Ciclo celular / Checkpoint
Los inhibidores del ciclo celular/puntos de control son compuestos que interrumpen la progresión normal del ciclo celular, particularmente en puntos de control regulatorios clave. Estos inhibidores son cruciales para estudiar la división celular, comprender la proliferación de células cancerosas y desarrollar terapias anticancerígenas. Al dirigirse a fases específicas del ciclo celular, estos inhibidores pueden inducir la detención del ciclo celular, lo que lleva a apoptosis o senescencia en células de división rápida. En CymitQuimica, ofrecemos una amplia gama de inhibidores de alta calidad del ciclo celular/puntos de control para apoyar su investigación en biología del cáncer, biología celular y desarrollo de fármacos.
Subcategorías de "Ciclo celular / Checkpoint"
- Aurora quinasa(114 productos)
- CDK(546 productos)
- Detención del ciclo celular(5 productos)
- Chk(48 productos)
- DYRK(47 productos)
- Dynamin(27 productos)
- Ferroptosis(227 productos)
- HSP(180 productos)
- Integrin(269 productos)
- Kinesina(87 productos)
- LIM quinasa(20 productos)
- Asociado a microtúbulos(274 productos)
- PKC(126 productos)
- PLK(25 productos)
- ROCK(62 productos)
- Rho(6 productos)
- Wee1(14 productos)
- c-Myc(76 productos)
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Se han encontrado 3904 productos de "Ciclo celular / Checkpoint"
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I-138
CAS:I-138 is an orally active and reversible inhibitor of USP1-UAF1.I-138 induces mono-ubiquitination of FANCD2 and PCNA and inhibits USP1 auto-cleavage in cells.Fórmula:C26H23F3N6OPureza:99.41%Forma y color:SolidPeso molecular:492.5Ref: TM-T73560
1mg170,00€5mg349,00€10mg492,00€25mg707,00€50mg982,00€100mg1.468,00€1mL*10mM (DMSO)384,00€Centrinone-B
CAS:Centrinone-B (LCR-323) is a Plk4 inhibitor with potential anticancer activity for the study of triple-negative breast cancer.Fórmula:C27H27F2N7O5S2Pureza:98.71%Forma y color:SolidPeso molecular:631.67DHODH-IN-15
CAS:DHODH-IN-15, a hydroxyfuran analogue of A771726, inhibits rat liver DHODH with an IC50 of 11 μM, and is used for rheumatoid arthritis.Fórmula:C15H11N3O3Pureza:99.8%Forma y color:SolidPeso molecular:281.27Ref: TM-T11024
1mg109,00€5mg241,00€10mg355,00€25mg532,00€50mg745,00€100mg1.018,00€200mg1.378,00€1mL*10mM (DMSO)225,00€DNA Gyrase-IN-3
CAS:DNA Gyrase-IN-3 inhibits E. coli DNA gyrase B with IC50 5.41-15.64 μM; shows anti-TB and antibacterial properties.Fórmula:C18H20N6OS2Forma y color:SolidPeso molecular:400.52L 888607 Racemate
CAS:L 888607 Racemate blocks DP1 and TP receptors with 132 nM and 17 nM affinity.Fórmula:C19H15ClFNO2SForma y color:SolidPeso molecular:375.84Ilorasertib hydrochloride
CAS:Ilorasertib hydrochloride (ABT-348 hydrochloride) is an ATP-competitive multitargeted kinase inhibitor, which inhibits Aurora C, Aurora B, and Aurora A (IC50s:Fórmula:C25H22ClFN6O2SPureza:98.45%Forma y color:SolidPeso molecular:525TC-Mps1-12
CAS:TC-Mps1-12 is an effective and selective inhibitor of monopolar spindle 1 (IC50: 6.4 nM) .Fórmula:C17H20N6OPureza:98%Forma y color:SolidPeso molecular:324.38CLK1-IN-1
CAS:CLK1-IN-1 is a potent and selective inhibitor of the Cdc2-like kinase 1 (CLK1; IC50: 2 nM).Fórmula:C24H16FN5OForma y color:SolidPeso molecular:409.42THZ1-R
CAS:THZ1-R is a non-covalent active analogue of THZ1, with the acrylamide group removed from THZ1, not covalently bind to the C312 cysteine residue of CDK7.Fórmula:C31H30ClN7O2Pureza:98%Forma y color:SolidPeso molecular:568.07Y-33075
CAS:Y-33075 (Y-39983 free base) is a ROCK inhibitor that lowers IOP, increases blood flow to ONH, and increases the number of RGCs with regenerating axons.Fórmula:C16H16N4OPureza:98%Forma y color:SolidPeso molecular:280.32Datelliptium chloride
CAS:Datelliptium chloride is a DNA-intercalating agent derived from ellipticine. Datelliptium chloride shows anti-tumor activities.Fórmula:C23H28ClN3OPureza:98%Forma y color:SolidPeso molecular:397.94Kif15-IN-1
CAS:Kif15-IN-1 is a Kif15 inhibitor with antiproliferative and potential anticancer activity, which can be used to study gastric cancer.Fórmula:C20H22N4O5SPureza:99.39% - 99.39%Forma y color:SolidPeso molecular:430.48KIF18A-IN-3
CAS:KIF18A-IN-3 is a KIF18A inhibitor (IC50=61 nM) that causes significant mitotic arrest and increases the number of mitotic cells in tumor tissues.Fórmula:C28H38N4O5S2Pureza:98.45%Forma y color:SolidPeso molecular:574.76CDK8/19-IN-51
CAS:CDK8/19-IN-51 is a CDK8 and CDK19 inhibitor with anticancer activity, used in research on colorectal and gastric cancers.Fórmula:C23H22N6O2Pureza:98.65% - 99.62%Forma y color:SoildPeso molecular:414.46Digeranyl bisphosphonate
CAS:Digeranyl bisphosphonate (DGBP) is a potent geranylgeranyl pyrophosphate (GGPP) synthase inhibitor that inhibits geranyl pyrophosphorylation of Rac1.DigeranylFórmula:C21H34Na4O6P2Pureza:98.5%Forma y color:SolidPeso molecular:536.4ST7612AA1
CAS:ST7612AA1: potent, oral HDAC inhibitor; reactivates HIV-1 latency; shows antitumor effects; may study malaria.Fórmula:C20H27N3O4SPureza:99.71%Forma y color:SolidPeso molecular:405.518-Azido-ADP disodium
CAS:8-Azido-ADP (disodium) is a covalent inhibitor of ADP/ATP exchange in mitochondria, causing irreversible inhibition in light.Fórmula:C10H13N8NaO10P2Forma y color:SolidPeso molecular:490.197Triaziquone
CAS:Triaziquone is an alkylating agent that can react with DNA to form intrastrand crosslinks.Fórmula:C12H13N3O2Forma y color:SolidPeso molecular:231.25CCG-257081
CAS:CCG-257081 blocks Rho/MRTF/SRF pathway; prevents fibrosis in mice; useful in cancer and fibrosis research.Fórmula:C24H19ClF3N3O2Pureza:99.60% - 99.94%Forma y color:SolidPeso molecular:473.87Laromustine
CAS:Laromustine (VNP40101M) is a sulfonyl hydrolysis alkylation prodrug for cancer treatment with significant anticancer activity, inhibiting thioredoxin reductase.Fórmula:C6H14ClN3O5S2Pureza:≥98%Forma y color:SolidPeso molecular:307.7810-Formyl-5,8-dideazafolic acid
CAS:10-Formyl-5,8-dideazafolic acid is a thymidylate synthase inhibitor.Fórmula:C22H21N5O7Pureza:96.04%Forma y color:SolidPeso molecular:467.43tBID
CAS:tBID is a selective homeodomain-interacting protein kinase 2 (HIPK2) inhibitor (IC50 of 0.33 μM)Fórmula:C11H3Br4N3O2Pureza:98%Forma y color:SolidPeso molecular:528.78Cdc7-IN-3
CAS:Cdc7-IN-3 is a potent inhibitor of Cdc7 kinase.Fórmula:C20H22N4O5Pureza:98%Forma y color:SolidPeso molecular:398.41FN-1501-propionic acid
CAS:FN-1501-propionic acid, a CDK2/9 ligand, in conjunction with a CRBN ligand, has been utilized in the design of a PROTAC CDK2/9 degrader.Fórmula:C25H27N9O4Pureza:98%Forma y color:SolidPeso molecular:517.5410-Methyl-10-deazaaminopterin
CAS:10-Methyl-10-deazaaminopterin is a folate analog that shows antitumor activity.Fórmula:C21H23N7O5Pureza:98%Forma y color:SolidPeso molecular:453.45N2-Ethylguanosine
CAS:N2-Ethylguanosine is a Nucleoside Derivative - 2-Modified purine nucleoside.Fórmula:C12H17N5O5Forma y color:SolidPeso molecular:311.29S-(N-PhenethylthiocarbaMoyl)-L-cysteine
CAS:PEITC-Cys: anticarcinogenic, antileukemic, inhibits DNA synthesis in HL60, P450 inhibitor.Fórmula:C12H16N2O2S2Forma y color:SolidPeso molecular:284.48-Deazahomofolic acid
CAS:8-Deazahomofolic acid is a potential thymidylate synthase (TS) inhibitor and other folate related enzymes inhibitor.Fórmula:C21H22N6O6Pureza:98%Forma y color:SolidPeso molecular:454.44CLT-28643
CAS:CLT-28643 is a specific α5β1-Integrin inhibitor that prevents fibrosis in GFS, inhibits tumor growth and angiogenesis, suppresses fibrosis and inflammation.Fórmula:C19H17N3O4Pureza:99.89%Forma y color:SolidPeso molecular:351.36Direct Black 38 free acid
CAS:Ferristatin II (Direct Black 38 free acid) is a polysulphonated dye and promotes the degradation of transferrin receptor-1 in vitro and in vivo.Fórmula:C34H27N9O7S2Pureza:98%Forma y color:SolidPeso molecular:737.77PFM03
CAS:PFM03 is a endonuclease inhibitor that specifically blocks Mre11,reduce MRN endonuclease activity, blocking hMRN-mediated endonucleotomy and nuclear exocytosis.Fórmula:C14H15NO2S2Pureza:99.81% - 99.98%Forma y color:SolidPeso molecular:293.4CRT5
CAS:CRT5, a selective PKD inhibitor, blocks VEGF effects on histone deacetylase 5, CREB, HSP27, and endothelial functions. IC50s: 1-2 nM for PKD1-3.Fórmula:C28H30N4O2Forma y color:SolidPeso molecular:454.56PF-2771
CAS:PF-2771: potent CENP-E inhibitor, IC50 of 16.1 nM, used in cancer treatment.Fórmula:C29H36ClN5O4Pureza:98%Forma y color:SolidPeso molecular:554.08Cyclapolin 9
CAS:Cyclapolin 9: Selective PLK1 inhibitor, IC50 500 nM, ATP-competitive, inactive against other kinases.Fórmula:C9H4F3N3O4SPureza:99.64%Forma y color:SolidPeso molecular:307.21Ref: TM-T22700
1mg96,00€5mg205,00€10mg319,00€25mg512,00€50mg707,00€100mg964,00€500mg1.935,00€1mL*10mM (DMSO)227,00€Clociguanil
CAS:Clociguanil has antimalarial activity.Fórmula:C12H15Cl2N5OForma y color:SolidPeso molecular:316.191-Methylcytosine
CAS:1-Methylcytosine (4-amino-1-methylpyrimidin-2(1H)-one) is a methylated form of the cytosine and can be used as the nucleobase of hachimoji DNA paired withFórmula:C5H7N3OPureza:99.88%Forma y color:SolidPeso molecular:125.13ANI-7
CAS:ANI-7, an AhR pathway activator, selectively impedes MCF-7 breast cancer cell growth (GI50: 0.56 μM).Fórmula:C13H8Cl2N2Pureza:99.07%Forma y color:SolidPeso molecular:263.12Ref: TM-T10325
5mg38,00€10mg62,00€25mg105,00€50mg164,00€100mg222,00€200mg330,00€1mL*10mM (DMSO)33,00€CAY10746
CAS:CAY10746 selectively inhibits ROCK I/II with IC50s: 0.014/0.003 μM, useful for diabetic retinopathy research.Fórmula:C26H23N3O5Pureza:99.71%Forma y color:SolidPeso molecular:457.48Ref: TM-T36196
2mg34,00€5mg54,00€10mg86,00€25mg172,00€50mg260,00€100mg411,00€200mg552,00€1mL*10mM (DMSO)54,00€FRα-IN-1
CAS:FRα-IN-1 (Compound 4) is a tumour targeting agent. FRα-IN-1 exhibits selective anti-cancer effects on FRα and FRβ expressing cells.Fórmula:C21H24N6O6Forma y color:SolidPeso molecular:456.45Metioprim
CAS:Metioprim is a competitive bacterial dihydrofolate reductases inhibitor.Fórmula:C14H18N4O2SPureza:98%Forma y color:SolidPeso molecular:306.38L-Cytidine
CAS:L-Cytidine, pyrimidine nucleoside in RNA, regulates glial glutamate, brain lipids, catecholamines, and mitochondria.Fórmula:C9H13N3O5Forma y color:SolidPeso molecular:243.22LY 222306
CAS:LY 222306 is a glycinamide ribonucleotide formyltransferase (GARFT) inhibitor with a Ki of 0.77 nM.Fórmula:C19H23N5O7Pureza:98%Forma y color:SolidPeso molecular:433.42GW8510
CAS:GW8510 is a CDK2 and RRM2 inhibitor that affects DNA synthesis and antiproliferation in tumor cells. In mammalian aging models, GW851 prolongs lifespan.Fórmula:C21H15N5O3S2Pureza:99.32%Forma y color:SolidPeso molecular:449.51IDD388
CAS:IDD388 is a selective and potent aldose reductase (ALR2) inhibitor with antitumor activity that inhibits the ALR1 receptor.Fórmula:C16H12BrClFNO4Pureza:99.56%Forma y color:SolidPeso molecular:416.63Ipivivint
CAS:Ipivivint: orally active, potent CLK inhibitor; hinders CLK1, CLK2, & CLK3; curbs Wnt signaling & SRSF phosphorylation for cancer research.Fórmula:C26H21FN8Forma y color:SolidPeso molecular:464.5CDK8-IN-6
CAS:CDK8-IN-6 (compound 9) is a potent inhibitor of cyclin-dependent kinase 8 (CDK8) (Kd: 13 nM), CDK8-IN-6 showed potential research value in AML cancers.Fórmula:C26H37ClN2Forma y color:SolidPeso molecular:413.04KH-CB19
CAS:KH-CB19 is an effective and highly specific inhibitor of the CDC2-like kinase isoforms 1 and 4 (CLK1/CLK4).Fórmula:C15H13Cl2N3O2Forma y color:SolidPeso molecular:338.19Ref: TM-T15657
2mgA consultar5mgA consultar25mgA consultar50mgA consultar100mgA consultar1mL*10mM (DMSO)A consultarLitronesib Racemate
CAS:Litronesib is a selective, allosteric inhibitor of kinesin Eg5.Litronesib (Racemate) is the racemate of litronesib.Fórmula:C23H37N5O4S2Forma y color:SolidPeso molecular:511.7GP29
CAS:GP29 is a Type II kinase inhibitor of the IRE1α endoribonuclease that acts by targeting the ATP-binding pocket of IRE1α.Fórmula:C33H28F3N5O3Pureza:98%Forma y color:SolidPeso molecular:599.6BI8622
CAS:BI8622 is a HUWE1 antagonist that restores levels of RP2 mutants in retinal cell lines and inhibits cellular activation of NLRP3 and AIM2 inflammatory vesicles.Fórmula:C25H26N6OPureza:98.28% - 98.28%Forma y color:SolidPeso molecular:426.51Enocitabine
CAS:Enocitabine is a nucleoside analog.Fórmula:C31H55N3O6Pureza:97.22%Forma y color:SolidPeso molecular:565.78BMVC2
CAS:BMVC2 (o-BMVC), a carbazole derivative of BMVC, is a G-quadruplex (G4) stabilizer.Fórmula:C28H25I2N3Forma y color:SolidPeso molecular:657.33BMH-22
CAS:BMH-22 is an RNA polymerase I inhibitor that acts by causing nucleolar stress and showing potent anticancer activity across many tumor types.Fórmula:C16H17N3Forma y color:SolidPeso molecular:251.33M443
CAS:M443 is a potent small molecule inhibitor of MRK that inhibits radiation-induced activation of p38 and Chk2 and can be used in cancer research.Fórmula:C31H30F3N7O2Pureza:98.95%Forma y color:SolidPeso molecular:589.61MMV688845
CAS:MMV688845: NTM RNA polymerase inhibitor, kills Mycobacterium abscessus, and fights TB.Fórmula:C24H25N3O3SForma y color:SolidPeso molecular:435.54HBV-IN-14
CAS:HBV-IN-14: a pyridinopyrimidinone, potent cccDNA inhibitor for HBV study (patent WO2021190502A1, comp 5).Fórmula:C22H21ClN2O5Forma y color:SolidPeso molecular:428.875,10-Dideazaaminopterin
CAS:5,10-Dideazaaminopterin is an antileukemic drug.Fórmula:C21H22N6O5Pureza:98%Forma y color:SolidPeso molecular:438.44Antibacterial agent 124
CAS:Antibacterial agent 124 inhibits Sa ProRS with an IC50 of 0.18 μM.Fórmula:C16H17ClFN3O2Forma y color:SolidPeso molecular:337.78FUBP1-IN-2
CAS:FUBP1-IN-2 hinders FUBP1, affects c-Myc and p21 expression, and depletes polyamines.Fórmula:C26H26ClN3O4Forma y color:SolidPeso molecular:479.96JA2131
CAS:JA2131: Small PARG inhibitor, IC50 0.4μM, induces DNA damage, stalls replication, kills cancer cells.Fórmula:C13H19N5O2S2Forma y color:SolidPeso molecular:341.45Poloxipan
CAS:Poloxipan inhibits PLK1 (IC50: 3.2µM), PLK2 (1.7µM), PLK3 (3µM); minimal effect on Chk2, STAT1, STAT5b, Lck.Fórmula:C14H10BrN3O3SForma y color:SolidPeso molecular:380.22DNA Gyrase-IN-4
CAS:DNA Gyrase-IN-4 inhibits DNA cyclooxygenase (IC50: 0.13 μM) and is effective against Salmonella and E. coli.Fórmula:C22H15Cl2NO4SForma y color:SolidPeso molecular:460.33BOP sodium
CAS:BOP sodium salt is an inhibitor of alpha9beta1 and alpha4beta1 integrin.Fórmula:C25H29N3NaO7SForma y color:SolidPeso molecular:538.57GSK317354A
CAS:GSK317354A is a GRK2 inhibitor.Fórmula:C25H18F4N6OForma y color:SolidPeso molecular:494.44SRPIN-803
CAS:SRPIN-803 is a selective dual SRPK1 and CK2 inhibitor.Fórmula:C14H9F3N4O3SPureza:98%Forma y color:SolidPeso molecular:370.31Aurora Kinases-IN-3
CAS:Aurora Kinases-IN-3 is an oral AURKB inhibitor that disrupts its mitotic localization, not its H3 Ser10 phosphorylation.Fórmula:C20H16F3N3O4Forma y color:SolidPeso molecular:419.35RSK-IN-1
CAS:RSK-IN-1 (compound 7d) shows anti-tumor activity. RSK-IN-1 is an inhibitor of RSK that inhibits the phosphorylation of YB-1 [1].Fórmula:C22H17NO2Forma y color:SolidPeso molecular:327.38Akt1&PKA-IN-1
CAS:Akt1&PKA-IN-1 inhibits Akt/PKA: IC50 = 0.03μM (PKAa), 0.11μM (Akt), 9.8μM (CDK2); selective for CDK2.Fórmula:C20H17Cl2N3OForma y color:SolidPeso molecular:386.27CRT-0105446
CAS:CRT-0105446 is an effective LIMK inhibitor that acts by suppressing cofilin phosphorylation and increasing αTubulin acetylation in cells.Fórmula:C20H18F3N3O2SPureza:98%Forma y color:SolidPeso molecular:421.44Crozbaciclib fumarate
CAS:Crozbaciclib fumarate is a CDK4/6 inhibitor with IC 50 s of 3 and 1 nM, respectively.Fórmula:C32H34F2N6O4Forma y color:SolidPeso molecular:604.65Dyrk1A-IN-5
CAS:Potent DYRK1A inhibitor with IC50s: 6 nM overall, 0.5 μM SF3B1, 2.1 μM tau phosphorylation. Useful for Down syndrome studies.Fórmula:C16H9IN2O2Forma y color:SolidPeso molecular:388.16Aurora kinase inhibitor-10
CAS:Aurora kinase inhibitor-10 is an orally active Aurora B inhibitor (IC50: 8 nM) that exhibits antitumour effects.Fórmula:C21H19F5N6O4SForma y color:SolidPeso molecular:546.47cp028
CAS:cp028 inhibits pre-mRNA splicing in vitro.Fórmula:C23H17FN2O4Forma y color:SolidPeso molecular:404.39TH470
CAS:TH470, a potent and highly selective inhibitor of LIM kinase 1/2 (LIMK1/2), demonstrates specificity with IC50 values of 9.8 nM for LIMK1 and 13 nM for LIMK2,Fórmula:C30H31N5O5S2Forma y color:SolidPeso molecular:605.73DHODH-IN-19
CAS:DHODH-IN-19, a strong DHODH blocker, may help treat cancer and inflammation. (Patent WO2021238881A1)Fórmula:C22H18ClF6N3O3Forma y color:SolidPeso molecular:521.84CAY10760
CAS:CAY10760 inhibits RAD51-BRCA2 interaction (EC50=19 μM), reduces homologous recombination by 54%, and hinders BxPC-3/Capan-1 cancer cell proliferation.Fórmula:C28H24ClN3O3Forma y color:SolidPeso molecular:485.96CDK4/6-IN-7
CAS:CDK4/6-IN-7 is an oral, potent CDK4/6 inhibitor with IC50s of 1.58/4.09 nM, crucial for breast cancer studies.Fórmula:C18H18ClN5O3Forma y color:SolidPeso molecular:387.82HBV-IN-21
CAS:HBV-IN-21 inhibits HBV DNA replication (IC50: 2.2 μM) and binds HBV capsid protein well (KD: 60.0 μM).Fórmula:C17H17FN4OS2Forma y color:SolidPeso molecular:376.47Edatrexate
CAS:Edatrexate (CGP 30694), a Methotrexate analog, combats MTX-resistant tumors and researches various cancers.Fórmula:C22H25N7O5Forma y color:SolidPeso molecular:467.48CB10-277
CAS:CB10-277 is a synthetic anti-cancer drug related to dacarbazine that alkylates DNA, inhibits DNA replication and repair, and may block DNA synthesis.Fórmula:C9H11N3O2Forma y color:SolidPeso molecular:193.2SP-471P
CAS:SP-471P inhibits DENV protease; EC50: DENV1-5.9 μM, DENV2-1.4 μM, DENV3-5.1 μM, DENV4-1.7 μM; CC50 >100 μM; lowers viral RNA synthesis.Fórmula:C33H26BrN5O2Forma y color:SolidPeso molecular:604.5Carbonic anhydrase inhibitor 14
CAS:CA inhibitor 14 blocks hCA I/II/IX/XII (K i of 1203/99.7/9.4/27.7 nM) and CDK2 (IC50: 20.3 μM), showing antitumor effects.Fórmula:C18H17N7O2SForma y color:SolidPeso molecular:395.44Crisnatol
CAS:Crisnatol (BWA770U) is an oral anticancer DNA intercalator, toxic to breast cancer cells, not skin fibroblasts.Fórmula:C23H23NO2Forma y color:SolidPeso molecular:345.43CDK7-IN-2
CAS:CDK7-IN-2 inhibits CDK7, essential for RNA polymerase II activation and cell cycle control, with cancer research potential.Fórmula:C26H39N7O3Forma y color:SolidPeso molecular:497.63FLDP-5
CAS:FLDP-5: BBB-penetrant curcuminoid, induces ROS, DNA damage, S phase arrest, suppresses tumors in LN-18 cells.Fórmula:C21H21NO5Forma y color:SolidPeso molecular:367.4CDK1-IN-1
CAS:CDK1-IN-7 inhibits CDK1 at 161.2 nM, triggers p53-dependent apoptosis, and selectively targets tumor growth.Fórmula:C27H23N5O3Forma y color:SolidPeso molecular:465.5Akt1&PKA-IN-2
CAS:Akt1&PKA-IN-2 ((R)-29) inhibits AKT1, PKAα, CDK2 with IC50s: 0.007, 0.01, 0.69 µM respectively.Fórmula:C20H17Cl2N3OForma y color:SolidPeso molecular:386.27JH-XIV-68-3
CAS:JH-XIV-68-3: Selective DYRK1A/B inhibitor; effective in HNSCC cell lines.Fórmula:C21H17F3N8OForma y color:SolidPeso molecular:454.41Cdc7-IN-17
CAS:Cdc7-IN-17 is a potent inhibitor of CDC7 with an IC 50 of <10 μM that can be used in cancer research [1].Fórmula:C13H15N5OSForma y color:SolidPeso molecular:289.36USP28-IN-2
CAS:USP28-IN-2 selectively inhibits USP28 (IC50=0.3 μM), degrades c-Myc, kills cancer cells, lowers ankyrin-1/2, and enhances Regorafenib effects.Fórmula:C23H20Cl2N2O3SForma y color:SolidPeso molecular:475.39ROCK-IN-4
CAS:ROCK-IN-4: Inhibits ROCK, sustains NO release, disrupts F-actin, hinders HTM cell respiration, aids glaucoma research.Fórmula:C20H26ClFN4O7SForma y color:SolidPeso molecular:520.96TCS 2314
CAS:TCS 2314, Selective VLA-4 antagonist (IC50=4.4 nM), high clearance/low oral bioavailability, for asthma research.Fórmula:C28H34N4O6Pureza:99.86%Forma y color:SolidPeso molecular:522.59Trimetrexate glucuronate
CAS:Trimetrexate glucuronate, a folic acid foe, blocks DNA/RNA synthesis by inhibiting purine and thymidylic acid production, may fight tumors.Fórmula:C25H33N5O10Forma y color:SolidPeso molecular:563.564CDK4/6-IN-14
CAS:CDK4/6-IN-14: potent CDK4/6 inhibitor, IC50s 10/16 nM, >60-fold selectivity over CDKs 1/2/7/9, selective across 205 kinases.Fórmula:C24H27ClFN7OForma y color:SolidPeso molecular:483.97CI-898 HCl
CAS:CI-898 HCl: lipophilic antifolate, DHFR inhibitor, effective on methotrexate-resistant cancers, synergizes with other drugs in advanced P338 leukemia.Fórmula:C19H26Cl3N5O3Forma y color:SolidPeso molecular:478.8XIE18-6
CAS:XIE18-6 is a novel INK4C inhibitor that blocks p18 activity and promotes ex vivo expansion of human and murine hematopoietic stem cells.Fórmula:C18H15NO6SPureza:99.712%Forma y color:SolidPeso molecular:373.38BA-1049
CAS:BA-1049 is a selective ROCK2 inhibitor.Fórmula:C16H21N3O2SForma y color:SolidPeso molecular:319.423'-Deoxyuridine-5'-triphosphate
CAS:3'-dUTP, a nucleotide analogue, competitively inhibits RNA polymerases I & II, with a Ki of 2.0 µM.Fórmula:C9H15N2O14P3Forma y color:SolidPeso molecular:468.14WF-536 Hydrochloride
CAS:WF-536 Hydrochloride, a novel inhibitor of ROCK, inhibits tumour metastasis in some animal models.Fórmula:C14H16ClN3OForma y color:SolidPeso molecular:277.75CDK8-IN-7
CAS:CDK8-IN-7 is a potent CDK8 inhibitor with a Kd of 3.5 nM, showing promise for AML research.Fórmula:C30H40N2Forma y color:SolidPeso molecular:428.65
