Enzyme Modulators
Subcategories of "Enzyme Modulators"
Found 693 products of "Enzyme Modulators"
BMS 777607
CAS:A potent Met kinase inhibitor (IC50 = 3.9 nM). Also inhibits Axl, Ron, and Tyro-3 (IC50 = 1.1, 1.8 and 4.3 nM, respectively). Anti-proliferative in Met-driven tumors in vitro and in vivo. Induces polyploidy in breast cancer cells and thereby chemoresistance.Formula:C25H19ClF2N4O4Purity:Min. 95%Molecular weight:512.10629Dihydrocyclosporin A
CAS:Dihydrocyclosporin A is an immunosuppressant, which is a cyclic undecapeptide derived from fungal metabolites, specifically from the soil fungus Tolypocladium inflatum. This compound functions through the inhibition of calcineurin, which is a crucial phosphatase involved in the activation of T-cells. By binding to the intracellular protein cyclophilin, Dihydrocyclosporin A forms a complex that inhibits calcineurin activity, subsequently blocking the transcription of interleukin-2 and other cytokines essential for T-cell proliferation.
Formula:C62H113N11O12Purity:Min. 95 Area-%Color and Shape:PowderMolecular weight:1,204.63 g/molSU11652
CAS:Inhibitor of FLT3 kinase and acid sphingomyelinase
Formula:C22H27ClN4O2Purity:Min. 95%Molecular weight:414.93 g/molPemetrexed - Bio-X ™
CAS:Pemetrexed is a chemotherapy drug that belongs to the class of drugs called folate antimetabolites. It is used for the treatment of various cancers such as non-small cell lung cancer and pleural mesothelioma. Pemetrexed targets the enzymes thymidylate synthase, dihydrofolate reductase and glycinamide ribonucleotide formyltransferase. The drug works by inhibiting those enzymes so that the formation of DNA and RNA is prevented.Formula:C20H21N5O6Purity:Min. 95%Color and Shape:PowderMolecular weight:427.41 g/molAS 2863619
CAS:Cyclin-dependent kinase 8 (CDK8) and CDK19 inhibitor
Formula:C16H14Cl2N8OPurity:Min. 95%Molecular weight:405.24 g/molLapatinib ditosylate monohydrate
CAS:Inhibitor of EGFR (ErbB1) and HER2 (ErbB2) receptor tyrosine kinases. Used for sensitization of HER2-overexpressing cancer cells to radiation as well as chemotherapy to tamoxifen- and trastuzumab-resistant cell lines. The compound blocks signalling via Akt and mitogen-activated protein kinase (MAPK) pathways leading to reduced cell survival. In trastuzumab resistant cancer cells, it inhibits HER2 phosphorylation, prevents receptor ubiquitination and causes accumulation of inactive HER2 dimers on the cell surface.Formula:C29H26ClFN4O4S•(C7H8O3S)2•H2OPurity:Min. 95%Molecular weight:943.48 g/molGI 254023X
CAS:Inhibitor of ADAM10 metalloproteaseFormula:C21H33N3O4Purity:Min. 95%Molecular weight:391.5 g/molCalpain Inhibitor III
CAS:Inhibitor of calpain and cathepsin BFormula:C22H26N2O4Purity:Min. 95%Color and Shape:PowderMolecular weight:382.45 g/molSimvastatin Na
CAS:Simvastatin Na is the salt form of Simvastatin. It acts as HMG-CoA reductase inhibitor and suppresses TNF-mediated NF-kappaB activation.Formula:C25H39O6NaPurity:Min. 95%Color and Shape:Beige To Brown SolidMolecular weight:458.56 g/molLifirafenib
CAS:Lifirafenib is a targeted anticancer therapy, which is a small molecule inhibitor sourced through pharmaceutical development processes. Its mode of action involves the selective inhibition of the RAF kinase family, including B-RAF, which plays a critical role in the MAPK/ERK signaling pathway. By targeting these kinases, Lifirafenib effectively disrupts the aberrant signaling that contributes to tumor growth and survival in certain cancers with mutations such as BRAF V600E.
Formula:C25H17F3N4O3Purity:Min. 95%Molecular weight:478.42 g/molLGX 818
CAS:Inhibitor of B-Raf mutant (V600E); anti-neoplasticFormula:C22H27ClFN7O4SPurity:Min. 95%Color and Shape:White/Off-White SolidMolecular weight:540.01 g/molTPPB
CAS:TPPB is a small molecule inhibitor, which is synthetically derived for targeted biochemical studies. It functions by selectively modulating G-protein-coupled receptor (GPCR) signaling pathways through the inhibition of specific protein-protein interactions. This mode of action makes TPPB an insightful tool for dissecting the complex mechanisms by which G-proteins relay extracellular signals to intracellular responses.
Formula:C27H30F3N3O3Purity:Min. 95 Area-%Color and Shape:PowderMolecular weight:501.54 g/molTegafur - Bio-X ™
CAS:Tegafur is an antineoplastic agent that is used for the treatment of gastric and colorectal cancers in combination with other medications. This drug is a prodrug of 5-fluorouracil and has anticancer properties by inhibiting thymidylate synthase during DNA synthesis. Additionally, Tegafur causes disruptions of RNA functions.
Tegafur is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready-to-use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.Formula:C8H9FN2O3Purity:Min. 95%Color and Shape:PowderMolecular weight:200.17 g/molTolcapone - Bio-X ™
CAS:Controlled ProductTolcapone is a catechol-O-methyltransferase (COMT) inhibitor that is used as adjunct therapy to manage symptoms of Parkinson’s disease. Although its precise mechanism is unknown, it is thought to be an inhibitor of COMT and allows for a greater reduction in the symptoms of Parkinson’s.Formula:C14H11NO5Purity:Min. 95%Color and Shape:PowderMolecular weight:273.24 g/molOdevixibat
CAS:Odevixibat is a pharmacological agent that functions as an ileal bile acid transport inhibitor, which is synthesized through complex organic chemistry methods to create a specific molecular structure targeting bile acid transport mechanisms. It works by inhibiting the apical sodium-dependent bile acid transporter (ASBT) in the terminal ileum. This action reduces the reabsorption of bile acids from the small intestine back into the liver, thereby reducing overall bile acid levels in the body.Formula:C37H48N4O8S2Purity:Min. 95%Color and Shape:PowderMolecular weight:740.93 g/molTizoxanide
CAS:Anti-parasitic; pyruvate ferredoxin oxidoreductase inhibitorFormula:C10H7N3O4SPurity:Min. 95%Color and Shape:PowderMolecular weight:265.25 g/molFlavopiridol hydrochloride
CAS:Inhibitor of CKD1, CDK2, and CDK4 serine/threonine kinases
Formula:C21H21Cl2NO5Purity:Min. 95%Color and Shape:Light (Or Pale) Tan SolidMolecular weight:438.3 g/molNeostigmine methyl sulfate
CAS:Inhibitor of acetylcholinesteraseFormula:C13H22N2O6SPurity:Min. 95%Color and Shape:PowderMolecular weight:334.39 g/molCanertinib dihydrochloride
CAS:Inhibitor of EGFR, HER2 and HER4 tyrosine kinasesFormula:C24H25ClFN5O3·2HClPurity:Min. 95%Molecular weight:558.86TDZD 8
CAS:TDZD 8 is a selective, non-ATP competitive inhibitor of the glycogen synthase kinase GSK3β. TDZD 8 inhibits GSK3β with IC50 of 2 μM and was reported to not significantly affect Cdk-1/cyclin B, casein kinase CK-II, protein kinase A and C (PKA, PKC) activities. TDZD 8 was also identified as an inhibitor of the main protease in coronaviruses. In an in vitro study, TDZD 8 was characterised as an aggregate-based inhibitor as the presence of Triton-X decreased the inhibitory potency to Mpro protease of the SARS-CoV-2 virus (IC50 without Triton-X: 2.15 μM).Formula:C10H10N2O2SPurity:Min. 98 Area-%Color and Shape:PowderMolecular weight:222.26 g/mol
