Enzyme Modulators
Subcategories of "Enzyme Modulators"
Found 693 products of "Enzyme Modulators"
WM 1119
CAS:Selective and potent inhibitor of lysine acetyltransferases KAT6A and KAT6B with IC50 values in low nanomolar range. The compound is a reversible competitor of acetyl coenzyme A domain of KAT6A/B enzymes. It inhibits MYST-catalysed histone acetylation and was shown to arrest lymphoma progression in mice models. The compound opened the door to a new class of cancer therapeutics that could potentially direct the cancer cells in senescence or permanent dormancy.
Formula:C18H13F2N3O3SPurity:Min. 95%Color and Shape:White/Off-White SolidMolecular weight:389.38 g/molMethotrexate disodium
CAS:Methotrexate is a drug that suppresses the immune system by inhibiting the production of white blood cells. It is used in the treatment of a number of diseases, including some cancers and autoimmune diseases such as rheumatoid arthritis and psoriasis. Methotrexate is metabolized to its active form, methotrexate, by an enzyme called dihydrofolate reductase (DHFR). The DHFR inhibitor activity of methotrexate blocks the synthesis of folate-dependent enzymes and prevents DNA synthesis in rapidly dividing cells. Methotrexate has been used in combination with other drugs to treat cancer. Methotrexate has also been shown to have antifungal properties against opportunistic fungal infections.Formula:C20H20N8Na2O5Purity:Min. 95%Color and Shape:PowderMolecular weight:498.4 g/molDoramapimod
CAS:p38α MAP kinase inhibitor; JNK2α2 protein kinase inhibitorFormula:C31H37N5O3Purity:Min. 95%Color and Shape:PowderMolecular weight:527.66 g/molGKA 50
CAS:Glucokinase activatorFormula:C26H28N2O6Purity:Min. 95%Color and Shape:White PowderMolecular weight:464.51 g/molMLN 8237
CAS:Antagonist of Aurora A serine/threonine protein kinase; antineoplastic
Formula:C27H20ClFN4O4Purity:Min. 95%Color and Shape:PowderMolecular weight:518.92 g/molSildenafil
CAS:Sildenafil is a pharmaceutical compound, which is a synthetic product derived from chemical processes. It functions as a selective inhibitor of the enzyme phosphodiesterase type 5 (PDE5). By inhibiting PDE5, sildenafil increases cyclic guanosine monophosphate (cGMP) levels within the smooth muscle cells of the corpus cavernosum. This leads to smooth muscle relaxation and vasodilation, allowing increased blood flow and facilitating penile erection in the presence of sexual stimulation.Formula:C22H30N6O4SPurity:Min. 95%Color and Shape:PowderMolecular weight:474.58 g/molRosuvastatin
CAS:Rosuvastatin is a synthetic lipid-lowering agent, which is a product of pharmaceutical manufacturing derived from extensive research in cardiovascular pharmacology. It functions as an HMG-CoA reductase inhibitor, effectively blocking the enzyme responsible for cholesterol biosynthesis in the liver. By inhibiting this enzyme, Rosuvastatin reduces the production of cholesterol, especially low-density lipoprotein (LDL) cholesterol, which is known to contribute to atherosclerosis.Formula:C22H28FN3O6SPurity:Min. 95%Molecular weight:481.54 g/molL 690330
CAS:Inositol monophosphatase (IMPase) inhibitorFormula:C8H12O8P2Purity:Min. 95%Molecular weight:298.12 g/molCyclosporine U
CAS:Cyclosporine U is a cyclic polypeptide immunosuppressant, which is a derivative of the natural product Cyclosporine A, produced by the fermentation process involving the filamentous fungus *Tolypocladium inflatum*. It primarily acts by inhibiting the activity of calcineurin, a phosphatase enzyme, which in turn blocks the transcription of interleukin-2 and other cytokines. This mechanism suppresses the activation of T-lymphocytes, a crucial component in the immune response.
Formula:C61H109N11O12Purity:Min. 95%Molecular weight:1,188.58 g/molN-alpha-Benzoyl-L-argininamide
CAS:N-alpha-Benzoyl-L-argininamide is a synthetic compound that is used as an enzyme inhibitor. It binds to the active site of proteases, thereby inhibiting their activity. This drug has been shown to inhibit the activities of phosphodiesterase and phosphatase enzymes in vitro. N-alpha-Benzoyl-L-argininamide also inhibits the proteolytic degradation of hippuric acid and casein in vitro. The binding affinity for this drug is due to its structural similarity with substrates such as glutamate and rhizosphere exudates.
Formula:C13H19N5O2Purity:Min 98%Color and Shape:White PowderMolecular weight:277.32 g/molCyclosporin G
CAS:Cyclosporin G is an immunosuppressive agent, which is derived from fungal sources with a specific mode of action that involves inhibiting calcineurin. The source of Cyclosporin G is primarily from the fermentation of the fungus *Tolypocladium inflatum*. Its mode of action involves binding to the cytosolic protein cyclophilin in T-lymphocytes, which subsequently inhibits the phosphatase activity of calcineurin. This inhibition prevents the dephosphorylation and nuclear translocation of the nuclear factor of activated T-cells (NFAT), thereby reducing the transcription of interleukin-2 and other cytokines critical for T-cell activation.Formula:C63H113N11O12Purity:Min. 95%Molecular weight:1,216.64 g/mol(+/-)-Blebbistatin
CAS:Inactive enantiomer of the inhibitor of myosin II-ATPaseFormula:C18H16N2O2Purity:Min. 95%Molecular weight:292.33 g/molABT 494
CAS:Inhibitor of Janus kinase JAK-1Formula:C17H19F3N6OPurity:Min. 95%Molecular weight:380.37 g/molLY 294002
CAS:First generation PI 3-kinase inhibitor
Formula:C19H17O3NPurity:Min. 95%Color and Shape:White To Off-White SolidMolecular weight:307.12084AR-AO 14418
CAS:Inhibitor of GSK3β kinaseFormula:C12H12N4O4SPurity:Min. 95%Color and Shape:PowderMolecular weight:308.31 g/molN-(5-Aminopentyl) methotrexate amide-LC-biotin
N-(5-Aminopentyl) methotrexate amide-LC-biotin is a specialized bioconjugate, derived through the conjugation of methotrexate, an established antifolate drug, with an LC-biotin moiety. This product is synthesized by covalently linking methotrexate, which is known for its role in cancer therapy through the inhibition of dihydrofolate reductase (DHFR), to a biotin moiety via a long-chain spacer. The resultant bioconjugate retains the therapeutic effects of methotrexate, particularly in its ability to interrupt nucleotide synthesis, thereby affecting cell division in rapidly proliferating cancer cells.The inclusion of biotin in the structure allows for facile attachment to avidin or streptavidin-labeled systems, facilitating targeted delivery and enhanced detection in molecular and cellular studies. The primary application of N-(5-Aminopentyl) methotrexate amide-LC-biotin lies in the realm of targeted drug delivery and advanced research into methotrexate metabolism. By leveraging the high affinity of biotin-streptavidin interactions, researchers can effectively study the biodistribution and cellular uptake of methotrexate, advancing cancer therapeutic strategies and providing insights into antifolate drug mechanisms at the molecular level.Formula:C41H59N13O7SPurity:Min. 95%Color and Shape:PowderMolecular weight:878.06 g/molCAY10727
CAS:CAY10727 is a potent biochemical inhibitor, which is derived from synthetic sources with specific action targeting cyclooxygenase-2 (COX-2) enzymes. It functions by selectively blocking the enzymatic activity of COX-2, which plays a critical role in the biosynthesis of prostaglandins involved in inflammatory responses. This targeted inhibition allows the study of COX-2-related pathways without interference from COX-1, which is significant for maintaining gastrointestinal integrity.The use and applications of CAY10727 are primarily in research settings where understanding the pathways involved in inflammation, pain, and cancer progression are critical. This compound is utilized in various in vitro experiments to delineate the role of COX-2 in cellular and molecular contexts, enabling scientists to dissect complex signaling networks. Given its specificity, CAY10727 is instrumental in the development of new therapeutic approaches where selective COX-2 inhibition might offer benefits over non-selective inhibitors.Formula:C21H22Cl2N4O2Purity:Min. 95%Molecular weight:433.3 g/molUNC 0379
CAS:Inhibitor of the histone methyltransferase SETD8 that supresses methylation of the K20 residue in histone 4. UNC 0379 treatment of human glioma reduced recruitment of 53BP1 protein to double strand breaks and sensitised cells to radiotherapy without altering cell cycle kinetics.
Formula:C23H35N5O2Purity:Min. 95%Color and Shape:SolidMolecular weight:413.56 g/molAnagrelide HCl - Bio-X ™
CAS:Anagrelide is a thrombocytopenic drug that is used to treat thrombocythemia and related conditions. This drug works by decreasing the platelet count by suppressing transcription factors that are necessary for the maturation of platelets. This drug is also a phosphodiesterase III inhibitor.Formula:C10H7Cl2N3O•HClPurity:Min. 95%Color and Shape:PowderMolecular weight:292.55 g/molGSK 583
CAS:A potent and selective inhibitor of cell death-inducing kinase RIP2 (IC50 = 5 nM). Reduces release of pro-inflammatory cytokines. Inhibits production of TNF-α and IL-6 in intestinal explants from patients with Crohn's disease and ulcerative colitis.
Formula:C20H19FN4O2SPurity:Min. 95%Color and Shape:PowderMolecular weight:398.46 g/mol
