Ciclo celular / Checkpoint
Los inhibidores del ciclo celular/puntos de control son compuestos que interrumpen la progresión normal del ciclo celular, particularmente en puntos de control regulatorios clave. Estos inhibidores son cruciales para estudiar la división celular, comprender la proliferación de células cancerosas y desarrollar terapias anticancerígenas. Al dirigirse a fases específicas del ciclo celular, estos inhibidores pueden inducir la detención del ciclo celular, lo que lleva a apoptosis o senescencia en células de división rápida. En CymitQuimica, ofrecemos una amplia gama de inhibidores de alta calidad del ciclo celular/puntos de control para apoyar su investigación en biología del cáncer, biología celular y desarrollo de fármacos.
Subcategorías de "Ciclo celular / Checkpoint"
- Aurora quinasa(94 productos)
- CDK(500 productos)
- Detención del ciclo celular(4 productos)
- Chk(42 productos)
- DYRK(48 productos)
- Dynamin(23 productos)
- Ferroptosis(215 productos)
- HSP(169 productos)
- Integrin(224 productos)
- Kinesina(66 productos)
- LIM quinasa(19 productos)
- Asociado a microtúbulos(261 productos)
- PKC(102 productos)
- PLK(28 productos)
- ROCK(70 productos)
- Rho(2 productos)
- Wee1(15 productos)
- c-Myc(69 productos)
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Se han encontrado 3477 productos de "Ciclo celular / Checkpoint"
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10-Formylfolic acid
CAS:<p>10-Formylfolic acid is a novel and potent inhibitor of dihydrofolate reductase, which can be used in leukemia research.</p>Fórmula:C20H19N7O7Pureza:98.42%Forma y color:SolidPeso molecular:469.419-Isopropylolomoucine
CAS:<p>9-Isopropylolomoucine (N9-Isopropylolomoucine), a cell cycle protein-dependent kinase inhibitor, is a thiopurine.</p>Fórmula:C17H22N6OPureza:99.82%Forma y color:SolidPeso molecular:326.4TC-S 7005
CAS:<p>TC-S 7005 is an effective inhibitor of Polo-like kinases (IC50s: 214 nM, 4 nM and 24 nM for Plk1, Plk2, and Plk3).</p>Fórmula:C21H17N3O3Pureza:99.516%Forma y color:SolidPeso molecular:359.38CRT-0105950
CAS:<p>CRT-0105950 is an effective LIMK inhibitor that acts by suppressing cofilin phosphorylation and increasing αTubulin acetylation in cells.</p>Fórmula:C21H16ClN3OSPureza:99.78% - 99.86%Forma y color:SolidPeso molecular:393.89CDK8-IN-1
CAS:<p>CDK8-IN-1 is a selective CDK8 inhibitor (IC50: 3 nM).</p>Fórmula:C11H8F3N3OPureza:98.48%Forma y color:SolidPeso molecular:255.2AGX51
CAS:<p>AGX51 is an antagonist of inhibitor of DNA binding (ID) proteins. AGX51 treatment lead to pan-Id degradation, cell cycle arrest, and cell death.</p>Fórmula:C27H29NO4Pureza:97.65%Forma y color:OilPeso molecular:431.52Peldesine
CAS:<p>Peldesine (BCX 34), an oral purine nucleoside phosphorylase blocker, halts T-cell growth; used in CTCL, psoriasis, HIV research. IC50: 800 nM.</p>Fórmula:C12H11N5OPureza:99.27% - 99.9%Forma y color:SolidPeso molecular:241.256-Hydroxy-DOPA
CAS:<p>6-Hydroxy-DOPA is an allosteric inhibitor of RAD52, it inhibits proliferation of BRCA-deficient cancer cells in vitro and also inhibits APE1.</p>Fórmula:C9H11NO5Pureza:97.78% - 97.95%Forma y color:SolidPeso molecular:213.19NR2F6 modulator-1
CAS:<p>NR2F6 modulator-1, a potent agent for NR2F6, affects immune response and tumor stem cell activity.</p>Fórmula:C23H17NO5SPureza:98.31%Forma y color:SolidPeso molecular:419.45Chiauranib
CAS:<p>Chiauranib, a potent anticancer agent, inhibits angiogenesis kinases (VEGFR1-3, PDGFRα, c-Kit), Aurora B, and CSF1R with IC50 values of 1-9 nM.</p>Fórmula:C27H21N3O3Pureza:99.22%Forma y color:SolidPeso molecular:435.47Cytembena
CAS:<p>Cytembena is a cytostatic and a carcinogenic compound that may increase the incidence of fibroadenomas.Cytembena broadly inhibits DNA biosynthesis.</p>Fórmula:C11H8BrNaO4Pureza:99.35%Forma y color:White PowderPeso molecular:307.07Talviraline
CAS:<p>Talviraline (Bay 10-8979) is an RNA-induced DNA polymerase inhibitor.Talviraline is a potent inhibitor of HIV-1-induced cell killing and HIV-1 replication in a</p>Fórmula:C15H20N2O3S2Pureza:99.82%Forma y color:SolidPeso molecular:340.46HA-1004
CAS:<p>HA-1004 is a inhibitor of PKG, PKA, PKC and MLC.</p>Fórmula:C12H15N5O2SPureza:99.56% - 99.63%Forma y color:SolidPeso molecular:293.34dCeMM2
CAS:<p>dCeMM2 degrades glue by promoting CDK12-cyclin K ubiquitination and degradation via CRL4B ligase interaction.</p>Fórmula:C16H11ClN6OSPureza:99.68%Forma y color:SolidPeso molecular:370.82TTP-8307
CAS:<p>TTP-8307 is an antiviral compound that inhibits the replication of rhinoviruses and enteroviruses and is used in the study of viral infections.</p>Fórmula:C27H21FN4OPureza:98.95%Forma y color:SolidPeso molecular:436.48BioE-1115
CAS:<p>BioE-1115 is a selective and potent inhibitor of serine-threonine protein kinase (PASK, IC50 = 4 nM). BioE-1115 is a potent inhibitor of CK2α (IC50 = 10 μM).</p>Fórmula:C19H18FN3O2Pureza:97.54%Forma y color:SolidPeso molecular:339.36CHD1Li 6.11
CAS:<p>CHD1Li 6.11 inhibits CHD1L protein (IC50: 3.3 µM), shrinks CRC tumors in vivo, and is orally active.</p>Fórmula:C21H22BrN5OSPureza:99.04%Forma y color:SolidPeso molecular:472.4(S)-PF-06873600
CAS:<p>(S)-PF-06873600 is the S enantiomer of PF-06873600 which is an inhibitor of CDK.</p>Fórmula:C20H27F2N5O4SPureza:98.59%Forma y color:SolidPeso molecular:471.52Haspin-IN-3
CAS:<p>Haspin-IN-3 is a potent haspin inhibitor with an IC50 of 14 nM.Haspin-IN-3 has anticancer activity.</p>Fórmula:C16H10N2O3Pureza:98.78%Forma y color:SolidPeso molecular:278.26Ryuvidine
CAS:<p>Ryuvidine is a dual inhibitor of KDM5A and SETD8, an inducer of the DNA damage response, and can be used to study breast cancer and erythroderma.</p>Fórmula:C15H12N2O2SPureza:98.6%Forma y color:SolidPeso molecular:284.33GRK6-IN-1
CAS:<p>GRK6-IN-1 (compound 18) is a potent GRK6 blocker, with an IC50 of 120 nM, showing promise for multiple myeloma research.</p>Fórmula:C22H23ClN6O2Pureza:99.37%Forma y color:SolidPeso molecular:438.91UMK57
CAS:<p>UMK57 is a CENP-Ei and MCAK enhancer, selectively promoting k-MT attachment error correction to inhibit chromosome missegregation of small molecule compounds,</p>Fórmula:C17H17N3SPureza:99.81%Forma y color:SolidPeso molecular:295.4Eprociclovir
CAS:<p>Eprociclovir (A-5021) is a novel acyclovir analog that is a potent inhibitor of EHV1 replication and may be used for the treatment and/or prevention of</p>Fórmula:C11H15N5O3Pureza:98.50% - 99.86%Forma y color:SolidPeso molecular:265.27CDK4/6/1 Inhibitor
CAS:<p>CDK4/6/1 Inhibitor (Crozbaciclib) is a type of CDK4/6 inhibitor (IC50s: 3 and 1 nM).</p>Fórmula:C28H30F2N6Pureza:99.26% - 99.72%Forma y color:SolidPeso molecular:488.57hSMG-1 inhibitor 11e
CAS:<p>hSMG-1 inhibitor 11e is an effective and selective inhibitor of hSMG-1 (IC50 <0.05 nM) and can be used in studies about cancer treatment.</p>Fórmula:C26H27N7O3SPureza:99.89%Forma y color:SolidPeso molecular:517.6BML-259
CAS:<p>BML-259 inhibits CDK5/CDK2 (IC50: 64/98 nM) for cancer and neurodegeneration research.</p>Fórmula:C14H16N2OSPureza:99.84%Forma y color:SolidPeso molecular:260.35SB-747651A Dihydrochloride
CAS:<p>SB-747651A dihydrochloride, an MSK1 inhibitor (IC50=11 nM), also targets PRK2, RSK1, p70S6K, ROCK-II; potential in inflammation study.</p>Fórmula:C16H24Cl2N8OPureza:98.05%Forma y color:SolidPeso molecular:415.32RP-6306
CAS:<p>Lunresertib (RP-6306) is a potent, selective, and orally active PKMYT1 inhibitor with an IC50 of 14 nM.Cost-effective and quality-assured.</p>Fórmula:C18H20N4O2Pureza:98.41% - 99.28%Forma y color:SolidPeso molecular:324.38SEL120-34A
CAS:<p>SEL120-34A inhibits CDK8 (IC50: 4.4 nM) & CDK19 (10.4 nM), less on CDK9 (1070 nM), has antitumor properties.</p>Fórmula:C15H18Br2N4Pureza:99.764% - 99.84%Forma y color:SolidPeso molecular:414.14CDK-IN-2
CAS:<p>CDK-IN-2 (CDK inhibitor II) is a potent and specific CDK9 inhibitor (IC50: <8 nM).</p>Fórmula:C18H19ClFN3O2Pureza:99.67%Forma y color:SolidPeso molecular:363.81DDRI-18
CAS:<p>DDRI-18 is an inhibitor that regulates the DNA damage response, has anticancer activity, and inhibits non-homologous end-joining (NHEJ) DNA repair.</p>Fórmula:C26H20N6Pureza:98%Forma y color:SolidPeso molecular:416.48ZIM
CAS:<p>ZIM, from 4-Aminoantipyrine, induces DNA and chromosomal damage, cell death, and phagocytosis, with potential in cancer therapy.</p>Fórmula:C20H19N3O3Pureza:99.85%Forma y color:SolidPeso molecular:349.38Cdk2 Inhibitor II
CAS:<p>Cdk2 Inhibitor II is a selective and potent CDK2 inhibitor50 at 60 nM.</p>Fórmula:C14H11BrN4O3SPureza:97.07%Forma y color:SolidPeso molecular:395.23Talotrexin ammonium
CAS:<p>Talotrexin ammonium, a non-polyglutamic antifolate, inhibits cancer by targeting DHFR.</p>Fórmula:C27H30N10O6Pureza:97.49%Forma y color:SolidPeso molecular:590.59NSC16168
CAS:<p>NSC16168 is a selective ERCC1-XPF inhibitor that inhibits DNA repair and potentiates the antitumor activity of cisplatin.</p>Fórmula:C17H15NO9S3Pureza:99.88%Forma y color:SolidPeso molecular:473.5PS423
CAS:<p>PS423 is a substrate-selective protein kinase PDK1 inhibitor that acts by binding to the PIF-pocket allosteric docking site.</p>Fórmula:C25H23F3O9Pureza:98.81% - 99.26%Forma y color:SolidPeso molecular:524.44ERCC1-XPF-IN-2
CAS:<p>ERCC1-XPF-IN-2: Nucleotide repair active, boosts cisplatin, inhibits ERCC1-XPF (IC50: 0.6 μM).</p>Fórmula:C15H13Cl2NO3Pureza:98.21%Forma y color:SolidPeso molecular:326.17(S)-Enitociclib
CAS:<p>(S)-Enitociclib (VIP152) is a selective CDK9 inhibitor that inhibits the transcription of anti-apoptotic and pro-survival proteins.</p>Fórmula:C19H18F2N4O2SPureza:98.98%Forma y color:SolidPeso molecular:404.43SMN-C2
CAS:<p>SMN-C2, a SMN2 gene splicing regulator, is an RNA-binding ligand that regulates pre-mRNA splicing and has potential for studying spinal muscular atrophy.</p>Fórmula:C24H27N5O2Pureza:99.14%Forma y color:SolidPeso molecular:417.5Netivudine
CAS:<p>Netivudine, a potent NRTI with anti-varicella activity, treats HIV by inhibiting reverse transcriptase, reducing viral load.</p>Fórmula:C12H14N2O6Pureza:99.78%Forma y color:SolidPeso molecular:282.25Poloxin-2
CAS:<p>Poloxin-2 is a potent and selective Plk1 PBD inhibitor with anti-tumour activity that reduces the protein level of Plk1 in HeLa cells.</p>Fórmula:C16H15NO3Pureza:99.67%Forma y color:SolidPeso molecular:269.3PCSK9-IN-10
CAS:<p>PCSK9-IN-10: potent oral PCSK9 inhibitor (IC50 = 6.4 µM), upregulates LDLR, curbs atherosclerosis, for hyperlipidemia research.</p>Fórmula:C18H23N5O4Pureza:99.06%Forma y color:SoildPeso molecular:373.41COH34
CAS:<p>COH34 (1-[(E)-(4-methylphenyl)sulfanyliminomethyl]naphthalen-2-ol) is a selective inhibitor of PARG with an IC50 of 0.37 nM and a Kd of 0.547 μM.</p>Fórmula:C18H15NOSPureza:99.57%Forma y color:SolidPeso molecular:293.38L82
CAS:<p>L82: A selective, non-competitive DNA Lig1 inhibitor with anti-proliferative effects on breast cancer cells. IC50=12 μM.</p>Fórmula:C11H8ClN5O4Pureza:97.45% - 98.91%Forma y color:SolidPeso molecular:309.67RP-6685
CAS:<p>RP-6685 is a potent, selective DNA Polθ inhibitor with strong oral efficacy, an IC50 of 5.8 nM, and marked antitumor effects in mice.</p>Fórmula:C22H14F7N5OPureza:99.65%Forma y color:SoildPeso molecular:497.37SB 328437
CAS:<p>SB 328437 ((S)-methyl 2-(1-naphthamido)-3-(4-nitrophenyl)propanoate) is an effective and selective antagonist of CCR3 (IC50 = 4.5 nM).</p>Fórmula:C21H18N2O5Pureza:99.54%Forma y color:SolidPeso molecular:378.38DENV-IN-5
CAS:<p>Denv-in-5 is an effective and selective dengue virus (DENV) inhibitor with EC50 values of 1.47, 9.23, 7.08, 8.91 μM for denV-I-IV and 0.1512 μM for HIV-1IIIB.</p>Fórmula:C23H25ClF2N4OSPureza:99.06%Forma y color:SolidPeso molecular:478.99CDK-IN-11
CAS:<p>CDK-IN-11, a heterocyclic compound, promotes cardiomyocyte maturation [1].</p>Fórmula:C25H21BrN4O2Forma y color:SolidPeso molecular:489.36WRN inhibitor 3
CAS:<p>WRN Inhibitor 3 (example 110), a cyclic vinyl sulfone-based compound, serves as an inhibitor of the Werner Syndrome ATP-dependent helicase enzyme (WRN).</p>Fórmula:C20H20N2O5SForma y color:SolidPeso molecular:400.45WRN inhibitor 4
CAS:<p>WRN Inhibitor 4 (Example 107), a cyclic vinyl sulfone-based compound, serves as an inhibitor of the Werner Syndrome ATP-dependent helicase enzyme (WRN).</p>Fórmula:C16H14N2O5SForma y color:SolidPeso molecular:346.36QR-6401
CAS:<p>QR-6401, a selective macrocyclic CDK2 inhibitor, is orally active with IC50 values of 0.37 nM for CDK2/E1, 10 nM for CDK9/T1, 22 nM for CDK1/A2, 34 nM for CDK6/</p>Fórmula:C19H23N5O3Pureza:98%Forma y color:SolidPeso molecular:369.42CDK9-IN-8
CAS:<p>CDK9-IN-8 is a highly potent and selective CDK9 inhibitor (IC50: 12 nM).</p>Fórmula:C31H32FN7O3Pureza:99.54%Forma y color:SolidPeso molecular:569.63G4/HDAC-IN-1
<p>G4/HDAC-IN-1, a G4/HDAC dual inhibitor, IC50 1.1 µM, blocks TNBC growth, useful in cancer research.</p>Fórmula:C36H49ClFN7O4Forma y color:SolidPeso molecular:698.27CDK9-IN-29
CAS:<p>CDK9-IN-29 (compound Z11) is a potent inhibitor of CDK9, exhibiting high kinase selectivity and an IC50 value of 3.20 nM.</p>Fórmula:C29H33F2N5O4Pureza:98%Forma y color:SolidPeso molecular:553.6CDK/HDAC-IN-3
CAS:<p>CDK/HDAC-IN-3 is an orally active dual inhibitor of HDACs and CDKs, offering potent and selective inhibition of CDK9, CDK12, CDK13, HDAC1, HDAC2, and HDAC3,</p>Fórmula:C24H18Cl2N6O3Pureza:98%Forma y color:SolidPeso molecular:509.34c-Myc inhibitor 8
CAS:<p>c-Myc inhibitor 8 suppresses cell growth in various cancers and is used in research.</p>Fórmula:C19H12BrClF3NO3S2Forma y color:SolidPeso molecular:538.79Sapacitabine
CAS:<p>Sapacitabine (CS682) is a nucleoside analog precursor with anticancer activity used in the study of leukemia.</p>Fórmula:C26H42N4O5Pureza:98.82%Forma y color:SolidPeso molecular:490.64Nε-(1-Carboxyethyl)-L-lysine
CAS:<p>Nε-(1-Carboxyethyl)-L-lysine (CEL) is an advanced glycation end-product (AGE). Exposure to CEL reduces glutamate uptake and S100B secretion in the hippocampus.</p>Fórmula:C9H18N2O4Forma y color:SolidPeso molecular:218.25BVDU 5′-Triphosphate
CAS:<p>BVDU 5′-Triphosphate is an antiviral agent labeled with 5′-Triphosphate that specifically targets viral DNA polymerase.</p>Fórmula:C11H16BrN2O14P3Pureza:98%Forma y color:SolidPeso molecular:573.08GGTI 2147
CAS:<p>GGTI 2147 decreased Rac1 activity, down-regulated p65 expression, and ameliorated OGD/R-induced neuronal apoptosis.</p>Fórmula:C28H30N4O3Pureza:98.69%Forma y color:SolidPeso molecular:470.565'-ODMT cEt m5U Phosphoramidite (Amidite)
CAS:<p>5'-ODMT cEt m5U Phosphoramidite Amidite, a locked nucleic acid (LNA) analog, demonstrates exceptional safety and antisense activity [1] [2].</p>Fórmula:C42H51N4O9PForma y color:SolidPeso molecular:786.859-Deazaguanine
CAS:<p>9-Deazaguanine is a nucleoside analogue exhibiting inhibitory activity against bovine purine nucleoside phosphorylase (PNP).</p>Fórmula:C6H6N4OPureza:98%Forma y color:SolidPeso molecular:150.148-Azahypoxanthine
CAS:<p>8-Azahypoxanthine (NSC-22709) inhibits hypoxanthine-guanine-xanthine phosphoribosyltransferase and has antimalarial properties.</p>Fórmula:C4H3N5OPureza:99.66%Forma y color:Light Yellow To Light Beige Fine CrystallinePeso molecular:137.1ATN-161
CAS:<p>ATN-161 is an integrin α5β1 binding peptide and antagonist that inhibits VEGF-induced hCECs migration and angiogenesis.</p>Fórmula:C23H35N9O8SPureza:98%Forma y color:SolidPeso molecular:597.64Raluridine
CAS:<p>Raluridine is an HIV treatment inhibiting RNA-directed DNA polymerase with IC50 of 1.8 microM, compared to FLT, AZT, ddI, and ddC.</p>Fórmula:C9H10ClFN2O4Pureza:98%Forma y color:SolidPeso molecular:264.64(2S,3R)-Voruciclib
CAS:<p>(2S,3R)-Voruciclib is the (2S,3R)-enantiomer of Voruciclib. It is an orally active CDK inhibitor.</p>Fórmula:C22H19ClF3NO5Pureza:98%Forma y color:SolidPeso molecular:469.84TC-I 15
CAS:<p>α2β1 integrin inhibitor</p>Fórmula:C23H28N4O6S2Pureza:98%Forma y color:SolidPeso molecular:520.62αvβ1 integrin-IN-2
CAS:<p>αvβ1 integrin-IN-2 (compound 32) is a potent inhibitor of ανβ1 and α5β1 integrins, exhibiting IC50 values of 0.9 nM and 33 nM, respectively.</p>Fórmula:C29H38N4O4Pureza:98%Forma y color:SolidPeso molecular:506.64α7β1 integrin modulator-1
CAS:<p>α7β1 Integrin Modulator-1 is a potent modulator with research potential for muscular dystrophy [1].</p>Fórmula:C23H29N3O6SPureza:98%Forma y color:SolidPeso molecular:475.56DAM-IN-1
CAS:<p>DMA-IN-1 is a DNA adenine methyltransferase (DAM) inhibitor with an IC50 value of 48 μM.</p>Fórmula:C16H17NO4Pureza:98%Forma y color:SolidPeso molecular:287.31CT1113
CAS:<p>CT1113, a potent inhibitor of both USP28 and USP25, effectively reduces MYC levels in vivo and demonstrates anti-tumor efficacy in a mouse pancreatic cancer CDX</p>Fórmula:C25H29N5O2SForma y color:SolidPeso molecular:463.6Votoplam
CAS:<p>Votoplam functions as a gene splicing modulator, employed in the inhibition of Huntington's disease [1].</p>Fórmula:C21H25N9OPureza:98%Forma y color:SolidPeso molecular:419.48NITD008
CAS:<p>NITD008 (7-Deaza-2'-C-acetylene-adenosine) is an adenosine nucleoside inhibitor with antiviral activity that inhibits dengue and Zika viruses.</p>Fórmula:C13H14N4O4Pureza:98.04%Forma y color:SolidPeso molecular:290.27Aurora Kinases-IN-4
CAS:<p>Aurora Kinases-IN-4 (Compound 11c) is a covalent, ATP-competitive inhibitor of aurora kinase A with an IC50 value of 1.7 nM.</p>Fórmula:C26H28N8OPureza:98%Forma y color:SolidPeso molecular:468.55G-5758
CAS:<p>G-5758 is an orally active IRE1α inhibitor with an IC50 of 38 nM for XBP1s. It is used in studies involving multiple myeloma models [KMS-11], demonstrating good tolerance in rats at oral doses up to 500 mg/kg. G-5758 exhibits pharmacodynamic effects comparable to those induced by IRE1 knockdown.</p>Fórmula:C27H24F4N6O3SForma y color:SolidPeso molecular:588.58ON 108600
CAS:<p>ON 108600 is a chemical inhibitor targeting CK2 (Casein Kinase 2), TNIK, and DYRK1, demonstrating IC50 values of 0.016 μM and 0.007 μM for DYRK1A and DYRK1B, 0.</p>Fórmula:C22H14Cl2N2O6S2Pureza:98%Forma y color:SolidPeso molecular:537.392'-Deoxypseudoisocytidine
CAS:<p>2'-Deoxypseudoisocytidine is a nucleoside analogue.</p>Fórmula:C9H13N3O4Pureza:98%Forma y color:SolidPeso molecular:227.22ROCK2-IN-7
CAS:<p>ROCK2 inhibitor is a chemical compound associated with the therapeutic management of psoriasis.</p>Fórmula:C26H28FN5OPureza:98%Forma y color:SolidPeso molecular:445.53PD-1/PD-L1-IN-34
CAS:<p>PD-1/PD-L1-IN-34 (Compound (1S,2S)-A25) effectively inhibits the PD-1/PD-L1 interaction (IC 50 = 0.029 μM) and demonstrates selective binding affinity to PD-L1</p>Fórmula:C35H33ClN2O3Pureza:98%Forma y color:SolidPeso molecular:565.1SZ-015268
CAS:<p>SZ-015268: CDK7 inhibitor, IC50=23.56 nM; hinders HCC70, OVCAR-3, HCT116, HCC1806 cell growth; strong anti-tumor effect.</p>Fórmula:C25H38N8O3Forma y color:SolidPeso molecular:498.62ASC-69
CAS:<p>ASC-69 (APY69) is a promising potent inhibitor of the PD-1/PD-L1 signaling pathway, classified as a small-molecule compound [1].</p>Fórmula:C19H19N7Pureza:98%Forma y color:SolidPeso molecular:345.4ML-099
CAS:<p>ML-099 is a pan Ras-related GTPases activator that activates Rac1, Ras, GTP-binding protein (Rab7), Rab2A and cell division cycle 42.</p>Fórmula:C14H13NO2SPureza:99.73%Forma y color:SolidPeso molecular:259.32Alatrofloxacin
CAS:<p>Alatrofloxacin is a prodrug of trovafloxacin.</p>Fórmula:C26H25F3N6O5Forma y color:SolidPeso molecular:558.51L-739758
CAS:<p>L-739758 is a glycoprotein IIb/IIIa inhibitor.</p>Fórmula:C22H26N4O5S3Forma y color:SolidPeso molecular:522.66CCT-271850
CAS:<p>CCT-271850 is an inhibitor of the spindle checkpoint function of Monospindle 1.</p>Fórmula:C24H29N7OPureza:98%Forma y color:SolidPeso molecular:431.53Palbociclib orotate
CAS:<p>Palbociclib (PD 0332991) orotate, an orally active selective inhibitor of CDK4 and CDK6, exhibits IC50 values of 11 and 16 nM, respectively.</p>Fórmula:C29H33N9O6Pureza:98%Forma y color:SolidPeso molecular:603.63Lerociclib
CAS:<p>Lerociclib (G1T38) is a CDK4/6 inhibitor with anticancer and antitumor activities, inhibiting CDK4/CyclinD1 and CDK6/CyclinD3.</p>Fórmula:C26H34N8OPureza:99%Forma y color:SolidPeso molecular:474.6UNC2170 maleate
CAS:<p>53BP1-binding protein 1 (53BP1) engages with dimethylated lysine 20 on histone 4 (H4K20me2) through its tandem tudor domains within a homodimer configuration, crucial for the DNA damage response. UNC2170, a micromolar 53BP1 ligand, selectively interacts with this site, demonstrating at least 17-fold preference for 53BP1 over similar proteins. This interaction occurs in a pocket formed by the 53BP1's tudor domains. Moreover, UNC2170 acts as an antagonist to 53BP1 in cellular lysates, effectively inhibiting class switch recombination, a process dependent on the functional 53BP1 tudor domain, thus confirming its cellular activity.</p>Fórmula:C14H21BrN2OC4H4O4Forma y color:SolidPeso molecular:429.31CDK9-IN-23
CAS:<p>CDK9-IN-23 (Example 4) is a potent inhibitor of CDK9, exhibiting an IC50 value of less than 20 nM [1].</p>Fórmula:C22H25ClN4O3Pureza:98%Forma y color:SolidPeso molecular:428.91Aurora kinase inhibitor-8
CAS:<p>Aurora kinase inhibitor-8 is a highly selective inhibitor of Aurora kinase.</p>Fórmula:C30H29N7O3Forma y color:SolidPeso molecular:535.6DUB-IN-7
CAS:<p>DUB-IN-7 (compound 43), a deubiquitinating enzyme (DUB) inhibitor, has utility in researching diseases driven by aberrant JAK2 activity, including leukemia [1].</p>Fórmula:C17H19N5OForma y color:SolidPeso molecular:309.37m-Se3
CAS:<p>m-Se3 is a potent, selective inhibitor of c-MYC transcription with demonstrated capability to inhibit tumor growth and exhibit anti-cancer activity [1].</p>Fórmula:C29H23IN2SePureza:98%Forma y color:SolidPeso molecular:605.373-Hydroxyxanthone
CAS:<p>3-Hydroxyxanthone (3-Hydroxy-xanthen-9-one), a xanthone derivative, exhibits inhibitory effects on NADPH-catalyzed lipid peroxidation in human umbilical vein</p>Fórmula:C13H8O3Pureza:98%Forma y color:SolidPeso molecular:212.2WRN inhibitor 2
CAS:<p>WRN Inhibitor 2 (example 118), a potent inhibitor of the WRN (Werner Syndrome ATP-dependent helicase enzyme), exhibits a pIC50 value of 7.0 or greater [1].</p>Fórmula:C15H11F3N2O5S2Pureza:98%Forma y color:SolidPeso molecular:420.38Voruciclib hydrochloride
CAS:<p>Voruciclib hydrochloride is an orally active and selective inhibitor of CDK (Ki: 0.626 nM-9.1 nM).</p>Fórmula:C22H20Cl2F3NO5Pureza:98%Forma y color:SolidPeso molecular:506.3ROCK-IN-9
CAS:<p>ROCK-IN-9 (Compound T345), a ROCK inhibitor, exhibits cytotoxicity in HepG2 cells with an IC50 of 40.8 μM.</p>Fórmula:C20H20FN5O2Pureza:98%Forma y color:SolidPeso molecular:381.4Gly-Arg-Gly-Asp-Ser TFA
CAS:<p>Gly-Arg-Gly-Asp-Ser (TFA), osteopontin domain, binds αvβ3 and αvβ5 integrins; IC50s: ~5 μM, ~6.5 μM.</p>Fórmula:C19H31F3N8O11Forma y color:SolidPeso molecular:604.49CDK4/6-IN-17
CAS:<p>CDK4/6-IN-17 (compound 12) is an orally bioavailable inhibitor of CDK4/6, demonstrating potent activity with IC50 values between 10-100 nM in BE(2) cells.</p>Fórmula:C27H28F4N8Pureza:98%Forma y color:SolidPeso molecular:540.56CCG-232964
CAS:<p>CCG-232964 is an orally active Rho/MRTF/SRF inhibitor that suppresses LPA-induced CTGF gene expression [1].</p>Fórmula:C15H15ClN2O3SPureza:98%Forma y color:SolidPeso molecular:338.81NU6300
CAS:<p>NU6300 is a covalent CDK2 inhibitor exhibiting irreversible and ATP-competitive properties and also functions as a GSDMD (Gasdermin D) inhibitor.</p>Fórmula:C20H23N5O3SPureza:96.08%Forma y color:SolidPeso molecular:413.49
