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Ciclo celular / Checkpoint

Ciclo celular / Checkpoint

Los inhibidores del ciclo celular/puntos de control son compuestos que interrumpen la progresión normal del ciclo celular, particularmente en puntos de control regulatorios clave. Estos inhibidores son cruciales para estudiar la división celular, comprender la proliferación de células cancerosas y desarrollar terapias anticancerígenas. Al dirigirse a fases específicas del ciclo celular, estos inhibidores pueden inducir la detención del ciclo celular, lo que lleva a apoptosis o senescencia en células de división rápida. En CymitQuimica, ofrecemos una amplia gama de inhibidores de alta calidad del ciclo celular/puntos de control para apoyar su investigación en biología del cáncer, biología celular y desarrollo de fármacos.

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Se han encontrado 3486 productos de "Ciclo celular / Checkpoint"

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  • CB 30900
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    CB 30900

    CAS:
    <p>CB30900 is a novel and effective thymidylate synthase inhibitor.</p>
    Fórmula:C31H32FN5O9
    Forma y color:Solid
    Peso molecular:637.61

    Ref: TM-T30760

  • MU1409
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    MU1409

    CAS:
    <p>MU1409 is an MRE11 nuclease inhibitor with an IC50 of 12.1 μM. It also inhibits FEN1 and EXO1, with IC50 values of 24.2 μM and 176.4 μM, respectively. MU1409 impacts cellular DNA repair and prevents the degradation of stalled replication forks in BRCA2-deficient cells, making it a promising candidate for studying BRCA2 mutation-induced cancers.</p>
    Fórmula:C20H14BrN3O3S
    Forma y color:Solid
    Peso molecular:456.312

    Ref: TM-T205338

  • NSC 641396
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    NSC 641396

    CAS:
    <p>NSC 641396 is a ribonucleotide reductase (RNR) inhibitor with an IC50 value of 1.2 μM. Additionally, it acts as an inhibitor of protein arginine N-methyltransferase 9 (PRMT9) and exhibits antitumor properties.</p>
    Fórmula:C18H13NO3
    Forma y color:Solid
    Peso molecular:291.301

    Ref: TM-T204449

  • TREX1-IN-4
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    TREX1-IN-4

    CAS:
    <p>TREX1-IN-4 (Compound 96) is an inhibitor of TREX1 and TREX2, exhibiting an IC50 of less than 0.1 μM for TREX1 and an IC50 of less than 1 μM for TREX2. It has an EC50 ranging from 0.1 to 10 μM in HCT116 cells. TREX1-IN-4 is applicable for research in the field of cancer.</p>
    Fórmula:C24H19ClN6O4
    Forma y color:Solid
    Peso molecular:490.898

    Ref: TM-T205208

  • Glycyl H-1152 hydrochloride
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    Glycyl H-1152 hydrochloride

    CAS:
    <p>Glycyl-H-1152 is a potent ROCK-II inhibitor (IC50=11.8 nM) with high selectivity over CaMKII, PKG, Aurora A, PKA, and PKC. Better than Y-27632 and HA-1077.</p>
    Fórmula:C18H26Cl2N4O3S
    Forma y color:Solid
    Peso molecular:449.39

    Ref: TM-T35459

  • Haspin-IN-2
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    Haspin-IN-2

    CAS:
    <p>Haspin-IN-2 is a potent haspin inhibitor (IC50: 50 nM) and also inhibits CLK1 (IC50: 445 nM) and DYRK1A (IC50: 917 nM).</p>
    Fórmula:C12H8N4O3
    Forma y color:Solid
    Peso molecular:256.22

    Ref: TM-T60394

  • 2'-O-MOE-GTP
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    2'-O-MOE-GTP

    CAS:
    <p>2'-O-MOE-GTP is a nucleotide analog utilized in the synthesis of oligonucleotides.</p>
    Fórmula:C13H22N5O15P3
    Forma y color:Solid
    Peso molecular:581.26

    Ref: TM-TSW-00970

  • CTX-712
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    CTX-712

    CAS:
    <p>CTX-712 is a potent inhibitor of cdc2-like kinase ( CLK ). CTX-712 inhibits inhibits cancer survival and cancer cell growth.</p>
    Fórmula:C19H17FN8O2
    Forma y color:Solid
    Peso molecular:408.39

    Ref: TM-T62049

  • DL-Alanosine
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    DL-Alanosine

    CAS:
    <p>DL-Alanosine is an amino acid analog with antitumor activity.</p>
    Fórmula:C3H7N3O4
    Forma y color:Solid
    Peso molecular:149.105

    Ref: TM-T205451

  • Zeltociclib
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    Zeltociclib

    CAS:
    <p>Zeltociclib is an inhibitor of cyclin-dependent kinases (CDKs) with anti-tumor properties.</p>
    Fórmula:C18H20F3N4O2P
    Forma y color:Solid
    Peso molecular:412.346

    Ref: TM-T205641

  • Cdc7-IN-10
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    Cdc7-IN-10

    CAS:
    <p>Cdc7-IN-10 is a potent inhibitor of Cdc7 (IC50 ≤ 1 nM) and can be used in studies of proliferative diseases.</p>
    Fórmula:C20H22F2N4O2S
    Forma y color:Solid
    Peso molecular:420.48

    Ref: TM-T62230

  • HPH-15
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    HPH-15

    CAS:
    <p>HPH-15 is an anti-cell migration compound that inhibits cell movement by binding to hnRNP U or suppressing TGF-β. Additionally, it prevents epithelial-to-mesenchymal transition (EMT). HPH-15 holds potential for research in areas such as anti-tumor metastasis and anti-fibrosis.</p>
    Fórmula:C19H31N3S4
    Forma y color:Solid
    Peso molecular:429.73

    Ref: TM-T205327

  • TREX1-IN-3
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    TREX1-IN-3

    CAS:
    <p>TREX1-IN-3 (Compound 95) is an inhibitor of TREX1 and TREX2, with an IC50 of less than 0.1 μM for TREX1 and less than 1 μM for TREX2, as well as an EC50 of less than 1 μM for HCT116 cells. It is applicable for research in the field of cancer.</p>
    Fórmula:C24H19ClN6O4
    Forma y color:Solid
    Peso molecular:490.898

    Ref: TM-T205254

  • MU147
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    MU147

    CAS:
    <p>MU147 is an MRE11 nuclease inhibitor and chemical probe with anticancer properties, exhibiting lethal effects on Ehrlich ascites tumor cells both in vivo and in vitro. It disrupts the MRE11 nuclease-dependent double-strand break repair mechanism without impairing ATM activation. Additionally, MU147 damages the degradation of nascent strands at stalled replication forks and selectively affects BRCA2-deficient cells.</p>
    Fórmula:C19H13N3O3S
    Forma y color:Solid
    Peso molecular:363.39

    Ref: TM-T205293

  • Logo de CymitQuimica
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    Aurora/LIM kinase-IN-1

    <p>Aurora/LIM kinase-IN-1 (Compound F114) is a dual inhibitor targeting aurora and lim kinases, potentially useful in GBM cancer treatment efforts.</p>
    Fórmula:C16H20N6O
    Forma y color:Solid
    Peso molecular:312.37

    Ref: TM-T60783

  • Cdc7-IN-8
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    Cdc7-IN-8

    CAS:
    <p>Cdc7-IN-8, inhibits Cdc7 kinase, key in DNA replication, and is promising for cancer research. (WO2021032170A1)</p>
    Fórmula:C19H21N5O2
    Forma y color:Solid
    Peso molecular:351.40

    Ref: TM-T61224

  • CDK2-IN-40
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    CDK2-IN-40

    CAS:
    <p>CDK9-IN-40 is an inhibitor of CDK2 (Cyclin-dependent kinase 2). It effectively inhibits CDK2/Cyclin E1, with an IC50 of ≤ 10 nM.</p>
    Fórmula:C16H21N7O2
    Forma y color:Solid
    Peso molecular:343.384

    Ref: TM-T205452

  • CDK2-IN-39
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    CDK2-IN-39

    CAS:
    <p>CDK2-IN-39 (compound 4) is a CDK2 inhibitor.</p>
    Fórmula:C14H15N3O4S
    Forma y color:Solid
    Peso molecular:321.352

    Ref: TM-T204890

  • Logo de CymitQuimica
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    Anticancer agent 29

    <p>Compound E/Z-6f, anticancer, IC50: CDK2 (0.054 μM), CDK1 (0.127 μM), CDK4 (0.129 μM), CDK6 (0.396 μM).</p>
    Fórmula:C22H15ClFNO
    Forma y color:Solid
    Peso molecular:363.81

    Ref: TM-T61378

  • GR 122222X
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    GR 122222X

    CAS:
    <p>GR 122222X is an inhibitor of topoisomerase II.</p>
    Fórmula:C26H35N5O11S
    Pureza:98%
    Forma y color:Solid
    Peso molecular:625.65

    Ref: TM-T24100