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Ciclo celular / Checkpoint

Ciclo celular / Checkpoint

Los inhibidores del ciclo celular/puntos de control son compuestos que interrumpen la progresión normal del ciclo celular, particularmente en puntos de control regulatorios clave. Estos inhibidores son cruciales para estudiar la división celular, comprender la proliferación de células cancerosas y desarrollar terapias anticancerígenas. Al dirigirse a fases específicas del ciclo celular, estos inhibidores pueden inducir la detención del ciclo celular, lo que lleva a apoptosis o senescencia en células de división rápida. En CymitQuimica, ofrecemos una amplia gama de inhibidores de alta calidad del ciclo celular/puntos de control para apoyar su investigación en biología del cáncer, biología celular y desarrollo de fármacos.

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Se han encontrado 3486 productos de "Ciclo celular / Checkpoint"

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  • LN-439A
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    LN-439A

    CAS:
    <p>LN-439A (compound LN-439A) is a novel BAP1 inhibitor that suppresses the growth of basal-like breast cancer by degrading KLF5.</p>
    Fórmula:C24H26FN3O4
    Forma y color:Solid
    Peso molecular:439.48

    Ref: TM-T200435

  • β-catenin-IN-8
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    β-catenin-IN-8

    CAS:
    <p>β-catenin-IN-8 (Compound 25) is an inhibitor of β-catenin. It effectively lowers the levels of both β-catenin and c-Myc proteins and suppresses Wnt target genes (Fgf20 and Sall4). Additionally, β-catenin-IN-8 exhibits anticancer activity against colorectal cancer and possesses metabolic stability.</p>
    Fórmula:C15H12ClN3O2S
    Forma y color:Solid
    Peso molecular:333.79

    Ref: TM-T201581

  • HNC-1664
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    HNC-1664

    CAS:
    <p>HNC-1664 is an orally active inhibitor of RNA-dependent RNA polymerase (RdRP). It exhibits broad-spectrum antiviral activity against coronaviruses, including SARS-CoV-2 wild type and its variants (XBB.1.18, HK.3.1, BF.7.14, BA.1, HCoV-229E, HCoV-OC43), as well as arenaviruses. HNC-1664 also demonstrates anti-infective efficacy in a mouse model infected with the SARS-CoV-2 Delta variant.</p>
    Fórmula:C12H13FIN3O3
    Forma y color:Solid
    Peso molecular:393.153

    Ref: TM-T205157

  • BET/Aurora kinase-IN-1
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    BET/Aurora kinase-IN-1

    CAS:
    <p>BET/Aurora kinase-IN-1 (Compound 38) is a dual inhibitor of BET and Aurora kinases. It exhibits antiproliferative activity against various tumor cell lines and demonstrates significant antitumor efficacy in xenograft models of renal cell carcinoma and colon cancer, with tumor growth inhibition (TGI) rates of 45.99% and 53.06%, respectively.</p>
    Fórmula:C25H30FN7O
    Forma y color:Solid
    Peso molecular:463.55

    Ref: TM-T205073

  • CDK7-IN-31
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    CDK7-IN-31

    CAS:
    <p>CDK7-IN-31 (compound 13) is an effective and orally active inhibitor of cyclin-dependent kinase 7 (CDK7) with a dissociation constant (Kd) of 0.18 nM. This compound exhibits anticancer activity.</p>
    Fórmula:C27H32F5N6O2P
    Forma y color:Solid
    Peso molecular:598.55

    Ref: TM-T201665

  • CDK6-IN-1
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    CDK6-IN-1

    CAS:
    <p>CDK6-IN-1 (compound 4i) is an inhibitor of CDK6 that suppresses cell growth and induces cell cycle arrest at the G1 phase.</p>
    Fórmula:C30H23N5
    Forma y color:Solid
    Peso molecular:453.54

    Ref: TM-T201591

  • SCH-1473759
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    SCH-1473759

    CAS:
    <p>SCH-1473759 is an inhibitor of the aurora (IC50s: 4 and 13 nM for Aurora A and B, respectively).</p>
    Fórmula:C20H26N8OS
    Pureza:98%
    Forma y color:Solid
    Peso molecular:426.54

    Ref: TM-T16862

  • Dencatistat
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    Dencatistat

    CAS:
    <p>Dencatistat is a highly selective and oral cytidine triphosphate synthase 1 CTPS1 inhibitor specific.CTPS1-IN-2 for B-cell, T-cell lymphomas and solid tumors.</p>
    Fórmula:C24H27N7O5S
    Pureza:98.85%
    Forma y color:Solid
    Peso molecular:525.58

    Ref: TM-T86106

  • BRD4 Inhibitor-40
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    BRD4 Inhibitor-40

    CAS:
    <p>BRD4 Inhibitor-40 (Compound 23) functions as an inhibitor of BRD, effectively targeting BRD4-BD1, BRD4-BD2, BRD2-BD1, and BRD2-BD2, with IC50 values of 16.1, 142.18, 29.35, and 302.35 nM, respectively. It modulates the expression of c-Myc and p21, induces cell cycle arrest in the G1 phase, and inhibits Pkd1-deficient (PN) renal cystic epithelial cells. Additionally, it prevents renal cyst formation in both Madin-Darby canine kidney and embryonic kidney cyst models, and demonstrates renal cyst inhibition activity in mouse models.</p>
    Fórmula:C27H32N8O
    Forma y color:Solid
    Peso molecular:484.596

    Ref: TM-T205510

  • EFdA-TP tetrasodium
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    EFdA-TP tetrasodium

    CAS:
    <p>EFdA-TP tetrasodium is a potent HIV-1 inhibitor that blocks DNA synthesis as an ICT or DCT.</p>
    Fórmula:C12H11FN5Na4O12P3
    Pureza:98%
    Forma y color:Solid
    Peso molecular:621.12

    Ref: TM-T72461

  • CDK9-IN-38
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    CDK9-IN-38

    CAS:
    <p>CDK9-IN-38 (compound 14) is a CDK9 inhibitor with IC50 values of 1.2 nM for wild-type CDK9 and 3.3 nM for the L156F mutant. It effectively inhibits tumor growth both in vitro and in vivo.</p>
    Fórmula:C22H23N5O3S
    Forma y color:Solid
    Peso molecular:437.515

    Ref: TM-T206913

  • DNA Gyrase-IN-16
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    DNA Gyrase-IN-16

    CAS:
    <p>DNA Gyrase-IN-16 (Compound 9) is an inhibitor of DNA gyrase, with an IC50 of 1.609 μM. It exhibits antibacterial properties, effectively inhibiting S. aureus and MRSA, with a MIC of 3.125 μM for both.</p>
    Fórmula:C17H15N3O3
    Forma y color:Solid
    Peso molecular:309.319

    Ref: TM-T205315

  • KWR095
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    KWR095

    CAS:
    <p>KWR095 is an orally active inhibitor of WRN, demonstrating an IC50 of 0.032 μM against WRN ATPase. It disrupts the double-stranded helicase activity of WRN and inhibits tumor cell proliferation, exhibiting antitumor properties.</p>
    Fórmula:C33H31ClF3N9O4
    Forma y color:Solid
    Peso molecular:710.105

    Ref: TM-T205595

  • Aurora A inhibitor 1
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    Aurora A inhibitor 1

    CAS:
    <p>Aurora A inhibitor 1: potent, selective, targets cancer-linked Aurora A overexpression, potential for cancer research. (WO2021147974A1, 49)</p>
    Fórmula:C25H28ClF2N5O2
    Forma y color:Solid
    Peso molecular:503.97

    Ref: TM-T63436

  • CDK7-IN-18
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    CDK7-IN-18

    CAS:
    <p>CDK7-IN-18: potent, pyrimidine-based CDK7 inhibitor with cancer research potential.</p>
    Fórmula:C22H24F3N7OS
    Forma y color:Solid
    Peso molecular:491.53

    Ref: TM-T63301

  • LY309887
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    LY309887

    CAS:
    <p>LY309887 is a potent inhibitor of glycinamide ribonucleotide formyltransferase (Ki: 6.5 nM). It also has antitumor activity.</p>
    Fórmula:C19H23N5O6S
    Forma y color:Solid
    Peso molecular:449.48

    Ref: TM-T15813

  • (Rac)-Plevitrexed
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    (Rac)-Plevitrexed

    CAS:
    <p>(Rac)-Plevitrexed is a racemate of Plevitrexed. Plevitrexed is an orally active and potent inhibitor of thymidylate synthase (TS).</p>
    Fórmula:C26H25FN8O4
    Pureza:98%
    Forma y color:Solid
    Peso molecular:532.53

    Ref: TM-T12674

  • (R)-Atuveciclib
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    (R)-Atuveciclib

    CAS:
    <p>Atuveciclib (BAY-1143572) is a potent and highly selective, oral PTEFb / CDK9 inhibitor that inhibits CDK9 / CycT1 with an IC 50 of 13 nM [1].</p>
    Fórmula:C18H18FN5O2S
    Pureza:98%
    Forma y color:Solid
    Peso molecular:387.43

    Ref: TM-T10464

  • ATIC-IN-2
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    ATIC-IN-2

    CAS:
    <p>ATIC-IN-2 (Compound 1) is a competitive inhibitor of the bifunctional enzyme AICAR Tfase/IMPCH (ATIC), binding to inosine monophosphate cyclohydrolase (IMPCH) with a Ki of 0.13 μM.</p>
    Fórmula:C4H4N4O3S
    Forma y color:Solid
    Peso molecular:188.165

    Ref: TM-T204433

  • CDK4/6-IN-24
    Targetmol
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    CDK4/6-IN-24

    CAS:
    <p>CDK4/6-IN-24 (Compound A) is an inhibitor of CDK4/6 with broad-spectrum antitumor activity. It can effectively inhibit various cancer cells, exhibiting an IC50 in the submicromolar range.</p>
    Fórmula:C32H41N7O3
    Forma y color:Solid
    Peso molecular:571.713

    Ref: TM-T205628