Ciclo celular / Checkpoint
Los inhibidores del ciclo celular/puntos de control son compuestos que interrumpen la progresión normal del ciclo celular, particularmente en puntos de control regulatorios clave. Estos inhibidores son cruciales para estudiar la división celular, comprender la proliferación de células cancerosas y desarrollar terapias anticancerígenas. Al dirigirse a fases específicas del ciclo celular, estos inhibidores pueden inducir la detención del ciclo celular, lo que lleva a apoptosis o senescencia en células de división rápida. En CymitQuimica, ofrecemos una amplia gama de inhibidores de alta calidad del ciclo celular/puntos de control para apoyar su investigación en biología del cáncer, biología celular y desarrollo de fármacos.
Subcategorías de "Ciclo celular / Checkpoint"
- Aurora quinasa(114 productos)
- CDK(543 productos)
- Detención del ciclo celular(5 productos)
- Chk(47 productos)
- DYRK(48 productos)
- Dynamin(27 productos)
- Ferroptosis(226 productos)
- HSP(179 productos)
- Integrin(229 productos)
- Kinesina(88 productos)
- LIM quinasa(20 productos)
- Asociado a microtúbulos(273 productos)
- PKC(119 productos)
- PLK(25 productos)
- ROCK(63 productos)
- Rho(6 productos)
- Wee1(14 productos)
- c-Myc(76 productos)
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Se han encontrado 3828 productos de "Ciclo celular / Checkpoint"
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Kinesore
CAS:Kinesore is a cell-permeable modulator that binds to the microtubule motor protein kinesin-1, thereby inhibiting the interaction between KLC2 and SKIP.Fórmula:C20H16Br2N4O4Pureza:97.24%Forma y color:SolidPeso molecular:536.17Ref: TM-T15663
2mg39,00€5mg58,00€10mg93,00€25mg150,00€50mg219,00€100mg329,00€200mg494,00€1mL*10mM (DMSO)70,00€5'-O-DMT-N2-ibu-dG
CAS:5'-O-DMT-N2-ibu-dG is a deoxynucleoside served as a building block in oligonucleotide synthesis, with protecting groups to prevent unwanted reactions.Fórmula:C35H37N5O7Pureza:98.71%Forma y color:SolidPeso molecular:639.78-Bromoadenosine
CAS:8-Bromoadenosine is an adenosine derivative. 8-Br-Adenosine inhibitis mitochondrial membrane potential, cytoplasmic Ca²⁺ levels, and RNA and protein synthesis.Fórmula:C10H12BrN5O4Pureza:99.11%Forma y color:SolidPeso molecular:346.14NSC 23766
CAS:NSC 23766 is a Rac1 GTPase inhibitor by targeting GEFs, inhibiting cell proliferation.NSC23766 competitively inhibits M2 mAChR-induced Rac1 activation.Fórmula:C24H35N7Pureza:99.49%Forma y color:SolidPeso molecular:421.58N2-Isobutyryl-2-deoxyguanosine
CAS:N2-Isobutyryl-2-deoxyguanosine（iBu-dG） is a nucleoside analog that can be used to synthesize oligonucleotides.Fórmula:C14H19N5O5Pureza:97.03%Forma y color:SolidPeso molecular:337.33APE1-IN-1
CAS:APE1-IN-1 is a purine/pyrimidine-free endonuclease 1 inhibitor with potential antitumor activity that enhances the toxicity of alkylating agents on cancer cellsFórmula:C19H21N3OS2Pureza:98.5%Forma y color:SolidPeso molecular:371.52PD 407824
CAS:PD 407824 is a chemical BMP sensitiser that promotes increased cellular sensitivity to subthreshold amounts of BMP4.PD 407824 is a potent inhibitor of the checkpoint kinases Chk1 and WEE1 (IC50s: 47 and 97 nM, respectively).Fórmula:C20H12N2O3Pureza:98.02%Forma y color:SolidPeso molecular:328.322'-O-Methyl-5-iodouridine
CAS:2'-O-Methyl-5-iodouridine (5-Iodo-2'-O-methyluridine) is a purine nucleoside analog that targets malignant tumors of the inert lymphatic system and possesses a
Fórmula:C10H13IN2O6Pureza:99.89%Forma y color:SolidPeso molecular:384.12TG003
CAS:TG003 is a Clk1/Sty inhibitor that inhibits Clk1 and Clk4, suppresses cancer cell growth, and induces apoptosis.Fórmula:C13H15NO2SPureza:99.46%Forma y color:SolidPeso molecular:249.33Ref: TM-T60367
1mg48,00€5mg92,00€10mg150,00€25mg266,00€50mg440,00€100mg530,00€200mg767,00€1mL*10mM (DMSO)167,00€Triazavirin
CAS:Triazavirin is a nucleoside analogue of nucleic acid and an antiviral agent.Fórmula:C5H7N6NaO5SPureza:99.55%Forma y color:SolidPeso molecular:286.2MTOB
CAS:MTOB, a CtBP substrate, inhibits CtBP-linked cancer activity in cells/mice and regulates TCF-4, affecting CSC proliferation.Fórmula:C5H7NaO3SPureza:98.23%Forma y color:SolidPeso molecular:170.16FEN1-IN-SC13
CAS:FEN1-IN-SC13 is a potent inhibitor of DNA fragmentation endonuclease 1 (FEN1)
Fórmula:C24H23N3O3SPureza:98.02%Forma y color:SolidPeso molecular:433.52Mps1-IN-3 hydrochloride
Mps1-IN-3 HCl: potent Mps1 inhibitor (IC50: 50 nM), hampers glioblastoma growth, enhances vincristine efficacy in vivo.Fórmula:C26H32ClN7O4SForma y color:SolidPeso molecular:574.09Piritrexim isethionate
CAS:Piritrexim isethionate, a fat-soluble DHFR inhibitor, shows efficacy in metastatic urothelial cancer with a 5-day oral regimen.Fórmula:C19H25N5O6SForma y color:SolidPeso molecular:451.49PNU112455A hydrochloride
CAS:PNU112455A hydrochloride is an ATP site competetive inhibitor of CDK2 and CDK5,binds to the ATP site of CDK2 and CDK5 with Kms of 3.6 and 3.2 μM, respectively.Fórmula:C10H12ClN5O2SPureza:98.58% - 99.22%Forma y color:SolidPeso molecular:301.75Ref: TM-T8230
2mg44,00€5mg71,00€10mg100,00€25mg172,00€50mg266,00€100mg434,00€500mg964,00€1mL*10mM (DMSO)79,00€BMS-3
CAS:BMS-3 is a potent LIMK inhibitor with IC50s of 5 nM and 6 nM for LIMK1 and LIMK2, respectively.Fórmula:C17H12Cl2F2N4OSPureza:99.31% - 99.81%Forma y color:SolidPeso molecular:429.27MSC2530818
CAS:MSC2530818 is an effective, selective and orally available CDK8 inhibitor (IC50: 2.6 nM).Fórmula:C18H17ClN4OPureza:98.93%Forma y color:SolidPeso molecular:340.81Ref: TM-TQ0266
1mg63,00€5mg137,00€10mg215,00€25mg462,00€50mg692,00€100mg964,00€1mL*10mM (DMSO)150,00€TCS7010
CAS:TCS7010 (Aurora A Inhibitor I) is a novel, potent, and selective inhibitor of Aurora A with IC50 of 3.4 nM in a cell-free assay.Fórmula:C31H31ClFN7O2Pureza:98.49% - 99.62%Forma y color:SolidPeso molecular:588.076-O-Methyl Guanosine
CAS:6-O-Methyl Guanosine inhibit colony-forming ability in a malignant xeroderma pigmentosum cell line.Fórmula:C11H15N5O5Pureza:97.5%Forma y color:SolidPeso molecular:297.27Roniciclib
CAS:Roniciclib (BAY 1000394) is a potent pan-CDK inhibitor and a novel oral cytotoxic agent. Roniciclib inhibits the activity of cell-cycle CDKs CDK1, CDK2, CDK3, CDK4, and of transcriptional CDKs CDK7 and CDK9 with IC(50) values in the range between 5 and 25 nmol/L.Fórmula:C18H21F3N4O3SPureza:98% - 98.63%Forma y color:SolidPeso molecular:430.44
