 101928281 A 20101229;<br></p>

<p>Applications 3-(5-amino-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione (cas# 1015474-32-4) is a useful research chemical.<br></p>

<p>Applications P-(1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-heptadecafluorooctyl)phosphonic Acid 4-Methylbenzeneamine shows various applications as a phosphonic acid, ranging from anti-foaming agents to lubricants for micro/nano-optoelectromechanical systems.<br>References Hosein, A. et al.: Inorg. Chem., 50, 1484 (2011);<br></p>

<p>Applications Furan-2-ylmethyl-phenethyl-amine is used in the preparation of carboxamido-isoindolinone derivatives as selective PARP-1 inhibitors.<br>References Papeo, G. M. E., et al.: PCT Int. Appl. 60 pp. (2014)<br></p>

<p>Applications Methyl(4-methylnaphthalen-1-ylmethyl)amine-d3 is the isotope analog of Methyl(4-methylnaphthalen-1-ylmethyl)amine. Methyl(4-methylnaphthalen-1-ylmethyl)amine is a reagent in the preparation of heterocyclic compounds as enoyl-acyl carrier protein reductase FabI inhibitors and antibacterial agents.<br>References Stuetz, A., et al.: J. Med. Chem., 29, 112 (1986); Berman, J., et al.: PCT Int. Appl., 2004:515512 (2004)<br></p>

<p>Applications trans-4-Methylcyclohexylamine is used to characterize spermidine synthase of malaria parasite.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Haider, N., et al.: Mol. Biochem. Parasitol., 142, 224 (2005);<br></p>

<p>Applications 3-methyl-5-phenylisoxazole (cas# 1008-75-9) is a useful research chemical.<br></p>

<p>Applications 4-(dimethylamino)-7-methyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxylic acid hydrochloride (cas# 1432681-71-4) is a useful research chemical.<br></p>

<p>Applications 2-(3-Ethoxy-4-methoxy-d3-phenyl)ethyl-1,1,2,2-d4-amine HCl (CAS# 1398065-60-5) is a useful isotopically labeled research compound. This compound can be used as FSH agonist to treat fertility disorders.<br>References Yu, H., et.al., PCT Int. Appl., 68,(2013);<br></p>

<p>Applications 4-Chloro-N-methylbenzenesulphonamide (cas# 6333-79-5) is a useful research chemical.<br></p>

<p>Applications N-(2,6-Dimethylphenyl)-3-methyl-2-butenamide is an intermediate in the synthesis of rac-trans-N-(2,6-Dimethylphenyl)-4-methyl-1-(2-methylphenyl)-5-oxo-3-propylimidazolidine-2-carboxamide (D480822), the trans-isomer of N-(2,6-Dimethylphenyl)-4-methyl-1-(2-methylphenyl)-5-oxo-3-propylimidazolidine-2-carboxamide, an impurity of Prilocaine (Prilocaine Hydrochloride P725000). Prilocaine is a local anesthetic of the amino amide type and is often used in dentistry. Prilocaine is also often combined with lidocaine as a preparation for dermal anesthesia (lidocaine/prilocaine or EMLA) towards the treatment of conditions like paresthesia.<br>References Caliaro, G., et al.: J. Pharm. Biomed. Anal., 26, 427 (2001), Ulmeanu, S., et al.: Pharm. Res., 20, 1317 (2003),<br></p>

<p>Applications 2'-OMe-Ac-C Phosphoramidite (CAS# 199593-09-4) is a nucleotide used in the solid-phase synthesis of phosphorothioate oligonucleotides using sulfurization byproducts for in situ capping.<br>References Yang, J.; et al.: J. Org. Chem., 83, 11577 (2018);<br></p>

<p>Applications Cyclopropyl-2,2,3,3-d4-methyl-d2 Alcohol (CAS# 1219805-67-0) is a useful isotopically labeled research compound.<br></p>

<p>Applications (2R,3R,4R,5R)-5-(6-Benzamido-9H-purin-9-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-methoxytetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite is a nucleotide used in the synthesis of native-like crosslinked duplex RNA.<br>References Onizuka, K.; et al.: Bioorg. Med. Chem., 25, 2191 (2017).<br></p>