Ciclo celular / Checkpoint
Los inhibidores del ciclo celular/puntos de control son compuestos que interrumpen la progresión normal del ciclo celular, particularmente en puntos de control regulatorios clave. Estos inhibidores son cruciales para estudiar la división celular, comprender la proliferación de células cancerosas y desarrollar terapias anticancerígenas. Al dirigirse a fases específicas del ciclo celular, estos inhibidores pueden inducir la detención del ciclo celular, lo que lleva a apoptosis o senescencia en células de división rápida. En CymitQuimica, ofrecemos una amplia gama de inhibidores de alta calidad del ciclo celular/puntos de control para apoyar su investigación en biología del cáncer, biología celular y desarrollo de fármacos.
Subcategorías de "Ciclo celular / Checkpoint"
- Aurora quinasa(114 productos)
- CDK(544 productos)
- Detención del ciclo celular(5 productos)
- Chk(47 productos)
- DYRK(47 productos)
- Dynamin(27 productos)
- Ferroptosis(226 productos)
- HSP(179 productos)
- Integrin(230 productos)
- Kinesina(87 productos)
- LIM quinasa(20 productos)
- Asociado a microtúbulos(272 productos)
- PKC(120 productos)
- PLK(25 productos)
- ROCK(63 productos)
- Rho(6 productos)
- Wee1(14 productos)
- c-Myc(76 productos)
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Se han encontrado 3835 productos de "Ciclo celular / Checkpoint"
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Cdc7-IN-18
CAS:Cdc7-IN-18 (1-2) inhibits CDC7 enzyme (IC50: 1.29 nM) and COLO205 cell proliferation (IC50: 53.62 nM).Fórmula:C19H21N5OSForma y color:SolidPeso molecular:367.47WRN inhibitor 12
CAS:WRN inhibitor 12 (compound 5) serves as an inhibitor for the WRN helicase.Fórmula:C33H33ClF3N9O5Forma y color:SolidPeso molecular:728.12Polθ-IN-6
CAS:Polθ-IN-6 (Compound 89) is an inhibitor of DNA polymerase theta (Polθ) and exhibits antitumor activity.Fórmula:C25H23N3O3SForma y color:SolidPeso molecular:445.53CDK12/13 ligand 1
CAS:ALK-IN-29 (compound 4c) exhibits notable inhibitory activity against tyrosine kinases such as ALK, CDK2/CyclinE1, and FAK, with the strongest inhibition observed against ALK kinase, showing a 40.63% inhibition rate at a concentration of 10 μM. ALK-IN-29 is useful for cancer research.Fórmula:C26H26BrN5OForma y color:SolidPeso molecular:504.42Tubulin inhibitor 49
CAS:Tubulin inhibitor 49 is a tubulin polymerization inhibitor that disrupts the cellular microtubule network, arrests the cell cycle. toxic toward HeLa cells.Fórmula:C18H14F3N3OSPureza:99.15%Forma y color:SolidPeso molecular:377.387-Methylguanosine 5′-monophosphate
CAS:7-Methylguanosine 5′-monophosphate (7-Methylguanylic acid) is a component of nucleic acids.Fórmula:C11H16N5O8PForma y color:SolidPeso molecular:377.25USP7-IN-6
CAS:USP7-IN-6 is a potent inhibitor of ubiquitin-specific protease 7 (USP7, IC50: 6.8 nM).Fórmula:C41H43N7O4SPureza:98%Forma y color:SolidPeso molecular:729.89CDK2/4-IN-2
CAS:CDK2/4-IN-2 (compound 56) serves as a dual inhibitor for CDK2 and CDK4, exhibiting an IC50 of less than 100 nM. It is applicable in cancer research.Fórmula:C18H20F3N7O3S2Forma y color:SolidPeso molecular:503.52CTPS1-IN-1
CAS:CTPS1-IN-1 is a cytidine-5′ triphosphate synthase 1 (CTPS1) inhibitor with potential antitumor activity and can be used to study autoimmune diseases.Fórmula:C21H22N6O4S2Pureza:99.46%Forma y color:SolidPeso molecular:486.57GFB-12811
CAS:GFB-12811 is an orally active, selective, and potent CDK5 inhibitor, used in the study of autosomal dominant polycystic kidney disease.Fórmula:C22H23F4N5OPureza:98.88%Forma y color:SolidPeso molecular:449.44Elacytarabine
CAS:Elacytarabine (M7594 0037), a lipid-conjugated derivative of the nucleoside analog cytarabine, is an antineoplastic drug. It has cytotoxicity in solid tumors.Fórmula:C27H45N3O6Pureza:97.69%Forma y color:SolidPeso molecular:507.66HRO761
CAS:HRO761 is a potent Werne r syndrome RecQ DNA deconjugase (WRN) inhibitor that can be used to study cancers such as colon and stomach cancer.Fórmula:C31H31ClF3N9O5Pureza:98.74% - 99.62%Forma y color:SolidPeso molecular:702.08Ref: TM-T72107
1mg57,00€5mg118,00€10mg167,00€25mg280,00€50mg475,00€100mg708,00€1mL*10mM (DMSO)778,00€VCPIP1-IN-1
CAS:VCPIP1-IN-1 is a VCPIP1 inhibitor used in cancer research.Fórmula:C13H15ClN2O2Pureza:99.3%Forma y color:SolidPeso molecular:266.72Ref: TM-T88664
1mg47,00€5mg92,00€10mg145,00€25mg281,00€50mg447,00€100mg715,00€200mg964,00€1mL*10mM (DMSO)101,00€LY3143921 hydrate
CAS:LY3143921 ((S)-Example 2) hydrate is an orally active CDC7 kinase inhibitor with broad in vitro anticancer activity [1].Fórmula:C16H14FN5O2Pureza:98.43%Forma y color:SolidPeso molecular:327.31SR 11302
CAS:SR 11302 is an inhibitor of activator protein-1 (AP-1).Fórmula:C26H32O2Pureza:98.65%Forma y color:SolidPeso molecular:376.53Ref: TM-T23384
1mg93,00€5mg137,00€10mg205,00€25mg356,00€50mg587,00€100mg888,00€1mL*10mM (DMSO)150,00€INCB086550
CAS:INCB086550 (PD-1/PD-L1-IN-8) (example 24) is a PD-1/PD-L1 inhibitor, with an IC50 <= 10 nM.Fórmula:C41H39N7O4Pureza:98.49%Forma y color:SolidPeso molecular:693.79Troxacitabine
CAS:Troxacitabine, a DNA polymerase inhibitor, is potentially used for the treatment of acute myeloid leukemia (AML). In comparison with gemcitabine, troxacitabine was equally active against MiaPaCa and was more efficacious against Panc-01.Fórmula:C8H11N3O4Pureza:98%Forma y color:SolidPeso molecular:213.19Bicyclomycin benzoate
CAS:Bicyclomycin benzoate (BCM benzoate, FR2054) is a broad-spectrum antibiotic and selective Rho protein inhibitor active against Gram-negative bacteria.Fórmula:C19H22N2O8Forma y color:SolidPeso molecular:406.39PLK1-IN-6
PLK1-IN-6: potent, selective PLK1 inhibitor, IC50 = 0.45 nM, hinders cancer cell growth.
Fórmula:C28H37N9O3Forma y color:SolidPeso molecular:547.65Ethynylcytidine
CAS:Ethynylcytidine is a nucleoside antimetabolite.Fórmula:C11H13N3O5Pureza:98%Forma y color:SolidPeso molecular:267.24NSC639828
CAS:NSC639828 is an efficient inhibitor of DNA polymerase α, exhibiting a remarkable IC50 value of 70 μM. Additionally, NSC639828 demonstrates substantial antitumor activity, making it a promising candidate for cancer research.Fórmula:C18H13BrClN5O3Forma y color:SolidPeso molecular:462.69N6-Benzoyl-5′-O-(4,4′-dimethoxytrityl)-2′-deoxyadenosine
CAS:N6-Benzoyl-5′-O-(4,4′-dimethoxytrityl)-2′-deoxyadenosine, catalog number T66118 and CAS number 64325-78-6, is a valuable organic compound for life sciences research.Fórmula:C38H35N5O6Forma y color:SolidPeso molecular:657.727GSK-3/CDK5/CDK2-IN-1
CAS:GSK-3/CDK5/CDK2-IN-1 is an imidazole derivative compound that inhibits cdk5, cdk2, and GSK-3.it has demonstrated applications in cancer research and the study of neurodegenerative diseases [1].Fórmula:C21H22N4O2Forma y color:SolidPeso molecular:362.433Formycin A
CAS:Formycin A shows antitumor and antiviral activities. Formycin A , a purine nucleoside antibiotic, is a potent human immunodeficiency virus type 1 (HIV-1) inhibitor with an EC50 of 10 μM.Fórmula:C10H13N5O4Pureza:98%Forma y color:SolidPeso molecular:267.245'-DMT-3'-TBDMS-ibu-rG
CAS:5'-DMT-3'-TBDMS-ibu-rG is a modified nucleoside employed in deoxyribonucleic acid (DNA) synthesis.Fórmula:C41H51N5O8SiForma y color:SolidPeso molecular:769.963BrB-PP1
CAS:3BrB-PP1 is an ATP-competitive analog that exhibits specific inhibitory activity towards protein kinase, particularly effective against protein kinases with mutations in the ATP-binding pocket, such as the Thr97 mutation within Sty1's ATP-binding pocket.Fórmula:C16H18BrN5Forma y color:SolidPeso molecular:360.2595'-O-DMT-N6-ibu-dA
CAS:5'-O-DMT-N6-ibu-dA can be utilized in the synthesis of oligodeoxyribonucleotides.Fórmula:C35H37N5O6Forma y color:SolidPeso molecular:623.712'-Deoxy-2'-fluoro-5-iodouridine
CAS:2'-Deoxy-2'-fluoro-5-iodouridine is a nucleoside, specifically a fluoro-modified and halo-nucleoside.Fórmula:C9H10FIN2O5Forma y color:SolidPeso molecular:372.09Tanuxiciclib
CAS:Tanuxiciclib is a cyclin dependent kinase (CDK) inhibitor, specifically designed to interfere with cell cycle progression by inhibiting the activity of CDKs, which are crucial regulators of cell division.Fórmula:C15H13FN6OForma y color:SolidPeso molecular:312.3086-Amino-5-nitropyridin-2-one
CAS:6-Amino-5-nitropyridin-2-one, a pyridine derivative, serves as a nucleobase within hachimoji DNA, where it is specifically paired with 5-aza-7-deazaguanine.Fórmula:C5H5N3O3Pureza:98%Forma y color:SolidPeso molecular:155.11MitoE10
CAS:MitoE10 is an effective mitochondrial targeting antioxidant.Fórmula:C42H55O5PSForma y color:SolidPeso molecular:702.92Ribocil-C
CAS:Ribocil-C is a selective inhibitor of the bacterial riboflavin riboswitch, a synthetic analogue of flavin mononucleotide (FMN), inhibits bacterial cell growth.Fórmula:C21H21N7OSPureza:98%Forma y color:SolidPeso molecular:419.5Tibremciclib
CAS:Tibremciclib is a cyclin-dependent kinase 4 (CDK4) inhibitor that exhibits antineoplastic properties [1].
Fórmula:C28H32F2N8Pureza:98%Forma y color:SolidPeso molecular:518.6PHI-101
CAS:PHI-101 is a checkpoint kinase 2 (Chk2) inhibitor that can be used for the study of refractory acute myeloid leukemia (AML) and ovarian cancer.
Fórmula:C19H19FN4O2SPureza:99.4%Forma y color:SolidPeso molecular:386.44YK-2168
CAS:YK-2168 is a differentiated selective inhibitor of CDK9.
Fórmula:C16H18ClN5Forma y color:SolidPeso molecular:315.80Ref: TM-T200769
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