Ciclo celular / Checkpoint
Los inhibidores del ciclo celular/puntos de control son compuestos que interrumpen la progresión normal del ciclo celular, particularmente en puntos de control regulatorios clave. Estos inhibidores son cruciales para estudiar la división celular, comprender la proliferación de células cancerosas y desarrollar terapias anticancerígenas. Al dirigirse a fases específicas del ciclo celular, estos inhibidores pueden inducir la detención del ciclo celular, lo que lleva a apoptosis o senescencia en células de división rápida. En CymitQuimica, ofrecemos una amplia gama de inhibidores de alta calidad del ciclo celular/puntos de control para apoyar su investigación en biología del cáncer, biología celular y desarrollo de fármacos.
Subcategorías de "Ciclo celular / Checkpoint"
- Aurora quinasa(116 productos)
- CDK(548 productos)
- Detención del ciclo celular(5 productos)
- Chk(49 productos)
- DYRK(46 productos)
- Dynamin(27 productos)
- Ferroptosis(233 productos)
- HSP(180 productos)
- Integrin(278 productos)
- Kinesina(87 productos)
- LIM quinasa(21 productos)
- Asociado a microtúbulos(275 productos)
- PKC(128 productos)
- PLK(25 productos)
- ROCK(61 productos)
- Rho(6 productos)
- Wee1(14 productos)
- c-Myc(77 productos)
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Se han encontrado 3944 productos de "Ciclo celular / Checkpoint"
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Antitumor agent-75
Antitumor agent-75 is a novel and potent antitumor agent.Fórmula:C26H23FN6Forma y color:SolidPeso molecular:438.5OPN expression inhibitor 1
CAS:OPN expression inhibitor 1 is an osteopontin expression inhibitor used in the study of breast cancer metastasis.Fórmula:C25H33N3O5Pureza:99.78%Forma y color:SolidPeso molecular:455.55Ref: TM-T62820
1mg126,00€5mg258,00€1mL*10mM (DMSO)259,00€10mg385,00€25mg695,00€50mg1.009,00€100mg1.314,00€EX05
CAS:EX05, an effective KIF18A inhibitor, exhibits an IC50 of 8.2 nM and holds potential for cancer research applications.Fórmula:C26H30F2N4O5SForma y color:SolidPeso molecular:548.60AM-9022
CAS:AM-9022 is a potent and selective KIF18A inhibitor, orally active and suitable for cancer research [1].Fórmula:C27H36F2N6O4SForma y color:SolidPeso molecular:578.67Y-99
CAS:Y-99 is a PORCN inhibitor with an IC50 value of 155.4 nM for suppressing the Wnt/β-catenin signaling pathway. Additionally, Y-99 inhibits the expression of p-LRP6, β-catenin, and c-Myc.Fórmula:C18H17F2N5O3Forma y color:SolidPeso molecular:389.36Aurora A inhibitor 4
CAS:Aurora A inhibitor4 (compound C9) is a potent inhibitor of Aurora A, with GI50 values of 4.26 μM in DU 145 cells and 7.08 μM in HT-29 cells.Fórmula:C22H23N5O3Forma y color:SolidPeso molecular:405.45PARG-IN-7
CAS:PARG-IN-7 (Example 38) is a Poly ADP-ribose glycohydrolase (PARG) inhibitor with an IC50 of less than 0.1 μM. It reduces the viability of HCC1806-XRCC1 knockdown (KD) cells, exhibiting an IC50 of less than 1 μM. PARG-IN-7 is applicable in cancer research.Fórmula:C22H24F2N8O3S2Forma y color:SolidPeso molecular:550.61PNR-3-80
CAS:PNR-3-80 is a selective inhibitor of apoptotic endonuclease G (EndoG), with an IC50 of 0.67 μM, showing greater inhibition than against DNase I. It exhibits no inhibitory activity against DNase II, RNase A, proteases, lactate dehydrogenase, and superoxide dismutase 1. PNR-3-80 effectively protects human prostate cancer cells from cell death induced by Cisplatin and Docetaxel and inhibits DNA damage and autophagy (autophagy) prompted by Etoposide. This compound is applicable in studies of cellular damage.Fórmula:C24H14ClN3O3SForma y color:SolidPeso molecular:459.903'-NH2-CTP
CAS:3'-NH2-CTP is a nucleotide analog modified with an amino group at the 3' position of CTP.Fórmula:C9H17N4O13P3Forma y color:SolidPeso molecular:482.17Mitotic kinesin-IN-1 hydrochloride
CAS:Mitotic kinesin-IN-1 hydrochloride (Example 80) is an inhibitor of mitotic kinesin, which suppresses cell proliferation by hindering mitosis. This compound is applicable in research related to cancer, cardiac hypertrophy, immune and inflammatory diseases, and fungal infections.Fórmula:C22H26ClF2N3OSForma y color:SolidPeso molecular:453.98FR-145715
CAS:FR-145715 is a histamine H2 receptor antagonist characterized by its specific anti-Helicobacter pylori activity. This compound is utilized in the study of gastric lesions.Fórmula:C16H21N5O2SForma y color:SolidPeso molecular:347.44Protein kinase inhibitor 14
CAS:Protein kinase inhibitor 14 (Compound 13) exhibits inhibitory effects on various serine/threonine kinases and receptor/non-receptor tyrosine kinases.Fórmula:C22H22F2N6OForma y color:SolidPeso molecular:424.447Tizolemide
CAS:Tizolemide, a sulfonamide diuretic compound with alkaline properties, is cleared through the tubular transport system. It induces changes in the passive transport components across the basolateral membrane of isolated frog skin.Fórmula:C11H14ClN3O3S2Forma y color:SolidPeso molecular:335.83Eprociclovir Na
CAS:Eprociclovir Na (A-5021) is 15x stronger than acyclovir at inhibiting herpesviruses, showing promise for EHV1 and herpetic keratitis treatment.Fórmula:C11H14N5NaO3Forma y color:SolidPeso molecular:287.25Tetrahydrouridine dihydrate
THU dihydrate, a potent CDA inhibitor, outperforms cytidine by blocking the enzyme's active site.Fórmula:C9H20N2O8Forma y color:SolidPeso molecular:284.26GFB-12811
CAS:GFB-12811 is an orally active, selective, and potent CDK5 inhibitor, used in the study of autosomal dominant polycystic kidney disease.Fórmula:C22H23F4N5OPureza:98.88%Forma y color:SolidPeso molecular:449.44USP15-IN-1
CAS:USP15-IN-1 is a potent USP15 inhibitor (IC50 is 3.76 μM).Fórmula:C22H23N3O3Pureza:99.509% - 99.81%Forma y color:SolidPeso molecular:377.44Zelasudil
CAS:Zelasudil (RXC007) is a Rho-related (ROCK) kinase inhibitor for the study of idiopathic pulmonary fibrosis and inflammation.Fórmula:C22H21F2N7OPureza:99.15%Forma y color:SolidPeso molecular:437.445Ref: TM-T69665
1mg69,00€5mg147,00€1mL*10mM (DMSO)164,00€10mg224,00€25mg358,00€50mg512,00€100mg707,00€Elacytarabine
CAS:Elacytarabine (M7594 0037), a lipid-conjugated derivative of the nucleoside analog cytarabine, is an antineoplastic drug. It has cytotoxicity in solid tumors.Fórmula:C27H45N3O6Pureza:97.69%Forma y color:SolidPeso molecular:507.66CTPS1-IN-1
CAS:CTPS1-IN-1 is a cytidine-5′ triphosphate synthase 1 (CTPS1) inhibitor with potential antitumor activity and can be used to study autoimmune diseases.Fórmula:C21H22N6O4S2Pureza:99.46%Forma y color:SolidPeso molecular:486.57HRO761
CAS:HRO761 is a potent Werne r syndrome RecQ DNA deconjugase (WRN) inhibitor that can be used to study cancers such as colon and stomach cancer.Fórmula:C31H31ClF3N9O5Pureza:98.74% - 99.62%Forma y color:SolidPeso molecular:702.08Ref: TM-T72107
1mg57,00€5mg118,00€10mg167,00€25mg280,00€50mg475,00€100mg708,00€1mL*10mM (DMSO)778,00€VCPIP1-IN-1
CAS:VCPIP1-IN-1 is a VCPIP1 inhibitor used in cancer research.Fórmula:C13H15ClN2O2Pureza:99.3%Forma y color:SolidPeso molecular:266.72Ref: TM-T88664
1mg47,00€5mg92,00€1mL*10mM (DMSO)101,00€10mg145,00€25mg281,00€50mg447,00€100mg715,00€200mg964,00€LY3143921 hydrate
CAS:LY3143921 ((S)-Example 2) hydrate is an orally active CDC7 kinase inhibitor with broad in vitro anticancer activity [1].Fórmula:C16H14FN5O2Pureza:98.43%Forma y color:SolidPeso molecular:327.31SR 11302
CAS:SR 11302 is an inhibitor of activator protein-1 (AP-1).Fórmula:C26H32O2Pureza:98.65%Forma y color:SolidPeso molecular:376.53Ref: TM-T23384
1mg93,00€5mg137,00€1mL*10mM (DMSO)150,00€10mg205,00€25mg356,00€50mg587,00€100mg888,00€INCB086550
CAS:INCB086550 (PD-1/PD-L1-IN-8) (example 24) is a PD-1/PD-L1 inhibitor, with an IC50 <= 10 nM.Fórmula:C41H39N7O4Pureza:98.49%Forma y color:SolidPeso molecular:693.79Troxacitabine
CAS:Troxacitabine, a DNA polymerase inhibitor, is potentially used for the treatment of acute myeloid leukemia (AML). In comparison with gemcitabine, troxacitabine was equally active against MiaPaCa and was more efficacious against Panc-01.Fórmula:C8H11N3O4Pureza:98%Forma y color:SolidPeso molecular:213.19Bicyclomycin benzoate
CAS:Bicyclomycin benzoate (BCM benzoate, FR2054) is a broad-spectrum antibiotic and selective Rho protein inhibitor active against Gram-negative bacteria.Fórmula:C19H22N2O8Forma y color:SolidPeso molecular:406.395'-DMT-3'-TBDMS-ibu-rG
CAS:5'-DMT-3'-TBDMS-ibu-rG is a modified nucleoside employed in deoxyribonucleic acid (DNA) synthesis.Fórmula:C41H51N5O8SiForma y color:SolidPeso molecular:769.96N6-Benzoyl-5′-O-(4,4′-dimethoxytrityl)-2′-deoxyadenosine
CAS:N6-Benzoyl-5′-O-(4,4′-dimethoxytrityl)-2′-deoxyadenosine, catalog number T66118 and CAS number 64325-78-6, is a valuable organic compound for life sciences research.Fórmula:C38H35N5O6Forma y color:SolidPeso molecular:657.727PLK1-IN-6
PLK1-IN-6: potent, selective PLK1 inhibitor, IC50 = 0.45 nM, hinders cancer cell growth.
Fórmula:C28H37N9O3Forma y color:SolidPeso molecular:547.65GSK-3/CDK5/CDK2-IN-1
CAS:GSK-3/CDK5/CDK2-IN-1 is an imidazole derivative compound that inhibits cdk5, cdk2, and GSK-3.it has demonstrated applications in cancer research and the study of neurodegenerative diseases [1].Fórmula:C21H22N4O2Forma y color:SolidPeso molecular:362.433Tanuxiciclib
CAS:Tanuxiciclib is a cyclin dependent kinase (CDK) inhibitor, specifically designed to interfere with cell cycle progression by inhibiting the activity of CDKs, which are crucial regulators of cell division.Fórmula:C15H13FN6OForma y color:SolidPeso molecular:312.308Formycin A
CAS:Formycin A shows antitumor and antiviral activities. Formycin A , a purine nucleoside antibiotic, is a potent human immunodeficiency virus type 1 (HIV-1) inhibitor with an EC50 of 10 μM.Fórmula:C10H13N5O4Pureza:98%Forma y color:SolidPeso molecular:267.24NSC639828
CAS:NSC639828 is an efficient inhibitor of DNA polymerase α, exhibiting a remarkable IC50 value of 70 μM. Additionally, NSC639828 demonstrates substantial antitumor activity, making it a promising candidate for cancer research.Fórmula:C18H13BrClN5O3Forma y color:SolidPeso molecular:462.695'-O-DMT-N6-ibu-dA
CAS:5'-O-DMT-N6-ibu-dA can be utilized in the synthesis of oligodeoxyribonucleotides.Fórmula:C35H37N5O6Forma y color:SolidPeso molecular:623.712'-Deoxy-2'-fluoro-5-iodouridine
CAS:2'-Deoxy-2'-fluoro-5-iodouridine is a nucleoside, specifically a fluoro-modified and halo-nucleoside.Fórmula:C9H10FIN2O5Forma y color:SolidPeso molecular:372.09Ethynylcytidine
CAS:Ethynylcytidine is a nucleoside antimetabolite.Fórmula:C11H13N3O5Pureza:98%Forma y color:SolidPeso molecular:267.243BrB-PP1
CAS:3BrB-PP1 is an ATP-competitive analog that exhibits specific inhibitory activity towards protein kinase, particularly effective against protein kinases with mutations in the ATP-binding pocket, such as the Thr97 mutation within Sty1's ATP-binding pocket.Fórmula:C16H18BrN5Forma y color:SolidPeso molecular:360.259MitoE10
CAS:MitoE10 is an effective mitochondrial targeting antioxidant.Fórmula:C42H55O5PSForma y color:SolidPeso molecular:702.926-Amino-5-nitropyridin-2-one
CAS:6-Amino-5-nitropyridin-2-one, a pyridine derivative, serves as a nucleobase within hachimoji DNA, where it is specifically paired with 5-aza-7-deazaguanine.Fórmula:C5H5N3O3Pureza:98%Forma y color:SolidPeso molecular:155.11Ribocil-C
CAS:Ribocil-C is a selective inhibitor of the bacterial riboflavin riboswitch, a synthetic analogue of flavin mononucleotide (FMN), inhibits bacterial cell growth.Fórmula:C21H21N7OSPureza:99.69%Forma y color:SolidPeso molecular:419.5Tibremciclib
CAS:Tibremciclib is a cyclin-dependent kinase 4 (CDK4) inhibitor that exhibits antineoplastic properties [1].
Fórmula:C28H32F2N8Pureza:98%Forma y color:SolidPeso molecular:518.6PHI-101
CAS:PHI-101 is a checkpoint kinase 2 (Chk2) inhibitor that can be used for the study of refractory acute myeloid leukemia (AML) and ovarian cancer.
Fórmula:C19H19FN4O2SPureza:99.4%Forma y color:SolidPeso molecular:386.44YK-2168
CAS:YK-2168 is a differentiated selective inhibitor of CDK9.
Fórmula:C16H18ClN5Forma y color:SolidPeso molecular:315.80Ref: TM-T200769
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